US20110286953A1 - Whitening agent, anti-aging agent, and anti-oxidant agent - Google Patents

Whitening agent, anti-aging agent, and anti-oxidant agent Download PDF

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Publication number
US20110286953A1
US20110286953A1 US13/138,378 US201013138378A US2011286953A1 US 20110286953 A1 US20110286953 A1 US 20110286953A1 US 201013138378 A US201013138378 A US 201013138378A US 2011286953 A1 US2011286953 A1 US 2011286953A1
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United States
Prior art keywords
extract
psilotum
agent
whitening
aging
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Abandoned
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US13/138,378
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English (en)
Inventor
Rikako Suzuki
Kiyotaka Hasegawa
Kiyoshi Sato
Tokiya Yokoi
Ken Kusakari
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Shiseido Co Ltd
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Shiseido Co Ltd
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Publication date
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Assigned to SHISEIDO COMPANY, LTD. reassignment SHISEIDO COMPANY, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HASEGAWA, KIYOTAKA, KUSAKARI, KEN, SATO, KIYOSHI, SUZUKI, RIKAKO, YOKOI, TOKIYA
Publication of US20110286953A1 publication Critical patent/US20110286953A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9741—Pteridophyta [ferns]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a whitening agent, an anti-aging agent, and an antioxidant agent, more specifically, relates to a whitening agent, an anti-aging agent, an antioxidant agent comprising a plant extract as an active ingredient, and a skin external preparation comprised thereof.
  • melanin pigments which cause pigmentation of the skin are produced in melanin-producing granules (melanosomes) within melanin cells (melanocytes) between the epidermis and the hypodermis, and the produced melanin diffuses to adjacent cells by osmosis.
  • the biochemical reaction in melanocytes is presumed to be as follows. Namely, the production process of melanin pigment is that tyrosine, an essential amino acid becomes dopaquinone by the action of the enzyme, tyrosinase, and the dopaquinone is converted to black melanin by enzymatic or non-enzymatic oxidation activity.
  • active oxygen is generated by ultraviolet rays.
  • free radical type active oxygen reacts with an oxidizable substrate such as lipid, inducing an oxidation chain reaction. Therefore, active oxygen which can become free radicals amplifies damage to body tissue such as skin.
  • the skin is always exposed to oxygen and ultraviolet rays, and thus, is the tissue which has the greatest oxidative stress damage by free radicals. Recently, it has been considered that a variety of active oxygen species generated by ultraviolet rays cause the peroxidation of sebum and lipid, protein degeneration, enzyme inhibition, etc., and thereby, the inflammation, etc., of the skin is induced over the short term, and aging, cancer, and the like are caused over a prolonged period of time.
  • active oxygen and peroxidized lipids are associated with skin diseases such as atopic dermatitis, contact dermatitis, and psoriasis. In this way, active oxygen (free radicals) is deeply involved in aging of the skin and skin diseases.
  • Substances having the ability to scavenge free radicals can control and terminate free radical chain reactions, and correspond to, for example, substances referred to as antioxidant agents.
  • skin external preparations comprising an antioxidant agent are anticipated to have an effect of prevention and improvement of aging in the skin (for example, aging spots, wrinkles, sagging skin, etc.) caused by photooxidative stress. Further, the skin external preparations can be anticipated to have an effect of prevention and improvement, as skin external preparations for various skin diseases associated with free radicals.
  • Vitamin E and vitamin C which are known as antioxidant agents are in vivo free radicals scavenger antioxidant substances. Further, the synthetic antioxidant substances of BHT and BHA are also known. Furthermore, as conventional antioxidant agents derived from plants, extracts of Chinese mushrooms, enoki mushrooms, shimeji mushrooms, maitake mushrooms, matsutake mushrooms, Ganoderma lucidum, Daedalea dickinsii, Pholiota nameko , and other basidiomycetes have been reported (Patent Documents 6 to 8).
  • antioxidant agents consisting of extracts of a plant belonging to the genus Verbascum of the family Scrophulariaceae (Patent Document 9) and antioxidant agents consisting of extracts of a plant belonging to the genus Cordia of the family Boraginaceae (Patent Document 10) have been reported.
  • Patent Document 5 mentions a solvent extraction of Psilotum nudum belonging to the family Psilotaceae as a plant extract comprising apigenin or amentoflavone. Patent Document 5 shows no data that this plant extract has a melanogenesis stimulation activity, thus, in Patent Document 5, the function of the solvent extraction of Psilotum nudum itself is unclear.
  • the present invention relates to the melanogenesis-inhibitory action and the free radical scavenging-type antioxidation activity due to the Psilotum extract. Thus, the description of Patent Document 5 and the contents of the present invention are completely different.
  • an object of the present invention is to provide a whitening agent, an anti-aging agent, and an antioxidant agent derived from a new plant.
  • the present inventors have performed extensive studies taking the above circumstances into account, and as a result, have found that there is a superior skin whitening activity and antioxidation activity in a specified plant extract, whereby the present invention has been completed.
  • the present invention is a whitening agent comprising an extract of Psilotum spp., the family Psilotaceae.
  • the present invention is a skin external preparation for whitening, comprising an extract of Psilotum spp., the family Psilotaceae.
  • the present invention is an anti-aging agent comprising an extract of Psilotum spp., the family Psilotaceae.
  • the present invention is a skin external preparation for anti-aging, comprising an extract of Psilotum spp., the family Psilotaceae.
  • the present invention is an antioxidant agent comprising an extract of Psilotum spp., the family Psilotaceae.
  • the present invention is a skin external preparation for antioxidation, comprising an extract of Psilotum spp., the family Psilotaceae.
  • the whitening agent of the present invention has a superior skin whitening activity, has a superior effect in lightening and whitening pigmentation, aging spots, freckles, chloasma, or the like after sunburn.
  • the anti-aging agent and the antioxidant agent of the present invention have a superior free radical scavenging ability for preventing and controlling aging in the skin and skin diseases caused by active oxygen (free radicals).
  • the skin external preparation for whitening of the present invention can bring about a superior a whitening effect when applied to the skin, has a superior effect in lightening and whitening pigmentation, aging spots, freckles, chloasma, or the like after sunburn, and has a high level of safety.
  • the skin external preparation for anti-aging and the skin external preparation for antioxidation of the present invention can bring about a superior free radical scavenging ability when applied to the skin, can prevent and control aging in the skin and skin diseases caused by active oxygen (free radicals), and has a high level of safety.
  • FIG. 1 is a drawing showing the melanogenesis-inhibitory action of the plant extract of the present invention.
  • FIG. 2 is a drawing showing the radical elimination method activity of the plant extract of the present invention.
  • the plant used in the present invention is a plant belonging to the family Psilotaceae, the genus Psilotum , which is a cohort of pteridophytes.
  • the genus Psilotum As plants of the genus Psilotum , there are known Psilotum nudum, Psilotum complanatum, Psilotum flabellatum, Psilotum flaccidum, Psilotum triquetrum, Psilotum truncatum , etc.
  • Psilotum nudum As a species which is distributed throughout Japan, Psilotum nudum may be mentioned and is widely distributed in sub-central Japan, Taiwan, southern China, Southeast Asia, etc. In the present invention, specifically, Psilotum nudum is preferable as a plant belonging to the family Psilotaceae, the genus Psilotum.
  • the extract of the plant of the genus Psilotum used in the present invention can be obtained by appropriately drying or crushing the whole plant, followed by extraction with a solvent.
  • the extraction may be performed by standing still at room temperature, or can be accelerated by heating, stirring, and refluxing according to need.
  • the obtained extract may be used directly or used after a treatment such as filtering, concentrating, or decoloring. Further, it is possible to use the extract by removing the solvent followed by the re-dissolution in a different solvent. It is also possible to use the extract by further purifying the extract by charcoal, column chromatography, etc.
  • extraction portion other than the whole plant, specific portions may be collected for extraction.
  • the extraction solvent used in the present invention may be any solvent commonly used in extraction. Specifically, alcohol such as methanol, ethanol, 1,3-butanediol, propylene glycol, and dipropylene glycol; aqueous alcohol; an organic solvent such as acetone, ethyl acetate, and chloroform can be used alone or in combination. However, methanol, ethanol, 1,3-butanediol, acetone, etc., are preferable. Further, these extracts may be purified by solvent fractionation, charcoal treatment, column chromatography, etc.
  • the whitening agent, the antioxidant agent, and the anti-aging agent of the present invention are characterized by comprising the extract of the plant of the genus Psilotum , but may comprise other various components unless the effect of the present invention is impaired.
  • the whitening agent or the anti-aging agent of the present invention may be blended with a skin external preparation to from a skin external preparation for whitening or a skin external preparation for anti-aging on the basis of the antioxidant activity.
  • These skin external preparations can be optimally used in the fields, specifically, cosmetics, pharmaceutical products, quasi drugs, etc.
  • the amount of the plant extract in the skin external preparation comprising the whitening agent or the anti-aging agent of the present invention, as the dried residue of the components derived from plants of the genus Psilotum is normally 0.00001 mass % or more, preferably, 0.0001 mass % or more. If the amount is too small, the effect cannot be sufficiently brought about.
  • the upper limit is not specifically limited unless the effect of the present invention is impaired. However, the excessive addition cannot bring about a remarkable effect appropriate for the increase, and exerts a bad influence in formulation design, usability, etc.
  • the amount is normally 10 mass % or less, more preferably, 5 mass % or less.
  • the skin external preparation comprising the whitening agent or the anti-aging agent of the present invention is prepared by blending the whitening agent or the anti-aging agent with a base for external use.
  • the skin external preparation may appropriately contain, if needed, components used in skin external preparations as, e.g., general cosmetics and pharmaceutical products, for example, moisturizer agents, antioxidants, oil ingredient, ultraviolet rays absorbents, surfactants, thickening agents, alcohols, powder ingredients, coloring materials, aqueous ingredients, water, plant extracts, and various skin nutrients, unless the effect of the present invention is impaired.
  • sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, and gluconic acid; medicines such as caffeine, tannin, verapamil, tranexamic acid, and their derivatives, licorice extract, glabridin, hot water extracts of the fruit of firethorn, various herbal medicines, tocopherol acetate, glycyrrhizinate, their derivatives, or their salts, other whitening agents such as vitamin C, magnesium ascorbyl phosphate, glucoside ascorbic acid, arbutin, kojic acid, alkoxybenzoic acid and/or their salts; sugars such as glucose, fructose, mannose, sucrose, trehalose, etc.
  • sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, and gluconic acid
  • medicines such as caffeine, tannin
  • the skin external preparation comprising the whitening agent or the anti-aging agent of the present invention may be in the form of, for example, an ointment, cream, emulsion, lotion, pack, bath agent, etc., conventional skin external preparations.
  • the form is not particularly limited.
  • the whitening agent or the anti-aging agent of the present invention may be blended with food, as well as used in the aforementioned preparations for external use.
  • the intake of such food is expected to bring about the whitening effect and the anti-aging effect from inside.
  • the Psilotum nudum extracts obtained by the respective extraction methods were used as test samples, and the melanogenesis inhibitory effect was measured and evaluated by the following method.
  • Mouse B16 melanoma cells were seeded in 6-well plates at 100,000 cells/well. The following day, the test sample (in the case of a dried substance, solvent: DMSO) was added.
  • the culture medium was removed three days after the addition of the test sample, and subsequently, 1 ml of EMEM culture medium containing 10% alamar blue solution was added to the culture. After incubation at 37° C. for 30 minutes, 100 ⁇ l of the medium was transferred to a 96-well plate, and the fluorescence was measured at a wavelength of 590 nm using an excitation wavelength of 544 nm. Cell numbers were expressed as relative values to that of the control (only the solvent containing no plant extract added) by comparing the fluorescence intensities, which reflect the number of viable cells.
  • the larger cell number indicates the lower toxicity of a test sample. If the cell number of a test sample was less 80%, the sample was considered as “cytotoxic”.
  • FIG. 1 shows the results when the respective solvent extracts were adjusted to a final concentration of 0.04% (volume/volume). In each case, cytotoxicity was not found. Note that, regarding the control, each solvent alone was similarly adjusted to 0.04% (volume/volume).
  • the plant extracts used in the present invention have a superior melanogenesis inhibitory action, and are useful as whitening agents.
  • the Psilotum nudum extracts obtained by the respective extraction methods were used as the test samples, and the antioxidant effect was measured and evaluated by the following method.
  • test substance dissolved in dimethyl sulfoxide was injected into a 96-well plate at 10 ⁇ l/well, and subsequently, 1 mmol/l of 1,1-diphenyl-2-picrylhydrazyl solution was added thereto at 90 ⁇ l/well. After leaving at room temperature for ten minutes, the absorbency at 517 nm was determined, and the scavenging ratio (%) of radicals to the amount in the control was obtained from the data of the absorbency.
  • the evaluation results are shown in Table 3.
  • the extracts of the plant of the genus Psilotum of the present invention show a superior antioxidant effect, and thus, bring about a superior antioxidant activity for human skin. Therefore, the plant extract, if blended with an external use agent, can be used as an anti-aging agent for preventing the aging of skin and maintaining the condition of youthful and healthy skin.
  • the Psilotum nudum extract amount in each formulation is shown as the amount of dry residue after removal of the extraction solvent.
  • Blending formulation example 1 trimethylglycine 1.0 Psilotum nudum ethanol extract 0.00001 glycerin 1.0 1,3-butylene glycol 5.0 sodium alginate 0.1 ethyl alcohol 5.0 polyoxyethylene polyoxypropylene decyltetra decylether 0.2 sodium hexametaphosphate q.s. citric acid q.s. sodium citrate q.s. phenoxyethanol q.s. fragrance q.s.
  • phenoxyethanol q.s. fragrance q.s. purified water balance Blending formulation example 7 (emulsion) L-arginine 0.1 royal jelly extract 0.1 yeast extract 0.1 Psilotum nudum 90% ethanol extract 10.0 stearyl glycyrrhetinate 0.05 tocopherol acetate 0.1 sodium acetylated hyaluronate 0.1 glycerin 5.0 dipropylene glycol 7.0 polyethylene glycol 1500 2.0 liquid paraffin 7.0 vaseline 3.0 behenyl alcohol 1.0 batyl alcohol 2.0 jojoba oil 1.0 stearic acid 0.5 isostearic acid 0.5 behenic acid 0.5 pentaerythritol tetra 2-ethylhexanoate 3.0 2-cetyl ethylhexanoate 3.0 glycerin monostearate 1.0 polyoxyethylene glycerin monostearate 1.0 carboxyvinyl polymer 0.15 sodium hexametaphosphate
  • Blending formulation example 8 (emulsion) glucoside ascorbic acid 1.5 tranexamic acid 1.0 tocopherol acetate 0.1 sodium hyaluronate 0.05 Psilotum nudum 1,3-butanediol extract 0.0003 pantothenyl ethyl ether 0.1 stearyl glycyrrhetinate 0.1 glycerin 7.0 1,3-butylene glycol 5.0 polyethylene glycol 20000 0.5 vaseline 2.0 jojoba oil 3.0 squalene 2.0 phytosteryl hydroxystearate 0.5 behenyl alcohol 0.5 batyl alcohol 0.2 dimethylpolysiloxane 2.0 pentaerythritol tetra 2-ethylhexanoate 0.1 polyoxyethylene hydrogenated castor oil 1.0 polyoxyethylene glycerin isostearate 3.0 4-t-buy

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US13/138,378 2009-02-09 2010-02-03 Whitening agent, anti-aging agent, and anti-oxidant agent Abandoned US20110286953A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009027227A JP5550839B2 (ja) 2009-02-09 2009-02-09 美白剤
JP2009-027227 2009-02-09
PCT/JP2010/000623 WO2010090001A1 (ja) 2009-02-09 2010-02-03 美白剤、抗老化剤および抗酸化剤

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US13/138,378 Abandoned US20110286953A1 (en) 2009-02-09 2010-02-03 Whitening agent, anti-aging agent, and anti-oxidant agent
US13/954,176 Expired - Fee Related US9364423B2 (en) 2009-02-09 2013-07-30 Whitening agent, anti-aging agent, and antioxidant agent

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US (2) US20110286953A1 (zh)
EP (1) EP2394635B1 (zh)
JP (1) JP5550839B2 (zh)
KR (1) KR101730189B1 (zh)
CN (1) CN102307566B (zh)
HK (1) HK1162138A1 (zh)
TW (1) TWI466686B (zh)
WO (1) WO2010090001A1 (zh)

Cited By (3)

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WO2014163717A1 (en) * 2013-03-11 2014-10-09 Avon Products, Inc. Hoya carnosa extracts and methods of use
US8865231B2 (en) 2012-12-11 2014-10-21 Avon Products, Inc. Hoya carnosa extracts and methods of use
US9265716B2 (en) 2012-12-11 2016-02-23 Avon Products, Inc. Hoya carnosa extracts and methods of use

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JP5943543B2 (ja) * 2010-12-16 2016-07-05 月桂冠株式会社 メラニン抑制剤およびその用途
JP2018177763A (ja) * 2017-04-19 2018-11-15 御木本製薬株式会社 トラネキサム酸類配合製剤
CN108785155A (zh) * 2017-04-28 2018-11-13 捷通国际有限公司 用于治疗皮肤色素沉着的组合物和相关方法
WO2021215409A1 (ja) * 2020-04-20 2021-10-28 株式会社 資生堂 光老化及び／又は真皮色素沈着を予防及び／又は改善する剤，それを用いた美容方法，及びその方法に適用するための美容装置
EP4397371A2 (en) 2020-05-19 2024-07-10 Cybin IRL Limited Deuterated tryptamine derivatives and methods of use

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865231B2 (en) 2012-12-11 2014-10-21 Avon Products, Inc. Hoya carnosa extracts and methods of use
US9265716B2 (en) 2012-12-11 2016-02-23 Avon Products, Inc. Hoya carnosa extracts and methods of use
WO2014163717A1 (en) * 2013-03-11 2014-10-09 Avon Products, Inc. Hoya carnosa extracts and methods of use

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JP2010180189A (ja) 2010-08-19
KR101730189B1 (ko) 2017-04-25
TWI466686B (zh) 2015-01-01
CN102307566B (zh) 2013-07-10
CN102307566A (zh) 2012-01-04
HK1162138A1 (en) 2012-08-24
JP5550839B2 (ja) 2014-07-16
EP2394635A1 (en) 2011-12-14
EP2394635B1 (en) 2014-04-09
TW201031433A (en) 2010-09-01
US9364423B2 (en) 2016-06-14
EP2394635A4 (en) 2012-11-14
WO2010090001A1 (ja) 2010-08-12
KR20110115128A (ko) 2011-10-20
US20130315850A1 (en) 2013-11-28

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