UA125284C2 - Рекомбінантне антитіло, яке специфічно зв'язується з tl1a - Google Patents

Рекомбінантне антитіло, яке специфічно зв'язується з tl1a Download PDF

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Publication number
UA125284C2
UA125284C2 UAA201804192A UAA201804192A UA125284C2 UA 125284 C2 UA125284 C2 UA 125284C2 UA A201804192 A UAA201804192 A UA A201804192A UA A201804192 A UAA201804192 A UA A201804192A UA 125284 C2 UA125284 C2 UA 125284C2
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Ukraine
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rgo
acid sequence
antibody
amino acid
variable region
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UAA201804192A
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English (en)
Ukrainian (uk)
Inventor
Лінн Дороті Паултон
Лин Дороти Паултон
Метью Поллард
Метью Полард
Ентоні Дж. Дойл
Энтони Дж. Дойл
Бриджет Енн Куксі
Бриджет Эн Кукси
Ванія Панд
Вания Панд
Адам Уілльям Кларк
Адам Уильям Кларк
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Сефалон, Інк.
Сефалон, Инк.
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Publication of UA125284C2 publication Critical patent/UA125284C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Sorting Of Articles (AREA)
UAA201804192A 2015-09-18 2016-09-16 Рекомбінантне антитіло, яке специфічно зв'язується з tl1a UA125284C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562220442P 2015-09-18 2015-09-18
PCT/US2016/052040 WO2017049024A1 (en) 2015-09-18 2016-09-16 Antibodies that specifically bind to tl1a

Publications (1)

Publication Number Publication Date
UA125284C2 true UA125284C2 (uk) 2022-02-16

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UAA201804192A UA125284C2 (uk) 2015-09-18 2016-09-16 Рекомбінантне антитіло, яке специфічно зв'язується з tl1a

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US (4) US10138296B2 (enExample)
EP (2) EP3350223B1 (enExample)
JP (2) JP7013366B2 (enExample)
KR (1) KR101998535B1 (enExample)
CN (1) CN108137693B (enExample)
AR (1) AR106055A1 (enExample)
AU (2) AU2016323460B2 (enExample)
BR (1) BR122021002400A8 (enExample)
CA (1) CA2997015A1 (enExample)
CL (1) CL2018000711A1 (enExample)
CO (1) CO2018003736A2 (enExample)
CY (1) CY1123499T1 (enExample)
DK (1) DK3350223T3 (enExample)
EA (1) EA201890756A1 (enExample)
ES (1) ES2810751T3 (enExample)
HR (1) HRP20201323T1 (enExample)
HU (1) HUE051496T2 (enExample)
IL (1) IL257761B2 (enExample)
LT (1) LT3350223T (enExample)
MA (2) MA42825B1 (enExample)
MD (1) MD3350223T2 (enExample)
MX (1) MX2018003185A (enExample)
PE (1) PE20181080A1 (enExample)
PH (1) PH12018500580B1 (enExample)
PL (1) PL3350223T3 (enExample)
PT (1) PT3350223T (enExample)
RS (1) RS60703B1 (enExample)
SI (1) SI3350223T1 (enExample)
SM (1) SMT202000500T1 (enExample)
TW (1) TWI703158B (enExample)
UA (1) UA125284C2 (enExample)
WO (1) WO2017049024A1 (enExample)
ZA (1) ZA201801427B (enExample)

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