UA57772C2 - Інгібітори протеази віл, фармацевтична композиція на їх основі та спосіб інгібування протеази реплікації віл - Google Patents

Інгібітори протеази віл, фармацевтична композиція на їх основі та спосіб інгібування протеази реплікації віл Download PDF

Info

Publication number
UA57772C2
UA57772C2 UA99095049A UA99095049A UA57772C2 UA 57772 C2 UA57772 C2 UA 57772C2 UA 99095049 A UA99095049 A UA 99095049A UA 99095049 A UA99095049 A UA 99095049A UA 57772 C2 UA57772 C2 UA 57772C2
Authority
UA
Ukraine
Prior art keywords
compound
group
purity
pharmaceutically acceptable
alkyl
Prior art date
Application number
UA99095049A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Кім Ф. Альбідзаті
Зігфрід Райх
Майкл Д. Варні
Канін Е. Джанг
Такуо Кобаясі
Original Assignee
Агурон Фармасутікалз, Інк.
Джепен Тобакко Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Агурон Фармасутікалз, Інк., Джепен Тобакко Інк. filed Critical Агурон Фармасутікалз, Інк.
Publication of UA57772C2 publication Critical patent/UA57772C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
UA99095049A 1997-03-13 1998-12-03 Інгібітори протеази віл, фармацевтична композиція на їх основі та спосіб інгібування протеази реплікації віл UA57772C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81595197A 1997-03-13 1997-03-13
PCT/US1998/004735 WO1998040357A2 (en) 1997-03-13 1998-03-12 Hiv protease inhibitors

Publications (1)

Publication Number Publication Date
UA57772C2 true UA57772C2 (uk) 2003-07-15

Family

ID=25219265

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99095049A UA57772C2 (uk) 1997-03-13 1998-12-03 Інгібітори протеази віл, фармацевтична композиція на їх основі та спосіб інгібування протеази реплікації віл

Country Status (35)

Country Link
EP (1) EP0970055A2 (zh)
JP (1) JP2001516350A (zh)
KR (1) KR100511089B1 (zh)
CN (1) CN1179948C (zh)
AP (1) AP1358A (zh)
AR (1) AR012556A1 (zh)
AU (1) AU743078B2 (zh)
BG (1) BG63540B1 (zh)
BR (1) BR9808867A (zh)
CA (1) CA2284163A1 (zh)
CO (1) CO4940496A1 (zh)
CZ (1) CZ296647B6 (zh)
EA (1) EA002378B1 (zh)
EE (1) EE04114B1 (zh)
GE (1) GEP20022764B (zh)
HR (1) HRP980112A2 (zh)
HU (1) HUP0001380A3 (zh)
IL (2) IL131870A0 (zh)
IS (1) IS5176A (zh)
MX (1) MXPA99008395A (zh)
MY (1) MY117535A (zh)
NO (1) NO315555B1 (zh)
NZ (1) NZ337706A (zh)
OA (1) OA11196A (zh)
PA (1) PA8448801A1 (zh)
PE (1) PE58799A1 (zh)
PL (1) PL192786B1 (zh)
SA (1) SA98181116B1 (zh)
SK (1) SK283636B6 (zh)
SV (1) SV1998000038A (zh)
TR (1) TR199902508T2 (zh)
TW (1) TW200517112A (zh)
UA (1) UA57772C2 (zh)
WO (1) WO1998040357A2 (zh)
ZA (1) ZA982047B (zh)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors

Also Published As

Publication number Publication date
SV1998000038A (es) 1999-02-15
MY117535A (en) 2004-07-31
IL131870A0 (en) 2001-03-19
CN1253548A (zh) 2000-05-17
NO994415D0 (no) 1999-09-10
ZA982047B (en) 1998-09-28
HUP0001380A3 (en) 2001-12-28
TR199902508T2 (xx) 2000-02-21
EE04114B1 (et) 2003-08-15
SK283636B6 (sk) 2003-11-04
CZ319199A3 (cs) 2000-06-14
HUP0001380A2 (hu) 2000-09-28
IS5176A (is) 1999-09-10
CN1179948C (zh) 2004-12-15
SA98181116B1 (ar) 2006-10-04
EA002378B1 (ru) 2002-04-25
BG103727A (en) 2000-04-28
KR100511089B1 (ko) 2005-08-31
AU6457598A (en) 1998-09-29
WO1998040357A3 (en) 1998-11-26
PA8448801A1 (es) 2000-05-24
CO4940496A1 (es) 2000-07-24
MXPA99008395A (es) 2003-08-12
NO315555B1 (no) 2003-09-22
KR20000076236A (ko) 2000-12-26
SK122299A3 (en) 2000-05-16
PL192786B1 (pl) 2006-12-29
BR9808867A (pt) 2000-07-11
PL335672A1 (en) 2000-05-08
EP0970055A2 (en) 2000-01-12
AP9901648A0 (en) 1999-09-30
AU743078B2 (en) 2002-01-17
PE58799A1 (es) 1999-07-12
HRP980112A2 (en) 1998-12-31
AR012556A1 (es) 2000-11-08
EA199900823A1 (ru) 2000-04-24
TW200517112A (en) 2005-06-01
JP2001516350A (ja) 2001-09-25
CZ296647B6 (cs) 2006-05-17
BG63540B1 (bg) 2002-04-30
AP1358A (en) 2004-12-03
CA2284163A1 (en) 1998-09-17
NZ337706A (en) 2001-04-27
WO1998040357A2 (en) 1998-09-17
IL131870A (en) 2006-04-10
NO994415L (no) 1999-11-10
OA11196A (en) 2003-05-21
EE9900416A (et) 2000-04-17
GEP20022764B (en) 2002-08-26

Similar Documents

Publication Publication Date Title
ES2236849T3 (es) Inhibidores de la proteasa de vih.
US5728718A (en) 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
CN108884029A (zh) Lsd1抑制剂
PT99553A (pt) Processo para a preparacao de compostos hidroxietilamina,contendo ureia,inibidores de protease retroviral
JP2006022106A (ja) Ｈｉｖプロテアーゼ阻害剤としてのｎ−（３−アミノ−２−ヒドロキシブチル）スルホンアミド誘導体
JPH06503092A (ja) レトロウイルスプロテアーゼ阻害剤
CA2182192A1 (en) Protease inhibitors
EA003906B1 (ru) Трипептидные ингибиторы вируса гепатита c
JPH08504815A (ja) 環状スルホン含有レトロウイルスプロテアーゼ阻害物質
JPH06234789A (ja) Ａｉｄｓの処置のために有用なｈｉｖ−プロテアーゼ阻害剤
JPH05230005A (ja) 免疫不全ウイルスプロテアーゼ阻害剤
JPH06234728A (ja) Ａｉｄｓの処置のために有用なｈｉｖ−プロテアーゼ阻害剤
JPH06234716A (ja) Ａｉｄｓの処置に有用なｈｉｖ−プロテアーゼ阻害剤
RO109540B1 (ro) Derivati de aminoacizi, procedee pentru prepararea lor, intermediari si compozitii farmaceutice, care ii contin
UA57772C2 (uk) Інгібітори протеази віл, фармацевтична композиція на їх основі та спосіб інгібування протеази реплікації віл
CN107619392A (zh) 1h‑吲唑‑4‑醚类化合物及其作为ido抑制剂的用途
US6001851A (en) HIV protease inhibitors
PT101026A (pt) 6-fenil-5-amino-4-hidroxi-hexanoil-valil-guanidinas substituidas como inibidores da protease de hiv
PT100752A (pt) Derivados do acido 4-amino-3-hidroxicarboxilico