UA81437C2 - Proline derivatives having affinity for the calcium channel alpha-2-delta subunit - Google Patents
Proline derivatives having affinity for the calcium channel alpha-2-delta subunit Download PDFInfo
- Publication number
- UA81437C2 UA81437C2 UAA200504092A UA2005004092A UA81437C2 UA 81437 C2 UA81437 C2 UA 81437C2 UA A200504092 A UAA200504092 A UA A200504092A UA 2005004092 A UA2005004092 A UA 2005004092A UA 81437 C2 UA81437 C2 UA 81437C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- pyrrolidine
- formula
- carboxylic acid
- compound
- Prior art date
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- 150000003147 proline derivatives Chemical class 0.000 title abstract description 4
- 108090000312 Calcium Channels Proteins 0.000 title description 3
- 102000003922 Calcium Channels Human genes 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 226
- -1 amino, hydroxycarbonyl Chemical group 0.000 claims abstract description 69
- 150000003839 salts Chemical class 0.000 claims abstract description 57
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 56
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- 229940002612 prodrug Drugs 0.000 claims abstract description 23
- 239000000651 prodrug Substances 0.000 claims abstract description 23
- 238000011282 treatment Methods 0.000 claims abstract description 21
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 17
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 15
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 12
- 150000002367 halogens Chemical class 0.000 claims abstract description 12
- 125000003118 aryl group Chemical group 0.000 claims abstract description 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims abstract description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 9
- 125000001424 substituent group Chemical group 0.000 claims abstract description 9
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 8
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- 125000004691 alkyl thio carbonyl group Chemical group 0.000 claims abstract 7
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 146
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- 125000003342 alkenyl group Chemical group 0.000 claims description 8
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
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- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
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Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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Landscapes
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- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Immunology (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GBGB0225379.7A GB0225379D0 (en) | 2002-10-31 | 2002-10-31 | Therapeutic proline derivatives |
PCT/IB2003/004697 WO2004039367A1 (en) | 2002-10-31 | 2003-10-22 | Proline derivatives having affinity for the calcium channel alpha-2-delta subunit |
Publications (1)
Publication Number | Publication Date |
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UA81437C2 true UA81437C2 (en) | 2008-01-10 |
Family
ID=9946940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200504092A UA81437C2 (en) | 2002-10-31 | 2003-10-22 | Proline derivatives having affinity for the calcium channel alpha-2-delta subunit |
Country Status (39)
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EP (1) | EP1558246B1 (hr) |
JP (2) | JP3940416B2 (hr) |
KR (2) | KR20070046213A (hr) |
CN (1) | CN100418525C (hr) |
AP (1) | AP2005003295A0 (hr) |
AR (1) | AR041865A1 (hr) |
AT (1) | ATE468116T1 (hr) |
AU (1) | AU2003269411B2 (hr) |
BR (1) | BR0315839A (hr) |
CA (1) | CA2499698C (hr) |
CO (1) | CO5550430A2 (hr) |
CR (1) | CR7802A (hr) |
DE (1) | DE60332646D1 (hr) |
DK (1) | DK1558246T3 (hr) |
EA (1) | EA009767B1 (hr) |
EC (1) | ECSP055769A (hr) |
ES (1) | ES2343624T3 (hr) |
GB (1) | GB0225379D0 (hr) |
GE (1) | GEP20074127B (hr) |
GT (1) | GT200300234A (hr) |
HK (1) | HK1081441A1 (hr) |
HR (1) | HRP20050351A2 (hr) |
IL (4) | IL167799A (hr) |
IS (1) | IS7754A (hr) |
MA (1) | MA27481A1 (hr) |
MX (1) | MXPA05004662A (hr) |
NL (1) | NL1024677C2 (hr) |
NO (1) | NO330496B1 (hr) |
OA (1) | OA12954A (hr) |
PA (1) | PA8587201A1 (hr) |
PE (1) | PE20040553A1 (hr) |
PL (1) | PL376703A1 (hr) |
RS (1) | RS20050333A (hr) |
TN (1) | TNSN05122A1 (hr) |
TW (2) | TW200416030A (hr) |
UA (1) | UA81437C2 (hr) |
UY (1) | UY28043A1 (hr) |
WO (1) | WO2004039367A1 (hr) |
ZA (1) | ZA200502305B (hr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0225379D0 (en) * | 2002-10-31 | 2002-12-11 | Pfizer Ltd | Therapeutic proline derivatives |
US20050043345A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
WO2005097741A1 (en) * | 2004-04-05 | 2005-10-20 | Pfizer Limited | Process for the recrystallisation of proline derivates |
WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
CN101460456A (zh) | 2006-06-06 | 2009-06-17 | 国立大学法人岐阜大学 | 抑制神经源性疼痛的吡咯烷类似物及其制造方法 |
AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA |
SG11201510256WA (en) | 2013-06-26 | 2016-01-28 | Zhejiang Jiuzhou Pharm Co Ltd | Preparation method for pyrrolidine-2-carboxylic acid derivatives |
WO2015003723A1 (en) * | 2013-07-12 | 2015-01-15 | Københavns Universitet | Substituted 4-proline derivatives as iglur antagonists |
CN104418785A (zh) * | 2013-09-05 | 2015-03-18 | 浙江九洲药业股份有限公司 | 一种药物中间体的制备方法 |
CN104829513B (zh) * | 2014-02-11 | 2019-02-19 | 浙江九洲药业股份有限公司 | 一种2-羧基-4-甲氧基甲基吡咯烷衍生物的制备方法 |
CN104844495A (zh) * | 2015-06-05 | 2015-08-19 | 武汉理工大学 | 一种(2s,4s)-4-苯硫基-l-脯氨酸盐酸盐的合成方法 |
WO2020120606A1 (en) * | 2018-12-12 | 2020-06-18 | Esteve Pharmaceuticals, S.A. | New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions |
TW202026281A (zh) * | 2018-12-12 | 2020-07-16 | 西班牙商艾斯提夫製藥股份有限公司 | 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物 |
EP3904339A1 (en) * | 2020-04-28 | 2021-11-03 | Esteve Pharmaceuticals, S.A. | Alkylaminoproline derivatives as alfa-2-delta-1 blockers |
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ZA817601B (en) * | 1980-11-24 | 1982-10-27 | Squibb & Sons Inc | Carboxyalkyl amino acid derivatives of various substituted prolines |
JPH07504155A (ja) * | 1991-04-19 | 1995-05-11 | シオス・ノヴァ・インコーポレイテット | ブラジキニンアンタゴニストペプチド |
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GB0225379D0 (en) * | 2002-10-31 | 2002-12-11 | Pfizer Ltd | Therapeutic proline derivatives |
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