CY1123299T1 - Ανοσοενισχυτικη μηνιγκιτιδοκοκκικη πρωτεϊνη προσδεσης παραγοντα η - Google Patents

Ανοσοενισχυτικη μηνιγκιτιδοκοκκικη πρωτεϊνη προσδεσης παραγοντα η

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Publication number
CY1123299T1
CY1123299T1 CY20201100679T CY201100679T CY1123299T1 CY 1123299 T1 CY1123299 T1 CY 1123299T1 CY 20201100679 T CY20201100679 T CY 20201100679T CY 201100679 T CY201100679 T CY 201100679T CY 1123299 T1 CY1123299 T1 CY 1123299T1
Authority
CY
Cyprus
Prior art keywords
fhbp
adjuvant
pzc
aluminum hydroxide
meningitococcal
Prior art date
Application number
CY20201100679T
Other languages
English (en)
Inventor
Mario Contorni
Lorenzo Tarli
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42382000&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1123299(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of CY1123299T1 publication Critical patent/CY1123299T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η πρωτεΐνη πρόσδεσης παράγοντα F (fHBP) έχει προταθεί για χρήση στην ανοσοποίηση έναντι μηνιγκιτιδόκοκκου ορομάδας Β («ΜenΒ»). Αυτό το αντιγόνο έχει προσροφηθεί αποτελεσματικά σε ένα ανοσοενισχυτικό υδροξειδίου αργιλίου με (i) διασφάλιση του ότι η προσρρόφηση λαμβάνει χώρα σε ένα pΗ το οποίο είναι ίσο με ή κάτω από το σημείο μηδενικού φορτίου του ανοσοενισχυτικού (PZC), και/ή (ii) επιλογή ενός fHBP και ανοσοενισχυτικού με ένα ισοηλεκτρικό σημείο/PZC εντός του εύρους 5,0 έως 7 και /ή (iii) επιλογή ενός fHBP με ένα ισοηλεκτρικό σημείο πάνω από το PZC του ανοσοενισχυτικού και χρησιμοποιώντας ένα ρυθμιστικό διάλυμα για να φέρει το pΗ εντός 1,2 pΗ μονάδων του PZC. Η προσρόφηση είναι ιδιαίτερα χρήσιμη για συνθέσεις οι οποίες περιλαμβάνουν πολλαπλές fΗΒΡ παραλλαγές και επίσης σε καταστάσεις όπου το ανοσοενισχυτικό υδροξειδίου του αργιλίου θα πρέπει να αποφευχθεί. Οι ρυθμισμένες φαρμακευτικές συνθέσεις μπορούν να περιλαμβάνουν τουλάχιστον δύο διαφορετικά μηνιγκιτιδοκοκκικά fHBP αντιγόνα, τα οποία αμφότερα είναι τουλάχιστον 85% προσροφημένα σε ανοσοενισχυτικό υδροξειδίου του αργιλίου.
CY20201100679T 2009-03-24 2020-07-23 Ανοσοενισχυτικη μηνιγκιτιδοκοκκικη πρωτεϊνη προσδεσης παραγοντα η CY1123299T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16299909P 2009-03-24 2009-03-24
PCT/IB2010/000733 WO2010109323A1 (en) 2009-03-24 2010-03-24 Adjuvanting meningococcal factor h binding protein

Publications (1)

Publication Number Publication Date
CY1123299T1 true CY1123299T1 (el) 2021-12-31

Family

ID=42382000

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100679T CY1123299T1 (el) 2009-03-24 2020-07-23 Ανοσοενισχυτικη μηνιγκιτιδοκοκκικη πρωτεϊνη προσδεσης παραγοντα η

Country Status (20)

Country Link
US (7) US20120070458A1 (el)
EP (1) EP2411048B1 (el)
JP (3) JP5597245B2 (el)
CN (2) CN102427826B (el)
AU (1) AU2010227219B2 (el)
BR (1) BRPI1009828A2 (el)
CA (1) CA2756522C (el)
CY (1) CY1123299T1 (el)
DK (1) DK2411048T3 (el)
ES (1) ES2797504T3 (el)
HK (1) HK1210015A1 (el)
HR (1) HRP20201076T1 (el)
HU (1) HUE049695T2 (el)
LT (1) LT2411048T (el)
NZ (1) NZ595234A (el)
PL (1) PL2411048T3 (el)
PT (1) PT2411048T (el)
RU (1) RU2557315C2 (el)
SI (1) SI2411048T1 (el)
WO (1) WO2010109323A1 (el)

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