MA42825B1 - Anticorps se liant spécifiquement à tl1a - Google Patents
Anticorps se liant spécifiquement à tl1aInfo
- Publication number
- MA42825B1 MA42825B1 MA42825A MA42825A MA42825B1 MA 42825 B1 MA42825 B1 MA 42825B1 MA 42825 A MA42825 A MA 42825A MA 42825 A MA42825 A MA 42825A MA 42825 B1 MA42825 B1 MA 42825B1
- Authority
- MA
- Morocco
- Prior art keywords
- antibodies
- tl1a
- disease
- cystic fibrosis
- specifically bind
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne des anticorps variants exprimés par recombinaison qui présentent une affinité accrue pour tl1a et une puissance améliorée par rapport à l'anticorps parent à partir duquel ils ont été dérivés. Les anticorps inhibent l'interaction entre le tl1a et le récepteur de mort 3 (dr3). Les anticorps, ou une composition de ces derniers, peuvent être utilisés pour traiter une ou plusieurs affections parmi l'asthme, la bpco, la fibrose pulmonaire, la fibrose kystique, la maladie intestinale inflammatoire, une maladie gastro-intestinale associée à la fibrose kystique, la maladie de crohn, la colite, la colite ulcéreuse, le syndrome du côlon irritable, l'œsophagite à éosinophiles, la dermatite atopique, l'eczéma, la sclérodermie, l'arthrite ou la polyarthrite rhumatoïde.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562220442P | 2015-09-18 | 2015-09-18 | |
PCT/US2016/052040 WO2017049024A1 (fr) | 2015-09-18 | 2016-09-16 | Anticorps se liant spécifiquement à tl1a |
Publications (1)
Publication Number | Publication Date |
---|---|
MA42825B1 true MA42825B1 (fr) | 2020-09-30 |
Family
ID=57043002
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA42825A MA42825B1 (fr) | 2015-09-18 | 2016-09-16 | Anticorps se liant spécifiquement à tl1a |
MA052643A MA52643A (fr) | 2015-09-18 | 2016-09-16 | Anticorps se liant spécifiquement au tl1a |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA052643A MA52643A (fr) | 2015-09-18 | 2016-09-16 | Anticorps se liant spécifiquement au tl1a |
Country Status (33)
Country | Link |
---|---|
US (3) | US10138296B2 (fr) |
EP (2) | EP3350223B1 (fr) |
JP (2) | JP7013366B2 (fr) |
KR (1) | KR101998535B1 (fr) |
CN (1) | CN108137693B (fr) |
AR (1) | AR106055A1 (fr) |
AU (2) | AU2016323460B2 (fr) |
BR (2) | BR122021002400A8 (fr) |
CA (1) | CA2997015A1 (fr) |
CL (1) | CL2018000711A1 (fr) |
CO (1) | CO2018003736A2 (fr) |
CY (1) | CY1123499T1 (fr) |
DK (1) | DK3350223T3 (fr) |
EA (1) | EA201890756A1 (fr) |
ES (1) | ES2810751T3 (fr) |
HK (2) | HK1251002A1 (fr) |
HR (1) | HRP20201323T1 (fr) |
HU (1) | HUE051496T2 (fr) |
IL (1) | IL257761B2 (fr) |
LT (1) | LT3350223T (fr) |
MA (2) | MA42825B1 (fr) |
MD (1) | MD3350223T2 (fr) |
MX (1) | MX2018003185A (fr) |
PE (1) | PE20181080A1 (fr) |
PH (1) | PH12018500580A1 (fr) |
PL (1) | PL3350223T3 (fr) |
PT (1) | PT3350223T (fr) |
RS (1) | RS60703B1 (fr) |
SI (1) | SI3350223T1 (fr) |
TW (1) | TWI703158B (fr) |
UA (1) | UA125284C2 (fr) |
WO (1) | WO2017049024A1 (fr) |
ZA (1) | ZA201801427B (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010062960A2 (fr) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | Méthodes de détermination d'une réceptivité à une thérapie par anti-tnfα lors d’une maladie intestinale inflammatoire |
KR101982899B1 (ko) | 2011-09-30 | 2019-05-27 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | TL1a에 대한 항체 및 그의 용도 |
AU2014241162A1 (en) | 2013-03-27 | 2015-10-22 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways |
WO2015010108A1 (fr) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature de la voie de signalisation de tl1a (tnfsf15) |
TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
CA3006968C (fr) * | 2015-12-04 | 2024-04-23 | University Of Iowa Research Foundation | Appareil, systemes et procedes de prediction, de depistage et de surveillance d'encephalopathie/delire |
CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
SG11201903737PA (en) | 2016-10-26 | 2019-05-30 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
KR20240111015A (ko) * | 2017-04-28 | 2024-07-16 | 아지노모토 가부시키가이샤 | 가용성 단백질에 대한 친화성 물질, 절단성 부분 및 반응성기를 갖는 화합물 또는 이의 염 |
MA52366A (fr) | 2018-04-25 | 2021-03-03 | Prometheus Biosciences Inc | Anticorps anti-tl1a optimisés |
MX2022004942A (es) | 2019-10-24 | 2022-07-27 | Prometheus Biosciences Inc | Anticuerpos humanizados contra el ligando 1a de tipo tnf (tl1a) y usos de los mismos. |
WO2024026395A1 (fr) | 2022-07-27 | 2024-02-01 | Cephalon Llc | Anticorps anti-tl1a pour le traitement de la colite ulcéreuse et de la maladie de crohn |
WO2024026386A1 (fr) | 2022-07-27 | 2024-02-01 | Cephalon Llc | Formulations d'anticorps anti-tl1a |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
US7820798B2 (en) | 1994-11-07 | 2010-10-26 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
US6548062B2 (en) * | 2000-02-29 | 2003-04-15 | Cephalon, Inc. | Method of treating cancer with anti-neurotrophin agents |
EP1355919B1 (fr) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules a demi-vies longues, compositions et utilisations de celles-ci |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
WO2005018571A2 (fr) | 2003-08-20 | 2005-03-03 | University Of Miami | Compositions et procedes pour le traitement de la maladie pulmonaire inflammatoire |
EP1756162A1 (fr) | 2004-03-23 | 2007-02-28 | Biogen Idec MA Inc. | Agents de couplage recepteurs et leurs applications therapeutiques |
GB0521621D0 (en) * | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
WO2006127900A2 (fr) | 2005-05-25 | 2006-11-30 | Biogen Idec Ma Inc. | Tl1a dans le traitement de maladie |
CA2621083C (fr) | 2005-08-30 | 2017-04-11 | University Of Miami | Immunomodulation des agonistes, des antagonistes et des immunotoxines du recepteur 25 du facteur de necrose tumorale (tnfr25) |
US20090269345A1 (en) | 2005-12-23 | 2009-10-29 | Rong Fan | CLN248 Antibody Compositions and Methods of Use |
US20110217310A1 (en) | 2007-01-10 | 2011-09-08 | Siegel Richard M | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology |
US20100190162A1 (en) * | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
CN101903402B (zh) | 2007-11-13 | 2014-07-16 | 泰华生物制药美国公司 | 抗tl1a的人源化抗体 |
US20120073585A1 (en) | 2009-04-08 | 2012-03-29 | Cedars-Sinai Medical Center | Methods of predicting complication and surgery in crohn's disease |
EP2519260A2 (fr) | 2009-12-31 | 2012-11-07 | Deutsches Krebsforschungszentrum | Nouveaux modulateurs de signalisation par trail |
JO3375B1 (ar) * | 2010-11-08 | 2019-03-13 | Regeneron Pharma | أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a) |
CA2836898A1 (fr) | 2011-05-20 | 2012-11-29 | Government Of The United States, As Represented By The Secretary, Department Of Health And Human Services | Blocage des interactions tl1a-dr3 pour ameliorer la pathologie des maladies mediees par les cellules t et anticorps afferents |
KR101982899B1 (ko) | 2011-09-30 | 2019-05-27 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | TL1a에 대한 항체 및 그의 용도 |
TR201815254T4 (tr) | 2013-01-02 | 2018-11-21 | Glenmark Pharmaceuticals Sa | Tl1a'ya bağlanan anti̇korlar ve bunlarin kullanimlari |
AU2014241162A1 (en) | 2013-03-27 | 2015-10-22 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways |
MX2015013901A (es) * | 2013-04-05 | 2015-12-11 | Genentech Inc | Anticuerpos anti-il-4 y anticuerpos biespecificos y sus usos. |
US20160096885A1 (en) | 2013-05-17 | 2016-04-07 | Cedars-Sinal Medical Center | Distinct effects of ifn-gamma and il-17 on tl1a modulated inflammation and fibrosis |
WO2015010108A1 (fr) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature de la voie de signalisation de tl1a (tnfsf15) |
EP3041580A4 (fr) | 2013-09-06 | 2017-05-03 | Cedars-Sinai Medical Center | Systèmes, dispositifs et procédés pour thérapie anti-tl1a |
BR112016009797A2 (pt) | 2013-11-13 | 2017-12-05 | Bristol Myers Squibb Co | anticorpos específicos de ligante 1a do tipo fator de necrose tumoral e composições e usos dos mesmos |
SG11201708480YA (en) | 2015-04-15 | 2017-12-28 | Biosearch Tech Inc | Dual quencher probes |
TWI703158B (zh) * | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
CR20180365A (es) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS |
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2016
- 2016-09-14 TW TW105130075A patent/TWI703158B/zh active
- 2016-09-16 MA MA42825A patent/MA42825B1/fr unknown
- 2016-09-16 RS RS20200983A patent/RS60703B1/sr unknown
- 2016-09-16 ES ES16774750T patent/ES2810751T3/es active Active
- 2016-09-16 WO PCT/US2016/052040 patent/WO2017049024A1/fr active Application Filing
- 2016-09-16 JP JP2018512167A patent/JP7013366B2/ja active Active
- 2016-09-16 IL IL257761A patent/IL257761B2/en unknown
- 2016-09-16 HU HUE16774750A patent/HUE051496T2/hu unknown
- 2016-09-16 PE PE2018000398A patent/PE20181080A1/es unknown
- 2016-09-16 AU AU2016323460A patent/AU2016323460B2/en active Active
- 2016-09-16 BR BR122021002400A patent/BR122021002400A8/pt unknown
- 2016-09-16 DK DK16774750.0T patent/DK3350223T3/da active
- 2016-09-16 CA CA2997015A patent/CA2997015A1/fr active Pending
- 2016-09-16 MD MDE20180714T patent/MD3350223T2/ro unknown
- 2016-09-16 SI SI201630885T patent/SI3350223T1/sl unknown
- 2016-09-16 EA EA201890756A patent/EA201890756A1/ru unknown
- 2016-09-16 LT LTEP16774750.0T patent/LT3350223T/lt unknown
- 2016-09-16 PT PT167747500T patent/PT3350223T/pt unknown
- 2016-09-16 EP EP16774750.0A patent/EP3350223B1/fr active Active
- 2016-09-16 KR KR1020187007337A patent/KR101998535B1/ko active IP Right Grant
- 2016-09-16 UA UAA201804192A patent/UA125284C2/uk unknown
- 2016-09-16 MA MA052643A patent/MA52643A/fr unknown
- 2016-09-16 AR ARP160102834A patent/AR106055A1/es unknown
- 2016-09-16 BR BR112018005407A patent/BR112018005407A8/pt active Search and Examination
- 2016-09-16 MX MX2018003185A patent/MX2018003185A/es unknown
- 2016-09-16 US US15/267,213 patent/US10138296B2/en active Active
- 2016-09-16 PL PL16774750T patent/PL3350223T3/pl unknown
- 2016-09-16 EP EP20151834.7A patent/EP3693393A1/fr active Pending
- 2016-09-16 CN CN201680053598.8A patent/CN108137693B/zh active Active
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2018
- 2018-02-28 ZA ZA2018/01427A patent/ZA201801427B/en unknown
- 2018-03-16 CL CL2018000711A patent/CL2018000711A1/es unknown
- 2018-03-16 PH PH12018500580A patent/PH12018500580A1/en unknown
- 2018-04-09 CO CONC2018/0003736A patent/CO2018003736A2/es unknown
- 2018-08-15 HK HK18110481.5A patent/HK1251002A1/zh unknown
- 2018-10-18 US US16/164,509 patent/US11220549B2/en active Active
- 2018-11-30 HK HK18115365.5A patent/HK1256300A1/zh unknown
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2020
- 2020-08-17 CY CY20201100767T patent/CY1123499T1/el unknown
- 2020-08-25 HR HRP20201323TT patent/HRP20201323T1/hr unknown
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2021
- 2021-11-30 US US17/538,530 patent/US20220185902A1/en active Pending
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2022
- 2022-01-17 JP JP2022005039A patent/JP7341259B2/ja active Active
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2023
- 2023-06-01 AU AU2023203440A patent/AU2023203440A1/en active Pending
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