US20040219141A1 - Reducer of blood glucose level increase reducer of body fat accumulation and food material - Google Patents

Reducer of blood glucose level increase reducer of body fat accumulation and food material Download PDF

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US20040219141A1
US20040219141A1 US10/715,125 US71512503A US2004219141A1 US 20040219141 A1 US20040219141 A1 US 20040219141A1 US 71512503 A US71512503 A US 71512503A US 2004219141 A1 US2004219141 A1 US 2004219141A1
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Prior art keywords
palatinose
blood glucose
glucose level
food material
reducer
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Jun Kashimura
Yukie Nagai
Tadashi Ebashi
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Mitsui DM Sugar Co Ltd
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Shin Mitsui Sugar Co Ltd
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Application filed by Shin Mitsui Sugar Co Ltd filed Critical Shin Mitsui Sugar Co Ltd
Assigned to SHIN MITSUI SUGAR CO., LTD. reassignment SHIN MITSUI SUGAR CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EBASHI, TADASHI, KASHIMURA, JUN, NAGAI, YUKIE
Publication of US20040219141A1 publication Critical patent/US20040219141A1/en
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Priority to US12/832,933 priority Critical patent/US9017744B2/en
Priority to US12/832,944 priority patent/US9017745B2/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/14—Organic oxygen compounds
    • A21D2/18—Carbohydrates
    • A21D2/181—Sugars or sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a reducer of blood glucose level increase, a reducer of body fat accumulation, a food material, a method for reducing blood glucose level and a method for reducing body fat accumulation.
  • Monoterpene glycoside is known to have an effect of reducing blood glucose level increase through a sucrase inhibition effect (JP Tokkai H6-100453).
  • Examples of such monoterpene glycoside include a betaine from a sugar beet (JP Tokkai H8-133970), a saponin mixture from Alaria elata (JP Tokkai H8-283169), and an ⁇ -glucosidase inhibitor (JP Tokkai H8-289783).
  • L-arabinose is also demonstrated to inhibit specifically the activity of small intestine sucrase which decomposes sucrose (Nihon Eiyo/Syokuryo Gakkai Shi (The Journal of JSNFS), Vol.50, No.2, 133-137 (1997)).
  • the Gymnema extract etc. taste so bitter as to block sweet taste, and hence can not be used without a particular treatment.
  • the indigestible dextrin and L-arabinose, though carbohydrate, are difficult to be digestibly absorbed, and sometimes cause diarrhea when they are ingested in a large amount.
  • a substance having an effect of inhibiting sucrase activity is pointed out that, when ingested together with sucrose, it allows the sucrose to reach a large intestine without decomposition.
  • all the above substances demonstrating the effect of reducing blood glucose level increase have various problems such as inconvenience at use and limited application.
  • An object of the present invention is to provide a reducer of blood glucose level increase which can solve the above problems in the prior art.
  • the present inventors have made a diligent study and found out that a combination of certain substance causing the blood glucose level increase and palatinose can be ingested, while solving the problems, to reduce blood glucose level increase caused by the substance, and have completed the invention.
  • the invention provides a reducer of blood glucose level increase comprising palatinose as an active ingredient, wherein the reducer is ingested before or after or simultaneously with consuming a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides, and wherein the reducer reduces an increase in blood glucose level caused by consuming said carbohydrate(or a reducer of blood glucose level increase for reducing a blood glucose level increase caused by consuming a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides characterized by comprising palatinose as an active ingredient and being ingested before or after or simultaneously with consuming the carbohydrate).
  • GI Glycemic Index
  • palatinose is a foodstuff having a low Glycemic Index and causes no sudden increase or decrease in blood glucose level after ingestion
  • GI Glycemic Index
  • sucrose ⁇ -D-glucohydrolase catalyzes to decompose sucrose into glucose and fructose and is specific for sucrose or maltose as the substrate, it does not catalyze to decompose palatinose or isomaltose having different bond of the same combinations of the constituent sugars to sucrose or maltose, respectively. Therefore, it is reported that, when sucrose and palatinose coexist, they are catalyzed independently to decompose without mutual influence.
  • isomaltase (oligo-1,6-glucosidase), which is an enzyme catalyzing decomposition of palatinose inside a digestive tract, catalyzes to decompose a carbohydrate having an ⁇ -1,6-glucosyl bond such as isomaltose, panose and isomaltotriose.
  • palatinose and these carbohydrates coexist, they competitively inhibit decomposition reaction catalyzed by the enzyme one another, resulting in their respective slow decomposition rates (Nihon Eiyo/Syokuryo Gakkai Shi(Journal of Japanese Society of Nutrition and Food Science), Vol.36, No.3, 169-173 (1983)).
  • palatinose can reduce the blood glucose level increase caused by consuming a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of 50% or more relative to the total bonds among constituent saccharides.
  • palatinose is not supposed to be able to reduce the blood glucose level increase caused by consuming a carbohydrate having no ⁇ -1,6-glucosyl bond including monosaccharide or a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of less than 50% relative to the total bonds among constituent saccharides.
  • the present invention provides a reducer of blood glucose level increase comprising palatinose as an active ingredient, wherein the reducer is ingested before or after or simultaneously with consuming at least one foodstuff being selected from the group consisting of sucrose, wheat flour, starch, dextrin and high fructose corn syrup, and wherein the reducer reduces an increase in blood glucose level caused by consuming the foodstuff (or a reducer of blood glucose level increase for reducing a blood glucose level increase caused by consuming at least one foodstuff selected from the group consisting of sucrose, wheat flour, starch, dextrin and high fructose corn syrup, characterized by comprising palatinose as the active ingredient and being ingested before or after or simultaneously with consuming the foodstuff).
  • Starch and dextrin are catalyzed by ⁇ -amylase, ⁇ -amylase and ⁇ -glucosidase (maltase) to decompose to glucose, which is absorbed at small intestine. Palatinose, though having a glucosyl group, is demonstrated to be hardly catalyzed by ⁇ -glucosidase.
  • High fructose corn syrup composed of glucose and fructose, a commercial product of saccharide (carbohydrate) composed of monosaccharides, is ingested to give a sudden increase and decrease curve in blood glucose level as is seen in sucrose. It has been considered that high fructose corn syrup, which is composed of the monosaccharides, is not competitive as to catalysis by the decomposition enzyme for palatinose and is easily absorbed.
  • sucrose, glucose, starch and dextrin are representative of carbohydrates which are apt to raise suddenly blood glucose level after ingestion and are used in a wide range of processed foods.
  • High fructose corn syrup a liquid sugar composed of glucose and fructose which are the constituent saccharides of sucrose, is ingested to show a blood glucose level increase curve similar to that of sucrose.
  • palatinose don't cause competitive inhibition because the decomposing enzymes for the above described carbohydrates, which are easily digestible, are significantly different from palatinose decomposing enzyme (palatinose is catalyzed to decompose at a rate about one fifth of that of sucrose), and that palatinose has no influence on the absorption of a monosaccharide such as glucose.
  • the invention that palatinose is ingested before or after or simultaneously with consuming at least one foodstuff being selected from the group consisting of sucrose, wheat flour, starch, dextrin and high fructose corn syrup to reduce an increase in blood glucose level caused by consuming the foodstuff, provides a completely novel knowledge.
  • the invention also provides a reducer of blood glucose level increase comprising palatinose as an active ingredient, wherein the reducer is ingested before or after or simultaneously with consuming food, and wherein the reducer reduces an increase in blood glucose level caused by consuming the food (or a reducer of blood glucose level increase for reducing an increase in blood glucose level caused by consuming food characterized by comprising palatinose as the active ingredient and being ingested before or after or simultaneously with consuming the food).
  • the amount of carbohydrate upon ingesting an ordinary food is considered to be 50-150 g per food. And the carbohydrate contained in one feed causes mainly blood glucose level increase after eating.
  • An ordinary food uses food material which contain a lot of carbohydrate such as potatoes, rice products (rice diet, noodles such as Vietnamese pho noodle or rice vermicelli, and rice cake) and wheat products (wheat flour, wheat noodle, bread, baked cake, pizza crust and Japanese pancake).
  • the carbohydrate contained in them is mainly starch.
  • palatinose it is more difficult to reduce an increase in blood glucose level through consuming a carbohydrate in food, which exists with other ingredients in being kneaded with or surrounded by the other ingredients, than to reduce an increase in blood glucose level through consuming a carbohydrate such as monosaccharide and disaccharide, which are consumed as an aqueous solution. Therefore, the fact that palatinose is ingested to reduce blood glucose level increase after eating provides a completely novel knowledge.
  • the invention provides a reducer of body fat accumulation comprising palatinose as an active ingredient, wherein the reducer is ingested before or after or simultaneously with consuming a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides, and wherein the reducer reduces body fat accumulation resulted from the increase in blood glucose level and insulin secretion caused by ingesting the carbohydrate (or a reducer of body fat accumulation for reducing body fat accumulation resulted from the increase in blood glucose level and insulin secretion amount caused by ingesting a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides, characterized by comprising palatinose as the active ingredient and being ingested before or after or simultaneously with consuming the carbohydrate).
  • the invention provides a reducer of body fat accumulation comprising palatinose as an active ingredient, wherein the reducer is ingested before or after or simultaneously with consuming at least one foodstuff being selected from the group consisting of sucrose, wheat flour, starch, dextrin and high fructose corn syrup, and wherein the reducer reduces body fat accumulation resulted from the increase in blood glucose level and insulin secretion caused by consuming the foodstuff (or a reducer of body fat accumulation for reducing body fat accumulation resulted from the increase in blood glucose level and insulin secretion amount caused by ingesting at least one foodstuff being selected from the group consisting of sucrose, wheat flour, starch, dextrin and high fructose corn syrup, characterized by comprising palatinose as the active ingredient and being ingested before or after or simultaneously with consuming the foodstuff).
  • the invention provides a reducer of body fat accumulation comprising palatinose as an active ingredient, wherein said reducer is ingested before or after or simultaneously with consuming food, and wherein the reducer reduces body fat accumulation resulted from the increase in blood glucose level and insulin secretion caused by consuming the food (or a reducer of body fat accumulation for reducing body fat accumulation resulted from the increase in blood glucose level and insulin secretion amount caused by consuming food, characterized by comprising palatinose as the active ingredient and being ingested before or after or simultaneously with consuming the food).
  • LPL lipoprotein lipase
  • palatinose is ingested before or after or simultaneously with consuming carbohydrate to result in a mild increase/decrease curve of blood glucose level, to inhibit activation of LPL and to make accumulating body fat difficult.
  • the invention provides a method for reducing blood glucose level increase by allowing an individual to ingest the above reducer of blood glucose level increase, and a method for reducing body fat accumulation by allowing an individual to ingest the above reducer of body fat accumulation.
  • the invention provides food materials as shown in following (1)-(6).
  • a food material comprising palatinose and a foodstuff composed of a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides, wherein the food material reduces blood glucose level increase caused by consuming the foodstuff (or a food material comprising palatinose and a foodstuff composed of a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides, characterized in that the food material comprises the palatinose in an amount necessary to reduce an increase in blood glucose level caused by consuming the foodstuff).
  • a food material comprising palatinose and at least one foodstuff being selected from the group consisting of sucrose, wheat flour, starch, dextrin and high fructose corn syrup, wherein the food material reduces blood glucose level increase caused by consuming said foodstuff (or a food material comprising palatinose and at least one foodstuff being selected from the group consisting of sucrose, wheat flour, starch, dextrin and high fructose corn syrup, characterized in that the food material comprises the palatinose in an amount necessary to reduce an increase in blood glucose level caused by ingesting the foodstuff).
  • Each of the above food material (1)-(6) or a food processed from the food material can be ingested to reduce an increase in blood glucose level caused by consuming the above foodstuff.
  • the invention provides food material as shown in following (7)-(12).
  • a food material comprising palatinose and a foodstuff composed of a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides, wherein the food material reduces body fat accumulation resulted from the increase in blood glucose level and insulin secretion caused by ingesting the foodstuff.
  • a food material comprising palatinose and at least one foodstuff being selected from the group consisting of sucrose, wheat flour, starch, dextrin and high fructose corn syrup, wherein the food material reduces body fat accumulation resulted from the increase in blood glucose level and insulin secretion caused by ingesting the foodstuff.
  • Each of the above food material (7)-(12) or food processed from the food material can be ingested to reduce body fat accumulation resulted from the increase in blood glucose level and insulin secretion caused by ingesting the above foodstuff.
  • FIG. 1 is a diagram showing the changes in blood glucose level after ingesting drinks in Example 1.
  • FIG. 2 is a diagram showing the areas under blood glucose level increase curve after ingesting sucrose-containing drinks in Example 1.
  • FIG. 3 is a diagram showing the areas under blood glucose level increase curve after ingesting glucose-containing drinks in Example 1.
  • FIG. 4 is a diagram showing the relation between palatinose percent in carbohydrate and GI value, wherein the carbohydrate is consumed by a weight of 50 g.
  • FIG. 5 is a diagram showing the changes in blood glucose level after ingesting drinks in Example 2.
  • FIG. 6 is a diagram showing the areas under blood glucose level increase curve after ingesting drinks in Example 2.
  • FIG. 7 is a diagram showing the transition in body weight after ingesting feeds in Example 3.
  • FIG. 8 is a diagram showing the wet weights of different fat tissues after ingesting feeds in Example 3.
  • FIG. 9 is a diagram showing the sum of the wet weights of different fat tissues in FIG. 8.
  • Palatinose in the invention which is also called as isomaltulose, is a disaccharide composed by allowing glucose to make an ⁇ -1,6-glucosyl bond to fructose.
  • Palatinose may be a hydrate. Monohydrate thereof has a melting point of 123-124° C., a specific rotation [ ⁇ ] 20 D of +97.2, a Fehling solution reduction of 52% relative to glucose, and a solubility of 38.4 g in 100 g water at 20° C.
  • the aqueous solution tastes fine sweet and has about 40% in sweetness relative to sucrose.
  • Palatinose is naturally found in honey or sugarcane juice. It is also found in a product transferred from sucrose by the action of an ⁇ -glucosyltransferase (isomaltulose synthase) from bacteria or yeasts.
  • ⁇ -glucosyltransferase isomaltulose synthase
  • Palatinose is industrially manufactured by treating sucrose with an ⁇ -glucosyltransferase produced by a bacteria such as Protaminobacter rubrum and Serratia plymuthica.
  • a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides is classified into “a carbohydrate having no ⁇ -1,6-glucosyl bond” and “a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from above 0% to less than 50% relative to the total bonds among constituent saccharides.”
  • Examples of “a carbohydrate having no ⁇ -1,6-glucosyl bond” include carbohydrates such as maltose, sucrose, high fructose corn syrup and glucose.
  • Examples of “a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from above 0% to less than 50% relative to the total bonds among constituent saccharides” include starch, dextrin and branched dextrin. Isomaltose, panose, isopanose and isomaltotriose do not correspond to the carbohydrate causing the increase in blood glucose level in the invention, because they have an ⁇ -1,6-glucosyl bond ratio of 50% or more relative to the total bonds among constituent saccharides.
  • a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides may be used alone or in combination of two or more.
  • the carbohydrate includes not only a carbohydrate commercially available as a purified high-grade single component, but also a carbohydrate in a state contained in cereals such as wheat flour and potatoes.
  • Wheat flour contains carbohydrate in a content of about 75%. About 98% of the carbohydrate is starch.
  • palatinose is ingested before or after or simultaneously with means that palatinose and one or more other carbohydrates are ingested during a meal or a between-meal snack. It does not always limitedly mean that they are mixed and ingested. Therefore, it includes ingesting a food or drink containing palatinose and one or more other carbohydrates which easily causes a blood glucose level increase. For example, a case where a drink containing palatinose is ingested before or after or simultaneously with consuming a cake or a cookie containing sucrose and starch corresponds to the condition: “palatinose is ingested before or after or simultaneously with” of the invention.
  • palatinose is ingested before or after or simultaneously with means a time range within which palatinose and one or more other carbohydrates can be mixed in stomach by consuming food at meal or between-meals when the palatinose stays in the stomach, or by ingesting palatinose when food at meal or between-meals stays in the stomach.
  • the time range is generally from 30 minutes before consuming food to 2 hours after consuming the food, but varies depending on an individual, body condition or ingestion timing.
  • Palatinose is ingested includes ingesting palatinose alone and ingesting a food material containing palatinose , for example, a drink such as a refreshing drink, coffee and black tea, household dishes such as omelet and cooked dish, confectionery such as baked goods, pudding and bun with bean-jam filling, and breads including a sweet bun.
  • a drink such as a refreshing drink, coffee and black tea
  • household dishes such as omelet and cooked dish
  • confectionery such as baked goods
  • pudding and bun with bean-jam filling and breads including a sweet bun.
  • sweetener is a substance to make food and drink sweet. It means a sweetener prepared for the purpose of coffee or black tea, or means a sweetener for use in household or business.
  • the sweetener may be formed in powder, granule, a cube or liquid. It can be packaged in a stick, a small bag, a box or a portion.
  • Premix material means a foodstuff which is sold by previously mixing several materials containing palatinose and one or more other materials including a hot cake mix, a pound cake mix, a bread mix, a pancake mix, a steamed bread mix, a crepe mix, a cookie mix, a doughnut mix, a sponge cake mix, a jelly mix, a pudding mix, bean-jam with sugar and a dumpling powder.
  • “Powder drink” means a cocoa mix, coffee, a powdery juice, a powdered black tea, a powdered lemonade and an instant soup mix. It means a drink product which can be dissolved in a liquid such as hot water, water and milk to serve as a drink.
  • sucrose and high fructose corn syrup are sweetener. Therefore, the sweetness can be reduced by substituting a part of the sweetener with palatinose. Since consumers recently tend to like low sweet confectioneries and drinks, these products can be used as foods for such consumers.
  • a highly sweet material such as high fructose corn syrup, fructose, aspartame, stevia sweetener or acesulfam K can be used together to adjust the product to a favorite sweetness. From the viewpoint of processing characteristics, palatinose in combination with sucrose prevent the food from coloring and prevent low soluble palatinose from crystallization, comparing with the case where palatinose is used alone.
  • palatinose when ingested before or after or simultaneously with consuming a carbohydrate having an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides such as sucrose, dextrin, starch and high fructose corn syrup, reduces an increase in blood glucose level caused by consuming the carbohydrate.
  • the areas of a region surrounded by the blood glucose level increase curve and the baseline (area under blood glucose level increase curve) were nearly identical and high values.
  • the values were slightly lower.
  • palatinose when ingested before or after or simultaneously with consuming glucose or sucrose, does not work additively in blood glucose level caused by the consumed glucose or sucrose, but reduces reversely the increase in blood glucose level caused by glucose and sucrose.
  • a reducer of blood glucose level increase or of body fat accumulation of the invention may contain palatinose as an active ingredient. It may contain palatinose alone or a mixture of palatinose with one or more other constituent components. Other constituent components include a pharmaceutically acceptable and publicly known ingredient or a carrier. In addition, It may include sucrose, wheat flour, starch, dextrin, and high fructose corn syrup as described above.
  • the reducer of blood glucose level increase or of the body fat accumulation contains one or more other constituent components
  • they can have an optionally determined ratio between the reducer of blood glucose level or the reducer of body fat accumulation and one or more other constituent components depending on an ingestion amount and timing.
  • the typical ratio of the reducer of blood glucose level increase : one or more other constituent components is 99.99:0.01-10.00:90.00, preferably 99.99:0.01-20.00:80.00, and more preferably 99.99:0.01-30.00:70.00.
  • the ratio of reducer of the body fat accumulation : the other constituent component is 99.99:0.01-20.00:80.00, preferably 99.99:0.01-30.00:70.00, and more preferably 99.99:0.01-40.00:60.00.
  • the food material of the invention for reducing blood glucose level increase has an A/B ratio of 10% or more, and is preferably combined with palatinose to give an intake of 5 g or more per 60 kg of body weight of an individual.
  • the A/B ratio of 20% or more is preferable, and 30% or more is more preferable.
  • the palatinose is preferably incorporated to give an intake of 10 g or more, more preferably 15 g or more per 60 kg of body weight of an individual.
  • the food material of the invention for reducing body fat accumulation has an A/B ratio of 20% or more, and palatinose is preferably combined to give an intake of 10 g or more per 60 kg of body weight of an individual.
  • the A/B ratio of 30% or more is preferable, and 40% or more is more preferable.
  • the palatinose is preferably combined to give an intake of 15 g or more, more preferably 20 g or more per 60 kg of body weight of an individual.
  • Palatinose can be obtained by the method as described above. When it is applied to a reducer of blood glucose level increase or a reducer of body fat accumulation with one or more other constituent components, they can be prepared by a publicly known mixing or formulating method.
  • An individual for the reducer of blood glucose level increase, the reducer of body fat accumulation and the food material of the invention may be human and a non-human animal (particularly a mammal). Oral ingestion can be used for an ingesting method.
  • a combination of 25 g of sucrose and 25 g of palatinose, a combination of 42.5 g of glucose and 7.5 g of palatinose, a combination of 35 g of glucose and 15 g of palatinose, a combination of 25 g of glucose and 25 g of palatinose, and a combination of 25 g of glucose and 2.78 g of palatinose were each dissolved in distilled water to get a total weight of 190 g to prepare the drink (Example drink 1 , Example drink 2 , Example drink 3 , Example drink 4 and Example drink 5 , respectively).
  • a blood glucose level test after ingesting the drink was performed.
  • the blood glucose level test was as follows. Five healthy volunteers (4 males and 1 female), 31-40 aged, were selected as the test subjects. They took no breakfast on a test day and kept fasting for 12 hrs or more before the start of the test. Their bloods were collected before ingesting a drink (0 min), and 30 min, 60 min, 90 min, and 120 min after ingesting it. As a result their blood glucose levels are determined. One kind of drink was ingested for one test. Another drink was ingested on another day and the test was carried out once a day for total 8 days. The same five test subjects were applied to all the tests for blood glucose levels. In the Example 1, the free style Kissei kit (made by Kissei Pharmaceutical Co., LTD) was used to collect blood samples and test a blood glucose level.
  • FIG. 1 The blood glucose level increase curves are shown in FIG. 1 to compare the changes in blood glucose level after ingesting each of the drinks.
  • FIG. 1 reveals that a blood glucose level increase is reduced after the simultaneous ingestion of 25 g of palatinose and 25 g of glucose, compared with after the ingestion of 25 g of glucose alone.
  • a blood glucose level increase is reduced after the simultaneous ingestion of 25 g of palatinose and 25 g of sucrose, compared with after the ingestion of 50 g of sucrose alone and 25 g of sucrose alone.
  • there is a remarkable difference between the Example drink and the Comparative drink as to a sudden increase in blood glucose level at 30 min after ingesting.
  • FIG. 3 shows the effect when glucose and palatinose are ingested together.
  • the area under blood glucose level increase curve decreased according to the increase of the ratio of palatinose.
  • the area under blood glucose level increase curve decreased according to the increase of palatinose amount ingested simultaneously, though the consumed carbohydrate amount increased.
  • FIG. 4 shows a graph for plotting GI values versus palatinose ratio in the consumed carbohydrate (total 50 g) as the horizontal axis using the thus obtained data, the palatinose GI value (palatinose 100%) and the glucose GI value (palatinose 0%).
  • the palatinose GI value palatinose 100%
  • the glucose GI value palatinose 0%
  • FIG. 4 indicates that the GI value surely decreased when a palatinose ratio in a total carbohydrate (the total weight 50 g) was 10% or more.
  • Example drink 5 containing glucose 25 g and palatinose 2.78 g
  • Comparative drink 3 glucose 25 g
  • Example drink 5 had a palatinose ratio of 10% in the total carbohydrate.
  • This teaches that there exists the minimum intake of palatinose necessary for the palatinose effect in addition to the palatinose ratio in the consumed carbohydrate.
  • the result of the Example indicates that the minimum intake of palatinose necessary to reduce an increase in blood glucose level is 5 g or more.
  • the blood glucose level test was as follows. Seven healthy volunteers (5 males and 2 females), 31-55 aged, were selected as the test subjects. They took breakfast by the time of 4 hours before determining a blood glucose level and the blood glucose level prior to the drink ingestion was measured. The Example drink (190 g) or the Control drink (190 g) was ingested while ingesting a packed lunch (trade name: Nidan Orizume Makunouchi, made by Warabeya Nichiyo KK, energy: 718Kcal, protein: 29.8 g, fat: 20.0 g, carbohydrate: 104.6 g, and sodium: 1.4 g).
  • the test subjects' blood was collected with time 30 min, 60 min, 90 min and 120 min after the meal to measure their blood glucose levels.
  • One kind of drink was ingested for one test.
  • the other drink was ingested on another day and the test was carried out once a day for total 2 days. Accordingly, one test subject was tested twice for blood glucose level, that is, after ingesting the Example drink and after ingesting the Control drink.
  • the free style Kissei kit (made by Kissei Pharmaceutical Co., LTD) was used to collect blood and to measure blood glucose level, as Example 1.
  • FIG. 5 The blood glucose level increase curves are shown in FIG. 5 to compare the changes in blood glucose level after ingesting the respective drinks.
  • FIG. 5 reveals that the increase in blood glucose level after ingesting the Example drink (palatinose) was slower than that after ingesting the Control drink (distilled water).
  • the areas under blood glucose level curves are shown in FIG. 6.
  • the graph reveals that the value of the area under blood glucose level curve of the case where the Example drink was ingested simultaneously with consuming food was lower compared with that of the case where the Control drink was ingested simultaneously with consuming food.
  • mice were consecutively fed with a feed added with palatinose, a feed added with sucrose and no palatinose, and a feed added with both palatinose and sucrose to compare their body fat accumulation amount.
  • C57BL/6CrSlc (SPF) male mice (30 heads) aged 7 weeks were fed with a commercial powder feed (trade name: CRF-1 powder, made by Oriental Yeast Co., LTD) and water ad libitum to prefeed for a week. Then, they were separated into three groups each including 10 heads, that is, a group of feeding with a feed (Comparative feed) containing sucrose by 66.7% in carbohydrate, a group of feeding with a feed (Example feed 1) containing palatinose by 66.7% in carbohydrate, and a group of feeding with a feed (Example feed 2) containing palatinose by 30.0% and sucrose by 36.7% in carbohydrate.
  • a feed Comparative feed
  • Example feed 1 containing sucrose by 66.7% in carbohydrate
  • Example feed 1 containing palatinose by 66.7% in carbohydrate
  • Example feed 2 containing palatinose by 30.0% and sucrose by 36.7% in carbohydrate.
  • the groups were fed with their respective feeds and water ad libitum for 8 weeks. Detailed composition of each feed is shown in Table 1.
  • the feeding condition was as follows: temperature 22 ⁇ 3° C., humidity (relative humidity) 50 ⁇ 20%, ventilation cycles 13-17 times/hr, and lighting time 8:00-20:00 (light 12 hrs, dark 12 hrs).
  • Example feed 1 corn starch 14.95 14.95 14.95 sucrose 40.00 0.00 22.00 (granulated sugar) palatinose 0.00 40.00 18.00 cellulose 5.00 5.00 5.00 soybean oil 15.00 15.00 15.00 mineral 3.50 3.50 3.50 (AIN-93mineral mix) vitamin 1.00 1.00 1.00 (ATN-93vitamine mix) L-cystine 0.30 0.30 0.30 choline bitartarate 0.25 0.25 0.25 casein 20.00 20.00 20.00 20.00
  • mice were light anesthetized with ether and sectioned abdominally to exsanguinate from postcava to death.
  • digital photographs showing body fat accumulation inside the abdominal cavity were taken.
  • the kidney peripheral fat including the retroperitoneal fat
  • the epididymis peripheral fat were taken out to measure their wet weights separately in left and right.
  • the mesenteric fat also was taken out to measure its wet weight.
  • These three kinds of fat tissues are typical of visceral fat.
  • the data were statistically treated to ascertain the homoscedasticity and further to carry out the t-test, which is of correspondency, in the case of homoscedasticity.
  • mice fed with the Example feeds were significantly lower than those of the mice fed with the Comparative feed.
  • FIG. 8 comparing the fat tissue weights measured after feeding, the mice fed with the Example feed showed lower value of kidney peripheral fat and epididymis peripheral fat compared with the mice fed with the Comparative feed.
  • FIG. 9 comparing the summed values of weight of kidney peripheral fat, epididymis peripheral fat and mesentry fat as the total visceral fat weight, the mice fed with the Example feeds showed a significantly lower value compared with the mice fed with the comparative feed.
  • the result of this Example demonstrates that palatinose exerts the effect of reducing the accumulation of body fat when it is contained at a ratio of 20% or more in carbohydrate.
  • the minimum intake of palatinose necessary to reduce a body fat accumulation is presumed to be 10 g or more in terms of an intake ingested by a person having a body weight of 60 kg.
  • a tablet containing palatinose and sucrose with the composition as shown in Table 3 below was prepared.
  • the mixed powder with the following composition was compressed at a tableting pressure of 300 kg/cm 3 to make a 18 mm diametric, 5 mm thick, and 1.5 g weighing tablet.
  • TABLE 3 component compounding ratio (weight) pulverized palatinose 27.5 obtained by pulverizing crystalline palatinose (Trade name: Crystalline palatinose-IC, made by Shin Mitsui Sugar Co., LTD.) by an atomizer
  • powder sugar 27.5 citric acid 1 sugar ester 1 Aspartame 0.05 vitamin P 0.0002 water 0.6 lemon juice proper quantity
  • a powder drink containing palatinose and sucrose with the composition as shown in Table 4 below was prepared by a conventional method using a universal mixing stirrer.
  • TABLE 4 component compounding ratio (weight) crystalline palatinose 42.35 (Trade name: Crystalline palatinose-IC, made by Shin Mitsui Sugar Co., LTD.) sucrose (granulated sugar) 42.35 powder juice 10 anhydrous citric acid 3 sodium citrate 0.4 L-ascorbic acid 0.5 sodium ascorbate 0.3 riboflavin (content 10% by weight) 0.1
  • a refreshing drink containing palatinose and sucrose with the composition as shown in Table 5 below was prepared.
  • the raw materials were dissolved in 250 ml of boiling hot water to fill in a drink can (for 250 ml).
  • TABLE 5 component g/can crystalline palatinose 4 (Trade name: Crystalline palatinose-IC, made by Shin Mitsui Sugar Co., LTD.) sucrose (granulated sugar) 4 citric acid 0.15 vitamin C 0.03 sodium chloride 0.05 potassium chloride 0.04 calcium chloride 0.012 magnesium carbonate 0.002 sodium glutamate 0.006 stevia sweetener 0.01 vitamin P 0.0004 flavoring agent proper quantity
  • a sponge cake containing palatinose, sucrose and starch with the composition as shown in Table 6 below was prepared. Crystalline palatinose, sucrose (granulated sugar) and xanthan gum were powdery mixed to make a mixture called A. Wheat flour and baking powder were mixed to make a mixture called B. Milk and the Ryoto ester SP were added to A and mixed thoroughly, followed by adding egg and thorough mixing to become homogeneous, which was warmed up to about 25° C. in hot bath. This mixture was bubbled up by a universal stirrer until no more bubble could be generated. The resultant was mixed, with B to make a mixture without kneading B, The mixture was filled in a sponge cake tin to bake in an oven at 160° C.
  • the composition of this Example contained 70 g of palatinose, 30 g of sucrose and about 90 g of starch.
  • TABLE 6 component g egg 200 palatinose powder sugar 70 (Trade name: powder palatinose ICP, made by Shin Mitsui Sugar Co., LTD.) sucrose (granulated sugar) 30 wheat flour 120 milk 41 xanthan gum 0.6 foaming agent 9.2 (Trade name: Ryoto Ester SP, made by Mitsubishi-Kagaku Foods Corporation) baking powder 3
  • a refreshing drink containing palatinose and high fructose corn syrup with the composition as shown in Table 7 below was prepared.
  • the raw materials were dissolved in 250 ml of hot water to fill in a drink can (for 250 ml).
  • TABLE 7 component g/can crystalline palatinose 4 (Trade name: Crystalline palatinose-IC, made by Shin Mitsui Sugar Co., LTD.) high fructose corn syrup 5.33 citric acid 0.15 vitamin C 0.03 sodium chloride 0.05 potassium chloride 0.04 calcium chloride 0.012 magnesium carbonate 0.002 sodium glutamate 0.006 stevia sweetener 0.01 vitamin P 0.0004 flavoring agent proper quantity
  • a Madeleine containing palatinose and starch with the composition as shown in Table 8 below was prepared. Wheat flour and baking powder had been mixed and sieved. Butter had been melted in a hot bath. Egg was fed in a ball, to which granulated sugar, kitchen salt, lemon peel and lemon essence were added followed by warming in a hot bath. While warming, palatinose was fed in, and the mixture was stirred thoroughly by a eggbeater. The sieved wheat flour was added at a bulk to be mixed thoroughly and then the melted butter was added to be mixed. The resultant was separated to fill into aluminum foil cups and baked in an oven at 160° C. for about 10 min until browned.
  • the Madeleine prepared by the Example contained 60 g of palatinose and about 37 g of starch.
  • a cake mix with the composition as shown in Table 9 below was prepared. Materials excluding shortening were previously mixed and then the molten shortening was added and mixed to be sieved.
  • a hot cake mix was prepared by powdery mixing raw materials with the composition as shown in Table 10 below. Materials excluding shortening were previously mixed and then the molten shortening was added and mixed to be sieved.
  • the sample containing palatinose alone as the carbohydrate gave an absorbance of 0.004, and the sample containing sucrose alone gave that of 0.0015, while the sample containing palatinose and sucrose by the equal weight gave that of 0.002.
  • the sample containing palatinose and sucrose by the equal weight was more suppressed from coloring than the sample containing palatinose alone. This absorbance by the palatinose was a value which allowed a user to visually recognize the sample to be colored brown.
  • a solution containing 50 wt % of sucrose, a solution containing 50 wt % of palatinose, and a solution containing each 25 wt % of sucrose and palatinose were prepared by 100 ml respectively, and then they were filled in capped screw vials. Dissolution was performed until no crystal remained at 50° C. These vials were put in a refrigerator set at 5° C. to observe crystallization.
  • palatinose By ingesting palatinose before or after or simultaneously with consuming a kind of carbohydrate such as sucrose, glucose and high fructose corn syrup, which has an ⁇ -1,6-glucosyl bond ratio of from 0% to less than 50% relative to the total bonds among constituent saccharides, an increase in blood glucose level caused by the carbohydrate can be reduced. Furthermore, palatinose, when used as a raw material in combination with one or more other carbohydrates such as nonreducing sugar, can reduce a factor for coloring to make food resistant to coloring and, when used in a combination with one or more other carbohydrates with high solubility, becomes not to tend to crystallize.
  • carbohydrate such as sucrose, glucose and high fructose corn syrup
  • Palatinose when used in combination with a sweetener such as sucrose and high fructose corn syrup, reduces the sweetness caused by the sucrose, glucose or high fructose corn syrup, resulting in providing food with low sweetness.
  • a sweetener such as sucrose and high fructose corn syrup
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JP4048166B2 (ja) 2008-02-13
US20110008486A1 (en) 2011-01-13
TWI303992B (ja) 2008-12-11
EP1568285B1 (en) 2013-05-22
KR20050071697A (ko) 2005-07-07
ES2390416T3 (es) 2012-11-12
EP1568285A4 (en) 2005-12-28
EP2241197B1 (en) 2012-08-22
EP1568285A1 (en) 2005-08-31
AU2003280856B2 (en) 2009-05-21
AU2003280856A1 (en) 2004-06-15
KR101018610B1 (ko) 2011-03-02
WO2004045312A1 (ja) 2004-06-03
ES2409679T3 (es) 2013-06-27

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