US20200156942A1 - A nano-sulfur containing composition and application thereof - Google Patents

A nano-sulfur containing composition and application thereof Download PDF

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US20200156942A1
US20200156942A1 US16/627,842 US201816627842A US2020156942A1 US 20200156942 A1 US20200156942 A1 US 20200156942A1 US 201816627842 A US201816627842 A US 201816627842A US 2020156942 A1 US2020156942 A1 US 2020156942A1
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nano
sulfur
containing composition
sulfur containing
acid
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Kui XIA
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Suzhou Canastar New-Materials Technology Corp
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Suzhou Canastar New-Materials Technology Corp
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    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B17/00—Sulfur; Compounds thereof
    • C01B17/02—Preparation of sulfur; Purification
    • C01B17/0243—Other after-treatment of sulfur
    • C01B17/0248—Other after-treatment of sulfur of particulate sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B17/00—Sulfur; Compounds thereof
    • C01B17/02—Preparation of sulfur; Purification
    • C01B17/10—Finely divided sulfur, e.g. sublimed sulfur, flowers of sulfur
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/14—Boron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B7/00—Preservation or chemical ripening of fruit or vegetables
    • A23B7/14—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10
    • A23B7/153—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10 in the form of liquids or solids
    • A23B7/157—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B17/00—Sulfur; Compounds thereof
    • C01B17/02—Preparation of sulfur; Purification
    • C01B17/06—Preparation of sulfur; Purification from non-gaseous sulfides or materials containing such sulfides, e.g. ores
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer

Definitions

  • the following relates to a nano-sulfur containing composition and application thereof.
  • Sulfur is a very active non-metallic element that is widely used in the manufacture of sulfuric acid, agricultural chemicals, chemical fibers, rubber, dyes, paper-making, pharmaceuticals, explosives, matches, etc. Sulfur plays an important role in our daily lives, such as sulfuric acid for disinfection, sulfur ointment for treating skin diseases, etc. Sulfur in nature is also closely related to our health. For example, sulfur hot spring is called “ soup for skin”, which has the effect of softening the stratum corneum of skin and efficacy of antipruritic, detoxification and detoxification. Sulfur hot spring is especially useful to improvement of arthritis, dermatitis and neuralgia, mainly due to the disinfection and sterilization effects of sulfur.
  • CN105708770A discloses an acne toner comprising a mixture of a carrier and an active ingredient in a percentage by weight, including: carrier: propylene glycol 3-15%, 1,3-butanediol 6-10%, sorbitol 5-8%, deionized water 64.9-85.2%; functional components: nano-sulfur 0.5-1.3%; other functional ingredients 0.3-0.8%.
  • the description of the nano-sulfur in this patent is limited to the nanometer sulfur particle size of 50 nm and it can be obtained by processing elemental sulfur using nanotechnology (see paragraphs [0006] and [0031] of the specification), ie the patent does not specifically describe how to obtain nano-sulfur powder with a particle size of about 50 nm and the characterization data of the nano-sulfur powder.
  • An aspect relates to a nano-sulfur containing composition which can be used in various sulfur containing products instead of the known nano-sulfur or micro-sulfur, so that the function of the sulfur active component is more fully used of
  • Another aspect of the present disclosure is to provide a preparation method of a nano-sulfur containing composition which is simple in process, and in the obtained composition from which, particle size of nano-sulfur keeps relative small for a long time.
  • Another aspect of the present disclosure is to provide a sulfur containing product in which the function of the sulfur active component can be more fully used of and has a better application effect.
  • the present disclosure provides a nano-sulfur containing composition comprising nano-sulfur and anti-agglomerating agent(s) used for preventing or retarding agglomeration of the nano-sulfur.
  • the anti-agglomerating agent is one or a combination of more selected from thickener(s), suspending agent(s), dispersing agent(s), emulsion(s), binder(s), deflocculating agent(s), coupling agent(s), an antistatic agent(s), surfactant(s), and colloid(s).
  • the thickener is any one selected from natural thickener(s) and chemically synthesized thickener(s), or any combination thereof, wherein natural thickeners comprise starch, dextrin, acacia, carrageenan, pectin, agar, alginic acid and their salts or derivatives, tamarind gum, chitin, ablmoschus manihot gum, linseed gum, sesbania gum, guar gum, locust bean gum, xanthan gum; the chemically synthesized thickener(s) comprise sodium carboxymethyl starch, hydroxypropyl starch ether, sodium starch phosphate, acetyl distarch phosphate, phosphorylated distarch phosphate, and hydroxypropyl distarch phosphate.
  • natural thickeners comprise starch, dextrin, acacia, carrageenan, pectin, agar, alginic acid and their salts or derivatives, tamarind gum,
  • the suspending agent is one or a combination of more selected from glycerin, syrup, gum suspension, plant polysaccharide suspension, cellulose suspension, carbopol, povidone, glucan, silicon bentonite, and thixotrope.
  • the dispersing agent is one or a combination of more selected from sodium silicate, sodium tripolyphosphate, sodium hexametaphosphate, sodium pyrophosphate, triethylhexylphosphoric acid, sodium lauryl sulfate, methyl amyl alcohol, cellulose derivative, polyacrylamide, guar gum, polyethylene glycol, and fatty acid polyethylene glycol ester.
  • the surfactant is one or a combination of more selected from the group consisting of double-chain ionic surfactant, anionic surfactant, cationic surfactant, and nonionic surfactant.
  • a double-chain ionic surfactant such as sodium dioctyl sulfosuccinate (AOT); anionic surfactants such as sodium dodecyl sulfonate (SDS), sodium dodecyl benzene sulfonate (DBS); cationic surfactants such as cetyltrimethylammonium bromide (CTAB); nonionic surfactants such as TritonX series (polyoxyethylene ethers).
  • the colloid is one or a combination of more selected from silicic acid colloid, starch colloid, protein colloid, soybean milk, and colloidal silica.
  • the anti-agglomerating agent is food additive and/or pharmaceutical excipient.
  • the anti-agglomerating agent is one or a combination of more selected from starch, dextrin, gum arabic, carrageenan, pectin, agar, alginic acid, sodium alginate, alginic acid glycol ester, tamarind gum, chitin, ablmoschus manihot gum, linseed gum, sesbania gum, guar gum, locust bean gum, xanthan gum, sodium carboxymethyl starch, hydroxypropyl starch ether, starch sodium phosphate ester, acetyl distarch phosphate, phosphorylated distarch phosphate, hydroxypropyl distarch phosphate, glycerin, syrup, carbopol, povidone, glucan, silicon bentonite, thixotrope, sodium silicate, sodium tripolyphosphate, sodium hexametaphosphate, sodium pyrophosphate, triethylhexylphosphoric
  • the anti-agglomerating agent of the present disclosure may be any substance which can prevent or delay the agglomeration of nano-sulfur, and may be any anti-agglomerating substance or a combination of multiple anti-agglomerates.
  • the combination of the agglomerated substances has no particular limitation.
  • a mass ratio of the nano-sulfur to the anti-agglomerating agent in the nano-sulfur containing composition is 1-10:0.5-20. In some embodiments, a mass ratio of the nano-sulfur to the anti-agglomerating agent in the nano-sulfur containing composition is 1-10:0.5-10. In some embodiments, a mass ratio of the nano-sulfur to the anti-agglomerating agent in the nano-sulfur containing composition is 1-10:0.5-5. According to a specific aspect of embodiments of the invention, a mass ratio of the nano-sulfur to the anti-agglomerating agent in the nano-sulfur containing composition may be 1-5: 0.5-5.
  • the particle diameter of nano-sulfur is 10 ⁇ m or less, 5 ⁇ m or less, more 5 nm-3000 nm, further 10 nm-2000 nm, and the most 20 nm-500 nm.
  • the particle diameter of nano-sulfur may be 20-400 nm, 20-300 nm, 20-200 nm, or 20-150 nm.
  • the particle diameter of nano-sulfur may be 30-100 nm.
  • the nano-sulfur may have a particle size of 30-90 nm.
  • the nano-sulfur may have a particle size of 40-100 nm.
  • the size of the nanoparticles is controllable and adjustable. Specifically, size of the nanoparticles can be controlled by adjusting the component of anti-agglomerating agent and its amount.
  • change of the average particle size of the nano-sulfur is generally less than 30%, less than 20%, more less than 10%, when the nano-sulfur containing compositionis placed at room temperature for 6 months.
  • the nano-sulfur containing composition further comprises a solvent, and the nano-sulfur and anti-agglomerating agent are dispersed in the solvent.
  • the solvent is one or a combination of more selected from water, ethanol, glycerol, and polyethylene glycol. According to a particular aspect of the invention, the solvent is water.
  • the nano-sulfur containing composition is in a liquid state.
  • the nano-sulfur in the nano-sulfur containing composition, has a mass content of 0.01%-10%. In some embodiments of the present disclosure, the nano-sulfur containing composition may have a mass content of the nano-sulfur from 0.01% to 7%. In some embodiments of the present disclosure, the nano-sulfur containing composition may have a mass content of from 0.1% to 7%.
  • the anti-agglomerating agent has a mass content of 0.01-25%. In certain embodiments of the invention, the anti-agglomerating agent may have a mass content of 0.5-25%. In certain embodiments of the invention, the anti-agglomerating agent may have a mass content of 0.5-15%. In certain embodiments of the invention, the anti-agglomerating agent may have a mass content of 0.5-5%.
  • the nano-sulfur containing composition mainly consists of the nano-sulfur, the anti-agglomerating agent.
  • the nano-sulfur containing composition is mainly composed of nano-sulfur, anti-agglomerating agent, and solvent, wherein the solvent is not particularly limited, but is those commonly used in the field, especially water, alcohol solvents.
  • the specific solvents may be, for example, one or a combination of more selected from water, ethanol, propylene glycol, glycerin, polyethylene glycol, etc.
  • the nano-sulfur containing composition is prepared by the following method (a) or (b) or (c):
  • the methods (b) and (c) are more preferred.
  • the particle size of nano-sulfur is smaller, more uniform, more stable, and the use effect is significantly better.
  • the thiosulfate salt may be one or a combination of more selected from thiosulfate, ammonium thiosulfate, and potassium thiosulfate.
  • polysulfide is acidified, hydrogen sulfide and sulfur are released: Sx+2H ⁇ H 2 S+(x ⁇ 1)S.
  • the polysulfide may be one or a combination of more selected from sodium polysulfide, potassium polysulfide, and ammonium polysulfide.
  • the acid may be selected from any inorganic acid, organic acid or a combination of the two, wherein the organic acid includes, but is not limited to, citric acid, tartaric acid, salicylic acid, benzoic acid, carboxylic acid, lactic acid, etc.
  • the inorganic acids include, but are not limited to, hydrochloric acid, sulfuric acid, boric acid, nitric acid,etc.
  • the acid may be one or a combination of more selected from hydrochloric acid, benzoic acid, acetic acid, citric acid, tartaric acid, boric acid, salicylic acid, lactic acid, sulfuric acid, and nitric acid.
  • a preparation method of a nano-sulfur containing composition as described above comprising: making thiosulfate or polysulfide react with an acid in the presence of an anti-agglomerating agent and in a solvent to obtain a nano-sulfur containing composition.
  • the thiosulfate is one or a combination of more selected from sodium thiosulfate, ammonium thiosulfate, and potassium thiosulfate.
  • the polysulfide is one or a combination of more selected from sodium polysulfide, potassium polysulfide, ammonium polysulfide.
  • the acid is one or a combination of more selected from hydrochloric acid, benzoic acid, acetic acid, citric acid, tartaric acid, boric acid, salicylic acid, lactic acid, sulfuric acid, nitric acid.
  • yet another technical solution adopted by the present disclosure is as follows: Use of the nano-sulfur containing composition as described above for the preparation of a sulfur containing product.
  • the sulfur containing product are toiletries for use on the surface of the skin on humans or animals, drugs for treating skin disorders, drugs for treating tumors, drugs for treating hair disorders, agricultural chemicals, plant preservatives for vegetable and fruits, additives for animal feed, additives for mold-prevention in paint, mold prevention agents for textiles or textile mite-killing agents.
  • the sulfur containing product are toiletries for use on the surface of the skin on humans or animals, drugs for treating skin disorders, drugs for treating tumors, drugs for treating hair disorders, agricultural chemicals, plant preservatives for vegetable and fruits, additives for animal feed, additives for mold-prevention in paint, mold prevention agents for textiles or textile mite-killing agents.
  • the nano-sulfur containing composition improved according to the present disclosure can maintain the nano-sulfur in a nano-dispersed state for a long period, thereby effectively improving the activity and efficacy of sulfur, and helping to reduce the amount of sulfur used, and are particularly suitable for preparation of toiletries and drugs directed for the surface of the skin of humans or animals, and also suitable for adding to drugs for treating tumor, drugs for treating hair disorders, agricultural chemicals, preservatives for vegetables,fruits plant, etc, additives for animal feed, additives for mold-prevention in paint, mold prevention agents for textiles or (textile) mite-killing agents.
  • toiletries prepared in accordance with the conception of the present disclosure are effective in preventing, ameliorating, alleviating or eliminating fungal infections of the skin.
  • the toiletries are face cream, emulsifiable paste, body wash,hair shampoo, body lotion, moisturizer, facial cleanser, hand sanitizer, florida water, soap, cleansing foam, facial mask, shampoo, vanishing cream, anti-cracking oil, essence, whitening cream, sunscreen lotion, freckle cream, hand cream, moisturizing balance liquid, moisturizing cream, toner, firming lotion or astringent water.
  • the toiletries, with addition of the nano-sulfur containing composition when used on any skin surface of the whole body, has anti-fungal function, treating, alleviating, and preventing various skin disorders such as phlegm, dermatitis, pityriasis, eczema, etc;
  • hair care can treat fungal dandruff;
  • foot can treat and prevent fungal diseases of the foot such as tinea pedis.
  • the nano-sulfur containing composition may be added in a very small amount in the toiletries, and usually is added with the amount that the content of the nano-sulfur in the toiletries is about 0.005-0.25%.
  • the pharmaceutical composition prepared according to the conception of the present disclosure it is effective for treating skin fungal infections and treating various skin diseases such as skin dermatitis, dermatitis, pityriasis, eczema, etc.
  • the nano-sulfur containing composition is added in an effective amount.
  • the nano-sulfur containing composition may be added to the pharmaceutical composition in an amount less than the amount of nano-sulfur added in the prior art, and usually is added with the amount that the content of the nano-sulfur in the pharmaceutical composition is about 0.01%-0.5%.
  • the pharmaceutical composition further comprises a synergist.
  • the synergist may, for example, be one or a combination of more selected from alum, zinc oxide or borax.
  • the synergist may have a mass content of 1-5%.
  • the pharmaceutical composition may further comprise a humectant.
  • the humectant may be, for example, one or a combination of more selected from polyhydric alcohols, hyaluronic acid, ceramides, collagen, urea, chitin derivatives, aloe vera or seaweed extracts.
  • the humectant may have a mass content of 2-10% in the pharmaceutical composition.
  • the pharmaceutical composition may be in the form of ointment, gel, emulsifiable paste or liquid.
  • the pharmaceutical composition may further comprise an active substance that can treat a skin disorder other than the nano-sulfur containing composition.
  • the sulfur in the whole product has a content of only a few thousandths, thereby the drying and peeling of the skin is weakened or even avoided.
  • the prepared nano-sulfur containing composition may be directly added to other substrates, and although it contains a small amount of sodium salt, potassium salt or ammonium salt, etc., there is no need to remove, such as sodium chloride, which is harmless when used in a very small amount, and such as sodium acetate, which has antiseptic effect, so the prepared nano-sulfur containing composition can be directly applied to the product without additional operations to remove other substances. The effect of additional factors on the maintenance of the nanostate of nano-sulfur is reduced or even avoided.
  • the embodiments overcome the defects that the nano-sulfur is easy to agglomerate during the preparation or use of the traditional nano-sulfur, and realizes that the nano-sulfur can keep nano-state for a long time.
  • the nano-sulfur containing composition After the nano-sulfur containing composition has been kept for a long time by the inventor (more than half a year at present), the nano-sulfur in the prepared composition was still maintained in the nano-state and uniformly dispersed in the dispersion medium, which basically eliminated agglomeration.
  • the nano-sulfur containing composition of the present disclosure can be added to any product requiring sulfur, and can obtain a better effect with a lower addition amount.
  • the sulfur containing product of embodiments of the invention wherein the nano-sulfur keeps a very good dispersion and a small particle size, the sulfur activity can be fully exerted, and the application effect is significantly better. At the same time,due to that the activity of sulfur can be fully developed, the amount of sulfur can be greatly reduced, which can reduce or avoid the negative problems caused by the big amount of sulfur.
  • the sulfur containing product of embodiments of the invention has low cost. Therefore, the sulfur containing product of embodiments of the invention is easy to be popularized.
  • FIG. 1 is a photograph of a nano-sulfur containing composition, which was prepared in Example 1 of the present disclosure and placed in static station for half a year;
  • the nano-sulfur still maintains the initial state and is still uniformly dispersed in the dispersion medium.
  • the conventional preparation method of the sulfur containing product is to obtain a high-purity solid sulfur powder firstly, and then disperse the sulfur powder into other components of the sulfur containing product, and mix them to obtain a sulfur containing product.
  • the sulfur products obtained by the traditional method are easy to agglomerate even if the particle size of the raw material sulfur powder is very small and various auxiliary dispersion means are used, which will affect the use effect.
  • the inventor accidentally found that the nano-sulfur formed is not easy to agglomerate when an assistant (or anti agglomerate) which can prevent or delay agglomeration is added before the formation of nano-sulfur and the assistant is still retained after the formation of nano-sulfur. Furthermore, when the composition of the nano-sulfur and the auxiliary agent is used to prepare sulfur containing products, the nano-sulfur keeps a very good dispersion performance and a small particle size, so the activity of sulfur in the prepared sulfur containing products can be brought into full play, and the application effect is significantly better. Furthermore, as the activity of sulfur can be brought into full play, the amount of sulfur can be greatly reduced, which can reduce or avoid the negative problems caused by the big amount of sulfur
  • the embodiments overcome the traditional prejudice that the high-purity sulfur powder should be prepared first and then used (it is generally believed that there may be a small amount of impurities in the raw material, but the by-products are not allowed, otherwise the quality is not good, for example, the purity is emphasized in many literatures on nano-sulfur).
  • the nano-sulfur containing composition of some embodiments of the present disclosure contains auxiliary agent (anti-agglomerating agent) and residual thiosulfate, polysulfide and acid, etc. These components are not only harmless, but also beneficial in most cases. The following are illustrating examples:
  • appropriate anti-agglomerating agent, thiosulfate or polysulfide and acid for preparation can be selected to obtain nano-sulfur and beneficial additives at the same time, which can be described as killing two birds with one stone. More importantly, the complex and high-cost purification process is avoided, greatly reduce the cost of nano-sulfur production
  • the anti-agglomerating agent of the present disclosure may be any substance which can prevent or delay the agglomeration of nano-sulfur, and may be any anti-agglomerating substance or a combination of a plurality of anti-agglomerating substances, and is not particularly limited.
  • the types of substances that can prevent or delay nano-sulfur agglomeration are very broad, including but not limited to various thickeners, suspending agents, dispersing agents, emulsions, coupling agents, antistatic agents, surfactants, and sols, gel, etc. These specific anti-agglomerating agents all have anti-agglomeration effects, just that the degree of effect is different.
  • the thickener of the present disclosure is not particularly limited and may be selected from any one or a combination of more selected from natural thickener and chemically synthesized thickener.
  • Natural thickeners include, but are not limited to various starches (wheat flour, rice flour, potato flour, pueraria powder, etc.), dextrin, gelatin, gum arabic, carrageenan, pectin, agar, alginic acid thickener, tamarind gum, chitin, ablmoschus manihot gum, linseed gum, sesbania gum, guar gum, locust bean gum, xanthan gum.
  • Chemically synthesized thickeners include, but are not limited to, sodium carboxymethyl starch, hydroxypropyl starch ether, sodium starch phosphate,acetyl distarch phosphate, phosphorylated distarch phosphate, hydroxypropyl distarch phosphate, etc.
  • Suspending agents are additives that can increase the viscosity of the dispersion medium to reduce the sedimentation speed of the particles or increase the hydrophilicity of the particles.
  • the suspending agent of the present disclosure may be various suspending agents, and is not particularly limited. For example, it may be a low molecular suspending agent such as glycerin, syrup, etc., and glycerin is often added to the suspension for external use; it may be a polymeric suspending agent.
  • Polymeric suspending agents include:
  • suspending agents specifically employed are, for example, colloidal silica, carboxymethylcellulose (CMC), sodium alginate, sodium carboxymethylcellulose (CMC-Na), and etc.
  • Dispersing agent are agents that promote the uniform dispersion of material particles in a medium to form a stable suspension.
  • Dispersing agents are generally classified into two types: inorganic dispersing agents and organic dispersing agents.
  • Common inorganic dispersing agents are silicates (such as sodium silicate) and alkali metal phosphates (such as sodium tripolyphosphate, sodium hexametaphosphate, sodium pyrophosphate, etc.).
  • Organic dispersing agents include triethylhexylphosphoric acid, sodium lauryl sulfate, methylpentanol, cellulose derivatives, polyacrylamide, guar gum, fatty acid polyethylene glycol esters, etc.
  • the oil, surfactant, water (electrolyte aqueous solution) or co-surfactant are mixed evenly, then a co-surfactant or water (electrolyte aqueous solution) is added into the system, and a microemulsion can be formed within a certain range of proportions.
  • surfactants are: double-chain ionic surfactants, such as sodium dioctyl sulfosuccinate (AOT); anionic surfactants such as sodium dodecyl sulfonate (SDS), dodecyl benzene Sodium sulfonate (DBS); cationic surfactants such as cetyltrimethylammonium bromide (CTAB); nonionic surfactants such as TritonX series (polyoxyethylene ethers).
  • AOT sodium dioctyl sulfosuccinate
  • anionic surfactants such as sodium dodecyl sulfonate (SDS), dodecyl benzene Sodium sulfonate (DBS)
  • cationic surfactants such as cetyltrimethylammonium bromide (CTAB); nonionic surfactants such as TritonX series (polyoxyethylene ethers).
  • the colloid includes various sols, gels, etc, and specific examples are sillic acid colloid, starch colloid, protein colloid, soybean milk,etc.
  • Various colloidal substances are beneficial to the dispersion of nano-sulfur and prevent the aggregation of nano-sulfur.
  • anti-agglomerating agents such as coupling agents, antistatic agents, surfactants, emulsions,etc, can exert an anti-agglomeration effect by improving the surface characteristics of the particles or the interaction between the particles.
  • the type of the surfactant is not limited, and may be one or a combination of more from double-chain ionic surfactant, anionic surfactant, cationic surfactant, and nonionic surfactant, wherein the double-stranded ion surfactant may be, for example, sodium dioctyl sulfosuccinate, the anionic surfactant may be, for example, sodium dodecyl sulfonate or sodium dodecylbenzene sulfonate, and the cationic surfactant may be, for example,the cetyltrimethylammonium bromide, nonionic surfactant may be, for example, a polyoxyethylene ether surfactant.
  • the double-stranded ion surfactant may be, for example, sodium dioctyl sulfosuccinate
  • the anionic surfactant may be, for example, sodium dodecyl sulfonate or sodium dodecylbenzene sul
  • the emulsion is, for example, Tween 60 and Span 20.
  • the anti-agglomerating agent is a food additive or a pharmaceutical adjuvant.
  • the particle size of the nano-sulfur containing composition was tested by GBT 19627-2005 particle size analysis photon correlation spectroscopy and GB/T 29022-2012 particle size analysis dynamic light scattering (DLS).
  • the test temperature was room temperature 25° C.
  • Nano-Sulfur Containing Composition for Preparing Antifungal Drugs or Toiletries
  • the nano-sulfur containing composition of embodiments of the invention can make the nano-sulfur maintain the nano-state for a long period without agglomeration, avoid agglomerating into a large particle state, which is difficult to be absorbed by the skin, thus showing poor effect of anti-fungus and skin disease treatment, and at the same time, it can be used as an active ingredient in toiletries and pharmaceutical compositions.
  • active ingredient are not limited to the nano-sulfur containing composition of the present disclosure, other ingredients may also be present, which depends on needs of consumers; and appropriate forms of toiletries and pharmaceutical compositions such as paste, liquid, etc, may be selected according to the practical situation.
  • the embodiments are applied to an antifungal drug or toiletries, and solves the problem that the nano-sulfur in the traditional nano-sulfur containing product is not a true nanostate (the large particle sulfur is hard to be absorbed by the skin playing a bactericidal effect), on the one hand, the nano-sulfur is easily absorbed by the skin, which can greatly reduce the amount of sulfur used, reduce or even eliminate the side effects of dry skin caused by traditional sulfur containing products, and, on the other hand, due to great reduction of the amount of sulfur used, there is almost no smell odor of sulfur, and its appearance and fragrance (can be added additionally) are the same as ordinary skin care products.
  • the products containing nano-sulfur of embodiments of the invention do not contain hormones (the purpose of adding hormones in traditional anti bacteria drugs is to use its anti-allergic, anti-inflammatory, antipruritic and other effects, while the use of hormones has obvious side effects, long-term use will cause their own physiological function disorder), can replace the traditional antifungal drugs, to treat various dermatitis, stubborn tinea, eczema, etc
  • the toiletries according to the present disclosure especially refer to toiletries for using on the skin surface of humans or animals.
  • the toiletries are face cream, emulsifiable paste, body wash,hair shampoo, body lotion, moisturizer, facial cleanser, hand sanitizer, florida water, soap, cleansing foam, facial mask, shampoo, vanishing cream, anti-cracking oil, essence, whitening cream, sunscreen lotion, freckle cream, hand cream, moisturizing balance liquid, moisturizing cream, toner, firming lotion or astringent water.
  • the toiletries, with addition of the nano-sulfur, when used on any skin surface of the whole body, has anti-fungal function, treating, alleviating, and preventing many skin disorders such as tinea, dermatitis, pityriasis, eczema, etc;
  • the nano-sulfur containing composition may be added in a very small amount in the toiletries, and usually is added with the amount that the content of the nano-sulfur in the toiletries is about 0.005-0.25%.
  • the nano-sulfur containing composition is added in an effective amount.
  • the nano-sulfur containing composition may be added to the pharmaceutical composition in an amount less than the amount of nano-sulfur added in the prior art, and usually is added with the amount that the content of the nano-sulfur in the antifungal drugs for external use is about 0.01%-0.5%.
  • the antifungal drugs for external use further comprises a synergist.
  • the synergist may, for example, be one or a combination of more selected from alum, zinc oxide or borax.
  • the synergist may have a mass content of 1-5%.
  • the antifungal drugs for external use may comprise a humectant.
  • the humectant may be, for example, one or a combination of more selected from polyhydric alcohols, hyaluronic acid, ceramides, collagen, urea, chitin derivatives, aloe vera or seaweed extracts.
  • the humectant may have a mass content of 2-10%.
  • the antifungal drugs for external use is in the form of an ointment, a gel, a emulsifiable paste or a liquid.
  • the antifungal drugs for external use may include an active substance other than the nano-sulfur containing composition that can treat a skin disease.
  • the sulfur content in the whole product is only a few thousandths, thereby weakening or even avoiding the drying and peeling of the skin.
  • the prepared nano-sulfur containing composition may be directly added to other substrates, and although it contains a small amount of sodium salt, potassium salt or ammonium salt, etc., there is no need to remove, such as sodium chloride, very small amount of which is harmless, and such as sodium acetate, which itself has antiseptic effect, so the nano-sulfur containing composition prepared can be directly applied to the product without additional operations to remove other substances. Also the effect of additional factors on the maintenance of the nanostate of nanosulfur is reduced or even avoided.
  • the sulfur containing product comprises not only (i) elemental sulfur, (ii) anti-agglomerating agent, but also (iii) thiosulfate or sulfide and/or (iv) acid ion.
  • a sulfur containing product having all of (i), (ii) and (iii) or a sulfur containing product having all of (i), (ii) and (iv) or a sulfur containing products having all of (i), (ii), (iii) and(iv) shall be considered to be within the protection scope of this patent.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate pentahydrate, hydroxypropyl starch ether, hydrochloric acid and water.
  • the preparation method was as follows:
  • sodium thiosulfate pentahydrate and 1 g of hydroxypropyl starch ether were weighted, and sodium thiosulfate pentahydrate was dissolved in water to prepare an aqueous sodium thiosulfate solution containing 50% by mass of sodium thiosulfate.
  • the nano-sulfur containing composition prepared in this example contained sodium chloride as a by-product, which is beneficial in skin and hair care products such as shampoo and soap and is also beneficial in animal feed, so there is no need to remove them as taught by traditional prejudices, while the measured average particle size of sulfur therein was about 132 nanometer. After being placed at room temperature for 6 months post the preparation, a photograph taken is shown in FIG. 1 .
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, guar gum, acetic acid, and water.
  • the preparation method was as follows:
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 2.17%.
  • the nano-sulfur containing composition prepared in this example further contained sodium acetate as a by-product, which can be used as a buffering agent, a flavoring agent, a fumet agent and a pH adjusting agent, and has certain anti-mold and anti-fungal effects, and can be used in skin and hair care products, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur therein was about 173 nm.
  • This example provides a nano-containing sulfur composition, the raw materials of which comprise sodium thiosulfate, phosphorylated distarch phosphate, acetic acid and water.
  • the preparation method was as follows:
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 5.9%.
  • the nano-sulfur containing composition prepared in this example contained sodium acetate as a by-product, which can be used as a buffering agent, a flavoring agent and a fumet agent and pH adjuster, and has certain anti-mold and anti-fungal effects, and can be used in skin and hair care products, so there is no need to remove it as taught by traditional prejudices.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, xanthan gum, acetic acid and water.
  • the preparation method was as follows:
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 2.19%.
  • the nano-sulfur containing composition prepared in this example contained sodium acetate as a by-product, which can be used as a buffering agent, a flavoring agent, a fumet agent and a pH adjusting agent, and has certain anti-mold and anti-fungal effects, and can be used in skin and hair care products, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur therein was about 285 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, carboxymethylcellulose, hydrochloric acid, benzoic acid, and water.
  • the preparation method was as follows:
  • the mass content of the nano-sulfur in the obtained nano-sulfur containing composition was about 1.75%.
  • the nano-sulfur containing composition prepared in this example contained sodium chloride and sodium benzoate as by-products, while sodium chloride is beneficial in skin and hair care products such as shampoo and soap, and is also beneficial in animal feed, and sodium benzoate is often used as a bactericide, preservative, antimicrobial agent, etc., and can also be used in skin and hair care products, so it is unnecessary to remove these two materials as taught by traditional prejudices, and the measured average particle size of sulfur was about 46 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, hydroxyethyl cellulose, acetic acid, and water.
  • the preparation method was as follows:
  • the mass content of the nano-sulfur in the nano-sulfur containing composition obtained was about 2.22%.
  • the nano-sulfur containing composition prepared in this example contained sodium acetate as a by-product, which can be used as a buffering agent, a flavoring agent, a fumet agent and a pH adjusting agent, and has certain anti-mold and anti-fungal effects, and can be used in skin and hair care products, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur therein was about 43 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, polyethylene glycol, citric acid, and water.
  • the preparation method was as follows:
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 2.07%.
  • the nano-sulfur containing composition prepared in this example also contained sodium citrate as a by-product, which is often used as a food additive and a preservative and the like, and can also be added to skin and hair care products, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur therein was about 180 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, povidone, tartaric acid and water.
  • the preparation method was as follows:
  • the mass content of the nano-sulfur in the nano-sulfur containing composition obtained was about 1.81%.
  • the nano-sulfur containing composition prepared in this example contained sodium tartrate as a by-product, which is often used as food and beverage additives and antioxidants, and is also used in the pharmaceutical and food industries, so there is no need to be removed as taught by traditional prejudices.
  • the measured average particle size of sulfur therein was about 132 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, sodium alginate, benzoic acid and water.
  • the preparation method was as follows
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 1.16%.
  • the nano-sulfur containing composition prepared in this example contained sodium benzoate as a by-product, which is often used as a bactericide, a preservative, an antimicrobial agent, etc., and can be used in skin and hair care products, so there is no need to remove it as taught by traditional prejudices.
  • the measured average particle size of sulfur therein was about 30 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, starch, boric acid, and water.
  • the preparation method was as follows:
  • the nano-sulfur containing composition prepared in this example contained sodium borate as a by-product, which can be used for disinfection and antisepsis of skin mucous membrane, and the treatment of tinea pedis, colpomycosis, inflammation, cervical erosion, bedsore, acne, external ear canal eczema, and herpes viral skin disease, and also can be used for the treatment of tumors, and also as a feed additive.
  • boron-containing micronutrient fertilizers are effective for many crops, improving crop quality and raising production, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur was about 310 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, colloidal silica, salicylic acid, and water.
  • the preparation method was as follows:
  • the nano-sulfur mass content in the obtained nano-sulfur containing composition was about 1.07%, and the nano-sulfur containing composition prepared in the example contained sodium salicylate as a by-product, which can be used in foods and medicines, and can also be used as a preservative. Therefore, there is no need to remove it as taught by traditional prejudices, and the measured average particle diameter of sulfur therein was about 40 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, gum arabic, lactic acid and water.
  • the preparation method was as follows:
  • the nano-sulfur containing composition prepared in the example contained sodium lactate as a by-product, which can be used as a moisturizing agent that is beneficial in skin and hair care products and medicines; sulfur has adverse side effects of causing dry skin and even causing peeling, while sodium lactate has a moisturizing effect, which solves the problem of dry skin.
  • the preparation of nano-sulfur drugs and skin care products needs to, or even has to add a moisturizer to eliminate the adverse side effects of nano-sulfur, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur was 58 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise ammonium thiosulfate, pectin, lactic acid and water.
  • the preparation method was as follows:
  • ammonium thiosulfate 50 g of ammonium thiosulfate and 2 g of pectin were weighted, and ammonium thiosulfate was dissolved in water to prepare an ammonium thiosulfate aqueous solution containing 65% by mass of ammonium thiosulfate; pectin was added to a 10% by mass lactic acid solution to form a mixed solution, and the mixed solution was added to the ammonium thiosulfate aqueous solution (wherein the molar ratio of the added thiosulfate to the hydrogen ion was 1:2), and the system was ultrasonically stirred until the reaction was completed, to give a nano-sulfur containing composition.
  • the nano-sulfur mass content in the obtained nano-sulfur containing composition was about 1.58%.
  • the nano-sulfur containing composition prepared in the example contained ammonium lactate as a by-product, which is widely used in foods, beverages, dairy products, nutrient liquids, and medicines. etc., and can also be used as a feed additive, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur therein was about 71 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, glycol alginate, acetic acid, and water.
  • the preparation method was as follows:
  • sodium thiosulfate and 2 g of glycolic acid alginate were weighted, and sodium thiosulfate was dissolved in water to prepare a sodium thiosulfate aqueous solution containing 65% by mass of sodium thiosulfate, then alginate was added to a 10% by mass acetic acid solution to form a mixed solution, then the mixed solution was added to the sodium thiosulfate aqueous solution (wherein the molar ratio of the added thiosulfate to hydrogen ion was 1:2).), and the system was ultrasonically stirred until the reaction was completed, to give a nano-sulfur containing composition.
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 1.21%, and the nano-sulfur containing composition prepared in this example contained sodium acetate as a by-product,which can be used as a buffering agent, a flavoring agent, and a fumet agent, and a pH adjuster, has certain anti-mold and anti-fungal effects, and can be used in skin and hair care products, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur was about 42 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, lignin, benzoic acid and water.
  • the preparation method was as follows:
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 1.19%.
  • the nano-sulfur containing composition prepared in this example contained sodium benzoate as a by-product, which is often used as a bactericide, a preservative, an antimicrobial agent and the like, and can be used in skin and hair care products, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur therein was about 230 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium polysulfide (Na 2 S 2 ), sodium carboxymethyl starch, lactic acid, and water.
  • the preparation method was as follows:
  • sodium polysulfide and 2 g of sodium carboxymethyl starch were weighed, and sodium polysulfide was dissolved in water to prepare a sodium polysulfide aqueous solution containing 65% by mass of sodium polysulfide; sodium carboxymethyl starch was added to a 40% by mass lactic acid solution to form a mixed solution, and then the mixed solution was added to the sodium polysulfide aqueous solution (wherein, a molar ratio of the added polysulfide ion to hydrogen ion was 1:2), and the system was ultrasonically stirred until the reaction was completed, to give a nano-sulfur containing composition.
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 5.17%.
  • the nano-sulfur containing composition prepared in this example contained sodium lactate as a by-product, which can be used as a moisturizing agent that is beneficial in skin and hair care products and medicines; sulfur has adverse side effects of causing dry skin and even causing peeling, which sodium lactate has a moisturizing effect, which solves the problem of dry skin.
  • the preparation of nano-sulfur drugs and skin care products needs to, or even has to use moisturizers to eliminate the adverse side effects of nano-sulfur, so there is no need to remove it as taught by traditional prejudices.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise potassium polysulfide (K 2 S 2 ), guar gum, acetic acid, benzoic acid, and water.
  • the preparation method was as follows:
  • potassium polysulfide 50 g of potassium polysulfide and 2 g of guar gum were weighed, potassium polysulfide was dissolved in water to prepare a potassium persulfate aqueous solution containing 60% by mass of potassium polysulfate, guar gum was added to a complex acid solution of 20% by mass of acetic acid and benzoic acid (wherein the molar ratio of the added acetic acid to benzoic acid was 1:1) to form a mixed solution, and then the mixed solution was added to the potassium polysulfide aqueous solution (wherein the molar ratio of the added polysulfide ion to hydrogen ion was 1:2), and the system was ultrasonically stirred until the reaction was completed, to give a nano-sulfur containing composition.
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 2.79%.
  • the nano-sulfur containing composition prepared in this example contained potassium lactate as a by-product, which can be used as a food preservative; an anti-microbial agent, mainly used in foods such as margarine, diluted margarine, wine, so there is no need to remove it as taught by traditional prejudices.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise ammonium polysulfide ((NH 4 ) 2 S 2 ), agar, lactic acid and water.
  • the preparation method was as follows:
  • ammonium polysulfide 50 g of ammonium polysulfide and 3 g of agar were weighed, and the ammonium polysulfide was dissolved in water to prepare an aqueous solution of ammonium polysulfide containing 50% by mass of ammonium polysulfide; agar was added to a 10% by mass lactic acid solution to form a mixed solution, and then the mixed solution was added to the aqueous solution of ammonium polysulfide (wherein the molar ratio of the added polysulfide ion to hydrogen ion was 1:2), and the system was ultrasonically stirred until the reaction was completed, to give a nano-sulfur containing composition.
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 1.60%, and the nano-sulfur containing composition prepared in the example contained ammonium lactate as a by-product, which is widely used in foods, beverages, dairy products, nutrient liquids, medicines, etc., and can also be used as a feed additive, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur therein was about 84 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise potassium thiosulfate, hydroxypropylcellulose, hydrochloric acid and water.
  • the preparation method was as follows:
  • potassium thiosulfate 50 g of potassium thiosulfate and 2 g of hydroxypropylcellulose were weighed, and potassium thiosulfate was dissolved in water to prepare a potassium thiosulfate aqueous solution containing 65% by mass of potassium thiosulfate; hydroxypropylcellulose was added to a 40% by mass hydrochloric acid solution to form a mixed solution, and then the mixed solution was added to the potassium thiosulfate aqueous solution (Hence, the molar ratio of the added thiosulfate to hydrogen ion was 1:2), and the system was ultrasonically stirred until the reaction was completed, to give a nano-sulfur containing composition.
  • the mass content of the nano-sulfur in the obtained nano-sulfur containing composition was about 6.74%.
  • the nano-sulfur containing composition prepared in this example contained potassium chloride as a by-product, which is a kind of potash fertilizer in agriculture, and the fertilizer effect thereof is fast, and can be directly applied to farmland to raise water in the lower layer of soil and have the effect of drought resistance, so there is no need to remove it as taught by traditional prejudices.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, Span 20, citric acid, and water.
  • the preparation method was as follows:
  • nano-containing sulfur composition which was in a micro-emulsion state.
  • the mass content of nano-sulfur in the obtained nano-sulfur containing composition was about 2.07%.
  • the nano-sulfur containing composition prepared in this example also contained sodium citrate as a by-product, which is often used as a food additive and a preservative, and can also be added to skin and hair care products, so there is no need to remove it as taught by traditional prejudices, and the measured average particle size of sulfur therein was about 310 nm.
  • This example provides a nano-sulfur containing composition, the raw materials of which comprise sodium thiosulfate, Tween 60, acetic acid, and water.
  • the preparation method was as follows:
  • the nano-sulfur containing composition prepared in this example further contained sodium acetate as a by-product, which can be used as a buffering agent, a flavoring agent and a fumet agent and pH adjuster, has a certain anti-mold and anti-fungal effect and can be used in skin and hair care products, so there is no need to remove it as taught by traditional prejudices.
  • This example provides a pharmaceutical composition, which can be used for the treatment of scabies, tinea capitis, acne, seborrheic dermatitis, rosacea, pityriasis and chronic eczema and the like, the specific formulation thereof is as shown in Table 1 below.
  • the preparation method of the pharmaceutical composition comprised: step (1): preparing a nano-sulfur containing composition according to Example 2; step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 1.
  • This example provides a pharmaceutical composition, which can be used for the treatment of scabies, tinea capitis, acne, seborrheic dermatitis, rosacea, pityriasis and chronic eczema and the like, the specific formulation thereof is as shown in Table 2 below.
  • the preparation method of the pharmaceutical composition comprised: step (1): preparing a nano-sulfur containing composition according to Example 10; step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 2.
  • This example provides a vanishing cream, and the specific formulation thereof is shown in Table 3 below.
  • the preparation method of the vanishing cream comprised: step (1): preparing a nano-sulfur containing composition according to Example 6; step (2): then mixing the nano-sulfur containing composition prepared in the step (1) with the rest materials in Table 3.
  • This example provides a cold cream (skin cream), a kind of toiletries, and the specific formulation is shown in Table 4 below.
  • the preparation method of the cold cream comprised: step (1): preparing a nano-sulfur containing composition according to Example 12; and step (2): then mixing the nano-sulfur containing composition prepared in the step (1) with the rest materials in Table 4.
  • This example provides a moisturizer, a kind of toiletries, and the specific formulations are shown in Table 5 below.
  • the preparation method of the moisturizer comprised: Step (1): preparing a nano-sulfur containing composition according to Example 7; Step (2): then mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 5.
  • This example provides a moisturizing lotion, a kind of toiletries, and the specific formulation is shown in Table 6 below.
  • the preparation method of the moisturizing lotion comprised: (1): preparing a nano-sulfur containing composition according to Example 15; and step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 6.
  • This example provides a skin care gel/massage gel/cleansing gel/anti-acne gel in toiletries, and the specific formulations thereof are shown in Table 7 below.
  • step (1) preparing a nano-sulfur containing composition according to Example 12; step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the remaining raw materials in Table 7.
  • This example provides a cleaning cream, and the specific formulation thereof is shown in Table 8 below.
  • the preparation method of the cleaning cream comprised: step (1): preparing a nano-sulfur containing composition according to Example 1; step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the remaining raw materials in Table 8.
  • This example provides a facial cleanser, and the specific formulation thereof is shown in Table 9 below.
  • the preparation method of the facial cleanser comprised: step (1): preparing a nano-sulfur containing composition according to Example 5; and step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 9.
  • This example provides a soap-based facial cleanser, and the specific formulation thereof is shown in Table 10 below.
  • the preparation method of the soap-based facial cleanser comprises: step (1): preparing a nano-sulfur containing composition according to Example 11; step (2): mixing the nano-sulfur containing composition prepared by the step (1) with the remaining materials in Table 10.
  • This example provides a facial cleanser of surfactant type, and the specific formulation thereof is shown in Table 11 below.
  • the preparation method of the surfactant type cleanser comprised: Step (1): preparing a nano-sulfur containing composition according to Example 14; Step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest materials in Table 11.
  • This example provides a facial grinding cream/lotion, and the specific formulations thereof are shown in Table 12 below.
  • step (1) preparing a nano-sulfur containing composition according to Example 9
  • step (2) mixing the nano-sulfur containing compound prepared in step (1) with the rest raw materials in Table 12.
  • This example provides a peeling mask, and the specific formulations thereof are shown in Table 13 below.
  • the preparation method of the peeling mask comprised: step (1): preparing a nano-sulfur containing composition according to Example 11; and step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 13.
  • This example provides a molding mask liquid (for oily skin or moisturizing), and the specific formulations thereof are shown in Table 14 below.
  • the preparation method of the molding mask liquid comprised: step (1): preparing a nano-sulfur containing composition according to the Example 12; and step (2): mixing the nano-sulfur containing composition prepared in the step (1) and the rest raw materials in Table 14.
  • This example provides a bath lotion, and the specific formulations thereof are shown in Table 15 below.
  • the preparation method of the bath lotion comprised: step (1): preparing a nano-sulfur containing composition according to Example 1; step (2): mixing the nano-sulfur containing composition prepared in the step (1) and rest raw materials in Table 15.
  • This example provides a shampoo in hair washing products, and the specific formulation thereof is shown in Table 16 below.
  • the preparation method of the shampoo comprised: step (1): preparing a nano-sulfur containing composition according to Example 9; step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in the Table 16.
  • This example provides paste shampoos in hair washing products, and the specific formulations thereof are shown in Table 17 below.
  • the preparation method of the paste shampoos comprised: Step (1): preparing a nano-sulfur containing composition according to Example 6; Step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 17.
  • This example provides hair creams in hair protecting products, and the specific formulations thereof are shown in Table 18 below.
  • the preparation method of the hair care creams comprised: step (1): preparing a nano-sulfur containing composition according to Example 12; and step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 18.
  • This example provides a hair conditioner in hair protecting products, and the specific formulations thereof are shown in Table 19 below.
  • the preparation method of the hair conditioners comprised: Step (1): preparing a nano-sulfur containing composition according to Example 14; Step (2): mixing the nano-sulfur containing composition prepared in the step (1) with the rest raw materials in Table 19.
  • This example provides a soap, which was obtained by adding a certain proportion of the nano-sulfur containing composition prepared in Example 1 during the process of producing the ordinary soap.
  • this example provides a soap of the following formulation: 3% nano-sulfur containing composition prepared in Example 1, 1% essence, antioxidant (BHT 0.08%), 0.1% EDTA, pigment (little or absent), 1% super fatting agent (stearic acid), titanium dioxide (about 0.04% or no), about 13% water, and the rest was soap base.
  • BHT antioxidant
  • EDTA 0.1% EDTA
  • pigment little or absent
  • super fatting agent stearic acid
  • titanium dioxide about 0.04% or no
  • the present example provides a farm chemical, which was obtained by adding the nano-sulfur containing composition prepared in Example 19 to the ordinary farm chemicals, which can be used to treat powdery mildew of crops and the like. It can also be self-provisioned by adding a synergist, other excipients, etc, on the basis of the liquid nano-sulfur containing composition of the present disclosure, and the prepared farm chemical can be appropriately diluted according to the specific circumstances, and then sprayed to the crops.
  • the present example provides a feed, which can be obtained by directly adding the nano-sulfur containing composition prepared in Example 13 in ordinary feeds, thereby improving the disease resistance of the animals and the like.
  • the present example provides a preservative for vegetable and fruit.
  • the nano-sulfur containing composition prepared according to the Example 9 can be directly used as a preservative for vegetables and fruits. Specifically, it can be diluted as needed and directly used for preservation of vegetables and fruits.
  • Examples 22-44 merely exemplarily provide some sulfur containing products prepared by using the nano-sulfur containing composition prepared according to the concept of the present disclosure and preparation method thereof. And in the present disclosure, it is emphatically described that the nano-sulfur containing composition of the present disclosure is added into sulfur containing products such as pastes, lotions and creams, which specifically is to adding the nano-sulfur containing composition of the present disclosure into the existing or new formulations of the products and then stirring evenly, while it does not specifically define the order of the preparations of the the nano-sulfur containing composition of the present disclosure and the basic toiletries or pharmaceutical compositions, there are no time priorities between the two steps.
  • sulfur containing products such as pastes, lotions and creams
  • the inventor of the present disclosure was diagnosed with seborrheic dermatitis due to repeated redness, peeling and pain of the facial skin. After daubing the ointment prescribed by the doctor, the dermatitis was cured after a few days, but if the ointment was not used, it would recur about one or two weeks later. It has happened so many times and then went to see the doctor over and over again, but it wasn't cured.
  • the inventor used his self-made nano-sulfur cream, in which the sulfur content could be only a few thousandths, but it worked very well. Moreover, the inventor used it for more than one year, and there was no side effect such as dry skin peeling.
  • the inventor uses the self-made nano-sulfur shampoo (obtained by adding the nano-sulfur containing composition of the present disclosure into the existing shampoo), which has excellent effect, which has been used for more than one year, and has not found any adverse side effects, and basically avoids the generation of lots of dandruff

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