US20100248311A1 - Increasing methionine yield - Google Patents

Increasing methionine yield Download PDF

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Publication number
US20100248311A1
US20100248311A1 US12/681,177 US68117708A US2010248311A1 US 20100248311 A1 US20100248311 A1 US 20100248311A1 US 68117708 A US68117708 A US 68117708A US 2010248311 A1 US2010248311 A1 US 2010248311A1
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Prior art keywords
microorganism
methionine
expression
gene
reduced
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US12/681,177
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Rainer Figge
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Metabolic Explorer SA
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Metabolic Explorer SA
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Assigned to METABOLIC EXPLORER reassignment METABOLIC EXPLORER ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BARBIER, GUILLAUME, CHATEAU, MICHEL, BESTEL-CORRE, GWENAEELLE, BOISART, CEDRIC, SOUCAILLE, PHILIPPE, FIGGE, RAINER
Publication of US20100248311A1 publication Critical patent/US20100248311A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/0101—Formyltetrahydrofolate deformylase (3.5.1.10)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
US12/681,177 2007-10-02 2008-09-25 Increasing methionine yield Abandoned US20100248311A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2007/060433 2007-10-02
PCT/EP2007/060433 WO2009043372A1 (en) 2007-10-02 2007-10-02 Increasing methionine yield
PCT/EP2008/062859 WO2009043803A2 (en) 2007-10-02 2008-09-25 Increasing methionine yield

Related Parent Applications (1)

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PCT/EP2008/062859 A-371-Of-International WO2009043803A2 (en) 2007-10-02 2008-09-25 Increasing methionine yield

Related Child Applications (1)

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US15/043,138 Continuation US10858679B2 (en) 2007-10-02 2016-02-12 Increasing methionine yield

Publications (1)

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US20100248311A1 true US20100248311A1 (en) 2010-09-30

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US12/681,177 Abandoned US20100248311A1 (en) 2007-10-02 2008-09-25 Increasing methionine yield
US15/043,138 Active US10858679B2 (en) 2007-10-02 2016-02-12 Increasing methionine yield

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Country Status (16)

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US (2) US20100248311A1 (de)
EP (2) EP2205754B1 (de)
JP (1) JP5701604B2 (de)
KR (2) KR101636662B1 (de)
CN (2) CN103087971B (de)
AR (1) AR068722A1 (de)
BR (1) BRPI0818528B1 (de)
DK (2) DK2573189T3 (de)
ES (2) ES2600036T3 (de)
HR (1) HRP20160075T1 (de)
HU (2) HUE030032T2 (de)
MX (1) MX2010003609A (de)
MY (2) MY170749A (de)
PL (2) PL2573189T3 (de)
RU (1) RU2010115225A (de)
WO (2) WO2009043372A1 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150072382A1 (en) * 2012-02-17 2015-03-12 Evonik Industriaes Ag Cell with reduced ppgppase activity
US9017976B2 (en) 2009-11-18 2015-04-28 Myriant Corporation Engineering microbes for efficient production of chemicals
US9023624B2 (en) 2010-12-30 2015-05-05 Metabolic Explorer Fermentative production of methionine hydroxy analog (MHA)
CN112779200A (zh) * 2021-01-12 2021-05-11 浙江工业大学 高产l-甲硫氨酸的基因工程菌及其构建与应用

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4110641B2 (ja) 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
BRPI0807760A2 (pt) * 2007-02-19 2014-06-17 Evonik Degussa Gmbh Bactérias corineformes com atividade de formato-thf-sintetase e/ou atividade de clivagem de glicina
WO2010020289A1 (en) 2008-08-22 2010-02-25 Metabolic Explorer Production of n-acetylated sulphur-containing amino acids with microorganisms having enhanced n-acetyltransferase enzymatic activity
WO2010020290A1 (en) * 2008-08-22 2010-02-25 Metabolic Explorer Producing methionine without n-acetyl methionine
DE102009030342A1 (de) 2009-06-25 2010-12-30 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von organisch chemischen Verbindungen
FR2951195B1 (fr) * 2009-10-14 2014-01-31 Roquette Freres Composition riche en methionine destinee a l'alimentation animale
WO2011073738A1 (en) * 2009-12-14 2011-06-23 Metabolic Explorer Use of inducible promoters in the production of methionine
JP5819316B2 (ja) * 2009-12-30 2015-11-24 メタボリック エクスプローラー コハク酸デヒドロゲナーゼを過剰発現させることによるメチオニンの増産
KR101915819B1 (ko) 2009-12-30 2018-11-06 에보니크 데구사 게엠베하 메티오닌 생산을 위한 균주 및 방법
AR083468A1 (es) * 2010-10-25 2013-02-27 Metabolic Explorer Sa Aumento de la disponibilidad de nadph para la produccion de metionina
WO2012090021A1 (en) 2010-12-30 2012-07-05 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine
EP2479279A1 (de) * 2011-01-20 2012-07-25 Evonik Degussa GmbH Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren
US9234223B2 (en) 2011-04-01 2016-01-12 Ajinomoto Co., Inc. Method for producing L-cysteine
BR112013023465B1 (pt) 2011-04-01 2020-10-27 Ajinomoto Co., Inc método para produzir l-cisteína
DE102011006716A1 (de) 2011-04-04 2012-10-04 Evonik Degussa Gmbh Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung
DE102011118019A1 (de) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
AR086790A1 (es) * 2011-06-29 2014-01-22 Metabolic Explorer Sa Un microorganismo para la produccion de metionina con importacion de glucosa mejorada
FR2983870B1 (fr) 2011-12-08 2015-07-17 Roquette Freres Composition en methionine destinee a l'alimentation animale
WO2013160124A1 (en) 2012-04-27 2013-10-31 Evonik Industries Ag Feedback-resistant alpha-isopropylmalate synthases
CN104411821B (zh) 2012-06-18 2017-08-08 代谢探索者公司 用于发酵生产甲硫氨酸的重组微生物
ES2689754T3 (es) * 2012-08-20 2018-11-15 Evonik Degussa Gmbh Procedimiento para la preparación fermentativa de L-aminoácidos utilizando cepas mejoradas de la familia Enterobacteriaceae
WO2014049382A2 (en) 2012-09-26 2014-04-03 Metabolic Explorer Ethylenediamine fermentative production by a recombinant microorganism
DE102012024435A1 (de) 2012-12-14 2014-07-10 Forschungszentrum Jülich GmbH Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren
EP2762571A1 (de) 2013-01-30 2014-08-06 Evonik Industries AG Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren
DK2811028T3 (en) 2013-06-03 2017-05-01 Evonik Degussa Gmbh Process for Preparation of L-Valine Using Recombinant Coryn Bacteria Containing the Propionate Inducible IlvBN Operon
BR112016004367B1 (pt) 2013-08-30 2022-06-14 Evonik Operations Gmbh Microrganismo recombinante e método para a produção fermentativa de metionina e/ou seus derivados
EP2940039A1 (de) * 2014-04-30 2015-11-04 Evonik Degussa GmbH Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems
CN103981206B (zh) * 2014-06-06 2016-03-02 中国科学院天津工业生物技术研究所 一种筛选高产苏氨酸菌株的方法
MY194223A (en) * 2014-09-01 2022-11-22 Evonik Operations Gmbh Method and microorganism for methionine production by fermentation with improved methionine efflux
BR112017019631A2 (pt) * 2015-03-18 2018-05-15 Basf Se ?microrganismo recombinante, composição, métodos para produzir um microrganismo recombinante, para produzir piruvato, succinato, aspartato, malato, lactato, valina, leucina e/ou alanina, e para cultivar ou desenvolver um microrganismo geneticamente modificado, uso de um microrganismo recombinante, processo para produção fermentativa de piruvato, succinato, aspartato, malato, lactato, valina, leucina e/ou alanina, construção de expressão recombinante, e, vetor recombinante?
EP3280794B1 (de) 2015-04-07 2020-05-27 Metabolic Explorer Modifizierter mikroorganismus zur optimierten herstellung von 2,4-dihydroxybutyrat mit verlängertem 2,4-dihydroxybutyrat-ausfluss
CN108026516A (zh) * 2015-08-07 2018-05-11 赢创德固赛有限公司 通过发酵的蛋白硫代羧化物依赖性l-甲硫氨酸生产
FR3041659B1 (fr) 2015-09-30 2017-10-20 Arkema France Procede de production de l-methionine
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ES2748226T3 (es) 2015-11-27 2020-03-16 Evonik Operations Gmbh Procedimiento de producción de L-metionina
US11293029B2 (en) 2015-12-07 2022-04-05 Zymergen Inc. Promoters from Corynebacterium glutamicum
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
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RU2018128142A (ru) 2016-01-08 2020-02-10 Эвоник Дегусса Гмбх Способ получения l-метионина по ферментативной технологии
US10544411B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a glucose permease library and uses thereof
US10544390B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof
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US11560584B2 (en) 2016-12-30 2023-01-24 Quidel Corporation Phage-mediated immunoassay and methods for determining susceptibility of bacteria to antibiotic or probiotic agents
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US20230340428A1 (en) 2020-07-15 2023-10-26 Evonik Operations Gmbh Polynucleotide encoding an amino acid sequence, encoding an oxidoreductase
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CN117836314A (zh) 2021-08-09 2024-04-05 赢创运营有限公司 用于生产重组细菌胶原样蛋白(clp)的方法
WO2023016895A1 (en) 2021-08-09 2023-02-16 Evonik Operations Gmbh Polynucleotide encoding a bacterial collagen-like protein
CN117999103A (zh) 2021-09-20 2024-05-07 赢创运营有限公司 非粘附性胶原蛋白样水凝胶
WO2023161038A1 (en) 2022-02-25 2023-08-31 Evonik Operations Gmbh Sponges based on collagen-like proteins
WO2023165952A1 (en) 2022-03-01 2023-09-07 Evonik Operations Gmbh Biotechnological production of collagen proteins and bacterial collagen-like proteins by recombinant microorganisms

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796916A1 (de) * 1996-03-22 1997-09-24 Triple-A B.V. Verbesserung von Aminosäure-Fermentationsverfahren
US20060270013A1 (en) * 2003-02-18 2006-11-30 Michel Chateau Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3207746B2 (ja) 1996-03-25 2001-09-10 シャープ株式会社 ファクシミリ装置
GB9724627D0 (en) * 1997-11-20 1998-01-21 Genencor Int Bv Gram positive microorganism formate pathway
JP2000157267A (ja) 1998-11-24 2000-06-13 Ajinomoto Co Inc 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法
KR100488463B1 (ko) 2003-07-24 2005-05-11 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동장치 및 방법
WO2005111202A1 (en) 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
KR100651220B1 (ko) 2004-06-29 2006-11-29 씨제이 주식회사 Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법
KR100656590B1 (ko) * 2004-07-30 2006-12-11 한국과학기술원 박테리아 변이균주 및 이를 이용한 숙신산 및 아미노산의제조방법
JP2008529485A (ja) * 2005-02-07 2008-08-07 メタボリック エクスプローラー 低いγ脱離活性を有する発現酵素を含む微生物
MX2008000480A (es) 2005-07-18 2008-03-07 Basf Ag Microorganismos recombinantes que producen metionina.
WO2007020295A2 (en) * 2005-08-18 2007-02-22 Basf Ag Microorganisms with increased efficiency for methionine synthesis
CN101291590A (zh) 2005-10-31 2008-10-22 巴斯夫欧洲公司 用于制备l-甲硫氨酸的微生物和方法
JP5172697B2 (ja) * 2006-01-04 2013-03-27 メタボリック エクスプローラー 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法
BRPI0807760A2 (pt) * 2007-02-19 2014-06-17 Evonik Degussa Gmbh Bactérias corineformes com atividade de formato-thf-sintetase e/ou atividade de clivagem de glicina

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796916A1 (de) * 1996-03-22 1997-09-24 Triple-A B.V. Verbesserung von Aminosäure-Fermentationsverfahren
US20060270013A1 (en) * 2003-02-18 2006-11-30 Michel Chateau Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Anderson, 1946, Growth Requirements of Virus-Resistant Mutants of Escherichia Coli Strain "B".Proc. Natl. Acad. Sci. USA 32:120-128. *
ATCC, Host cells ATCC# 27325; W3110. downloaded 09-OCT-2012 *
Trötschel et al, Characterization of methionine export in Corynebacterium glutamicum. J Bacteriol 2005 Jun;187(11):3786-94. *
Usuda et al, Effects of Deregulation of Methionine Biosynthesis on Methionine Excretion in Escherichia coli. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, June 2005, p. 3228-3234. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017976B2 (en) 2009-11-18 2015-04-28 Myriant Corporation Engineering microbes for efficient production of chemicals
KR20160114184A (ko) 2009-11-18 2016-10-04 미리안트 코포레이션 화합물들의 효과적인 생산을 위한 미생물 엔지니어링
US9023624B2 (en) 2010-12-30 2015-05-05 Metabolic Explorer Fermentative production of methionine hydroxy analog (MHA)
US20150072382A1 (en) * 2012-02-17 2015-03-12 Evonik Industriaes Ag Cell with reduced ppgppase activity
CN112779200A (zh) * 2021-01-12 2021-05-11 浙江工业大学 高产l-甲硫氨酸的基因工程菌及其构建与应用

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Publication number Publication date
RU2010115225A (ru) 2011-11-10
CN103087971B (zh) 2016-12-28
HUE030032T2 (en) 2017-04-28
WO2009043803A2 (en) 2009-04-09
US10858679B2 (en) 2020-12-08
US20160160249A1 (en) 2016-06-09
MY180720A (en) 2020-12-07
PL2573189T3 (pl) 2017-01-31
KR20150038696A (ko) 2015-04-08
EP2205754A2 (de) 2010-07-14
BRPI0818528A2 (pt) 2016-07-26
JP5701604B2 (ja) 2015-04-15
BRPI0818528A8 (pt) 2017-09-19
WO2009043803A3 (en) 2009-06-18
EP2573189B1 (de) 2016-08-03
KR20100075587A (ko) 2010-07-02
CN101821401B (zh) 2013-10-30
CN103087971A (zh) 2013-05-08
WO2009043372A1 (en) 2009-04-09
KR101636662B1 (ko) 2016-07-05
JP2010539962A (ja) 2010-12-24
MY170749A (en) 2019-08-27
AR068722A1 (es) 2009-12-02
DK2573189T3 (en) 2016-09-26
DK2205754T3 (en) 2015-12-21
EP2573189A1 (de) 2013-03-27
HUE026672T2 (en) 2016-07-28
CN101821401A (zh) 2010-09-01
PL2205754T3 (pl) 2016-04-29
ES2557487T3 (es) 2016-01-26
ES2600036T3 (es) 2017-02-06
KR101586098B1 (ko) 2016-01-19
BRPI0818528B1 (pt) 2023-01-17
HRP20160075T1 (hr) 2016-02-12
MX2010003609A (es) 2010-04-30
EP2205754B1 (de) 2015-11-04

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