CN108430589A - 个人护理组合物 - Google Patents
个人护理组合物 Download PDFInfo
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- CN108430589A CN108430589A CN201580085625.5A CN201580085625A CN108430589A CN 108430589 A CN108430589 A CN 108430589A CN 201580085625 A CN201580085625 A CN 201580085625A CN 108430589 A CN108430589 A CN 108430589A
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Abstract
本文描述了个人护理组合物，其包含：阳离子表面活性剂；非离子表面活性剂，其包含选自氧化胺和脂肪酸酰胺的至少一种表面活性剂；以及结构化剂，其包含按所述组合物的重量计量为1.5重量％至7重量％的聚丙烯酸酯‑1交联聚合物。还描述了制备和使用这些组合物的方法。
Description
背景技术
阳离子表面活性剂可以为清洁组合物提供抗菌特性。然而，当阳离子表面活性剂与非离子表面活性剂混合时，所得组合物可能不具有个人护理组合物所需的流变特性。在许多应用中，例如在液体肥皂、乳膏或洗液中，希望产品是可流动的、具有抗菌品质和令消费者愉快的感官品质并且在搅拌时容易形成泡沫。在包含阳离子表面活性剂和非离子表面活性剂混合物的体系中，通常需要使用增稠剂、增粘剂或结构化剂来将粘度增加至消费者对清洁组合物所预期的水平。然而，表面活性剂体系在组成上变得越来越复杂。在许多基于阳离子的皮肤清洁体系中，寻找合适的结构化剂存在更大的挑战，所述结构化剂可以提供必要的流变学特征以使颗粒和活性剂悬浮，从而提供感官和/或化妆益处以及其他性能特性，同时在标准老化条件下在低pH表面活性剂体系中保持可接受的长期产品稳定性。
因此，需要一种化妆或抗菌个人护理清洁组合物，其包含能够使珠粒和其他颗粒悬浮于包含阳离子和非离子表面活性剂的低pH液体清洁组合物中的结构化剂。还期望该组合物提供可接受的物理和性能特性的平衡，例如流动性、抗菌和发泡特征以及令消费者愉悦的感官品质。本发明的实施方案被设计为满足这些需求。
发明内容
本文提供了个人护理清洁组合物，其包含能够使珠粒和其他颗粒悬浮于包含阳离子和非离子表面活性剂的低pH液体清洁组合物中的结构化剂。还提供了组合物，其提供可接受的物理和性能特性的平衡，例如流动性、抗菌和发泡特征以及令消费者愉悦的感官品质。
已经发现，在包含相容性阳离子和非离子表面活性剂的组合的个人清洁体系中使用聚丙烯酸酯例如聚丙烯酸酯-1交联聚合物提供了期望制剂特性的平衡。已经发现，在高于1wt％的浓度下，聚丙烯酸酯-1交联聚合物出乎意料地增加了阳离子和非离子表面活性剂体系的泡沫特征，并且向该体系提供使颗粒长时段悬浮的能力。
在第一个示例性实施方案中，提供了一种个人护理组合物，其包含：阳离子表面活性剂；非离子表面活性剂，其包含选自氧化胺和脂肪酸酰胺的至少一种表面活性剂；以及结构化剂，其包含按所述组合物的重量计量大于1重量％，例如1.5重量％至约7重量％的聚丙烯酸酯-1交联聚合物。
在第二个示例性实施方案中，提供了一种清洁皮肤的方法，其包括以下步骤：提供个人护理组合物，所述人护理组合物包含阳离子表面活性剂；非离子表面活性剂，其包含选自氧化胺和脂肪酸酰胺的至少一种表面活性剂；以及结构化剂，其包含量大于所述组合物的1重量％，例如1.5重量％至约7重量％的聚丙烯酸酯-1交联聚合物；以及将所述组合物施用于皮肤以提供清洁效果。
具体实施方式
除非另外规定，否则本文和在本说明书中其他处表达的所有百分比和量应理解为是指重量百分比。另外，术语“约”在用于提及数值范围时，应理解为是指在该范围内的任何一个值或在该范围内的两个值。
本公开提供了个人护理组合物，其包含添加到具有低pH的阳离子和非离子表面活性剂体系中的聚丙烯酸酯聚合物。在各种实施方案中，所述聚丙烯酸酯聚合物包括聚丙烯酸酯-1交联聚合物或由其组成。已经发现，约1.5重量％至约7重量％的聚丙烯酸酯-1交联聚合物的浓度出乎意料地增加了阳离子和非离子表面活性剂体系的泡沫特征，并且向该体系提供使颗粒长时段悬浮的能力。
在一个示例性实施方案中，本公开提供了一种个人护理组合物(组合物1)，其包含：
阳离子表面活性剂
非离子表面活性剂，其包含选自氧化胺和脂肪酸酰胺的至少一种表面活性剂；以及
结构化剂，其包含按所述组合物的重量计量为约1.5重量％至约7重量％的聚丙烯酸酯-1交联聚合物。
本公开提供另外的示例性实施方案，包括：
1.1组合物1，其中所述聚丙烯酸酯-1交联聚合物按所述组合物的重量计以约1.5重量％至约5重量％、约2重量％至约4重量％或约2.5重量％至约3重量％的量存在。
1.2组合物1或1.1中的任一种，其中所述阳离子表面活性剂包含烷基三甲基铵盐。
1.3组合物1或1.1-1.2中的任一种，其中所述阳离子表面活性剂包含十六烷基三甲基氯化铵。
1.4组合物1或1.1-1.3中的任一种，其还包含阳离子抗菌剂。
1.5组合物1或1.1-1.4中的任一种，其还包含选自苯扎氯铵、苄索氯铵及其组合的阳离子抗菌剂。
1.6组合物1或1.1-1.5中的任一种，其中所述非离子表面活性剂体系包含月桂酰胺丙基二甲基氧化胺、肉豆蔻酰胺丙基二甲基氧化胺、椰油单乙醇酰胺或其组合。
1.7组合物1或1.1-1.6中的任一种，其中所述组合物不含阴离子表面活性剂。
1.8组合物1或1.1-1.7中的任一种，其中所述组合物为液体洗手肥皂、洗发剂、调理剂、液体洗脸肥皂、洗碗肥皂、止汗剂、除臭剂、沐浴露、皮肤乳霜、皮肤乳膏、皮肤调理剂或液体洗涤剂。
1.9组合物1或1.1-1.8中的任一种，其中所述阳离子表面活性剂以所述组合物的约0.1重量％至约10重量％的量存在。
1.10组合物1或1.1-1.9中的任一种，其中所述阳离子表面活性剂以所述组合物的约0.1重量％至约5重量％、约0.5重量％至约10重量％、约0.5重量％至约5重量％、约1重量％至约5重量％或约2重量％至约4重量％的量存在。
1.11组合物1或1.1-1.10中的任一种，其中所述非离子表面活性剂体系以所述组合物的约0.1重量％至约6.0重量％的量存在。
1.12组合物1或1.1-1.11中的任一种，其中所述非离子表面活性剂体系以所述组合物的约0.5重量％至约10重量％、约0.5重量％至约5重量％或约0.5重量％至约3重量％的量存在。
1.13组合物1或1.1-1.12中的任一种，其中所述组合物具有约1∶1至约7∶1的剪切储能模量与剪切损耗模量比率。
1.14组合物1或1.1-1.13中的任一种，其中所述组合物具有约2∶1至约4∶1的剪切储能模量与剪切损耗模量比率。
1.15组合物1或1.1-1.14中的任一种，其中所述组合物具有0.8∶1至1∶0.8的阳离子表面活性剂与总非离子表面活性剂比率。
1.16组合物1或1.1-1.15中的任一种，其中所述组合物还包含选自以下的一种或多种成分：
(a)湿润剂(如，甘油、山梨糖醇、丙二醇)；
(b)脂肪酸(如，己酸、辛酸、癸酸、月桂酸、肉豆蔻酸、棕榈酸、棕榈油酸、硬脂酸、油酸、亚麻酸、亚油酸、花生酸、花生四烯酸)；
(c)脂肪醇(如，鲸蜡硬脂醇、鲸蜡醇、硬脂醇、油醇)；
(d)脂肪酸的酯(如，己酸、辛酸、癸酸、月桂酸、肉豆蔻酸、棕榈酸、棕榈油酸、硬脂酸、油酸、亚麻酸、亚油酸、花生酸、花生四烯酸与醇诸如甘油、丙二醇、脱水山梨糖醇、异丙醇、己醇、辛醇、癸醇、月桂醇、肉豆蔻醇、鲸蜡硬脂醇、鲸蜡醇、棕榈油醇、硬脂醇、油醇、亚油醇、亚麻醇、花生醇、花生四烯醇的酯)，诸如肉豆蔻酸异丙酯、硬脂酸辛酯、橄榄油酸异丙酯、橄榄油酸鲸蜡硬脂醇酯(cetearyl olivate)、油酸鲸蜡硬脂醇酯(cetearyl oleate)、辛酸甘油酯、甘油硬脂酸酯柠檬酸酯和橄榄油酸脱水山梨糖醇酯、天然和合成的甘油三酯(如，脂肪酸的甘油二酯或甘油三酯，诸如癸酸甘油酯或辛酸/癸酸甘油三酯)；
(e)天然脂肪和油(如，植物油、椰子油、芝麻油、鳄梨油、玉米油、蓖麻油、乳木果油、可可脂、大豆油、向日葵油、红花油、橄榄油和牛脂)；
(f)蜡(如，鲸蜡硬脂蜡(cetearyl wax)、蜂蜡、巴西棕榈蜡、羊毛脂蜡、小烛树蜡和石蜡)；
(g)增稠剂(如，二氧化硅、黄原胶、瓜尔胶、琼脂、藻酸盐、角叉菜胶、结冷胶、果胶和改性纤维素聚合物，诸如羟基纤维素、羟丙基纤维素、羟乙基纤维素、羟丁基纤维素、羟丙基甲基纤维素、羟乙基丙基纤维素)；
(h)乳化剂(如，聚乙二醇酯、脂肪醇聚乙二醇醚、脂肪酸聚乙二醇醚、聚甘油脂肪酸酯、山梨糖醇、脱水山梨糖醇和脱水山梨糖醇的单脂肪酸酯及二脂肪酸酯)、
(i)防晒活性物(如，二氧化钛、氧化锌和紫外线吸收抑制剂，诸如甲氧基肉桂酸辛酯、二苯甲酮-3和亚甲基双-苯并三唑基四甲基丁基苯酚)；
(j)维生素(如，维生素A、维生素E、维生素A或维生素E的酯，诸如维生素E乙酸酯和棕榈酸视黄酯)。
1.17组合物1或1.1-1.16中的任一种，其中所述组合物是用于皮肤(如，脸、手、脚等)的乳膏、乳霜或凝胶。
1.18组合物1或1.1-1.17中的任一种，其还包括无机盐、增白剂、香精、着色剂、掩蔽剂、乳浊剂、珠光剂、螯合剂(例如，EDTA)或其任何组合。
1.19组合物1或1.1-1.18中的任一种，其中所述组合物是化妆产品、卸妆产品、除臭剂或止汗剂产品、护发产品、剃须产品(如，乳膏、凝胶和泡沫)、日光浴产品(如，防晒组合物和晒黑组合物)、驱虫产品、护肤产品或个人清洁产品(如，液体肥皂、泡沫、凝胶和乳霜)。
1.20组合物1或1.1-1.19中的任一种，还包含天然生物提取物，诸如精油或香料(如，檀香油、雪松木油、可可原精、古巴香脂、薄荷油、没药树脂、广藿香油、香草醛、香根草油、芦荟提取物、柠檬提取物、橙子提取物、橘子提取物，以及茴香、丁香、罗勒、八角、肉桂、天竺葵、玫瑰、薄荷、薰衣草、百里香、迷迭香、香茅、柏树、桉树、薄荷和檀香的油或提取物)。
1.21组合物1或1.1-1.20中的任一种，还包含水，例如按所述组合物的重量计5-90％例如10％-80％、15％-80％、20％-80％、25％-80％、25％-75％、30％-75％、30％-80％、40％-80％、40％-70％、50％-75％、50％-70％、50％-65％、或60％-70％、或65-70％、或约65％、或约66％、或约67％、或约68％的水。
1.22组合物1或1.1-1.21中的任一种，其中所述组合物的pH为1-8，例如3.0-7.0、或4.0-6.0、或4.8-5.4、或约5.0。
1.23组合物1或1.1-1.22中的任一种，还包含一种或多种类型的悬浮颗粒。
1.24组合物1.23，其中所述颗粒是珠粒。
1.25组合物1.24，其中所述珠选自藻酸盐珠粒、琼脂珠粒、角叉菜胶珠及其组合。
本发明的个人护理组合物包含高负载的阳离子和非离子表面活性剂以及包含聚丙烯酸酯-1交联聚合物的结构化剂。所述组合物与诸如苯扎氯铵的阳离子抗菌剂特别相容。
本公开的新颖组合物能够使颗粒材料悬浮。对于使颗粒悬浮的组合物，组合物的剪切储能模量(G′)必须大于组合物的剪切损耗模量(G“)。也就是说，G′∶G“的比率必须大于1∶1。在本发明组合物的一些实施方案中，组合物的剪切储能模量(G′)与剪切损耗模量(G“)的比率为约1∶1至约7∶1之间，或约2∶1至约4∶1。在一些实施方案中，所述比率为约1.5∶1、约1.6∶1、约1.7∶1、约1.8∶1、约1.9∶1、约2.0∶1、约2.1∶1、约2.2∶1、约2.3∶1、约2.4∶1、约2.5∶1、约2.6∶1、约2.7∶1、约2.8∶1、约2.9∶1、约3.0∶1、约3.1∶1、约3.2∶1、约3.3∶1、约3.4∶1、约3.5∶1、约3.6∶1、约3.7∶1、约3.8∶1；约3.9∶1；或约4.0∶1。
本发明组合物包含至少一种阳离子表面活性剂。阳离子表面活性剂可以是适用于个人护理组合物的任何阳离子表面活性剂在某些实施方案中，阳离子表面活性剂包括季铵烷基盐，例如烷基三甲基铵盐。在一些实施方案中，盐可以是卤化物，例如氯化物或溴化物，或甲硫酸盐。在一些实施方案中，季铵烷基盐的烷基部分可以是C8-C24烷基或C14-C18烷基。在某些实施方案中，阳离子表面活性剂是十六烷基三甲基氯化铵。在一些实施方案中，所述组合物包含一种或多种阳离子表面活性剂的混合物。在某些实施方案中，阳离子表面活性剂以所述组合物的约0.1重量％至约20重量％；或约0.1重量％至约10重量％，约0.1重量％至约5重量％，约0.5重量％至约10重量％，约0.5重量％至约5重量％，约1重量％至约5重量％或约2重量％至约4重量％的量存在。
本发明组合物包含至少一种非离子表面活性剂，其在本文中一起被称为非离子表面活性剂体系。可用于组合物中的非离子型表面活性剂可广义地定义为通过使氧化烯基团(本质上亲水的)与本质上可为脂族或烷基芳族化合物的有机疏水性化合物缩合而产生的化合物。合适的非离子表面活性剂的实例包括泊洛沙姆(以商品名销售)、聚氧乙烯、聚氧乙烯脱水山梨糖醇酯(以商品名销售)、聚乙二醇40氢化蓖麻油、脂肪醇乙氧基化物、烷基酚的聚环氧乙烷缩合物、衍生自环氧乙烷与环氧丙烷和乙二胺的反应产物的缩合的产物、脂族醇的环氧乙烷缩合物、烷基多糖苷(例如，多糖苷的脂肪醇醚，诸如多葡糖苷的脂肪醇醚，如葡萄糖的癸醚、月桂醚、辛醚、辛酰醚、肉豆寇醚、硬脂醚和其他醚以及多葡糖苷聚合物，包括诸如辛基/辛酰基((C8-10))葡糖苷、椰油基(C8-16)葡糖苷和月桂基(C12-16)葡糖苷的混合醚)、长链叔胺氧化物、长链叔膦氧化物、长链二烷基亚砜以及这些物质的混合物。
在一些实施方案中，非离子表面活性剂体系包括下列中的一种或多种：氧化胺、脂肪酸酰胺、乙氧基化脂肪醇、聚乙二醇和聚丙二醇的嵌段共聚物、甘油烷基酯、聚氧乙二醇辛基酚醚、脱水山梨糖醇烷基酯、聚氧乙二醇脱水山梨糖醇烷基酯，以及它们的混合物。氧化胺的实例包括但不限于月桂酰胺丙基二甲基氧化胺、肉豆蔻酰胺丙基二甲基氧化胺以及它们的混合物。脂肪酸酰胺的实例包括但不限于椰油单乙醇酰胺、月桂酰胺单乙醇酰胺、椰油二乙醇酰胺以及它们的混合物。在某些实施方案中，非离子表面活性剂是氧化胺和脂肪酸酰胺的组合。在一些此类实施方案中，氧化胺是月桂酰胺丙基二甲基氧化胺和肉豆蔻酰胺丙基二甲基氧化胺的混合物。在某些实施方案中，非离子表面活性剂是月桂/肉豆蔻酰胺丙基二甲基氧化胺和椰油单乙醇酰胺的组合。在某些实施方案中，非离子表面活性剂体系(即组合物中的组合量的非离子表面活性剂)以所述组合物的约0.1重量％至约20重量％的量存在。在其他实施方案中，所述量为约0.1重量％至约10重量％、约0.1重量％至约6.0重量％、约0.5重量％至约10重量％、约0.5重量％至约5重量％或约0.5重量％至约3重量％。
在一些实施方案中，阳离子表面活性剂和非离子表面活性剂体系以大于0.8∶1的阳离子表面活性剂：非离子表面活性剂体系的重量比率存在于所述组合物中。任选地，所述比率为至少为1∶1。在一些实施方案中，阳离子表面活性剂与总非离子表面活性剂的比率为约0.8∶1至约1∶0.8。在一些实施方案中，阳离子表面活性剂与总非离子表面活性剂的比率为约0.8∶1、约0.81∶1、约0.82∶1、约0.83∶1、约0.84∶1、约0.85∶1、约0.86∶1、约0.87∶1、约0.88∶1、约0.89∶1、约0.9∶1、约0.91∶1、约0.92∶1、约0.93∶1、约0.94∶1、约0.95∶1、约0.96∶1、约0.97∶1、约0.98∶1、约0.99∶1、约1∶1、约1.01∶1、约1.02∶1、约1.03∶1、约1.04∶1、约1.05∶1、约1.06∶1、约1.07∶1、约1.08∶1、约1.09∶1、约1.1∶1、约1.11∶1、约1.12∶1、约1.13∶1、约1.14∶1、约1.15∶1、约1.16∶1、约1.17∶1、约1.18∶1、约1.19∶1或约1.2∶1。
在一些实施方案中，本公开的个人护理组合物包含至少一种结构化剂。结构化剂可以以水溶液、分散液或乳液的形式添加到组合物中。结构化剂增加组合物的粘度。在各种实施方案中，结构化剂与同时具有阳离子和非离子表面活性剂的表面活性剂体系相容。在某些实施方案中，结构化剂包括聚丙烯酸酯-1交联聚合物或由其组成。聚丙烯酸酯-1交联聚合物由Lubrizol Advanced Materials，Inc.以商品名出售。
在某些实施方案中，结构化试剂以大于组合物的1重量％；例如约1.5重量％至约7重量％、约2重量％至约5重量％或约2.5重量％至约3.5重量％的量存在。在一些实施方案中，结构化试剂以所述组合物的约2.00重量％、约2.05重量％、约2.10重量％、约2.15重量％、约2.20重量％、约2.25重量％、约2.30重量％、约2.35重量％、约2.40重量％、约2.45重量％、约2.50重量％、约2.55重量％、约2.60重量％、约2.65重量％、约2.70重量％、约2.75重量％、约2.80重量％、约2.95重量％、约3.00重量％、约3.05重量％、约3.10重量％、约3.15重量％、约3.20重量％、约3.25重量％、约3.30重量％、约3.35重量％、约3.40重量％、约3.45重量％、约3.50重量％、约3.55重量％、约3.60重量％、约3.65重量％、约3.70重量％、约3.75重量％、约3.80重量％、约3.85重量％、约3.90重量％、约3.95重量％或约4.00重量％的量存在。
在一些实施方案中，本公开的组合物可以包含一种或多种润肤剂组分。此类润肤剂组分的示例性实例包括矿物油(如，石蜡油、凡士林油)、动物油(如，鱼油和羊毛脂油)、植物油(如，甜杏仁油、棕榈油、鳄梨油、橄榄油、蓖麻油、谷类胚芽油、芥花油、向日葵油、大豆油和霍霍巴油)、甘油三酯(如，辛酸/癸酸甘油三酯)、硅油(如，环甲硅油)、酯油(如，肉豆蔻酸丁酯、肉豆蔻酸异丙酯、肉豆蔻酸鲸蜡酯、棕榈酸异丙酯、硬脂酸异丙酯、硬脂酸辛酯、硬脂酸异鲸蜡醇酯(isocearyl stearate))、有机脂肪醇(如，油醇、亚麻醇、亚油醇、异硬脂醇、辛基十二醇)。
乳化剂的说明性实例包括乙氧基化羧酸、乙氧基化甘油酯、多元醇醚和乙氧基化脂肪醇。
在一些实施方案中，本公开的个人护理组合物还包含一种或多种选自下列的成分：着色剂、香料、保湿剂和氨基酸。
本公开的个人护理组合物包括至少一种粘度调节剂，其可用于例如抑制成分的沉降或分离或者促进液体组合物在搅拌时的再分散性。在一些实施方案中，粘度调节剂选自聚合物和水溶助长剂。任选地，所述聚合物包含环氧丙烷和环氧乙烷的嵌段共聚物，例如泊洛沙姆。在一些实施方案中，泊洛沙姆包含泊洛沙姆407，其可以商品名F127购自BASF Corporation。一种或多种粘度调节剂任选地以所述组合物的0.01重量％至10重量％，例如0.1重量％至5重量％或约0.01重量％至约1重量％的总量存在。
在一些实施方案中，所公开的组合物包含能够使珠粒、颗粒或颗粒物质悬浮的流变学特征。在一些实施方案中，颗粒具有从球形到到不规则形状的形状。颗粒可以源自无机源或有机来源。示例性的无机颗粒包括碳酸盐、粘土、二氧化硅、硅酸盐、页岩灰、珍珠岩和石英砂。示例性的有机颗粒包括聚合物珠粒如聚丙烯、PVC、三聚氰胺、尿素、聚丙烯酸酯和衍生物。颗粒也可能来源于天然来源。一种类型的合适的颗粒是天然颗粒诸如坚果壳颗粒和植物颗粒，以及种子粉诸如杏仁粉。示例性天然颗粒包括衍生自阿月浑子坚果壳、胡桃壳、杏仁壳以及它们的混合物的那些。其他合适的天然颗粒包括衍生自大米、玉米芯、棕榈生物质、竹、红麻、苹果种子、杏核、橄榄核以及它们的混合物的那些。
珠粒的其他实例包括但不限于明胶、纤维素、琼脂、阿拉伯胶、藻酸盐、角叉菜胶、蜡、聚乙烯、聚乙烯醇、聚(甲基)丙烯酸酯、聚苯乙烯、聚氨酯、聚酰胺、聚环氧化物、乙酸乙烯酯和聚乙烯吡咯烷酮。一些优选的珠粒包括但不限于由琼脂、海藻酸盐或角叉菜胶中的至少一种或其中两种或更多种的组合制成的珠粒。一些前述类型的珠粒可以商品名LIPOSPHERES从CAPTIVATES从Lipo Technologies，Inc.获得，或以商品名CAPTIVATES从International Specialty Products获得。这些类型的珠粒是多孔的并且允许其中放置珠粒的散装液体扩散到珠粒中。这有助于珠粒与组合物在密度方面匹配以帮助使珠粒悬浮。或者，可将材料包封到珠粒中以改变其密度，从而匹配散装液体的密度。
所述组合物中的珠粒的量可以是任何期望的量。在一个实施方案中，珠粒的量为组合物的0.01重量％至10重量％，或0.01重量％至2重量％。
在一些实施方案中，珠粒具有人可见的任何尺寸。所述可见是指无色盲的人可以以20/20或用眼镜或隐形眼镜校正至20/20的肉眼在距组合物30cm的距离处在白炽灯、荧光灯或阳光看见珠粒。在其他实施方案中，至少50％、至少60％、至少70％、至少80％、至少90％、至少95％或至少99％的珠粒的是人可见的。在一个实施方案中，在珠粒的最长尺寸中，粒度为100至2500微米。在另一个实施方案中，粒度为250至2250微米。在另一个实施方案中，粒度为500至1500微米。在另一个实施方案中，粒度为700至1000微米。在另一个实施方案中，可以使用不止一种粒度的组合。在另一个实施方案中，存在五种粒度的组合。
任选的成分可存在于个人护理组合物中。非限制性实例包括皮肤调理剂、保湿剂、香料、染料和颜料、二氧化钛、螯合剂(如EDTA)、防晒活性成分诸如丁基甲氧基苯甲酰基甲烷；抗衰老化合物诸如α-羟基酸、β-羟基酸；防腐剂，如乙内酰脲、咪唑啉；多元醇诸如甘油、山梨糖醇、丙二醇和聚乙二醇；颗粒物诸如二氧化硅、滑石或碳酸钙；抗氧化剂诸如丁基化羟基甲苯(BHT)；维生素诸如A、E、K和C；精油及其提取物，诸如红木和荷荷巴(jojoba)；颗粒物诸如聚乙烯珠粒、荷荷巴珠粒、lufa或燕麦粉。
一些实施方案还包含抗菌剂，所述抗菌剂选自卤化二苯基醚(例如，三氯生)，厚朴酚衍生物，草药提取物或精油(例如，迷迭香提取物、茶叶提取物、百里酚、薄荷醇、桉叶脑、香叶醇、香芹酚、柠檬醛、日桧醇、儿茶酚、水杨酸甲酯、表没食子儿茶素没食子酸酯、表没食子儿茶素、没食子酸、米斯瓦克(miswak)提取物、沙棘提取物)，双胍防腐剂(例如，氯己定、阿来西定或奥替尼啶)，季铵化合物(例如，西吡氯铵(CPC)、苯扎氯铵、十四烷基氯化吡啶(TPC)、N-十四烷基-4-乙基氯化吡啶(TDEPC))，酚类防腐剂，海克替啶，奥替尼啶，血根碱，聚维酮碘，地莫匹醇，salifluor，金属离子(例如，锌盐例如柠檬酸锌，亚锡盐，铜盐，铁盐)，血根碱，蜂胶和氧化剂(例如，过氧化氢、缓冲的过氧硼酸钠或过氧碳酸钠)，邻苯二甲酸或其盐，单过氧邻苯二甲酸或其盐或酯，硬脂酸抗坏血酸酯，肌氨酸油酰酯，硫酸烷酯，磺基琥珀酸二辛酯，水杨酰苯胺、溴化度米芬，地莫匹醇，辛哌乙醇或另一种哌啶子基衍生物，烟酸制剂，亚氯酸盐；及其中两种或更多种的组合。在优选的实施方案中，抗菌剂选自苯扎氯铵，苄索氯铵及其组合。
在一些实施方案中，抗菌剂以总组合物重量的约0.01％至约5％的量存在。在一些实施方案中，苯扎氯铵、苄索氯铵、其组合以总组合物重量的0.01至1％；例如总组合物重量的约0.1％至约0.3％的量存在。
在一些实施方案中，所述个人护理组合物包含按所述组合物的重量计量为约0.001重量％至约2重量％的香料。
在一些实施方案中，所述个人护理组合物包含按重量计量为约0.001重量％至约1重量％的一种或多种颜料，如氧化铬绿。
在一些实施方案中，所述个人护理组合物包含以约0.1重量％至约15重量％，优选约1重量％至约10重量％，更优选约3重量％至约7重量％的水平掺入的硅石或二氧化硅。二氧化硅可为多种形式，包括但不限于晶态、非晶态、火成态、沉淀形态、胶体形态以及胶质形态。
在一些实施方案中，所述个人护理组合物包含无机盐、增白剂、香精、着色剂、掩蔽剂、乳浊剂、螯合剂(例如，EDTA)、湿润剂(例如，多元醇，如甘油)或其任何组合。
在一些实施方案中，所述个人护理组合物包含游离脂肪酸以提供增强的皮肤感益处，例如皮肤感更柔软或更光滑。适宜的游离脂肪酸包括源于动物脂、椰子油、棕榈油和棕榈仁油的那些游离脂肪酸。
在第二示例性实施方案中，本发明包括清洁皮肤的方法(方法1)，其包括以下步骤：提供如上所述的个人护理清洁组合物(例如，组合物1和1.1-1.27中的任一种)的步骤；以及将所述组合物施用于皮肤以提供清洁效果。
本公开提供另外的示例性实施方案，包括：
1.1方法1，其还包括充分搅拌皮肤上的组合物以形成一定体积的泡沫的步骤。
1.2方法1或1.1中的任何一种，其中所形成的泡沫的体积比搅拌60秒后不含聚丙烯酸酯-1交联聚合物的组合物大约60％。
在第三示例性实施方案中，本发明包括用于制备个人护理清洁组合物的方法(方法2)，其包括将有效量的聚丙烯酸酯-1交联聚合物与阳离子表面活性剂和非离子表面活性剂组合。
本文的组合物可以通过本领域已知的工序制备。通常，所述组合物的各种组分与水组合并混合均匀。可采用预混物来预分散或预溶解组分，特别是粉末组分，和/或同时添加若干种组分。
本公开的示例性实施方案将通过参考下列实施例举例说明，这些实施例被包括在内以例证而非限制本发明的范围。
实施例
实施例1
表1示出了紧接着包含很少至没有结构化剂的比较组合物布置的根据本公开的示例性组合物。
表1
根据表1(上文)中所述的配方制备本发明的两种示例性组合物(组合物I和组合物II)。组合物I包含2.5重量％的作为结构化剂的聚丙烯酸酯-1交联聚合物；并且组合物II包含3.00重量％的作为结构化剂的聚丙烯酸酯-1交联聚合物。比较例I不包括作为结构化剂的聚丙烯酸酯-1交联聚合物；并且比较例II包含1重量％的作为结构化剂的聚丙烯酸酯-1交联聚合物。
如下所示，出乎意料地发现，当将相对高浓度的聚丙烯酸酯-1交联聚合物(如在组合物I和II中)添加到在低pH下具有约0.8∶1的阳离子表面活性剂与非离子表面活性剂比率的表面活性剂体系时，所述组合物表现出增强的流变学特征和发泡特征。
实施例2
对组合物I、组合物II、比较例I和比较例II中的每一种进行综合流变学评估。测试在TA系列AR2000或AR G2应力控制流变仪上进行。
观察到，当结构化剂以1重量％或更少的量存在于组合物中时，所述组合物不满足使颗粒悬浮的结构参数要求。
表2
在进行的测试中，组合物在25℃下储存4周。紧接着四周储存期后，分析样品的流变学参数。表2中的结果说明，在组合物I和组合物II中，即使在长时间储存之后，珠粒仍保持悬浮。相比之下，比较例I和比较例II都无法在储存四(4)周后使颗粒保持悬浮。
为了使颗粒悬浮，组合物的剪切储能模量(G′)必须大于组合物的剪切损耗模量(G“)。也就是说，G′/G“的比率必须大于1∶1。如下表3(如下)所示，测试的组合物I和II的G/G“的比率出乎意料得高，分别为2.16和3.60。相比之下，在本发明的某些实施方案的上下文中，比较例I和II分别具有0.28和0.40的G′/G“比率，这等同于不合适的结构性能。
表3
| 组合物I | 组合物II | 比较例I | 比较例II |
| 2.16 | 3.6 | 0.28 | 0.4 |
实施例3
对组合物I、组合物II、比较例I和比较例II中的每一种进行泡沫特征评估。测试在SITA泡沫测试仪R-2000上进行。制备每种组合物的250mL样品，并在40℃的温度下搅拌相同的时段。发现阳离子结构化剂的加入出乎意料地在搅拌时提供增加的泡沫产生。
在试验中，将组合物I、组合物II、比较例I和比较例II各自搅拌80秒的时段，记录产生的泡沫体积。与比较制剂(比较例I和比较例II)相比，组合物I和组合物II出乎意料地在整个测试期间表现出优异的发泡。例如，在搅拌约20秒后，组合物I和组合物II提供了比比较例I大约40％的泡沫产生。这种差异在50秒的搅拌后增长至约50％。搅拌60秒后，与两种对比制剂(比较例I和比较例II)相比，本发明的两种示例性组合物(比较例I和比较例II)显示出约60％的泡沫形成。
实施例4
根据欧洲标准NF EN 1040的工序进行体外抗菌(AB)效力评估。使用短间隔杀灭时间(SIKT)测试来确定当在本发明的几种示例性组合物中测试时化合物的体外短期抗微生物活性。此测试评价了测试生物体的微生物群体在暴露于体外组合物之后的减少。将测试材料与细菌接种物混合，持续所选定的时间间隔，在此之后中和测试体系并已列举存活的细菌。SIKT接触时间为1分钟。必须稀释肥皂样品或其他粘性或固体样品。将与水相比的细菌减少用作表达活性的基础。
选择金黄色葡萄球菌和大肠杆菌作为测试生物体。大肠杆菌是肠道正常菌群的一部分。金黄色葡萄球菌经常在出汗的皮肤上被发现。金黄色葡萄球菌是皮肤感染的常见原因，诸如脓肿、呼吸道感染如鼻窦炎和食物中毒。金黄色葡萄球菌是革兰氏阳性细菌，大肠杆菌是革兰氏阴性细菌。对组合物I和比较例I进行SIKT分析。
表4
| 样品 | 对数减少 |
| 组合物 | 金黄色葡萄球菌＝7.05，大肠杆菌＝7.31 |
| 比较例I | 金黄色葡萄球菌＝7.05，大肠杆菌＝7.31 |
表4(上文)中所示的SIKT测试结果证明组合物I显示出与比较制剂1相同的金黄色葡萄球菌和大肠杆菌杀灭率的效力。因此，发现结构化剂的存在对抗菌效力没有负面效应。
本发明已参考说明性实施例进行描述，但是应理解本发明不限于所公开的实施方案。本领域技术人员在阅读本说明书后将做出的改变和修改也处于本发明的范围，所述范围在所附权利要求书中限定。
Claims (24)
1.一种个人护理组合物，其包含：
阳离子表面活性剂
非离子表面活性剂体系，其包含选自氧化胺和脂肪酸酰胺的至少一种表面活性剂；和
结构化剂，其包含按所述组合物的重量计量为约1.5重量％至约7重量％的聚丙烯酸酯-1交联聚合物。
2.根据权利要求1所述的个人护理组合物，其中所述聚丙烯酸酯-1交联聚合物以按所述组合物的重量计约2重量％至约4重量％的量存在。
3.根据权利要求1或权利要求2所述的个人护理组合物，其中所述阳离子表面活性剂包含烷基三甲基铵盐。
4.根据任一项前述权利要求所述的个人护理组合物，其中所述阳离子表面活性剂包含十六烷基三甲基氯化铵。
5.根据任一项前述权利要求所述的个人护理组合物，其还包含阳离子抗菌剂。
6.根据任一项前述权利要求所述的个人护理组合物，其还包含选自苯扎氯铵、苄索氯铵及其组合的阳离子抗菌剂。
7.根据任一项前述权利要求所述的个人护理组合物，其中所述非离子表面活性剂体系包含月桂酰胺丙基二甲基氧化胺、肉豆蔻酰胺丙基二甲基氧化胺、椰油单乙醇酰胺或其组合。
8.根据任一项前述权利要求所述的个人护理组合物，其中所述组合物基本上不含阴离子表面活性剂。
9.根据任一项前述权利要求所述的个人护理组合物，其中所述组合物是选自液体洗手皂、洗发剂、调理剂、液体洗脸肥皂、止汗剂、除臭剂、沐浴露、皮肤乳霜、皮肤乳膏和皮肤调理剂的形式。
10.根据任一项前述权利要求所述的个人护理组合物，其中所述阳离子表面活性剂以所述个人护理组合物的约0.1重量％至约10重量％的量存在。
11.根据任一项前述权利要求所述的个人护理组合物，其中所述非离子表面活性剂体系以所述个人护理组合物的约0.1重量％至约6.0重量％的量存在。
12.根据任一项前述权利要求所述的个人护理组合物，其中所述组合物具有约1∶1至约7∶1的剪切储能模量与剪切损耗模量比率。
13.根据任一项前述权利要求所述的个人护理组合物，其中所述组合物具有约2∶1至约4∶1的剪切储能模量与剪切损耗模量比率。
14.根据任一项前述权利要求所述的个人护理组合物，其中阳离子表面活性剂与非离子表面活性剂体系的重量比率为约0.8∶1至约1∶0.8。
15.根据任一项前述权利要求所述的个人护理组合物，其中所述组合物的pH为约1至约8.0，例如约3.0至约7.0、约4.0至约6.0、约5.0至约5.4、或约5.0。
16.根据任一项前述权利要求所述的个人护理组合物，其还包含一种或多种悬浮颗粒；例如珠粒，如藻酸盐珠粒、琼脂珠粒、角叉菜胶珠粒或其组合。
17.一种清洁皮肤的方法，其包括以下步骤：
提供个人护理组合物，其包含：阳离子表面活性剂；非离子表面活性剂，其包含选自氧化胺和脂肪酸酰胺的至少一种表面活性剂；以及结构化剂，其包含量为所述组合物的约1.5重量％至约7重量％的聚丙烯酸酯-1交联聚合物；以及
将所述个人护理组合物施用于有需要的受试者的皮肤。
18.根据权利要求17所述的方法，其还包括充分搅拌所述皮肤上的所述组合物以形成一定体积的泡沫的步骤。
19.根据权利要求17或权利要求18所述的方法，其中所述组合物具有约2∶1至约4∶1的剪切储能模量与剪切损耗模量比率。
20.根据权利要求17至19中任一项所述的方法，其中所述聚丙烯酸酯-1交联聚合物以约2重量％至约4重量％的量存在。
21.根据权利要求17至20中任一项所述的方法，其中所述阳离子表面活性剂包含烷基三甲基铵盐。
22.根据权利要求17至21中任一项所述的方法，其中所述非离子表面活性剂体系包含月桂酰胺丙基二甲基氧化胺、肉豆蔻酰胺丙基二甲基氧化胺、椰油单乙醇酰胺或其组合。
23.根据权利要求17至22中任一项所述的方法，其中所述组合物基本上不含阴离子表面活性剂。
24.根据权利要求17至23中任一项所述的方法，其中所形成的泡沫的体积比搅拌60秒后不含聚丙烯酸酯-1交联聚合物的组合物大约60％。
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| EP3383505B1 (en) | 2020-11-11 |
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