UA75592C2 - Inhibitors of dipeptidyl peptidase iv, pharmaceutical composition based thereof, composition for treatment and method for treatment of diseases - Google Patents
Inhibitors of dipeptidyl peptidase iv, pharmaceutical composition based thereof, composition for treatment and method for treatment of diseases Download PDFInfo
- Publication number
- UA75592C2 UA75592C2 UA2002108483A UA2002108483A UA75592C2 UA 75592 C2 UA75592 C2 UA 75592C2 UA 2002108483 A UA2002108483 A UA 2002108483A UA 2002108483 A UA2002108483 A UA 2002108483A UA 75592 C2 UA75592 C2 UA 75592C2
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- Ukraine
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- сно
- carbonyl
- carbonitrile
- pyrrolidine
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 8
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 16
- 238000000034 method Methods 0.000 title claims description 14
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- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 title abstract 2
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 title abstract 2
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- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 16
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
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- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Hematology (AREA)
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- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
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- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0010183.2A GB0010183D0 (en) | 2000-04-26 | 2000-04-26 | Inhibitors of dipeptidyl peptidase IV |
| PCT/GB2001/001888 WO2001081304A1 (en) | 2000-04-26 | 2001-04-26 | Inhibitors of dipeptidyl peptidase iv |
Publications (1)
| Publication Number | Publication Date |
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| UA75592C2 true UA75592C2 (en) | 2006-05-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| UA2002108483A UA75592C2 (en) | 2000-04-26 | 2001-04-26 | Inhibitors of dipeptidyl peptidase iv, pharmaceutical composition based thereof, composition for treatment and method for treatment of diseases |
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| EP (2) | EP1693365A1 (no) |
| JP (1) | JP2003531191A (no) |
| KR (1) | KR20020093913A (no) |
| CN (2) | CN100355728C (no) |
| AU (1) | AU781245B2 (no) |
| BR (1) | BR0110267A (no) |
| CA (1) | CA2407663A1 (no) |
| CZ (1) | CZ20023514A3 (no) |
| EE (1) | EE200200604A (no) |
| GB (1) | GB0010183D0 (no) |
| HR (1) | HRP20020812A2 (no) |
| HU (1) | HUP0300542A2 (no) |
| IL (2) | IL151588A0 (no) |
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| NZ (1) | NZ521166A (no) |
| PL (1) | PL357820A1 (no) |
| RU (1) | RU2283303C2 (no) |
| SK (1) | SK15282002A3 (no) |
| UA (1) | UA75592C2 (no) |
| WO (1) | WO2001081304A1 (no) |
| ZA (1) | ZA200207739B (no) |
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| US20060052382A1 (en) * | 2002-12-20 | 2006-03-09 | Duffy Joseph L | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| JP4887139B2 (ja) | 2003-03-25 | 2012-02-29 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
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| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
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|---|---|---|---|---|
| US4623715A (en) * | 1984-10-22 | 1986-11-18 | Hoechst Aktiengeselleschaft | Novel peptides which are active on the central nervous system and have an action on the cholinergic system |
| EP0490379A3 (de) * | 1990-12-13 | 1992-06-24 | BERLIN-CHEMIE Aktiengesellschaft | Diaminosäurederivate und pharmazeutische Zusammensetzungen |
| IL111785A0 (en) * | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| US6011155A (en) * | 1996-11-07 | 2000-01-04 | Novartis Ag | N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
| TW492957B (en) * | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| DE19826972A1 (de) | 1998-06-18 | 1999-12-23 | Univ Magdeburg Tech | Verwendung von Enzyminhibitoren und pharmazeutische Zubereitung zur Therapie von dermatologischen Erkrankungen mit follikulären und epidermalen Hyperkeratosen und einer verstärkten Keratinozytenproliferation |
| DE19940130A1 (de) * | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
| FR2822826B1 (fr) * | 2001-03-28 | 2003-05-09 | Servier Lab | Nouveaux derives sulfonyles d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2000
- 2000-04-26 GB GBGB0010183.2A patent/GB0010183D0/en not_active Ceased
-
2001
- 2001-04-26 HU HU0300542A patent/HUP0300542A2/hu unknown
- 2001-04-26 CZ CZ20023514A patent/CZ20023514A3/cs unknown
- 2001-04-26 NZ NZ521166A patent/NZ521166A/en unknown
- 2001-04-26 EP EP06075990A patent/EP1693365A1/en not_active Withdrawn
- 2001-04-26 UA UA2002108483A patent/UA75592C2/uk unknown
- 2001-04-26 BR BR0110267-2A patent/BR0110267A/pt not_active IP Right Cessation
- 2001-04-26 EE EEP200200604A patent/EE200200604A/xx unknown
- 2001-04-26 SK SK1528-2002A patent/SK15282002A3/sk not_active Application Discontinuation
- 2001-04-26 EP EP01923861A patent/EP1282600A1/en not_active Withdrawn
- 2001-04-26 MX MXPA02010438A patent/MXPA02010438A/es active IP Right Grant
- 2001-04-26 CN CNB018085040A patent/CN100355728C/zh not_active Expired - Fee Related
- 2001-04-26 PL PL01357820A patent/PL357820A1/xx not_active Application Discontinuation
- 2001-04-26 IL IL15158801A patent/IL151588A0/xx not_active IP Right Cessation
- 2001-04-26 KR KR1020027013781A patent/KR20020093913A/ko not_active Application Discontinuation
- 2001-04-26 US US10/221,129 patent/US7189728B2/en not_active Expired - Fee Related
- 2001-04-26 RU RU2002131640/04A patent/RU2283303C2/ru not_active IP Right Cessation
- 2001-04-26 CA CA002407663A patent/CA2407663A1/en not_active Abandoned
- 2001-04-26 CN CNA2005101377754A patent/CN1803797A/zh active Pending
- 2001-04-26 JP JP2001578399A patent/JP2003531191A/ja active Pending
- 2001-04-26 WO PCT/GB2001/001888 patent/WO2001081304A1/en not_active Application Discontinuation
- 2001-04-26 AU AU50544/01A patent/AU781245B2/en not_active Ceased
-
2002
- 2002-09-03 IL IL151588A patent/IL151588A/en unknown
- 2002-09-26 ZA ZA200207739A patent/ZA200207739B/en unknown
- 2002-10-10 HR HRP20020812 patent/HRP20020812A2/hr not_active Application Discontinuation
- 2002-10-22 NO NO20025079A patent/NO324364B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL151588A0 (en) | 2003-04-10 |
| HRP20020812A2 (en) | 2004-12-31 |
| GB0010183D0 (en) | 2000-06-14 |
| MXPA02010438A (es) | 2003-04-25 |
| KR20020093913A (ko) | 2002-12-16 |
| HUP0300542A2 (hu) | 2003-06-28 |
| CN1803797A (zh) | 2006-07-19 |
| EP1693365A1 (en) | 2006-08-23 |
| RU2283303C2 (ru) | 2006-09-10 |
| CZ20023514A3 (cs) | 2003-04-16 |
| WO2001081304A1 (en) | 2001-11-01 |
| US20030216450A1 (en) | 2003-11-20 |
| BR0110267A (pt) | 2003-02-18 |
| NZ521166A (en) | 2003-10-31 |
| PL357820A1 (en) | 2004-07-26 |
| NO20025079D0 (no) | 2002-10-22 |
| CN1426395A (zh) | 2003-06-25 |
| JP2003531191A (ja) | 2003-10-21 |
| EE200200604A (et) | 2004-04-15 |
| NO20025079L (no) | 2002-12-18 |
| US7189728B2 (en) | 2007-03-13 |
| AU781245B2 (en) | 2005-05-12 |
| NO324364B1 (no) | 2007-10-01 |
| AU5054401A (en) | 2001-11-07 |
| EP1282600A1 (en) | 2003-02-12 |
| CN100355728C (zh) | 2007-12-19 |
| SK15282002A3 (sk) | 2003-05-02 |
| RU2002131640A (ru) | 2004-03-27 |
| ZA200207739B (en) | 2003-05-22 |
| IL151588A (en) | 2008-03-20 |
| CA2407663A1 (en) | 2001-11-01 |
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