UY29115A1 - Un procedimiento para fabricar compuestos enantiomericos del imidazol - Google Patents

Un procedimiento para fabricar compuestos enantiomericos del imidazol

Info

Publication number
UY29115A1
UY29115A1 UY29115A UY29115A UY29115A1 UY 29115 A1 UY29115 A1 UY 29115A1 UY 29115 A UY29115 A UY 29115A UY 29115 A UY29115 A UY 29115A UY 29115 A1 UY29115 A1 UY 29115A1
Authority
UY
Uruguay
Prior art keywords
imidazol
procedure
manufacturing
enantiomeric compounds
sertaconazole mononitrate
Prior art date
Application number
UY29115A
Other languages
English (en)
Inventor
Ines Petschen
Xavier Camps
Juan Sallares
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35614444&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY29115(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of UY29115A1 publication Critical patent/UY29115A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

El procedimiento de la presente invención consiste en la reacción por transferencia de fase de R-(-)-1-(2,4-diclorofenil)-2-((IH-imidazol-l-il)-etanol con un 3-halometil-7-clorobenzo(b)tiofeno catalizda por una sal de tetrabutilamonio en tolueno y en presencia de una base fuerte, seguido de tratamiento con ácido nítrico y posteriormente con acetona, con lo que se obtiene el R-sertaconazol mononitrato hemiacetonato, el cual or calentamiento proorciona el R-sertaconazol mononitrato.
UY29115A 2004-09-13 2005-09-13 Un procedimiento para fabricar compuestos enantiomericos del imidazol UY29115A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200402184A ES2249992B1 (es) 2004-09-13 2004-09-13 Un procedimiento para fabricar compuestos enantiomericos del imidazol.

Publications (1)

Publication Number Publication Date
UY29115A1 true UY29115A1 (es) 2005-11-30

Family

ID=35614444

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29115A UY29115A1 (es) 2004-09-13 2005-09-13 Un procedimiento para fabricar compuestos enantiomericos del imidazol

Country Status (24)

Country Link
US (1) US7626038B2 (es)
EP (1) EP1794152B1 (es)
JP (1) JP5048500B2 (es)
KR (1) KR100903922B1 (es)
CN (1) CN101023077B (es)
AR (1) AR050931A1 (es)
AT (1) ATE402171T1 (es)
AU (1) AU2005284330B2 (es)
BR (1) BRPI0515259A (es)
CA (1) CA2577247C (es)
DE (1) DE602005008454D1 (es)
DK (1) DK1794152T3 (es)
ES (1) ES2249992B1 (es)
HK (1) HK1105416A1 (es)
MX (1) MX2007002939A (es)
NO (1) NO20071817L (es)
PA (1) PA8645501A1 (es)
PE (1) PE20060720A1 (es)
PL (1) PL1794152T3 (es)
PT (1) PT1794152E (es)
RU (1) RU2413728C2 (es)
TW (1) TWI405760B (es)
UY (1) UY29115A1 (es)
WO (1) WO2006029811A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8635593B2 (en) * 2008-05-13 2014-01-21 Hewlett-Packard Development Company, L.P. Dynamic autocompletion tool
CN112595803A (zh) * 2020-12-31 2021-04-02 海南海神同洲制药有限公司 一种硝酸舍他康唑乳膏的鉴别方法
CN113501814A (zh) * 2021-07-30 2021-10-15 海南海神同洲制药有限公司 一种硝酸舍他康唑的纯化方法
CN113501815A (zh) * 2021-07-30 2021-10-15 海南海神同洲制药有限公司 一种硝酸舍他康唑晶型的制备方法
CN113480517B (zh) * 2021-07-30 2022-09-09 海南海神同洲制药有限公司 3-溴甲基-7-氯苯并[b]噻吩的合成方法
CN113816947A (zh) * 2021-08-25 2021-12-21 海南海神同洲制药有限公司 一种硝酸舍他康唑的重结晶方法
CN113735843B (zh) * 2021-09-07 2023-05-26 海南海神同洲制药有限公司 一种低熔点硝酸舍他康唑的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1096361B (it) 1978-05-18 1985-08-26 Recordati Chem Pharm Dibenzileteri sostituiti terapeuticamente attivi
JPS57169466A (en) * 1981-04-14 1982-10-19 Ota Seiyaku Kk Preparation of imidazole derivative
ES8504779A1 (es) * 1984-02-02 1985-05-01 Ferrer Int Procedimiento de obtencion de nuevos derivados de 1h-imidazol
CA1250586A (en) 1984-02-02 1989-02-28 Manuel Raga 1h-imidazole derivatives and process for their production
US5135943A (en) * 1984-02-02 1992-08-04 Ferrer Internacional S.A. 1H-imidazole derivative compounds and pharmaceutical compositions containing the same
EP0748806B1 (en) * 1995-01-04 1998-07-08 Ferrer Internacional, S.A. PROCESS FOR PREPARING POLYMORPHS B AND C OF 1- 2,4-DICHLORO-BETA-[(7-CHLOROBENZO[b]THIEN-3-YL)METHOXY]PHENETYL]IMIDAZOLE MONONITRATE
CZ20012338A3 (cs) * 1998-12-24 2001-12-12 Fujisawa Pharmaceutical Co., Ltd. Imidazolové sloučeniny
CN1191250C (zh) * 2001-09-26 2005-03-02 河北省药物研究所 一种硝酸舍他康唑的合成方法
ES2203316B1 (es) * 2002-02-11 2005-03-01 Ferrer Internacional, S.A. R-(-)-1-(2-(7-cloro-benzo(b)tiofen-3-il-metoxi)-2-(2,4-dicloro-fenil)-etil)1h-imidazol.

Also Published As

Publication number Publication date
MX2007002939A (es) 2007-04-27
BRPI0515259A (pt) 2008-07-15
CA2577247A1 (en) 2006-03-23
AU2005284330B2 (en) 2011-01-06
EP1794152A1 (en) 2007-06-13
KR100903922B1 (ko) 2009-06-19
CN101023077B (zh) 2012-05-23
AR050931A1 (es) 2006-12-06
KR20070042206A (ko) 2007-04-20
US20080108682A1 (en) 2008-05-08
EP1794152B1 (en) 2008-07-23
ES2249992A1 (es) 2006-04-01
PE20060720A1 (es) 2006-07-11
AU2005284330A1 (en) 2006-03-23
RU2007113921A (ru) 2008-10-20
DE602005008454D1 (de) 2008-09-04
CA2577247C (en) 2011-07-05
HK1105416A1 (en) 2008-02-15
PT1794152E (pt) 2008-10-24
ATE402171T1 (de) 2008-08-15
CN101023077A (zh) 2007-08-22
JP5048500B2 (ja) 2012-10-17
JP2008512421A (ja) 2008-04-24
US7626038B2 (en) 2009-12-01
PL1794152T3 (pl) 2008-12-31
WO2006029811A1 (en) 2006-03-23
DK1794152T3 (da) 2008-11-17
NO20071817L (no) 2007-05-16
TW200621756A (en) 2006-07-01
TWI405760B (zh) 2013-08-21
RU2413728C2 (ru) 2011-03-10
ES2249992B1 (es) 2007-03-01
PA8645501A1 (es) 2006-05-16

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