UA80396C2 - Use of il-18 inhibitors for treating or traumatic head injury - Google Patents

Use of il-18 inhibitors for treating or traumatic head injury Download PDF

Info

Publication number
UA80396C2
UA80396C2 UA20031212328A UA20031212328A UA80396C2 UA 80396 C2 UA80396 C2 UA 80396C2 UA 20031212328 A UA20031212328 A UA 20031212328A UA 20031212328 A UA20031212328 A UA 20031212328A UA 80396 C2 UA80396 C2 UA 80396C2
Authority
UA
Ukraine
Prior art keywords
damage
brain
injury
inhibitor
mice
Prior art date
Application number
UA20031212328A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of UA80396C2 publication Critical patent/UA80396C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
UA20031212328A 2001-05-25 2002-05-23 Use of il-18 inhibitors for treating or traumatic head injury UA80396C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112067 2001-05-25
PCT/EP2002/005666 WO2002096456A1 (en) 2001-05-25 2002-05-23 Use of il-18 inhibitors for treating or preventing cns injuries

Publications (1)

Publication Number Publication Date
UA80396C2 true UA80396C2 (en) 2007-09-25

Family

ID=8177454

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20031212328A UA80396C2 (en) 2001-05-25 2002-05-23 Use of il-18 inhibitors for treating or traumatic head injury

Country Status (29)

Country Link
US (1) US7655616B2 (sr)
EP (1) EP1390070B1 (sr)
JP (1) JP4344142B2 (sr)
KR (1) KR20040030625A (sr)
CN (1) CN1305529C (sr)
AU (1) AU2002314103B2 (sr)
BG (1) BG66395B1 (sr)
BR (1) BR0210007A (sr)
CA (1) CA2445664C (sr)
CY (1) CY1119190T1 (sr)
CZ (1) CZ307321B6 (sr)
DK (1) DK1390070T3 (sr)
EA (1) EA006744B1 (sr)
EE (1) EE05263B1 (sr)
ES (1) ES2617084T3 (sr)
HR (1) HRP20030842B1 (sr)
HU (1) HU230294B1 (sr)
IL (2) IL159014A0 (sr)
LT (1) LT1390070T (sr)
ME (1) ME00550B (sr)
MX (1) MXPA03010743A (sr)
NO (1) NO331882B1 (sr)
PL (1) PL216228B1 (sr)
PT (1) PT1390070T (sr)
RS (1) RS56006B1 (sr)
SK (1) SK288413B6 (sr)
UA (1) UA80396C2 (sr)
WO (1) WO2002096456A1 (sr)
ZA (1) ZA200308172B (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080076708A1 (en) 2003-05-13 2008-03-27 Valter Altarocca Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
EP2177907B1 (en) * 2004-06-30 2014-01-01 Atsuo Sekiyama Indicator agent for noninflammatory stress response and use therefor
ES2376534T3 (es) * 2005-06-03 2012-03-14 Merck Serono Sa Uso de isoformas de il-18bp para el tratamiento y/o prevención de enfermedades inflamatorias neurológicas.
AU2006254103B2 (en) 2005-06-03 2012-09-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
US8685400B2 (en) 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
UA125204C2 (uk) * 2013-09-05 2022-02-02 Аб2 Біо Са Застосування il-18-зв'язувального білка (il-18bp) при запальних захворюваннях
US10882905B2 (en) * 2015-03-05 2021-01-05 Ab2 Bio Sa IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0873453A (ja) * 1994-09-02 1996-03-19 Otsuka Pharmaceut Co Ltd サイトカイン阻害剤
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
WO1999046248A1 (en) * 1998-03-09 1999-09-16 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
CZ300792B6 (cs) * 2000-05-05 2009-08-12 Applied Research Systems Ars Holding N. V. Farmaceutický prostredek
JP2003535892A (ja) * 2000-06-23 2003-12-02 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム ２−アラキドニルグリセロール（２−ＡＧ）−腫瘍壊死因子−αの阻害剤および閉鎖性頭部損傷における脳の神経保護因子
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
US6671553B1 (en) * 2001-05-23 2003-12-30 Pacesetter, Inc. Implantable cardiac lead having terminating connector strain relief and method of manufacture

Also Published As

Publication number Publication date
BG66395B1 (bg) 2013-12-31
EP1390070B1 (en) 2017-02-08
YU89403A (sh) 2006-05-25
IL159014A0 (en) 2004-05-12
HU230294B1 (hu) 2015-12-28
IL159014A (en) 2012-05-31
RS56006B1 (sr) 2017-09-29
ES2617084T3 (es) 2017-06-15
ME00550B (me) 2011-10-10
CN1535160A (zh) 2004-10-06
HUP0304067A3 (en) 2006-01-30
AU2002314103B8 (en) 2002-12-09
PT1390070T (pt) 2017-03-01
US7655616B2 (en) 2010-02-02
CY1119190T1 (el) 2018-02-14
CN1305529C (zh) 2007-03-21
JP2004534777A (ja) 2004-11-18
EE200300582A (et) 2004-02-16
EP1390070A1 (en) 2004-02-25
HRP20030842B1 (hr) 2017-06-02
CZ20033268A3 (en) 2004-07-14
NO331882B1 (no) 2012-04-23
MXPA03010743A (es) 2004-03-02
NO20035160D0 (no) 2003-11-20
AU2002314103B2 (en) 2007-07-12
SK16032003A3 (sk) 2004-05-04
PL216228B1 (pl) 2014-03-31
JP4344142B2 (ja) 2009-10-14
LT1390070T (lt) 2017-03-10
HRP20030842A2 (en) 2005-08-31
BR0210007A (pt) 2004-08-10
BG108451A (en) 2005-02-28
PL367545A1 (en) 2005-02-21
WO2002096456A1 (en) 2002-12-05
EE05263B1 (et) 2010-02-15
HK1069762A1 (en) 2005-06-03
CA2445664C (en) 2012-03-06
CZ307321B6 (cs) 2018-06-06
EA200301299A1 (ru) 2004-04-29
NO20035160L (no) 2003-11-20
KR20040030625A (ko) 2004-04-09
CA2445664A1 (en) 2002-12-05
ZA200308172B (en) 2004-10-21
EA006744B1 (ru) 2006-04-28
SK288413B6 (sk) 2016-10-03
HUP0304067A2 (hu) 2004-03-29
US20040191247A1 (en) 2004-09-30
DK1390070T3 (en) 2017-04-24

Similar Documents

Publication Publication Date Title
DE69434538T2 (de) Vaskulärer endothelialer Wachstumsfaktor 2
KR101873773B1 (ko) 류마티즘 관절염 예방 또는 치료 조성물
CN101227924A (zh) 用于治疗外伤性脑损伤、脊髓损伤及相关病症的补体旁路抑制
KR20220156935A (ko) 헌팅톤병의 치료 방법 및 약물
JP5208135B2 (ja) 組換え白血球阻害因子とヒルゲンのキメラタンパク質及びその薬物組成物
UA80396C2 (en) Use of il-18 inhibitors for treating or traumatic head injury
AU2002314103A1 (en) Use of IL-18 inhibitors for treating or preventing CNS injuries
US10160791B2 (en) Protamine in treatment of neuronal injuries
AU754982B2 (en) Compositions for promoting nerve regeneration
US20150274815A1 (en) Treatment of central nervous system (cns) injury
Brin Dystonia: genetics and treatment with botulinum toxin
JP3789147B2 (ja) 脊髄損傷後の神経障害に対する治療剤
CN114702600B (zh) SNAP25蛋白Ser187位点磷酸化抑制剂的用途
CN101873865A (zh) 编码破伤风毒素重链羧基端结构域的序列作为药物的用途
KR102057454B1 (ko) 수술 후 염증 반응 억제용 조성물 및 수술 후 인지 기능장애 예방용 또는 치료용 약학 조성물
US20230241183A1 (en) Emid2 protein as anti-cancer treatment
Johnson et al. AAV9 gene therapy restores lifespan and treats pathological and behavioral abnormalities in a mouse model of CLN8-Batten disease
Class et al. Patent application title: PROTAMINE IN TREATMENT OF NEURONAL INJURIES