US20040115197A1 - Remedies for infant chronic arthritis-relating diseases - Google Patents
Remedies for infant chronic arthritis-relating diseases Download PDFInfo
- Publication number
- US20040115197A1 US20040115197A1 US10/473,165 US47316503A US2004115197A1 US 20040115197 A1 US20040115197 A1 US 20040115197A1 US 47316503 A US47316503 A US 47316503A US 2004115197 A1 US2004115197 A1 US 2004115197A1
- Authority
- US
- United States
- Prior art keywords
- receptor
- antibody
- childhood
- therapeutic agent
- antibody against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/704,233 US7955598B2 (en) | 2001-04-02 | 2007-02-09 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US13/064,953 US9255145B2 (en) | 2001-04-02 | 2011-04-28 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US14/986,884 US20160194401A1 (en) | 2001-04-02 | 2016-01-04 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US15/946,866 US20180222988A1 (en) | 2001-04-02 | 2018-04-06 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001-103627 | 2001-04-02 | ||
JP2001103627 | 2001-04-02 | ||
JP2001-109131 | 2001-04-06 | ||
JP2001109131 | 2001-04-06 | ||
PCT/JP2002/003312 WO2002080969A1 (fr) | 2001-04-02 | 2002-04-02 | Remedes pour des maladies liees a l'arthrite chronique du nourrisson |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/003312 A-371-Of-International WO2002080969A1 (fr) | 2001-04-02 | 2002-04-02 | Remedes pour des maladies liees a l'arthrite chronique du nourrisson |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/704,233 Division US7955598B2 (en) | 2001-04-02 | 2007-02-09 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040115197A1 true US20040115197A1 (en) | 2004-06-17 |
Family
ID=26612973
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/473,165 Abandoned US20040115197A1 (en) | 2001-04-02 | 2002-04-02 | Remedies for infant chronic arthritis-relating diseases |
US11/704,233 Expired - Lifetime US7955598B2 (en) | 2001-04-02 | 2007-02-09 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US13/064,953 Expired - Fee Related US9255145B2 (en) | 2001-04-02 | 2011-04-28 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US14/986,884 Abandoned US20160194401A1 (en) | 2001-04-02 | 2016-01-04 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US15/946,866 Abandoned US20180222988A1 (en) | 2001-04-02 | 2018-04-06 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/704,233 Expired - Lifetime US7955598B2 (en) | 2001-04-02 | 2007-02-09 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US13/064,953 Expired - Fee Related US9255145B2 (en) | 2001-04-02 | 2011-04-28 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US14/986,884 Abandoned US20160194401A1 (en) | 2001-04-02 | 2016-01-04 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US15/946,866 Abandoned US20180222988A1 (en) | 2001-04-02 | 2018-04-06 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
Country Status (18)
Country | Link |
---|---|
US (5) | US20040115197A1 (uk) |
EP (4) | EP2298812A3 (uk) |
JP (5) | JP3702274B2 (uk) |
KR (2) | KR100842133B1 (uk) |
CN (1) | CN100562339C (uk) |
AU (1) | AU2002243032B2 (uk) |
BR (1) | BR0208636A (uk) |
CA (1) | CA2443294C (uk) |
HK (1) | HK1062408A1 (uk) |
HU (1) | HU230197B1 (uk) |
IL (3) | IL158079A0 (uk) |
MX (1) | MXPA03008955A (uk) |
NO (1) | NO20034388L (uk) |
NZ (1) | NZ528479A (uk) |
PL (1) | PL216534B1 (uk) |
RU (2) | RU2541165C2 (uk) |
UA (1) | UA80091C2 (uk) |
WO (1) | WO2002080969A1 (uk) |
Cited By (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010001663A1 (en) * | 1994-06-30 | 2001-05-24 | Tadamitsu Kishimoto | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
US20040071706A1 (en) * | 1998-03-17 | 2004-04-15 | Chugai Seiyaku Kabushiki Kaisha | Preventive or therapeutic agent for inflammatory bowel disease comprising IL-6 antagonist as an active ingredient |
US20060292147A1 (en) * | 2000-10-27 | 2006-12-28 | Chugai Seiyaku Kabushiki Kaisha | Blood MMP-3 level-lowering agent comprising IL-6 antagonist as active ingredient |
US20070036785A1 (en) * | 1994-10-21 | 2007-02-15 | Tadamitsu Kishimoto | Pharmaceutical composition for treatment of diseases caused by IL-6 production |
US20070098714A1 (en) * | 2003-12-19 | 2007-05-03 | Chugai Seiyaku Kabushiki Kaisha | Preventive agent for vasculitis |
US20080161262A1 (en) * | 2004-02-26 | 2008-07-03 | Baylor Research Institute | Compositions and Methods for the Systemic Treatment of Arthritis |
US20080274106A1 (en) * | 2003-10-17 | 2008-11-06 | Chugai Seiyaku Kabushiki Kaisha | Mesothelioma therapeutic agent |
US20090022719A1 (en) * | 1997-08-15 | 2009-01-22 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic method for systemic lupus erythematosus comprising anti-IL-6 receptor antibody administration |
US20090028784A1 (en) * | 2007-05-21 | 2009-01-29 | Alder Biopharmaceuticals, Inc. | Antibodies to IL-6 and use thereof |
US20090104187A1 (en) * | 2007-05-21 | 2009-04-23 | Alder Biopharmaceuticals, Inc. | Novel Rabbit Antibody Humanization Methods and Humanized Rabbit Antibodies |
US20090131639A1 (en) * | 2002-02-14 | 2009-05-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing solution formulations |
US20090181029A1 (en) * | 2003-04-28 | 2009-07-16 | Chugai Seiyaku Kabushiki Kaisha | Methods for treating interleukin-6 related diseases |
US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
US20090291082A1 (en) * | 2007-05-21 | 2009-11-26 | Smith Jeffrey T L | Antagonists of IL-6 to raise Albumin and/or lower CRP |
US20090291077A1 (en) * | 2007-05-21 | 2009-11-26 | Smith Jeffrey T L | Antagonists of IL-6 to prevent or treat Cachexia, weakness, fatigue, and/or fever |
US20090291089A1 (en) * | 2007-05-21 | 2009-11-26 | Smith Jeffrey T L | Antagonists of IL-6 to prevent or treat Thrombosis |
US20090291076A1 (en) * | 2005-12-28 | 2009-11-26 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
US20090297436A1 (en) * | 2007-05-21 | 2009-12-03 | Leon Garcia-Martinez | Antibodies to il-6 and use thereof |
US20090297513A1 (en) * | 2007-05-21 | 2009-12-03 | Leon Garcia-Martinez | Antibodies to il-6 and use thereof |
US20100129357A1 (en) * | 2008-11-25 | 2010-05-27 | Leon Garcia-Martinez | Antibodies to il-6 and use thereof |
US20100150829A1 (en) * | 2008-11-25 | 2010-06-17 | Leon Garcia-Martinez | Antibodies to IL-6 and use thereof |
US20100285011A1 (en) * | 2007-12-27 | 2010-11-11 | Chugai Seiyaku Kabushiki Kaish | High concentration antibody-containing liquid formulation |
US20100316636A1 (en) * | 2006-06-02 | 2010-12-16 | Regeneron Pharmaceuticals, Inc. | Method of Treating Rheumatoid Arthritis with an IL-6R Antibody |
WO2012064627A2 (en) | 2010-11-08 | 2012-05-18 | Genentech, Inc. | Subcutaneously administered anti-il-6 receptor antibody |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US8992908B2 (en) | 2010-11-23 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of oral mucositis |
US9017677B2 (en) | 1997-03-21 | 2015-04-28 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating a disease mediated by sensitized T cells |
US9187560B2 (en) | 2008-11-25 | 2015-11-17 | Alderbio Holdings Llc | Antagonists of IL-6 to treat cachexia, weakness, fatigue, and/or fever |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US9255145B2 (en) | 2001-04-02 | 2016-02-09 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US9265825B2 (en) | 2008-11-25 | 2016-02-23 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US9468676B2 (en) | 2009-11-24 | 2016-10-18 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
US10168326B2 (en) | 2013-07-04 | 2019-01-01 | F. Hoffmann-La Roche Inc. | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
US10501769B2 (en) | 2009-10-26 | 2019-12-10 | Hoffmann-La Roche Inc. | Method for the production of a glycosylated immunoglobulin |
US10584173B2 (en) | 2006-06-02 | 2020-03-10 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding high affinity antibodies to human IL-6 receptor |
WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
US10927435B2 (en) | 2011-10-11 | 2021-02-23 | Sanofi Biotechnology | Compositions for the treatment of rheumatoid arthritis and methods of using same |
US11033496B2 (en) | 2017-03-17 | 2021-06-15 | The Regents Of The University Of Michigan | Nanoparticles for delivery of chemopreventive agents |
US11098127B2 (en) | 2010-01-08 | 2021-08-24 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-interleukin-6 receptor (IL-6R) antibodies |
US11174317B2 (en) | 2015-06-04 | 2021-11-16 | National Center Of Neurology And Psychiatry | Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient |
US11484591B2 (en) | 2016-02-22 | 2022-11-01 | Ohio State Innovation Foundation | Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites |
US11498969B2 (en) | 2019-01-31 | 2022-11-15 | Sanofi Biotechnology | Compositions and methods for treating juvenile idiopathic arthritis |
US11673967B2 (en) | 2011-07-28 | 2023-06-13 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-PCSK9 antibodies |
US11904017B2 (en) | 2015-08-18 | 2024-02-20 | Regeneron Pharmaceuticals, Inc. | Methods for reducing or eliminating the need for lipoprotein apheresis in patients with hyperlipidemia by administering alirocumab |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8398980B2 (en) * | 2004-03-24 | 2013-03-19 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleuken-6 receptor |
AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
WO2006106905A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
JP5191235B2 (ja) | 2005-10-21 | 2013-05-08 | 中外製薬株式会社 | 心疾患治療剤 |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
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WO2008019061A2 (en) | 2006-08-03 | 2008-02-14 | Vaccinex, Inc. | Anti-il-6 monoclonal antibodies and uses thereof |
JP2010095445A (ja) * | 2006-12-27 | 2010-04-30 | Tokyo Medical & Dental Univ | Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤 |
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EP2297202B1 (en) | 2008-05-13 | 2016-01-13 | NovImmune SA | Anti-il-6/il-6r antibodies and methods of use thereof |
CN102256623A (zh) | 2008-06-05 | 2011-11-23 | 独立行政法人国立癌症研究中心 | 神经浸润抑制剂 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
WO2010131733A1 (ja) | 2009-05-15 | 2010-11-18 | 中外製薬株式会社 | 抗axl抗体 |
EP2481752B1 (en) | 2009-09-24 | 2016-11-09 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
JP5889181B2 (ja) | 2010-03-04 | 2016-03-22 | 中外製薬株式会社 | 抗体定常領域改変体 |
JP5904552B2 (ja) | 2010-05-28 | 2016-04-13 | 国立研究開発法人国立がん研究センター | 膵癌治療剤 |
DK2578231T3 (da) | 2010-05-28 | 2022-12-12 | Chugai Pharmaceutical Co Ltd | Antitumor-t-celle-reaktionsforstærker |
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CN104349787B (zh) | 2012-05-21 | 2019-02-15 | 韩国生命工学研究院 | 含有荔枝草提取物或其馏分作为活性成分的预防或治疗stat-3介导疾病的药物组合物 |
WO2014200018A1 (ja) | 2013-06-11 | 2014-12-18 | 独立行政法人 国立精神・神経医療研究センター | 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法 |
KR102441231B1 (ko) | 2013-09-27 | 2022-09-06 | 추가이 세이야쿠 가부시키가이샤 | 폴리펩티드 이종 다량체의 제조방법 |
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CN103739669B (zh) * | 2013-12-31 | 2015-08-26 | 浙江元太生物科技有限公司 | 一种抑制白介素-6多肽及其应用 |
TW202339800A (zh) * | 2015-02-27 | 2023-10-16 | 日商中外製藥股份有限公司 | Il-6受體抗體用於製備醫藥組成物的用途 |
EP3279216A4 (en) | 2015-04-01 | 2019-06-19 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR PREPARING POLYPEPTIDE HETERO OLIGOMER |
US10697883B2 (en) | 2015-05-19 | 2020-06-30 | National Center Of Neurology And Psychiatry | Method for determining application of therapy to multiple sclerosis (MS) patient |
AU2016381992B2 (en) | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
US11692037B2 (en) | 2017-10-20 | 2023-07-04 | Hyogo College Of Medicine | Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
TWI827585B (zh) | 2018-03-15 | 2024-01-01 | 日商中外製藥股份有限公司 | 對茲卡病毒具有交叉反應性的抗登革病毒抗體及其使用方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
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JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
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