BRPI0413081B8 - processo para produzir o cloridrato do composto imida - Google Patents
processo para produzir o cloridrato do composto imidaInfo
- Publication number
- BRPI0413081B8 BRPI0413081B8 BRPI0413081A BRPI0413081A BRPI0413081B8 BR PI0413081 B8 BRPI0413081 B8 BR PI0413081B8 BR PI0413081 A BRPI0413081 A BR PI0413081A BR PI0413081 A BRPI0413081 A BR PI0413081A BR PI0413081 B8 BRPI0413081 B8 BR PI0413081B8
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- imide compound
- hydrochloride
- formula
- compound hydrochloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
"processo para a produção de composto imida". a presente invenção refere-se a um processo industrial excelente para produzir um cloridrato de composto imida. o processo para produzir um cloridrato de composto imida da fórmula (2): ou um enantiômero do mesmo, que compreende tratar um composto da fórmula (1): ou um enantiômero do mesmo com uma solução aquosa de ácido clorídrico em um solvente hidrofílico, e em seguida cristalizar o produto resultante.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003281860 | 2003-07-29 | ||
JP2003-281860 | 2003-07-29 | ||
PCT/JP2004/011035 WO2005009999A1 (ja) | 2003-07-29 | 2004-07-27 | イミド化合物の製造方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0413081A BRPI0413081A (pt) | 2006-10-03 |
BRPI0413081B1 BRPI0413081B1 (pt) | 2018-03-20 |
BRPI0413081B8 true BRPI0413081B8 (pt) | 2021-05-25 |
Family
ID=34100970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413081A BRPI0413081B8 (pt) | 2003-07-29 | 2004-07-27 | processo para produzir o cloridrato do composto imida |
Country Status (12)
Country | Link |
---|---|
US (2) | USRE45573E1 (pt) |
EP (1) | EP1652848B1 (pt) |
JP (1) | JP4610485B2 (pt) |
KR (1) | KR101085806B1 (pt) |
CN (1) | CN100422178C (pt) |
AT (1) | ATE543817T1 (pt) |
AU (1) | AU2004259305B2 (pt) |
BR (1) | BRPI0413081B8 (pt) |
CA (1) | CA2538265C (pt) |
DK (1) | DK1652848T3 (pt) |
ES (1) | ES2378990T3 (pt) |
WO (1) | WO2005009999A1 (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2390353T3 (es) * | 2005-06-13 | 2012-11-12 | Dainippon Sumitomo Pharma Co., Ltd. | Preparación de disolución |
US8252799B2 (en) | 2007-04-04 | 2012-08-28 | Merck Sharp & Dohme Corp. | Hexahydro-1H-4,7-methanoisoindole-1,3-dione compounds |
WO2011093522A1 (en) * | 2010-01-28 | 2011-08-04 | Dainippon Sumitomo Pharma Co., Ltd. | A cycloalkane derivative |
ES2594709T3 (es) | 2010-04-26 | 2016-12-22 | Sumitomo Dainippon Pharma Co., Ltd. | Un proceso de preparación de una sal de amonio cuaternario |
CN103249416B (zh) * | 2010-10-18 | 2019-06-04 | 大日本住友制药株式会社 | 注射用缓释制剂 |
WO2012107890A2 (en) * | 2011-02-10 | 2012-08-16 | Ranbaxy Laboratories Limited | Crystalline forms of lurasidone hydrochloride |
WO2012123858A1 (en) * | 2011-03-14 | 2012-09-20 | Ranbaxy Laboratories Limited | Amorphous lurasidone hydrochloride |
WO2013014665A1 (en) | 2011-07-28 | 2013-01-31 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of lurasidone and salts thereof |
CZ304027B6 (cs) * | 2011-08-18 | 2013-08-28 | Farmak, A. S. | Zpusob prípravy polymorfu (1R,2S,3R,4S)-N-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl]-1-cyklohexylmethyl]-2,3-bicyklo[2.2.1]heptandikarboximidu hydrochloridu |
CN102952064A (zh) * | 2011-08-19 | 2013-03-06 | 天津药物研究院 | 一种医药中间体顺式-外-二环[2.2.1]庚烷-2.3-二甲酰亚胺的制备方法 |
WO2013030722A1 (en) | 2011-08-26 | 2013-03-07 | Ranbaxy Laboratories Limited | Crystalline lurasidone hydrochloride |
CN103130795A (zh) * | 2011-12-02 | 2013-06-05 | 苏州二叶制药有限公司 | 卢拉西酮盐酸盐的晶体a及其用途 |
CN103130794B (zh) * | 2011-12-02 | 2016-06-22 | 苏州二叶制药有限公司 | 卢拉西酮盐酸盐的晶体a的制备方法 |
US9409899B2 (en) | 2012-02-13 | 2016-08-09 | Cadila Healthcare Limited | Process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclo hexylmethanisoindol-1,3-dione and its intermediates |
CN103360383B (zh) * | 2012-04-11 | 2016-07-06 | 上海医药工业研究院 | 鲁拉西酮盐酸盐的晶型b及其制备方法 |
CN102746289B (zh) * | 2012-04-28 | 2016-06-08 | 上海医药工业研究院 | 一种盐酸卢拉西酮的制备方法 |
WO2013190455A2 (en) * | 2012-06-18 | 2013-12-27 | Shasun Pharmaceuticals Limited | Process for the preparation of lurasidone hydrochloride |
CN102863437A (zh) * | 2012-09-04 | 2013-01-09 | 济南百诺医药科技开发有限公司 | 一种鲁拉西酮的制备方法 |
WO2014064714A2 (en) * | 2012-10-22 | 2014-05-01 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of lurasidone hydrochloride |
CN102911170A (zh) * | 2012-11-15 | 2013-02-06 | 苏州第壹制药有限公司 | 酰亚胺化合物盐酸盐的制备方法 |
CN105524057A (zh) * | 2013-03-06 | 2016-04-27 | 江苏恩华药业股份有限公司 | 盐酸鲁拉西酮的新晶型及其制备方法 |
CN103539794A (zh) * | 2013-10-17 | 2014-01-29 | 常州大学 | 一种盐酸鲁拉西酮的成盐方法 |
CZ306203B6 (cs) * | 2013-12-06 | 2016-09-29 | Zentiva, K. S | Způsob syntézy lurasidonu |
SI3154967T1 (sl) | 2014-06-16 | 2020-11-30 | Johnson Matthey Public Limited Company, | Postopki za pripravo alkiliranih arilpiperazinskih in alkiliranih arilpiperidinskih spojin, ki vključujejo nove intermediate |
WO2016059649A1 (en) | 2014-10-14 | 2016-04-21 | Jubilant Generics Limited (Formerly Jubilant Life Sciences Division) | An improved process for the preparation of lurasidone hydrochloride |
EP3760206A4 (en) | 2018-02-28 | 2021-11-03 | Sumitomo Dainippon Pharma Co., Ltd. | AQUEOUS SUSPENSION TYPE PHARMACEUTICAL PREPARATION WITH CONTROLLED DISSOLUTION |
JPWO2019167977A1 (ja) | 2018-02-28 | 2021-02-04 | 大日本住友製薬株式会社 | 水性懸濁型医薬製剤 |
CN115950695B (zh) * | 2021-10-09 | 2023-07-28 | 北京阳光诺和药物研究股份有限公司 | 一种制备鲁拉西酮基毒杂质的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS517440A (pt) * | 1974-07-08 | 1976-01-21 | Japan Storage Battery Co Ltd | |
JPS57197265A (en) | 1981-05-29 | 1982-12-03 | Eisai Co Ltd | Carboxylic acid imide derivative, its preparation and medicament containing the same |
AU615966B2 (en) * | 1987-12-04 | 1991-10-17 | Takeda Chemical Industries Ltd. | Crystals of cephem hydrochloride |
JP2800953B2 (ja) * | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
US5663381A (en) * | 1995-04-21 | 1997-09-02 | Hexal Pharmaceuticals, Inc. | Process for preparing form 1 ranitidine hydrochloride |
US6673942B1 (en) * | 2000-02-11 | 2004-01-06 | Degussa Ag | Resolution of DL-racemic mixtures |
AU2001246861A1 (en) * | 2000-04-10 | 2001-10-23 | Sumitomo Pharmaceuticals Co. Ltd. | Sustained release preparations |
JP2004517112A (ja) * | 2001-01-02 | 2004-06-10 | ファルマシア・アンド・アップジョン・カンパニー | 新規薬物コンビネーション |
-
2004
- 2004-07-27 ES ES04748182T patent/ES2378990T3/es active Active
- 2004-07-27 US US14/137,464 patent/USRE45573E1/en active Active
- 2004-07-27 KR KR1020067001255A patent/KR101085806B1/ko active IP Right Grant
- 2004-07-27 BR BRPI0413081A patent/BRPI0413081B8/pt active IP Right Grant
- 2004-07-27 CN CNB2004800221687A patent/CN100422178C/zh active Active
- 2004-07-27 WO PCT/JP2004/011035 patent/WO2005009999A1/ja active Application Filing
- 2004-07-27 EP EP04748182A patent/EP1652848B1/en active Active
- 2004-07-27 US US10/565,105 patent/US7605260B2/en active Active
- 2004-07-27 JP JP2005512110A patent/JP4610485B2/ja active Active
- 2004-07-27 AT AT04748182T patent/ATE543817T1/de active
- 2004-07-27 CA CA2538265A patent/CA2538265C/en active Active
- 2004-07-27 AU AU2004259305A patent/AU2004259305B2/en active Active
- 2004-07-27 DK DK04748182.5T patent/DK1652848T3/da active
Also Published As
Publication number | Publication date |
---|---|
US20060194970A1 (en) | 2006-08-31 |
CN1832946A (zh) | 2006-09-13 |
JPWO2005009999A1 (ja) | 2006-09-07 |
WO2005009999A1 (ja) | 2005-02-03 |
DK1652848T3 (da) | 2012-02-27 |
BRPI0413081A (pt) | 2006-10-03 |
CA2538265A1 (en) | 2005-02-03 |
BRPI0413081B1 (pt) | 2018-03-20 |
ATE543817T1 (de) | 2012-02-15 |
EP1652848A1 (en) | 2006-05-03 |
EP1652848A4 (en) | 2009-04-15 |
US7605260B2 (en) | 2009-10-20 |
KR20060052840A (ko) | 2006-05-19 |
AU2004259305A1 (en) | 2005-02-03 |
CA2538265C (en) | 2012-10-02 |
USRE45573E1 (en) | 2015-06-23 |
ES2378990T3 (es) | 2012-04-19 |
EP1652848B1 (en) | 2012-02-01 |
AU2004259305B2 (en) | 2009-06-04 |
JP4610485B2 (ja) | 2011-01-12 |
KR101085806B1 (ko) | 2011-11-22 |
CN100422178C (zh) | 2008-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B25D | Requested change of name of applicant approved |
Owner name: SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/03/2018, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/07/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B25D | Requested change of name of applicant approved | ||
B25G | Requested change of headquarter approved |