US20120258063A1 - Preventing or ameliorating agent for pigmentation - Google Patents
Preventing or ameliorating agent for pigmentation Download PDFInfo
- Publication number
- US20120258063A1 US20120258063A1 US13/516,170 US201013516170A US2012258063A1 US 20120258063 A1 US20120258063 A1 US 20120258063A1 US 201013516170 A US201013516170 A US 201013516170A US 2012258063 A1 US2012258063 A1 US 2012258063A1
- Authority
- US
- United States
- Prior art keywords
- group
- atoms
- carbon atom
- linear
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 [1*]C(=O)NC(CO[2*])C(=O)O[3*] Chemical compound [1*]C(=O)NC(CO[2*])C(=O)O[3*] 0.000 description 8
- NHNOKTNUQMEKAC-UHFFFAOYSA-N CC1=CC=C(C(=O)NC(CO)C(=O)O)C=C1 Chemical compound CC1=CC=C(C(=O)NC(CO)C(=O)O)C=C1 NHNOKTNUQMEKAC-UHFFFAOYSA-N 0.000 description 4
- PLVJUXIGSPRNEF-UHFFFAOYSA-N CC(=O)OCC(NC(=O)C1=CC=C(C)C=C1)C(=O)O Chemical compound CC(=O)OCC(NC(=O)C1=CC=C(C)C=C1)C(=O)O PLVJUXIGSPRNEF-UHFFFAOYSA-N 0.000 description 1
- VPNHXUHYPSGVGL-UHFFFAOYSA-N CCC1=CC=C(C(=O)NC(CO)C(=O)O)C=C1 Chemical compound CCC1=CC=C(C(=O)NC(CO)C(=O)O)C=C1 VPNHXUHYPSGVGL-UHFFFAOYSA-N 0.000 description 1
- JTHWYASMSJOOOA-UHFFFAOYSA-N CCOC(=O)C(CO)NC(=O)C1=CC=C(C)C=C1 Chemical compound CCOC(=O)C(CO)NC(=O)C1=CC=C(C)C=C1 JTHWYASMSJOOOA-UHFFFAOYSA-N 0.000 description 1
- KZRMCGCIPKDWPL-UHFFFAOYSA-N COC(=O)C(CO)NC(=O)C1=CC2=C(C=CC=C2)C=C1 Chemical compound COC(=O)C(CO)NC(=O)C1=CC2=C(C=CC=C2)C=C1 KZRMCGCIPKDWPL-UHFFFAOYSA-N 0.000 description 1
- JORNLPMGQPDHGA-UHFFFAOYSA-N COC(=O)C(CO)NC(=O)C1=CC=C(C)C=C1 Chemical compound COC(=O)C(CO)NC(=O)C1=CC=C(C)C=C1 JORNLPMGQPDHGA-UHFFFAOYSA-N 0.000 description 1
- RUZRZEKDIKONQJ-UHFFFAOYSA-N COCC(NC(=O)C1=CC2=C(C=CC=C2)C=C1)C(=O)O Chemical compound COCC(NC(=O)C1=CC2=C(C=CC=C2)C=C1)C(=O)O RUZRZEKDIKONQJ-UHFFFAOYSA-N 0.000 description 1
- ZZRBOBWFIJQUMS-UHFFFAOYSA-N COCC(NC(=O)C1=CC=C(C)C=C1)C(=O)O Chemical compound COCC(NC(=O)C1=CC=C(C)C=C1)C(=O)O ZZRBOBWFIJQUMS-UHFFFAOYSA-N 0.000 description 1
- VMWDGISMIJACEK-UHFFFAOYSA-N COCC(NC(=O)C1=CC=CC=C1)C(=O)O Chemical compound COCC(NC(=O)C1=CC=CC=C1)C(=O)O VMWDGISMIJACEK-UHFFFAOYSA-N 0.000 description 1
- RPKXPCYNVQWUAY-UHFFFAOYSA-N COc(cc1)ccc1C(NC(CO)C(O)=O)=O Chemical compound COc(cc1)ccc1C(NC(CO)C(O)=O)=O RPKXPCYNVQWUAY-UHFFFAOYSA-N 0.000 description 1
- GSYDRICHDWADGO-UHFFFAOYSA-N O=C(NC(CO)C(=O)O)C1=CC2=C(C=CC=C2)C=C1 Chemical compound O=C(NC(CO)C(=O)O)C1=CC2=C(C=CC=C2)C=C1 GSYDRICHDWADGO-UHFFFAOYSA-N 0.000 description 1
- AVICWUSEDAKRRY-UHFFFAOYSA-N O=C(NC(CO)C(=O)O)C1=CC=C(C(F)(F)F)C=C1 Chemical compound O=C(NC(CO)C(=O)O)C1=CC=C(C(F)(F)F)C=C1 AVICWUSEDAKRRY-UHFFFAOYSA-N 0.000 description 1
- PEPWUDKVPQPZMZ-UHFFFAOYSA-N O=C(NC(CO)C(=O)O)C1=CC=C(C2=CC=CC=C2)C=C1 Chemical compound O=C(NC(CO)C(=O)O)C1=CC=C(C2=CC=CC=C2)C=C1 PEPWUDKVPQPZMZ-UHFFFAOYSA-N 0.000 description 1
- UXACWZYNADSDND-UHFFFAOYSA-N O=C(NC(CO)C(=O)O)C1=CC=C(F)C=C1 Chemical compound O=C(NC(CO)C(=O)O)C1=CC=C(F)C=C1 UXACWZYNADSDND-UHFFFAOYSA-N 0.000 description 1
- MWCDMTCWMZHVAQ-UHFFFAOYSA-N O=C(NC(CO)C(=O)O)C1=CC=CC=C1 Chemical compound O=C(NC(CO)C(=O)O)C1=CC=CC=C1 MWCDMTCWMZHVAQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009-285001 | 2009-12-16 | ||
| JP2009285001 | 2009-12-16 | ||
| PCT/JP2010/072689 WO2011074643A1 (ja) | 2009-12-16 | 2010-12-16 | 色素沈着予防又は改善剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2010/072689 A-371-Of-International WO2011074643A1 (ja) | 2009-12-16 | 2010-12-16 | 色素沈着予防又は改善剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US14/325,724 Division US9414998B2 (en) | 2009-12-16 | 2014-07-08 | Preventing or ameliorating agent for pigmentation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20120258063A1 true US20120258063A1 (en) | 2012-10-11 |
Family
ID=44167394
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US13/516,170 Abandoned US20120258063A1 (en) | 2009-12-16 | 2010-12-16 | Preventing or ameliorating agent for pigmentation |
| US14/325,724 Active 2031-01-22 US9414998B2 (en) | 2009-12-16 | 2014-07-08 | Preventing or ameliorating agent for pigmentation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US14/325,724 Active 2031-01-22 US9414998B2 (en) | 2009-12-16 | 2014-07-08 | Preventing or ameliorating agent for pigmentation |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20120258063A1 (ja) |
| EP (1) | EP2514402B1 (ja) |
| JP (1) | JP5746977B2 (ja) |
| KR (1) | KR101877575B1 (ja) |
| CN (1) | CN102711720B (ja) |
| AU (1) | AU2010331250B2 (ja) |
| BR (1) | BR112012014196B1 (ja) |
| CA (1) | CA2784308C (ja) |
| ES (1) | ES2604104T3 (ja) |
| HK (1) | HK1173662A1 (ja) |
| IL (1) | IL220413B (ja) |
| MX (1) | MX341841B (ja) |
| MY (1) | MY179437A (ja) |
| RU (1) | RU2564897C2 (ja) |
| SG (1) | SG181702A1 (ja) |
| UA (1) | UA111709C2 (ja) |
| WO (1) | WO2011074643A1 (ja) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10568822B2 (en) | 2014-04-03 | 2020-02-25 | Pola Chemical Industries, Inc. | Melanogenesis inhibitor comprising d-pantothenyl alcohol, and skin-whitening cosmetic containing same melanogenesis inhibitor |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5908678B2 (ja) * | 2011-06-14 | 2016-04-26 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| JP6255154B2 (ja) * | 2012-12-10 | 2017-12-27 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| JP6249598B2 (ja) * | 2012-12-10 | 2017-12-20 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| KR101651605B1 (ko) * | 2015-12-10 | 2016-08-26 | 대봉엘에스 주식회사 | 신규 페놀산류 유도체 화합물, 및 이의 용도 |
| RU2757906C1 (ru) * | 2018-05-29 | 2021-10-22 | Пола Кемикал Индастриз, Инк. | Агент для отбеливания кожи |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007013662A1 (ja) * | 2005-07-26 | 2007-02-01 | Shiseido Company, Ltd. | しわ防止・改善剤 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3091270B2 (ja) | 1990-09-28 | 2000-09-25 | 協和醗酵工業株式会社 | 美白化粧料 |
| JP3736405B2 (ja) * | 1992-12-21 | 2006-01-18 | 味の素株式会社 | アミノ酸誘導体及び抗活性酸素剤 |
| JP3091045B2 (ja) | 1993-03-04 | 2000-09-25 | 丸善製薬株式会社 | 皮膚化粧料 |
| GB9703201D0 (en) * | 1997-02-15 | 1997-04-02 | Zeneca Ltd | Chemical compounds |
| JPH10298151A (ja) * | 1997-04-30 | 1998-11-10 | Japan Energy Corp | Ｃ型肝炎ウイルスプロテアーゼ阻害剤 |
| JPH1149630A (ja) * | 1997-07-31 | 1999-02-23 | Shiseido Co Ltd | 美白用化粧料 |
| JP3545173B2 (ja) * | 1997-07-31 | 2004-07-21 | アマノ株式会社 | ダクト管用粉塵堆積防止装置 |
| US5882665A (en) * | 1997-11-18 | 1999-03-16 | Elizabeth Arden Co., Division Of Conopco, Inc. | Phytosphingosine salicylates in cosmetic compositions |
| US6238655B1 (en) * | 1997-12-15 | 2001-05-29 | The Gillette Company | α-amides of L-amino acid as fragrance precursors |
| JPH11310510A (ja) | 1998-04-27 | 1999-11-09 | Kanebo Ltd | 保湿剤並びに皮膚化粧料及び入浴剤 |
| JP2001247443A (ja) | 2000-03-08 | 2001-09-11 | Kanebo Ltd | 皮膚化粧料 |
| JP2002087928A (ja) | 2000-09-18 | 2002-03-27 | Kyowa Hakko Kogyo Co Ltd | 化粧用保湿剤および化粧料 |
| AU2003220896A1 (en) * | 2002-03-28 | 2003-11-10 | Sumitomo Pharmaceuticals Co., Ltd. | Novel heteroaryl compounds |
| JP4664069B2 (ja) | 2002-05-29 | 2011-04-06 | イーライ リリー アンド カンパニー | フェニル−チオフェン型ビタミンｄ受容体調節物資 |
| JP2006511445A (ja) | 2002-06-07 | 2006-04-06 | コーティカル・ピーティーワイ・リミテッド | マクロファージ遊走阻止因子（ｍｉｆ）のサイトカインまたは生物学的活性を阻害するナフタレン誘導体 |
| EP2319838A1 (en) | 2002-06-07 | 2011-05-11 | Cortical Pty Ltd | Therapeutic Molecules and Methods-1 |
| JP4286513B2 (ja) | 2002-09-26 | 2009-07-01 | 株式会社ファンケル | 抗老化用組成物 |
| EP1692093B1 (en) * | 2003-12-08 | 2008-11-19 | Galderma Research & Development | Biphenyl derivatives useful as ligands that activate the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics |
| BRPI0516483A (pt) * | 2004-10-15 | 2008-09-02 | Bayer Pharmaceuticals Corp | preparo e uso de derivados de ácido bifenil-4-il-carbonilamino para o tratamento de obesidade |
| US20060166901A1 (en) * | 2005-01-03 | 2006-07-27 | Yu Ruey J | Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids |
| JP5014592B2 (ja) | 2005-05-25 | 2012-08-29 | 株式会社 資生堂 | 不全角化抑制剤、毛穴縮小剤，肌荒れ防止・改善剤 |
| US8338415B2 (en) | 2006-01-24 | 2012-12-25 | Allergan, Inc. | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors |
| CN101511783A (zh) * | 2006-09-08 | 2009-08-19 | 诺瓦提斯公司 | 用于治疗淋巴细胞相互作用介导的疾病的n-联芳(杂)芳基磺酰胺衍生物 |
-
2010
- 2010-12-16 UA UAA201208560A patent/UA111709C2/uk unknown
- 2010-12-16 BR BR112012014196-1A patent/BR112012014196B1/pt active IP Right Grant
- 2010-12-16 SG SG2012043907A patent/SG181702A1/en unknown
- 2010-12-16 AU AU2010331250A patent/AU2010331250B2/en active Active
- 2010-12-16 MX MX2012006925A patent/MX341841B/es active IP Right Grant
- 2010-12-16 WO PCT/JP2010/072689 patent/WO2011074643A1/ja active Application Filing
- 2010-12-16 MY MYPI2012002721A patent/MY179437A/en unknown
- 2010-12-16 CA CA2784308A patent/CA2784308C/en active Active
- 2010-12-16 EP EP10837668.2A patent/EP2514402B1/en active Active
- 2010-12-16 CN CN201080057325.3A patent/CN102711720B/zh active Active
- 2010-12-16 RU RU2012129932/15A patent/RU2564897C2/ru active
- 2010-12-16 US US13/516,170 patent/US20120258063A1/en not_active Abandoned
- 2010-12-16 KR KR1020127018298A patent/KR101877575B1/ko active IP Right Grant
- 2010-12-16 JP JP2011546169A patent/JP5746977B2/ja active Active
- 2010-12-16 ES ES10837668.2T patent/ES2604104T3/es active Active
-
2012
- 2012-06-14 IL IL220413A patent/IL220413B/en active IP Right Grant
-
2013
- 2013-01-17 HK HK13100760.3A patent/HK1173662A1/xx unknown
-
2014
- 2014-07-08 US US14/325,724 patent/US9414998B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007013662A1 (ja) * | 2005-07-26 | 2007-02-01 | Shiseido Company, Ltd. | しわ防止・改善剤 |
Non-Patent Citations (1)
| Title |
|---|
| Schnabelrauch et al., Title: New synthetic catecholate-type siderophores based on amono acids and peptides, Biometals, volume 13, pages 333-348, 2000 published by Kluwer Academic publishers. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10568822B2 (en) | 2014-04-03 | 2020-02-25 | Pola Chemical Industries, Inc. | Melanogenesis inhibitor comprising d-pantothenyl alcohol, and skin-whitening cosmetic containing same melanogenesis inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1173662A1 (en) | 2013-05-24 |
| UA111709C2 (uk) | 2016-06-10 |
| JPWO2011074643A1 (ja) | 2013-04-25 |
| RU2564897C2 (ru) | 2015-10-10 |
| BR112012014196A2 (pt) | 2016-05-31 |
| US20140322150A1 (en) | 2014-10-30 |
| RU2012129932A (ru) | 2014-01-27 |
| MX2012006925A (es) | 2012-07-17 |
| KR101877575B1 (ko) | 2018-07-12 |
| AU2010331250A1 (en) | 2012-08-02 |
| AU2010331250B2 (en) | 2015-07-30 |
| IL220413A0 (en) | 2012-08-30 |
| KR20120092709A (ko) | 2012-08-21 |
| SG181702A1 (en) | 2012-07-30 |
| ES2604104T3 (es) | 2017-03-03 |
| JP5746977B2 (ja) | 2015-07-08 |
| CA2784308C (en) | 2017-11-28 |
| MX341841B (es) | 2016-09-05 |
| EP2514402A1 (en) | 2012-10-24 |
| US9414998B2 (en) | 2016-08-16 |
| CN102711720B (zh) | 2014-08-27 |
| EP2514402B1 (en) | 2016-08-31 |
| EP2514402A4 (en) | 2014-05-28 |
| WO2011074643A1 (ja) | 2011-06-23 |
| CA2784308A1 (en) | 2011-06-23 |
| CN102711720A (zh) | 2012-10-03 |
| BR112012014196B1 (pt) | 2023-10-03 |
| MY179437A (en) | 2020-11-06 |
| IL220413B (en) | 2018-07-31 |
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| JP2013001657A (ja) | 皮膚外用剤 | |
| JP2013001657A5 (ja) |
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