CN108137693B - 特异性地结合至tl1a的抗体 - Google Patents

特异性地结合至tl1a的抗体 Download PDF

Info

Publication number
CN108137693B
CN108137693B CN201680053598.8A CN201680053598A CN108137693B CN 108137693 B CN108137693 B CN 108137693B CN 201680053598 A CN201680053598 A CN 201680053598A CN 108137693 B CN108137693 B CN 108137693B
Authority
CN
China
Prior art keywords
ser
val
leu
thr
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201680053598.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN108137693A (zh
Inventor
林恩·多萝西·普尔顿
马修·波拉德
安东尼·G·道尔
布丽吉特·安·库克西
万尼亚·潘德
亚当·威廉·克拉克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Safran SA
Original Assignee
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon LLC filed Critical Cephalon LLC
Publication of CN108137693A publication Critical patent/CN108137693A/zh
Application granted granted Critical
Publication of CN108137693B publication Critical patent/CN108137693B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Sorting Of Articles (AREA)
CN201680053598.8A 2015-09-18 2016-09-16 特异性地结合至tl1a的抗体 Active CN108137693B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562220442P 2015-09-18 2015-09-18
US62/220,442 2015-09-18
PCT/US2016/052040 WO2017049024A1 (en) 2015-09-18 2016-09-16 Antibodies that specifically bind to tl1a

Publications (2)

Publication Number Publication Date
CN108137693A CN108137693A (zh) 2018-06-08
CN108137693B true CN108137693B (zh) 2021-11-26

Family

ID=57043002

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680053598.8A Active CN108137693B (zh) 2015-09-18 2016-09-16 特异性地结合至tl1a的抗体

Country Status (33)

Country Link
US (4) US10138296B2 (enExample)
EP (2) EP3693393A1 (enExample)
JP (2) JP7013366B2 (enExample)
KR (1) KR101998535B1 (enExample)
CN (1) CN108137693B (enExample)
AR (1) AR106055A1 (enExample)
AU (2) AU2016323460B2 (enExample)
BR (2) BR122021002400A8 (enExample)
CA (1) CA2997015A1 (enExample)
CL (1) CL2018000711A1 (enExample)
CO (1) CO2018003736A2 (enExample)
CY (1) CY1123499T1 (enExample)
DK (1) DK3350223T3 (enExample)
EA (1) EA201890756A1 (enExample)
ES (1) ES2810751T3 (enExample)
HR (1) HRP20201323T1 (enExample)
HU (1) HUE051496T2 (enExample)
IL (1) IL257761B2 (enExample)
LT (1) LT3350223T (enExample)
MA (2) MA52643A (enExample)
MD (1) MD3350223T2 (enExample)
MX (1) MX2018003185A (enExample)
PE (1) PE20181080A1 (enExample)
PH (1) PH12018500580B1 (enExample)
PL (1) PL3350223T3 (enExample)
PT (1) PT3350223T (enExample)
RS (1) RS60703B1 (enExample)
SI (1) SI3350223T1 (enExample)
SM (1) SMT202000500T1 (enExample)
TW (1) TWI703158B (enExample)
UA (1) UA125284C2 (enExample)
WO (1) WO2017049024A1 (enExample)
ZA (1) ZA201801427B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
BR112014007426B1 (pt) 2011-09-30 2023-01-03 Teva Pharmaceuticals Australia Pty Ltd Anticorpos contra tl1a e seus usos
EP3639841B1 (en) 2013-03-27 2023-09-06 Cedars-Sinai Medical Center Treating fibrosis by inhibiting tl1a
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
TWI703158B (zh) * 2015-09-18 2020-09-01 美商希佛隆公司 特異性結合tl1a之抗體
AU2016364992B2 (en) * 2015-12-04 2021-12-09 University Of Iowa Research Foundation Apparatus, systems and methods for predicting, screening and monitoring of encephalopathy / delirium
JP7082945B2 (ja) 2016-03-17 2022-06-09 シーダーズ―シナイ メディカル センター Rnaset2により炎症性腸疾患を診断する方法
SG11201903737PA (en) 2016-10-26 2019-05-30 Cedars Sinai Medical Center Neutralizing anti-tl1a monoclonal antibodies
EP3617235A4 (en) * 2017-04-28 2020-12-16 Ajinomoto Co., Inc. COMPOUND CONTAINING A SUBSTANCE HAVING AFFINITY FOR A SOLUBLE PROTEIN, CLIVABLE FRACTION, AND REACTIVE GROUP, OR SALT OF THE SAME
MA52366A (fr) 2018-04-25 2021-03-03 Prometheus Biosciences Inc Anticorps anti-tl1a optimisés
WO2020232125A1 (en) 2019-05-14 2020-11-19 Prometheus Biosciences, Inc. Tl1a patient selection methods, systems, and devices
JP7504992B2 (ja) 2019-10-24 2024-06-24 プロメテウス バイオサイエンシーズ,インク. Tnf様リガンド1a(tl1a)に対するヒト化抗体およびその使用
JP2023538902A (ja) * 2020-08-19 2023-09-12 ヤンセン バイオテツク,インコーポレーテツド 操作されたリガンドを使用する材料及び方法
IL318428A (en) 2022-07-27 2025-03-01 Cephalon Llc Antibodies against TL1A for the treatment of ulcerative colitis and Crohn's disease
WO2024026386A1 (en) 2022-07-27 2024-02-01 Cephalon Llc Anti-tl1a antibody formulations
WO2024239006A1 (en) 2023-05-17 2024-11-21 Genentech, Inc. Anti-tl1a antibody therapeutic methods
TW202515910A (zh) * 2023-06-22 2025-04-16 美商派拉岡醫療公司 Il-17抗體組合物及使用方法
WO2024263900A2 (en) * 2023-06-22 2024-12-26 Paragon Therapeutics, Inc. Il-23 antibody compositions and methods of use
WO2025038473A1 (en) 2023-08-11 2025-02-20 Paragon Therapeutics, Inc. Tl1a binding antibodies and methods of use
WO2025076081A1 (en) 2023-10-03 2025-04-10 Absci Corporation Tl1a associated antibody compositions and methods of use
CN120058933A (zh) * 2023-11-30 2025-05-30 北京智仁美博生物科技有限公司 抗肿瘤坏死因子样配体1a的抗体及其用途
US20250230251A1 (en) 2023-12-20 2025-07-17 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rb) and related methods
CN120424214A (zh) * 2024-02-05 2025-08-05 三生国健药业(上海)股份有限公司 一种抗tl1a抗体及其制备方法和用途
US20250376530A1 (en) 2024-05-17 2025-12-11 Genentech, Inc. Methods for treatment of inflammatory bowel disease with an anti-tl1a antibody
CN119552252B (zh) * 2025-01-16 2025-11-25 华润生物医药有限公司 抗tl1a抗体及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1420785A (zh) * 2000-02-29 2003-05-28 赛福伦公司 采用抗神经营养蛋白剂治疗癌症的方法
CN101346397A (zh) * 2005-10-24 2009-01-14 杜门蒂斯有限公司 用于治疗呼吸道疾病的可结合肺组织内靶标的结合剂
CN104114577A (zh) * 2011-09-30 2014-10-22 特瓦制药澳大利亚私人有限公司 针对TL1a的抗体及其用途
CN105307676A (zh) * 2013-04-05 2016-02-03 豪夫迈·罗氏有限公司 抗il-4抗体和双特异性抗体及其用途

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7597886B2 (en) 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7820798B2 (en) 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
BR0008758A (pt) 1999-01-15 2001-12-04 Genentech Inc Variantes de polipeptìdeos parentais com funçãoefetora alterada, polipeptìdeos, composição ácidonucleico isolado, vetor, célula hospedeira,método para produzir uma variante depolipeptìdeo, método para o tratamento de umadesordem em mamìferos e método para produziruma região fc variante
PT1355919E (pt) 2000-12-12 2011-03-02 Medimmune Llc Moléculas com semivida longa, composições que as contêm e suas utilizações
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
AU2003293543A1 (en) 2002-12-13 2004-07-09 Abgenix, Inc. System and method for stabilizing antibodies with histidine
CA2536086C (en) 2003-08-20 2013-03-19 University Of Miami Inhibition of dr3 in the treatment of allergic lung inflammation
EP1756162A1 (en) 2004-03-23 2007-02-28 Biogen Idec MA Inc. Receptor coupling agents and therapeutic uses thereof
WO2006127900A2 (en) 2005-05-25 2006-11-30 Biogen Idec Ma Inc. Tl1a in the treatment of disease
CA2621083C (en) 2005-08-30 2017-04-11 University Of Miami Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists and immunotoxins
WO2007076465A2 (en) 2005-12-23 2007-07-05 Diadexus, Inc. Cln248 antibody compositions and methods of use
US20110217310A1 (en) 2007-01-10 2011-09-08 Siegel Richard M Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology
WO2008106451A2 (en) 2007-02-26 2008-09-04 Cedars-Sinai Medical Center Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
WO2009052512A2 (en) 2007-10-19 2009-04-23 Cedars-Sinai Medical Center Methods of using genetic variants to diagnose and predict inflammatory bowel disease
CA2705292C (en) 2007-11-13 2016-06-21 Teva Biopharmaceuticals Usa, Inc. Humanized antibodies against tl1a
WO2010118210A1 (en) 2009-04-08 2010-10-14 Cedars-Sinai Medical Center Methods of predicting complication and surgery in crohn's disease
WO2011080314A2 (en) 2009-12-31 2011-07-07 Deutsches Krebsforschungszentrum Novel modulators of trail signalling
JO3375B1 (ar) 2010-11-08 2019-03-13 Regeneron Pharma أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a)
WO2012161856A1 (en) 2011-05-20 2012-11-29 Government Of The United States, As Represented By The Secretary, Department Of Health And Human Services Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof
US20140170157A1 (en) 2011-06-15 2014-06-19 Glaxosmithkline Intellectual Property (No.2) Limited Method of selecting therapeutic indications
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
ES2689080T3 (es) 2013-01-02 2018-11-08 Glenmark Pharmaceuticals S.A. Anticuerpos que se unen a TL1A y sus usos
EP3639841B1 (en) 2013-03-27 2023-09-06 Cedars-Sinai Medical Center Treating fibrosis by inhibiting tl1a
KR102295125B1 (ko) 2013-05-17 2021-08-31 세다르스-신나이 메디칼 센터 크론병과 연관된 tnfsf15와 dcr3의 변이체
EP2996717A4 (en) 2013-05-17 2016-11-23 Cedars Sinai Medical Center DIFFERENT EFFECTS OF IFN-GAMMA AND IL-17 ON TL1A-MODULATED INFLAMMATION AND FIBROSIS
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
WO2015035261A1 (en) 2013-09-06 2015-03-12 Cedars-Sinai Medical Center Systems, devices and methods for anti-tl1a therapy
CA2929784C (en) 2013-11-13 2019-11-26 Pfizer Inc. Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof
SG11201708480YA (en) 2015-04-15 2017-12-28 Biosearch Tech Inc Dual quencher probes
CN107835694A (zh) 2015-05-15 2018-03-23 西达-赛奈医疗中心 用于治疗炎症性肠病的模型、方法和组合物
EP3337509A4 (en) 2015-08-21 2019-01-02 The Children's Hospital of Philadelphia Methods of treating autoimmune conditions in patients with genetic variations in dcr3 or in a dcr3 network gene
TWI703158B (zh) 2015-09-18 2020-09-01 美商希佛隆公司 特異性結合tl1a之抗體
WO2017077715A1 (en) 2015-11-02 2017-05-11 La Jolla Institute For Allergy & Immunology Method and medicament for treating airway and/or lung diseases
CR20180365A (es) 2015-12-16 2018-09-28 Amgen Inc PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS
JP7082945B2 (ja) 2016-03-17 2022-06-09 シーダーズ―シナイ メディカル センター Rnaset2により炎症性腸疾患を診断する方法
EA039084B1 (ru) 2016-05-09 2021-12-01 Бристол-Майерс Сквибб Компани Антитела к tl1a и их применения
GB201608323D0 (en) 2016-05-12 2016-06-29 Ucb Biopharma Sprl Pharmaceutical compositions
CN109219620B (zh) 2016-06-09 2023-01-31 派立卡恩治疗公司 抗-tnfrsf25抗体
SG11201903737PA (en) 2016-10-26 2019-05-30 Cedars Sinai Medical Center Neutralizing anti-tl1a monoclonal antibodies
US10626180B2 (en) 2017-04-20 2020-04-21 Cedars-Sinai Medical Center Methods of treating and predicting non-response to anti-TNF treatment in subjects with inflammatory bowel disease
MA52366A (fr) 2018-04-25 2021-03-03 Prometheus Biosciences Inc Anticorps anti-tl1a optimisés
RS64747B1 (sr) 2018-04-30 2023-11-30 Cedars Sinai Medical Center Postupci i sistemi za odabir i lečenje pacijenata sa inflamatornim bolestima
WO2020113116A1 (en) 2018-11-29 2020-06-04 Cedars-Sinai Medical Center Methods of stratifying and treating a sub-population of inflammatory bowel disease patients
WO2020232125A1 (en) 2019-05-14 2020-11-19 Prometheus Biosciences, Inc. Tl1a patient selection methods, systems, and devices
WO2021081365A1 (en) 2019-10-24 2021-04-29 Prometheus Biosciences, Inc. Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof
WO2021108694A1 (en) 2019-11-27 2021-06-03 Cedars-Sinai Medical Center Predicting extraintestinal manifestations of inflammatory bowel disease
CA3180628A1 (en) 2020-06-03 2021-12-09 Rebecca GONSKY Treatments for a sub-population of inflammatory bowel disease patients
CA3180632A1 (en) 2020-06-03 2021-12-09 Cedars-Sinai Medical Center Methods and systems for measuring post-operative disease recurrence
EP4171632A2 (en) 2020-06-26 2023-05-03 Pfizer Inc. Methods of treating inflammatory bowel disease with tl1a antibodies
WO2022103961A1 (en) 2020-11-13 2022-05-19 Prometheus Biosciences, Inc. Methods, systems, and kits for treatment of inflammatory diseases targeting tl1a
EP4256086A4 (en) 2020-12-01 2025-01-15 Cedars-Sinai Medical Center METHODS AND SYSTEMS FOR STRATIFICATION OF PATIENTS WITH INFLAMMATORY DISEASES
CA3202510A1 (en) 2020-12-21 2022-06-30 Dermot P. Mcgovern Tl1a therapy compositions and methods of treatment therewith
US20240336691A1 (en) 2021-02-18 2024-10-10 Prometheus Biosciences, Inc. Anti-tl1a antibody compositions and methods of treatment in the lung
AU2022223420A1 (en) 2021-02-18 2023-09-21 Cedars-Sinai Medical Center Compositions comprising humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof
WO2022232253A1 (en) 2021-04-28 2022-11-03 Cedars-Sinai Medical Center Patient selection methods and kits for therapies targeting tl1a
WO2023102051A1 (en) 2021-12-01 2023-06-08 Cedars-Sinai Medical Center Intestinal mononuclear phagocytes as prognostic biomarker for crohn's disease
WO2023102071A1 (en) 2021-12-01 2023-06-08 Cedars-Sinai Medical Center Microbial metabolites on intestinal inflammation
WO2023133538A2 (en) 2022-01-07 2023-07-13 Prometheus Biosciences, Inc. Methods of treating inflammatory diseases with combination of tl1a inhibitors and il23 inhibitors
US20240059799A1 (en) 2022-05-11 2024-02-22 Pfizer Inc. Anti-tl1a antibodies and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1420785A (zh) * 2000-02-29 2003-05-28 赛福伦公司 采用抗神经营养蛋白剂治疗癌症的方法
CN101346397A (zh) * 2005-10-24 2009-01-14 杜门蒂斯有限公司 用于治疗呼吸道疾病的可结合肺组织内靶标的结合剂
CN104114577A (zh) * 2011-09-30 2014-10-22 特瓦制药澳大利亚私人有限公司 针对TL1a的抗体及其用途
CN105307676A (zh) * 2013-04-05 2016-02-03 豪夫迈·罗氏有限公司 抗il-4抗体和双特异性抗体及其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
《A general method for greatly improving the affinity of antibodies by using combinatorial libraries》;Arvind Rajpal等;《PNAS》;20050614;第102卷(第24期);第8466-8471页 *
《TL1A及其受体与炎症性肠病的研究进展》;严冬梅等;《胃肠病学》;20101130;第15卷(第11期);第684-686页 *

Also Published As

Publication number Publication date
TW201722990A (zh) 2017-07-01
EP3350223B1 (en) 2020-06-17
EP3350223A1 (en) 2018-07-25
RS60703B1 (sr) 2020-09-30
CA2997015A1 (en) 2017-03-23
CN108137693A (zh) 2018-06-08
US10138296B2 (en) 2018-11-27
IL257761B2 (en) 2023-03-01
TWI703158B (zh) 2020-09-01
PT3350223T (pt) 2020-08-05
BR112018005407A2 (en) 2018-10-09
MA52643A (fr) 2021-03-24
BR122021002400A8 (pt) 2023-01-24
MD3350223T2 (ro) 2020-09-30
IL257761A (en) 2018-04-30
HRP20201323T1 (hr) 2020-11-27
SMT202000500T1 (it) 2020-11-10
DK3350223T3 (da) 2020-08-24
JP2018528773A (ja) 2018-10-04
PH12018500580B1 (en) 2023-01-11
US20220185902A1 (en) 2022-06-16
IL257761B (en) 2022-11-01
EP3693393A1 (en) 2020-08-12
MX2018003185A (es) 2018-08-01
HK1256300A1 (zh) 2019-09-20
SI3350223T1 (sl) 2020-10-30
US20190106486A1 (en) 2019-04-11
CL2018000711A1 (es) 2018-11-23
AU2023203440A1 (en) 2023-06-29
MA42825B1 (fr) 2020-09-30
CY1123499T1 (el) 2022-03-24
PE20181080A1 (es) 2018-07-05
HK1251002A1 (en) 2019-01-18
US11220549B2 (en) 2022-01-11
CO2018003736A2 (es) 2018-07-10
JP7013366B2 (ja) 2022-02-15
JP2022051771A (ja) 2022-04-01
KR20180048712A (ko) 2018-05-10
US12162946B2 (en) 2024-12-10
ZA201801427B (en) 2019-06-26
ES2810751T3 (es) 2021-03-09
LT3350223T (lt) 2020-10-26
EA201890756A1 (ru) 2018-08-31
AR106055A1 (es) 2017-12-06
US20250179202A1 (en) 2025-06-05
PH12018500580A1 (en) 2018-10-15
AU2016323460B2 (en) 2023-06-15
KR101998535B1 (ko) 2019-07-09
BR112018005407A8 (pt) 2023-01-24
PL3350223T3 (pl) 2021-03-08
AU2016323460A1 (en) 2018-03-29
HUE051496T2 (hu) 2021-03-01
JP7341259B2 (ja) 2023-09-08
US20170081400A1 (en) 2017-03-23
NZ740731A (en) 2024-07-26
BR122021002400A2 (enExample) 2018-10-09
UA125284C2 (uk) 2022-02-16
WO2017049024A1 (en) 2017-03-23

Similar Documents

Publication Publication Date Title
CN108137693B (zh) 特异性地结合至tl1a的抗体
CN111518214B (zh) 靶向cldn18.2的双特异性抗体及其制备方法和应用
CN110234349A (zh) 特异性地结合人il-15的抗体及其用途
AU2016226098B2 (en) Modified-IgG antibodies that bind Transforming Growth Factor-Beta1 with high affinity, avidity and specificity
JP2023541627A (ja) Il1rapに結合する抗体及びその使用
KR20190002644A (ko) FcγRIIA에 특이적인 결합 분자 및 이의 용도
CN116761821B (zh) 抗par-2抗体及其使用方法
JP6501650B2 (ja) ヒト抗il−33中和モノクローナル抗体
CN113574072A (zh) 靶向C5aR的抗体
TWI724393B (zh) 抗糖皮質激素誘導的腫瘤壞死因子受體(gitr)的小型化抗體、其聚合物及應用
HK1256300B (zh) 特异性地结合至tl1a的抗体
HK40035876A (en) Antibodies that specifically bind to tl1a
EA042971B1 (ru) Антитела, которые специфически связываются с tl1a
HK1251002B (en) Antibodies that specifically bind to tl1a
HK40061359A (en) Antibodies targeting c5ar

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1256300

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CP02 Change in the address of a patent holder
CP02 Change in the address of a patent holder

Address after: Westchester, Pennsylvania, USA

Patentee after: CEPHALON, Inc.

Address before: Pennsylvania, America

Patentee before: CEPHALON, Inc.

CP01 Change in the name or title of a patent holder
CP01 Change in the name or title of a patent holder

Address after: Westchester, Pennsylvania, USA

Patentee after: Safran Co.,Ltd.

Address before: Westchester, Pennsylvania, USA

Patentee before: CEPHALON, Inc.