US20120189611A1 - Dipeptidyl peptidase-4 inhibitor - Google Patents

Dipeptidyl peptidase-4 inhibitor Download PDF

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Publication number
US20120189611A1
US20120189611A1 US13/388,913 US201013388913A US2012189611A1 US 20120189611 A1 US20120189611 A1 US 20120189611A1 US 201013388913 A US201013388913 A US 201013388913A US 2012189611 A1 US2012189611 A1 US 2012189611A1
Authority
US
United States
Prior art keywords
dpp
bean
inhibitor
enzyme
treated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/388,913
Other languages
English (en)
Inventor
Yuji Tominaga
Shinichi Yokota
Hozumi Tanaka
Hideyuki Kishida
Masayasu Kitagawa
Hiroshi Tachi
Toru Ota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Assigned to KANEKA CORPORATION reassignment KANEKA CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KISHIDA, HIDEYUKI, KITAGAWA, MASAYASU, OTA, TORU, TACHI, HIROSHI, TANAKA, HOZUMI, TOMINAGA, YUJI, YOKOTA, SHINICHI
Assigned to KANEKA CORPORATION reassignment KANEKA CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KISHIDA, HIDEYUKI, KITAGAWA, MASAYASU, OTA, TORU, TACHI, HIROSHI, TANAKA, HOZUMI, TOMINAGA, YUJI, YOKOTA, SHINICHI
Publication of US20120189611A1 publication Critical patent/US20120189611A1/en
Assigned to KANEKA CORPORATION reassignment KANEKA CORPORATION CHANGE OF ADDRESS Assignors: KANEKA CORPORATION
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
    • C12Y304/14005—Dipeptidyl-peptidase IV (3.4.14.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
US13/388,913 2009-08-03 2010-08-03 Dipeptidyl peptidase-4 inhibitor Abandoned US20120189611A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009180829 2009-08-03
JP2009-180829 2009-08-03
PCT/JP2010/004872 WO2011016220A1 (ja) 2009-08-03 2010-08-03 ジペプチジルペプチダーゼ－４阻害剤

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2010/004872 A-371-Of-International WO2011016220A1 (ja) 2009-08-03 2010-08-03 ジペプチジルペプチダーゼ－４阻害剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/171,121 Division US9399051B2 (en) 2009-08-03 2014-02-03 Dipeptidyl peptidase-4 inhibitor

Publications (1)

Publication Number Publication Date
US20120189611A1 true US20120189611A1 (en) 2012-07-26

Family

ID=43544130

Family Applications (2)

Application Number Title Priority Date Filing Date
US13/388,913 Abandoned US20120189611A1 (en) 2009-08-03 2010-08-03 Dipeptidyl peptidase-4 inhibitor
US14/171,121 Active 2030-12-31 US9399051B2 (en) 2009-08-03 2014-02-03 Dipeptidyl peptidase-4 inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
US14/171,121 Active 2030-12-31 US9399051B2 (en) 2009-08-03 2014-02-03 Dipeptidyl peptidase-4 inhibitor

Country Status (5)

Country Link
US (2) US20120189611A1 (ja)
EP (1) EP2462943A4 (ja)
JP (1) JP5916387B2 (ja)
CN (1) CN102470166B (ja)
WO (1) WO2011016220A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5854674B2 (ja) * 2011-07-15 2016-02-09 丸善製薬株式会社 ジペプチジルペプチダーゼｉｖ阻害剤
MY165122A (en) 2013-06-12 2018-02-28 Maruha Nichiro Corp Dipeptidyl peptidase-iv (dppiv) inhibitory peptide compound, composition containing the same, and production method for the same
CN104256047B (zh) * 2014-09-09 2017-09-29 安徽省农业科学院农产品加工研究所 一种豆渣蛋白质的提取方法及其用于制备dpp‑iv抑制肽的方法
NZ735710A (en) * 2015-02-27 2019-02-22 Asan Found Composition for preventing or treating valve calcification, containing dpp-4 inhibitor
CN106578961A (zh) * 2016-12-13 2017-04-26 黑龙江省农业科学院食品加工研究所 一种发酵法制作具有降压降糖功效的红豆肽口服液方法
JP2019030229A (ja) * 2017-08-04 2019-02-28 マルコメ株式会社 麹菌、麹菌由来の酵素、血糖値上昇抑制剤、飲食品、医薬組成物、食品添加物、サプリメント及びこれらの製造方法、並びに血糖値上昇抑制方法及び糖取り込み促進方法
CN110800858B (zh) * 2019-11-22 2021-06-15 中国农业大学 一种鲟鱼蛋白肽粉及其制备方法与应用
JP7453662B2 (ja) 2019-12-13 2024-03-21 国立大学法人鳥取大学 ジペプチジルペプチダーゼｉｖ阻害活性が高い豆類発酵物およびその製造方法
JP2023069271A (ja) * 2021-11-05 2023-05-18 住友化学株式会社 Ｄｐｐ－４阻害剤およびその製造方法。

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117933A1 (en) * 2004-05-27 2005-12-15 Campina Nederland Holding B.V. Use of protein hydrolysates for the manufacture of a medicament for prophylaxis and/or treatment of a dpp-iv mediated condition
US20060052382A1 (en) * 2002-12-20 2006-03-09 Duffy Joseph L 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US20090155239A1 (en) * 2005-03-22 2009-06-18 Sodx Co., Ltd. Novel Protease, Microorganism Producing the Same, and Application Thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5940424B2 (ja) * 1981-05-12 1984-09-29 亜児 浅野 大豆以外の豆等を原料とするなつとうの製造法
EP0897012A1 (en) 1997-07-05 1999-02-17 Societe Des Produits Nestle S.A. Cloning of the prolyl-dipeptidyl-peptidase from aspergillus oryzae
JPH1175765A (ja) * 1997-09-03 1999-03-23 Amano Pharmaceut Co Ltd 調味料の製造方法
JP2000072687A (ja) * 1998-08-26 2000-03-07 Nippon Synthetic Chem Ind Co Ltd:The α−グルコシダーゼ阻害剤
DE69903911T2 (de) * 1998-08-26 2003-08-28 Nippon Synthetic Chem Ind alpha-GLUCOSIDASE HEMMER
JP4121215B2 (ja) 1999-05-17 2008-07-23 財団法人微生物化学研究会 スルフォスチン類縁体、並びにスルフォスチン及びその類縁体の製造方法
JP3676637B2 (ja) * 2000-01-05 2005-07-27 日本合成化学工業株式会社 α−グルコシダーゼ阻害剤の製造法
JP4795512B2 (ja) * 2000-07-14 2011-10-19 日本サプリメント株式会社 α−グルコシダーゼ阻害剤の製造法
JP4795511B2 (ja) * 2000-07-14 2011-10-19 日本サプリメント株式会社 α−グルコシダーゼ阻害剤の製造法
JP4652586B2 (ja) 2001-02-08 2011-03-16 キヤノン株式会社 プリントシステムおよびプリンタ
US7183290B2 (en) 2001-06-27 2007-02-27 Smithkline Beecham Corporation Fluoropyrrolidines as dipeptidyl peptidase inhibitors
CN1197561C (zh) 2001-07-03 2005-04-20 北京巨能亚太生命科学研究中心 L－苏糖酸钙在制备预防或治疗损及软骨的疾病的药物中的用途
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
JP2004166628A (ja) * 2002-11-21 2004-06-17 Nippon Supplement Kk α−グルコシダーゼ阻害剤の製造方法
JP2005325062A (ja) * 2004-05-14 2005-11-24 Fuji Oil Co Ltd 糖尿病の予防用組成物
JP2006296251A (ja) * 2005-04-19 2006-11-02 Gunze Ltd α−グルコシダーゼ阻害剤
JP4915833B2 (ja) 2005-07-01 2012-04-11 雪印メグミルク株式会社 ジペプチジルペプチダーゼｉｖ阻害剤
JP2007277163A (ja) 2006-04-06 2007-10-25 Uha Mikakuto Co Ltd ジペプチジルペプチダーゼｉｖ阻害剤
WO2008066070A1 (fr) 2006-11-29 2008-06-05 Uha Mikakuto Co., Ltd. Inhibiteur de dipeptidylpeptidase-iv
JP2008239521A (ja) * 2007-03-26 2008-10-09 Kaneka Corp アンジオテンシン変換酵素阻害剤およびその製造方法
JP2008239522A (ja) * 2007-03-26 2008-10-09 Kaneka Corp 抗アレルギー剤
JP5061710B2 (ja) 2007-05-10 2012-10-31 ユーハ味覚糖株式会社 ジペプチジルペプチダーゼｉｖ阻害剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060052382A1 (en) * 2002-12-20 2006-03-09 Duffy Joseph L 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2005117933A1 (en) * 2004-05-27 2005-12-15 Campina Nederland Holding B.V. Use of protein hydrolysates for the manufacture of a medicament for prophylaxis and/or treatment of a dpp-iv mediated condition
US20090155239A1 (en) * 2005-03-22 2009-06-18 Sodx Co., Ltd. Novel Protease, Microorganism Producing the Same, and Application Thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Reynolds "Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes" Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2: 127-134, 2009 *

Also Published As

Publication number Publication date
EP2462943A4 (en) 2014-11-05
JP5916387B2 (ja) 2016-05-11
WO2011016220A1 (ja) 2011-02-10
US20140142036A1 (en) 2014-05-22
JPWO2011016220A1 (ja) 2013-01-10
EP2462943A1 (en) 2012-06-13
US9399051B2 (en) 2016-07-26
CN102470166A (zh) 2012-05-23
CN102470166B (zh) 2014-04-09

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Legal Events

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AS Assignment

Owner name: KANEKA CORPORATION, JAPAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TOMINAGA, YUJI;YOKOTA, SHINICHI;TANAKA, HOZUMI;AND OTHERS;REEL/FRAME:028042/0358

Effective date: 20120309

AS Assignment

Owner name: KANEKA CORPORATION, JAPAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TOMINAGA, YUJI;YOKOTA, SHINICHI;TANAKA, HOZUMI;AND OTHERS;REEL/FRAME:028206/0314

Effective date: 20120309

AS Assignment

Owner name: KANEKA CORPORATION, JAPAN

Free format text: CHANGE OF ADDRESS;ASSIGNOR:KANEKA CORPORATION;REEL/FRAME:031207/0283

Effective date: 20130107

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION