US20120070458A1 - Adjuvanting meningococcal factor h binding protein - Google Patents
Adjuvanting meningococcal factor h binding protein Download PDFInfo
- Publication number
- US20120070458A1 US20120070458A1 US13/260,534 US201013260534A US2012070458A1 US 20120070458 A1 US20120070458 A1 US 20120070458A1 US 201013260534 A US201013260534 A US 201013260534A US 2012070458 A1 US2012070458 A1 US 2012070458A1
- Authority
- US
- United States
- Prior art keywords
- composition
- adjuvant
- seq
- fhbp
- meningococcal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/260,534 US20120070458A1 (en) | 2009-03-24 | 2010-03-24 | Adjuvanting meningococcal factor h binding protein |
US13/403,865 US8398988B2 (en) | 2009-03-24 | 2012-02-23 | Adjuvanting meningococcal factor H binding protein |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16299909P | 2009-03-24 | 2009-03-24 | |
PCT/IB2010/000733 WO2010109323A1 (en) | 2009-03-24 | 2010-03-24 | Adjuvanting meningococcal factor h binding protein |
US13/260,534 US20120070458A1 (en) | 2009-03-24 | 2010-03-24 | Adjuvanting meningococcal factor h binding protein |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2010/000733 A-371-Of-International WO2010109323A1 (en) | 2009-03-24 | 2010-03-24 | Adjuvanting meningococcal factor h binding protein |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/403,865 Continuation US8398988B2 (en) | 2009-03-24 | 2012-02-23 | Adjuvanting meningococcal factor H binding protein |
Publications (1)
Publication Number | Publication Date |
---|---|
US20120070458A1 true US20120070458A1 (en) | 2012-03-22 |
Family
ID=42382000
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/260,534 Abandoned US20120070458A1 (en) | 2009-03-24 | 2010-03-24 | Adjuvanting meningococcal factor h binding protein |
US13/403,865 Active US8398988B2 (en) | 2009-03-24 | 2012-02-23 | Adjuvanting meningococcal factor H binding protein |
US13/767,853 Active US8834888B2 (en) | 2009-03-24 | 2013-02-14 | Adjuvanting meningococcal factor H binding protein |
US14/307,001 Active US9572884B2 (en) | 2009-03-24 | 2014-06-17 | Adjuvanting meningococcal factor H binding protein |
US15/393,092 Abandoned US20170119868A1 (en) | 2009-03-24 | 2016-12-28 | Adjuvanting meningococcal factor h binding protein |
US15/604,054 Active US10245311B2 (en) | 2009-03-24 | 2017-05-24 | Adjuvanting meningococcal factor H binding protein |
US16/269,370 Active US10568953B2 (en) | 2009-03-24 | 2019-02-06 | Adjuvanting meningococcal factor H binding protein |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/403,865 Active US8398988B2 (en) | 2009-03-24 | 2012-02-23 | Adjuvanting meningococcal factor H binding protein |
US13/767,853 Active US8834888B2 (en) | 2009-03-24 | 2013-02-14 | Adjuvanting meningococcal factor H binding protein |
US14/307,001 Active US9572884B2 (en) | 2009-03-24 | 2014-06-17 | Adjuvanting meningococcal factor H binding protein |
US15/393,092 Abandoned US20170119868A1 (en) | 2009-03-24 | 2016-12-28 | Adjuvanting meningococcal factor h binding protein |
US15/604,054 Active US10245311B2 (en) | 2009-03-24 | 2017-05-24 | Adjuvanting meningococcal factor H binding protein |
US16/269,370 Active US10568953B2 (en) | 2009-03-24 | 2019-02-06 | Adjuvanting meningococcal factor H binding protein |
Country Status (20)
Country | Link |
---|---|
US (7) | US20120070458A1 (ja) |
EP (1) | EP2411048B1 (ja) |
JP (3) | JP5597245B2 (ja) |
CN (2) | CN104548082A (ja) |
AU (1) | AU2010227219B2 (ja) |
BR (1) | BRPI1009828A2 (ja) |
CA (1) | CA2756522C (ja) |
CY (1) | CY1123299T1 (ja) |
DK (1) | DK2411048T3 (ja) |
ES (1) | ES2797504T3 (ja) |
HK (1) | HK1210015A1 (ja) |
HR (1) | HRP20201076T1 (ja) |
HU (1) | HUE049695T2 (ja) |
LT (1) | LT2411048T (ja) |
NZ (1) | NZ595234A (ja) |
PL (1) | PL2411048T3 (ja) |
PT (1) | PT2411048T (ja) |
RU (1) | RU2557315C2 (ja) |
SI (1) | SI2411048T1 (ja) |
WO (1) | WO2010109323A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120064103A1 (en) * | 2009-03-24 | 2012-03-15 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
US10245311B2 (en) | 2009-03-24 | 2019-04-02 | Glaxosmithkline Biologicals Sa | Adjuvanting meningococcal factor H binding protein |
US10328142B2 (en) | 2002-11-22 | 2019-06-25 | Glaxosmithkline Biologicals Sa | Multiple variants of meningococcal protein NMB1870 |
US10376573B2 (en) | 2012-06-14 | 2019-08-13 | Glaxosmithkline Biologicals Sa | Vaccines for serogroup X meningococcus |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ508366A (en) | 1998-05-01 | 2004-03-26 | Chiron Corp | Neisseria meningitidis antigens and compositions |
DK2270173T3 (en) | 1999-05-19 | 2016-03-07 | Glaxosmithkline Biolog Sa | Neisserial combination compositions |
MXPA02004283A (es) | 1999-10-29 | 2002-10-17 | Chiron Spa | Peptidos antigenicos neisseriales. |
CN1800385B (zh) * | 2000-02-28 | 2010-06-02 | 启龙有限公司 | 奈瑟球菌蛋白质的异源表达 |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
CA2716212A1 (en) | 2008-02-21 | 2009-08-27 | Novartis Ag | Meningococcal fhbp polypeptides |
JP2013521327A (ja) * | 2010-03-10 | 2013-06-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
ES2910199T3 (es) | 2010-03-30 | 2022-05-11 | Childrens Hospital & Res Center At Oakland | Proteínas de unión al factor H (fHbp) con propiedades alteradas y métodos de uso de las mismas |
AU2011268507B2 (en) * | 2010-06-25 | 2014-08-14 | Novartis Ag | Combinations of meningococcal factor H binding proteins |
HUE052850T2 (hu) * | 2010-08-23 | 2021-05-28 | Wyeth Llc | Neisseria meningitidis RLP2086 antigéneket tartalmazó stabil készítmények |
NZ607224A (en) | 2010-09-10 | 2014-11-28 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
CA2862247A1 (en) | 2011-12-29 | 2013-07-04 | Novartis Ag | Adjuvanted combinations of meningococcal factor h binding proteins |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
KR101763625B1 (ko) | 2012-03-09 | 2017-08-01 | 화이자 인코포레이티드 | 수막염균 조성물 및 이의 사용 방법 |
WO2014016152A1 (en) | 2012-07-27 | 2014-01-30 | Institut National De La Sante Et De La Recherche Medicale | Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
ES2685894T3 (es) | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
WO2015017817A1 (en) | 2013-08-02 | 2015-02-05 | Children's Hospital & Research Center Oakland | Non-naturally occurring factor h binding proteins (fhbp) and methods of use thereof |
RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
EP4074726A3 (en) | 2014-07-23 | 2022-11-23 | Children's Hospital & Research Center at Oakland | Factor h binding protein variants and methods of use thereof |
EP3270959A1 (en) | 2015-02-19 | 2018-01-24 | Pfizer Inc | Neisseria meningitidis compositions and methods thereof |
SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
CN112138155B (zh) * | 2019-06-28 | 2022-04-12 | 怡道生物科技(苏州)有限公司 | 一种复合佐剂系统及制备该佐剂的方法 |
GB202115151D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Methods |
WO2024030931A1 (en) | 2022-08-03 | 2024-02-08 | Sanofi Pasteur Inc. | Adjuvanted immunogenic composition against neisseria meningitidis b |
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US20120064103A1 (en) * | 2009-03-24 | 2012-03-15 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
US10245311B2 (en) | 2009-03-24 | 2019-04-02 | Glaxosmithkline Biologicals Sa | Adjuvanting meningococcal factor H binding protein |
US10568953B2 (en) | 2009-03-24 | 2020-02-25 | Glaxosmithkline Biologicals Sa | Adjuvanting meningococcal factor H binding protein |
US10376573B2 (en) | 2012-06-14 | 2019-08-13 | Glaxosmithkline Biologicals Sa | Vaccines for serogroup X meningococcus |
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