US6410561B1 - Amide derivatives and nociceptin antagonists - Google Patents

Amide derivatives and nociceptin antagonists Download PDF

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Publication number
US6410561B1
US6410561B1 US09/646,781 US64678100A US6410561B1 US 6410561 B1 US6410561 B1 US 6410561B1 US 64678100 A US64678100 A US 64678100A US 6410561 B1 US6410561 B1 US 6410561B1
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US
United States
Prior art keywords
methyl
amino
quinolyl
benzamide hydrochloride
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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US09/646,781
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English (en)
Inventor
Hisashi Shinkai
Takao Ito
Hideki Yamada
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Japan Tobacco Inc
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Japan Tobacco Inc
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Assigned to JAPAN TOBACCO INC. reassignment JAPAN TOBACCO INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ITO, TAKAO, SHINKAI, HISASHI, YAMADA, HIDEKI
Priority to US10/141,866 priority Critical patent/US6903094B2/en
Application granted granted Critical
Publication of US6410561B1 publication Critical patent/US6410561B1/en
Priority to US11/145,169 priority patent/US20060030565A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
US09/646,781 1998-03-26 1999-03-23 Amide derivatives and nociceptin antagonists Expired - Fee Related US6410561B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/141,866 US6903094B2 (en) 1998-03-26 2002-05-10 Amide derivatives and nociceptin antagonists
US11/145,169 US20060030565A1 (en) 1998-03-26 2005-06-06 Amide derivatives and nociceptin antagonists

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10-100029 1998-03-26
JP10002998 1998-03-26
PCT/JP1999/001462 WO1999048492A1 (fr) 1998-03-26 1999-03-23 Derives d'amide et antagonistes de nociceptine

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/001462 A-371-Of-International WO1999048492A1 (fr) 1998-03-26 1999-03-23 Derives d'amide et antagonistes de nociceptine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/141,866 Division US6903094B2 (en) 1998-03-26 2002-05-10 Amide derivatives and nociceptin antagonists

Publications (1)

Publication Number Publication Date
US6410561B1 true US6410561B1 (en) 2002-06-25

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US09/646,781 Expired - Fee Related US6410561B1 (en) 1998-03-26 1999-03-23 Amide derivatives and nociceptin antagonists
US10/141,866 Expired - Fee Related US6903094B2 (en) 1998-03-26 2002-05-10 Amide derivatives and nociceptin antagonists
US11/145,169 Abandoned US20060030565A1 (en) 1998-03-26 2005-06-06 Amide derivatives and nociceptin antagonists

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US11/145,169 Abandoned US20060030565A1 (en) 1998-03-26 2005-06-06 Amide derivatives and nociceptin antagonists

Country Status (21)

Country Link
US (3) US6410561B1 (zh)
EP (1) EP1072263A4 (zh)
KR (1) KR20010042161A (zh)
CN (1) CN1301154A (zh)
AR (1) AR018168A1 (zh)
AU (1) AU754716B2 (zh)
BR (1) BR9909666A (zh)
CA (1) CA2325638A1 (zh)
CO (1) CO5080780A1 (zh)
FI (1) FI20002103A (zh)
HU (1) HUP0101275A3 (zh)
ID (1) ID26099A (zh)
IL (1) IL138573A0 (zh)
NO (1) NO20004778L (zh)
NZ (1) NZ507760A (zh)
RU (1) RU2202344C2 (zh)
SK (1) SK14272000A3 (zh)
TR (1) TR200003598T2 (zh)
TW (1) TW487571B (zh)
WO (1) WO1999048492A1 (zh)
ZA (1) ZA200005881B (zh)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040092513A1 (en) * 2002-08-07 2004-05-13 Aventis Pharma Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
WO2004063330A2 (en) 2003-01-06 2004-07-29 Osi Pharmaceuticals, Inc. (2-carboxamido) (3-amino) thiophene compounds
US20050026942A1 (en) * 2000-09-15 2005-02-03 Anormed Chemokine receptor binding heterocyclic compounds
US20050026915A1 (en) * 2001-11-27 2005-02-03 Devita Robert J. 2-Aminoquinoline compounds
US20050119308A1 (en) * 2002-03-29 2005-06-02 Koji Teshima Remedy for sleep disturbance
US20050154014A1 (en) * 2003-01-06 2005-07-14 Jason Bloxham (2-carboxamido)(3-amino) thiophene compounds
US20070287751A1 (en) * 2004-03-12 2007-12-13 De La Torre Marta G Opioid Receptor Antagonists
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US20090176838A1 (en) * 2006-01-30 2009-07-09 Purdue Pharma L.P. Cyclourea Compounds as Calcium Channel Blockers
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US8722731B2 (en) 2010-06-07 2014-05-13 Novomedix, Llc Furanyl compounds and the use thereof
US8895606B2 (en) 2010-08-24 2014-11-25 Actelion Pharmaceuticals Ltd. Proline sulfonamide derivatives as orexin receptor antagonists
US9458161B1 (en) 2011-11-03 2016-10-04 Vanderblit University TSPO ligands for cancer imaging and treatment
WO2019020248A1 (de) * 2017-07-24 2019-01-31 Beiersdorf Ag Verwendung von n-(4-amino-2-methylchinolin-6-yl)-2-((4-ethylphenoxy)methyl)benzamid zur herstellung von kosmetischen oder dermatologischen zubereitungen zur behandlung und/oder prophylaxe der symptome der intrinsischen und/oder extrinsischen hautalterung sowie zur behandlung und prophylaxe der schädlichen auswirkungen ultravioletter strahlung auf die haut

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2369695A1 (en) * 1999-04-09 2000-10-19 Manabu Itoh Agent for treating neuropathic pain
WO2001039775A1 (en) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Benzimidazole compounds having nociceptin receptor affinity
WO2001039767A1 (en) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Tertiary amino compounds having opioid receptor affinity
DE60033071T2 (de) 1999-12-06 2007-08-23 Euro-Celtique S.A. Triazospiroverbindungen mit nociceptin-rezeptoraffinität
DE19963175A1 (de) * 1999-12-27 2001-07-12 Gruenenthal Gmbh Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel
AU2001244688A1 (en) * 2000-03-31 2001-10-08 Nippon Shinyaku Co. Ltd. Heterocycle derivatives and drugs
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
WO2002026714A1 (fr) * 2000-09-27 2002-04-04 Takeda Chemical Industries, Ltd. Composes spiraniques
SE0004054D0 (sv) 2000-11-06 2000-11-06 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
SE0004053D0 (sv) 2000-11-06 2000-11-06 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
WO2002040019A1 (fr) 2000-11-15 2002-05-23 Banyu Pharmaceutical Co.,Ltd. Derives benzimidazoles
AU2002218535A1 (en) * 2000-12-12 2002-06-24 Japan Tobacco Inc. Pharmaceutical composition containing an active with a hemolytic action and a surfactant
RU2003130752A (ru) * 2001-03-19 2005-03-10 Ниппон Синяку Ко., Лтд. (Jp) Противозудные средства
MXPA03009602A (es) 2001-04-18 2004-04-02 Euro Celtique Sa Analogos de nociceptina.
HUP0401333A3 (en) 2001-04-18 2004-11-29 Euro Celtique Sa Spiropyrazole compounds and pharmaceutical compositions containing them
ES2316559T3 (es) 2001-04-18 2009-04-16 Euro-Celtique S.A. Compuestos espiroindeno y espiroindano.
EP1918279A3 (en) 2001-04-18 2008-07-16 Euro-Celtique S.A. 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2-one derivatives and related compounds as nociceptin analogs and opioid receptor like receptor (orl1) ligands for the treatment of pain
DK1975164T3 (da) 2001-04-18 2010-05-25 Euro Celtique Sa Octahydrobenzimidazolon-forbindelser som analgetika
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US7049287B2 (en) 2001-10-09 2006-05-23 Synvax, Inc. Nociceptin-based analgesics
US7235558B2 (en) * 2002-06-06 2007-06-26 Sanofi-Aventis Deutschland Gmbh Inhibitors of the GPIb—vWF interaction, their preparation and use
EP1388342A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
AU2004241213B2 (en) 2003-05-21 2009-04-23 Banyu Pharmaceutical Co., Ltd. 2-aminoquinoline derivative
US7932272B2 (en) 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
AR046276A1 (es) 2003-10-07 2005-11-30 Renovis Inc Derivados de amida como ligandos de canales ionicos y composiciones farmaceuticas y metodos que los utilizan.
JP2007509059A (ja) 2003-10-16 2007-04-12 カイロン コーポレイション 癌の処置のためのＲａｆキナーゼのインヒビターとしての、２，６−二置換キナゾリン、キノキサリン、キノリンおよびイソキノリン
EP1568698A1 (en) * 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Pyrrole-derivatives as factor Xa inhibitors
WO2005121255A1 (ja) 2004-06-09 2005-12-22 Kaneka Corporation 硬化性組成物
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US7829585B2 (en) 2005-03-30 2010-11-09 Eisai R&D Management Co., Ltd. Antifungal agent containing pyridine derivative
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
WO2008023333A2 (en) * 2006-08-22 2008-02-28 Ranbaxy Laboratories Limited Process for the preparation of 4-(isobutylamino)-3-amino-quinoline
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
WO2009129301A2 (en) * 2008-04-15 2009-10-22 Schering Corporation Oral pharmaceutical compositions in a molecular solid dispersion
PT2326651E (pt) 2008-07-30 2014-02-12 Purdue Pharma Lp Análogos de buprenorfina
EP2483254B1 (en) 2009-09-29 2014-08-13 Glaxo Group Limited Novel compounds
DK2619212T3 (en) 2010-09-21 2016-03-21 Purdue Pharma Lp BUPRENORPHINANALOGER AS opioid receptor agonists and / or antagonists
AU2012324012A1 (en) 2011-12-08 2013-06-27 Purdue Pharma L.P. Quaternized buprenorphine analogs
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US20150210646A1 (en) 2012-05-11 2015-07-30 Purdue Pharma L.P. Benzomorphan compounds as opioid receptors modulators
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WO2014131847A1 (en) 2013-02-28 2014-09-04 Janssen R&D Ireland Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
WO2014165128A2 (en) 2013-03-12 2014-10-09 Novira Therapeutics, Inc. Hepatitis b antiviral agents
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
BR112015025052A2 (pt) 2013-04-03 2021-07-06 Janssen Sciences Ireland Uc derivados de n-fenil-carboxamida e o seu uso como medicamentos para o tratamento da hepatite b
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EP3357906B1 (en) 2013-07-25 2019-12-04 Janssen Sciences Ireland Unlimited Company Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
MX368158B (es) 2013-10-23 2019-09-20 Janssen Sciences Ireland Uc Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9181288B2 (en) 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
WO2015120178A1 (en) 2014-02-05 2015-08-13 Novira Therapeutics, Inc. Combination therapy for treatment of hbv infections
CN105980378B (zh) 2014-02-06 2019-09-27 爱尔兰詹森科学公司 氨磺酰基吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途
EA201691728A1 (ru) 2014-02-25 2017-02-28 Ачиллион Фармасьютикалс, Инк. Соединения с эфирными группами для лечения опосредованных комплементом нарушений
US9400280B2 (en) 2014-03-27 2016-07-26 Novira Therapeutics, Inc. Piperidine derivatives and methods of treating hepatitis B infections
US9975854B2 (en) 2014-05-06 2018-05-22 Purdue Pharma L.P. Benzomorphan analogs and use thereof
WO2016003886A1 (en) * 2014-07-02 2016-01-07 Lam Therapeutics, Inc. 4-aminoquinoline compositions and methods for using same
GB201416754D0 (en) 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
CN107847762A (zh) 2015-03-19 2018-03-27 诺维拉治疗公司 氮杂环辛烷和氮杂环壬烷衍生物以及治疗乙型肝炎感染的方法
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
US10000516B2 (en) 2015-08-26 2018-06-19 Achillion Pharmaceuticals, Inc. Phosphonate compounds for treatment of medical disorders
WO2017035351A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amino compounds for treatment of medical disorders
AR105808A1 (es) 2015-08-26 2017-11-08 Achillion Pharmaceuticals Inc Compuestos de amida para el tratamiento de trastornos médicos
WO2017035361A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Disubstituted compounds for the treatment of medical disorders
WO2017035401A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amide compounds for treatment of immune and inflammatory disorders
EP3340983B1 (en) 2015-08-26 2023-10-04 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR105809A1 (es) 2015-08-26 2017-11-08 Achillion Pharmaceuticals Inc Compuestos para el tratamiento de trastornos médicos
WO2017035405A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amino compounds for treatment of immune and inflammatory disorders
WO2017035355A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Ether compounds for treatment of medical disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
EP3356328A1 (en) 2015-09-29 2018-08-08 Novira Therapeutics, Inc. Crystalline forms of a hepatitis b antiviral agent
CN105461623A (zh) * 2015-12-29 2016-04-06 江苏理工学院 4-氨基-6-硝基-3-溴喹啉合成方法
SG11201808949SA (en) 2016-04-15 2018-11-29 Novira Therapeutics Inc Combinations and methods comprising a capsid assembly inhibitor
WO2018005552A1 (en) 2016-06-27 2018-01-04 Achillion Pharmaceuticals, Inc. Quinazoline and indole compounds to treat medical disorders
EP3589287B1 (en) 2017-03-01 2022-09-14 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for treatment of medical disorders
AU2018227849B2 (en) 2017-03-01 2022-04-28 Achillion Pharmaceuticals, Inc. Aryl, heteroary, and heterocyclic pharmaceutical compounds for treatment of medical disorders
WO2018160891A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceutical, Inc. Pharmaceutical compounds for treatment of medical disorders
AU2019235522A1 (en) 2018-03-14 2020-09-03 Janssen Sciences Ireland Unlimited Company Capsid assembly modulator dosing regimen
WO2020041301A1 (en) 2018-08-20 2020-02-27 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
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KR20220044753A (ko) * 2019-07-25 2022-04-11 큐라데브 파마 프라이버트 리미티드 아세틸 조효소 a 신테타제 단쇄 2(acss2)의 소분자 억제제

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5473784A (en) 1977-11-07 1979-06-13 Leo Pharm Prod Ltd Substituted quinolylguanidine derivatives and their manufacture and use
JPS59210084A (ja) 1983-04-06 1984-11-28 キエシ・フアルマチエウチチ・エツセ・ピ・ア 抗炎症作用を有する化合物、その製法およびそれを有効成分とする医薬
JPS62503030A (ja) 1985-05-07 1987-12-03 アルカロイダ　ベギエスゼテイ　ギヤル トリアゾリルキノリン誘導体
JPS6399069A (ja) 1985-10-18 1988-04-30 Shionogi & Co Ltd 縮合イミダゾピリジン誘導体
US4753951A (en) 1985-10-18 1988-06-28 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives useful as psychotropic agents
EP0277794A2 (en) 1987-02-02 1988-08-10 Ohmeda Pharmaceutical Products Division Inc. N-heterocyclic-N-(4-piperidyl) amides
JPH02167265A (ja) 1988-09-30 1990-06-27 Chugai Pharmaceut Co Ltd 新規な３，４―ジアミノキノリン及びピリジン系化合物
EP0381422A1 (en) 1989-02-02 1990-08-08 Yamanouchi Pharmaceutical Co. Ltd. Tetrahydrobenzimidazole derivatives
US5019574A (en) 1988-09-30 1991-05-28 Chugai Seiyaku Kabushiki Kaisha 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function
JPH07252228A (ja) 1994-02-07 1995-10-03 Fujisawa Pharmaceut Co Ltd キノリン誘導体
WO1996011930A1 (en) 1994-10-18 1996-04-25 Smithkline Beecham P.L.C. Cns-active pyridinylurea derivatives
WO1996013485A1 (en) 1994-10-27 1996-05-09 Fujisawa Pharmaceutical Co., Ltd. Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists
WO1997014681A1 (en) 1995-10-16 1997-04-24 Fujisawa Pharmaceutical Co., Ltd. Heterocyclic compounds as h+-atpases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE590239C (de) * 1931-08-19 1933-12-28 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von quaternaeren Abkoemmlingen heterocyclischer Stickstoffverbindungen
DE947552C (de) * 1944-04-18 1956-09-06 Hoechst Ag Verfahren zur Herstellung von 4-Aminochinaldinverbindungen
GB1185539A (en) * 1967-11-03 1970-03-25 Smith & Nephew Substituted Tetrazoles
AU638840B2 (en) * 1990-07-05 1993-07-08 Sumitomo Chemical Company, Limited Pyrimidine derivative

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293549A (en) 1977-11-07 1981-10-06 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktion-Saktieselskab) Quinolinyl guanidines having antiinflammatory, analgesic or antipyretic activity
JPS5473784A (en) 1977-11-07 1979-06-13 Leo Pharm Prod Ltd Substituted quinolylguanidine derivatives and their manufacture and use
US4839366A (en) 1983-04-06 1989-06-13 Chiesi Farmaceutici S.P.A. Methylthioquinolyl guanidine derivative, process of preparation thereof and pharmaceutical compositions therefrom
JPS59210084A (ja) 1983-04-06 1984-11-28 キエシ・フアルマチエウチチ・エツセ・ピ・ア 抗炎症作用を有する化合物、その製法およびそれを有効成分とする医薬
JPS62503030A (ja) 1985-05-07 1987-12-03 アルカロイダ　ベギエスゼテイ　ギヤル トリアゾリルキノリン誘導体
US5104884A (en) 1985-05-07 1992-04-14 Alkaloida Vegyeszeti Gyar Triazolyl quinoline derivatives
JPS6399069A (ja) 1985-10-18 1988-04-30 Shionogi & Co Ltd 縮合イミダゾピリジン誘導体
US4753951A (en) 1985-10-18 1988-06-28 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives useful as psychotropic agents
JPS63264460A (ja) 1987-02-02 1988-11-01 ビーオーシー　インコーポレーテッド Ｎ―複素環―ｎ―（４―ピペリジル）アミド及び該化合物を含む薬剤組成物
EP0277794A2 (en) 1987-02-02 1988-08-10 Ohmeda Pharmaceutical Products Division Inc. N-heterocyclic-N-(4-piperidyl) amides
JPH02167265A (ja) 1988-09-30 1990-06-27 Chugai Pharmaceut Co Ltd 新規な３，４―ジアミノキノリン及びピリジン系化合物
US5019574A (en) 1988-09-30 1991-05-28 Chugai Seiyaku Kabushiki Kaisha 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function
EP0381422A1 (en) 1989-02-02 1990-08-08 Yamanouchi Pharmaceutical Co. Ltd. Tetrahydrobenzimidazole derivatives
JPH03223278A (ja) 1989-02-02 1991-10-02 Yamanouchi Pharmaceut Co Ltd テトラヒドロベンズイミダゾール誘導体
JPH07252228A (ja) 1994-02-07 1995-10-03 Fujisawa Pharmaceut Co Ltd キノリン誘導体
WO1996011930A1 (en) 1994-10-18 1996-04-25 Smithkline Beecham P.L.C. Cns-active pyridinylurea derivatives
WO1996013485A1 (en) 1994-10-27 1996-05-09 Fujisawa Pharmaceutical Co., Ltd. Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists
WO1997014681A1 (en) 1995-10-16 1997-04-24 Fujisawa Pharmaceutical Co., Ltd. Heterocyclic compounds as h+-atpases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Aries Robert, "Analgesic 3-methylsalicyloylanthranilates," Brevet D'invention, (Feb. 21, 1969; 3 pp.,) 1.557.928 (with abstract).
Aries Robert, Salicylamidoquinoline Analgesics, "Brevet D'invention", (Oct. 25, 1968; 3pp.) 1.543.405 (with abstract).
Chu-Tzu Pen and T.C. Daniels "The Synthesis of Some 6-N Substituted Amido Derivatives of 4,6-Diaminoquinaldine and a Study of their in vitro Antibacterial Activity 1.2"; (Report No. PB-981 Jul. 1945), p. 17.
Dr. Heinrich Jensch, "Guanylhydrazones of the 4-Aminoquinoline series", 10- Organic Chemistry Ger. No. 831.100; 3pp.) (Feb. 11, 1952).
Dr. Heinrich Jensch, 4-Aminoquinaldine compound 10G-Heterocyclic compound and Chemical Abstract Ger. No. 947.552, Sep. 6, 1956; Cl 12p.).

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7312234B2 (en) * 2000-09-15 2007-12-25 Anormed Chemokine receptor binding heterocyclic compounds
US20050026942A1 (en) * 2000-09-15 2005-02-03 Anormed Chemokine receptor binding heterocyclic compounds
US20080090846A1 (en) * 2000-09-15 2008-04-17 Gary Bridger Chemokine receptor binding heterocyclic compounds
US7084156B2 (en) * 2001-11-27 2006-08-01 Merck & Co., Inc. 2-Aminoquinoline compounds
US20050026915A1 (en) * 2001-11-27 2005-02-03 Devita Robert J. 2-Aminoquinoline compounds
US8003669B2 (en) 2002-03-29 2011-08-23 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
US20050119308A1 (en) * 2002-03-29 2005-06-02 Koji Teshima Remedy for sleep disturbance
US20040092513A1 (en) * 2002-08-07 2004-05-13 Aventis Pharma Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
US7105513B2 (en) 2002-08-07 2006-09-12 Sanofi-Avertis Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
WO2004063330A2 (en) 2003-01-06 2004-07-29 Osi Pharmaceuticals, Inc. (2-carboxamido) (3-amino) thiophene compounds
US20060247275A1 (en) * 2003-01-06 2006-11-02 Crew Andrew P (2-carboxamido)(3-amino)thiophene compounds
US20050154014A1 (en) * 2003-01-06 2005-07-14 Jason Bloxham (2-carboxamido)(3-amino) thiophene compounds
US6949563B2 (en) 2003-01-06 2005-09-27 Graham Michael Wynne (2-carboxamido)(3-amino)thiophene compounds
US7696225B2 (en) 2003-01-06 2010-04-13 Osi Pharmaceuticals, Inc. (2-carboxamido)(3-Amino) thiophene compounds
US20040186124A1 (en) * 2003-01-06 2004-09-23 Wynne Graham Michael (2-carboxamido)(3-amino)thiophene compounds
US7524859B2 (en) 2003-01-06 2009-04-28 Osi Pharmaceuticals, Inc. (2-carboxamido)(3-amino)thiophene compounds
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US20070287751A1 (en) * 2004-03-12 2007-12-13 De La Torre Marta G Opioid Receptor Antagonists
US7381750B2 (en) * 2004-03-12 2008-06-03 Eli Lilly And Company Amino-phenoxymethyl-benzamide opioid receptor antagonists
WO2006047574A1 (en) 2004-10-26 2006-05-04 Osi Pharmaceuticals, Inc. (2-carboxamido)(3-amino) thiophene compounds
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20090176838A1 (en) * 2006-01-30 2009-07-09 Purdue Pharma L.P. Cyclourea Compounds as Calcium Channel Blockers
US8354434B2 (en) 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
US8722731B2 (en) 2010-06-07 2014-05-13 Novomedix, Llc Furanyl compounds and the use thereof
US9149527B2 (en) 2010-06-07 2015-10-06 Novomedix, Llc Furanyl compounds and the use thereof
US9663483B2 (en) 2010-06-07 2017-05-30 Novomedix, Llc Furanyl compounds and the use thereof
US8895606B2 (en) 2010-08-24 2014-11-25 Actelion Pharmaceuticals Ltd. Proline sulfonamide derivatives as orexin receptor antagonists
US9000029B2 (en) 2010-08-24 2015-04-07 Actelion Pharmaceuticals Ltd. Proline sulfonamide derivatives as orexin receptor antagonists
US9211279B2 (en) 2010-08-24 2015-12-15 Actelion Pharmaceuticals Ltd. Proline sulfonamide derivatives as orexin receptor antagonists
US9458161B1 (en) 2011-11-03 2016-10-04 Vanderblit University TSPO ligands for cancer imaging and treatment
WO2019020248A1 (de) * 2017-07-24 2019-01-31 Beiersdorf Ag Verwendung von n-(4-amino-2-methylchinolin-6-yl)-2-((4-ethylphenoxy)methyl)benzamid zur herstellung von kosmetischen oder dermatologischen zubereitungen zur behandlung und/oder prophylaxe der symptome der intrinsischen und/oder extrinsischen hautalterung sowie zur behandlung und prophylaxe der schädlichen auswirkungen ultravioletter strahlung auf die haut

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