UA80396C2 - Use of il-18 inhibitors for treating or traumatic head injury - Google Patents

Use of il-18 inhibitors for treating or traumatic head injury Download PDF

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Publication number
UA80396C2
UA80396C2 UA20031212328A UA20031212328A UA80396C2 UA 80396 C2 UA80396 C2 UA 80396C2 UA 20031212328 A UA20031212328 A UA 20031212328A UA 20031212328 A UA20031212328 A UA 20031212328A UA 80396 C2 UA80396 C2 UA 80396C2
Authority
UA
Ukraine
Prior art keywords
damage
brain
injury
inhibitor
mice
Prior art date
Application number
UA20031212328A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of UA80396C2 publication Critical patent/UA80396C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
UA20031212328A 2001-05-25 2002-05-23 Use of il-18 inhibitors for treating or traumatic head injury UA80396C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112067 2001-05-25
PCT/EP2002/005666 WO2002096456A1 (en) 2001-05-25 2002-05-23 Use of il-18 inhibitors for treating or preventing cns injuries

Publications (1)

Publication Number Publication Date
UA80396C2 true UA80396C2 (en) 2007-09-25

Family

ID=8177454

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20031212328A UA80396C2 (en) 2001-05-25 2002-05-23 Use of il-18 inhibitors for treating or traumatic head injury

Country Status (29)

Country Link
US (1) US7655616B2 (cs)
EP (1) EP1390070B1 (cs)
JP (1) JP4344142B2 (cs)
KR (1) KR20040030625A (cs)
CN (1) CN1305529C (cs)
AU (1) AU2002314103B2 (cs)
BG (1) BG66395B1 (cs)
BR (1) BR0210007A (cs)
CA (1) CA2445664C (cs)
CY (1) CY1119190T1 (cs)
CZ (1) CZ307321B6 (cs)
DK (1) DK1390070T3 (cs)
EA (1) EA006744B1 (cs)
EE (1) EE05263B1 (cs)
ES (1) ES2617084T3 (cs)
HR (1) HRP20030842B1 (cs)
HU (1) HU230294B1 (cs)
IL (2) IL159014A0 (cs)
LT (1) LT1390070T (cs)
ME (1) ME00550B (cs)
MX (1) MXPA03010743A (cs)
NO (1) NO331882B1 (cs)
PL (1) PL216228B1 (cs)
PT (1) PT1390070T (cs)
RS (1) RS56006B1 (cs)
SK (1) SK288413B6 (cs)
UA (1) UA80396C2 (cs)
WO (1) WO2002096456A1 (cs)
ZA (1) ZA200308172B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004238524B2 (en) 2003-05-13 2011-06-23 Merck Serono Sa Active variants of the IL-18 binding protein and medical uses thereof
NZ552908A (en) * 2004-06-30 2009-11-27 Atsuo Sekiyama Indicator agent for noninflammatory stress response and use thereof
RS52192B (en) * 2005-06-03 2012-10-31 Merck Serono Sa. The use of IL-18BP isoforms for the therapy and / or prevention of neurologic inflammatory diseases
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
ATE529433T1 (de) 2005-06-10 2011-11-15 Ares Trading Sa Verfahren zur reinigung eines il-18-bindenden proteins
US8685400B2 (en) 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
CN115925928A (zh) * 2013-09-05 2023-04-07 Ab2生物股份有限公司 炎性疾病中的il-18结合蛋白(il-18bp)
AU2016227644B2 (en) * 2015-03-05 2022-06-16 Ab2 Bio Sa IL-18 Binding Protein (IL-18BP) and antibodies in inflammatory diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0873453A (ja) * 1994-09-02 1996-03-19 Otsuka Pharmaceut Co Ltd サイトカイン阻害剤
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
AU2901899A (en) * 1998-03-09 1999-09-27 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
KR100798545B1 (ko) 2000-05-05 2008-01-28 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 죽상경화증의 치료 또는 예방을 위한 il-18 저해물질의용도
DE60106026T2 (de) * 2000-06-23 2006-02-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem 2-arachidonylglycerol (2-ag)-ein hemmer des tumor nekrose faktors-alfa und neuroprotektor des gehirns bei geschlossenen kopfverletzungen
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
US6671553B1 (en) * 2001-05-23 2003-12-30 Pacesetter, Inc. Implantable cardiac lead having terminating connector strain relief and method of manufacture

Also Published As

Publication number Publication date
EE200300582A (et) 2004-02-16
US20040191247A1 (en) 2004-09-30
US7655616B2 (en) 2010-02-02
ES2617084T3 (es) 2017-06-15
JP2004534777A (ja) 2004-11-18
HRP20030842A2 (en) 2005-08-31
IL159014A (en) 2012-05-31
HUP0304067A3 (en) 2006-01-30
NO331882B1 (no) 2012-04-23
CZ20033268A3 (en) 2004-07-14
AU2002314103B2 (en) 2007-07-12
ME00550B (me) 2011-10-10
NO20035160L (no) 2003-11-20
PL216228B1 (pl) 2014-03-31
NO20035160D0 (no) 2003-11-20
CY1119190T1 (el) 2018-02-14
IL159014A0 (en) 2004-05-12
AU2002314103B8 (en) 2002-12-09
SK16032003A3 (sk) 2004-05-04
RS56006B1 (sr) 2017-09-29
EA200301299A1 (ru) 2004-04-29
MXPA03010743A (es) 2004-03-02
CZ307321B6 (cs) 2018-06-06
CA2445664A1 (en) 2002-12-05
EP1390070A1 (en) 2004-02-25
EP1390070B1 (en) 2017-02-08
HK1069762A1 (en) 2005-06-03
ZA200308172B (en) 2004-10-21
BR0210007A (pt) 2004-08-10
PT1390070T (pt) 2017-03-01
CN1305529C (zh) 2007-03-21
YU89403A (sh) 2006-05-25
BG66395B1 (bg) 2013-12-31
JP4344142B2 (ja) 2009-10-14
EA006744B1 (ru) 2006-04-28
EE05263B1 (et) 2010-02-15
WO2002096456A1 (en) 2002-12-05
CA2445664C (en) 2012-03-06
HUP0304067A2 (hu) 2004-03-29
PL367545A1 (en) 2005-02-21
KR20040030625A (ko) 2004-04-09
LT1390070T (lt) 2017-03-10
CN1535160A (zh) 2004-10-06
HU230294B1 (hu) 2015-12-28
BG108451A (en) 2005-02-28
SK288413B6 (sk) 2016-10-03
DK1390070T3 (en) 2017-04-24
HRP20030842B1 (hr) 2017-06-02

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