UA105377C2 - Замещенные производные индазола и азаиндазола как модуляторы гамма-секретазы - Google Patents

Замещенные производные индазола и азаиндазола как модуляторы гамма-секретазы Download PDF

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Publication number
UA105377C2
UA105377C2 UAA201110540A UAA201110540A UA105377C2 UA 105377 C2 UA105377 C2 UA 105377C2 UA A201110540 A UAA201110540 A UA A201110540A UA A201110540 A UAA201110540 A UA A201110540A UA 105377 C2 UA105377 C2 UA 105377C2
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formula
hydrogen
methyl
alkyl
mmol
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UAA201110540A
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English (en)
Ukrainian (uk)
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Франсуа Пол Бішофф
Хенрікус Якобус Марія Гійсен
Серж Марія Алойзіус Пітерс
Гарретт Берлонд Мінне
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Янссен Фармасьютікелз, Інк
Селлзом Лімітед
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Publication of UA105377C2 publication Critical patent/UA105377C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение касается новых замещенных производных индазола и азаиндазола формулы (I) EMBED ISISServer , (I) где R1, R2, R3, R4, А1, А2, А3, А4, X1, X2, X3 и Het1 имеют значения, определенные в пунктах формулы изобретения. Соединения данного изобретения полезные как модуляторы гамма-секретазы. Изобретение дополнительно касается способов получения таких новых соединений, фармацевтических композиций, которые включают указанные соединения как активный ингредиент, а также применение указанных соединений как лекарственных средств.
UAA201110540A 2009-05-07 2010-05-05 Замещенные производные индазола и азаиндазола как модуляторы гамма-секретазы UA105377C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09159615 2009-05-07
PCT/EP2010/056074 WO2010145883A1 (en) 2009-05-07 2010-05-05 Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators

Publications (1)

Publication Number Publication Date
UA105377C2 true UA105377C2 (ru) 2014-05-12

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UAA201110540A UA105377C2 (ru) 2009-05-07 2010-05-05 Замещенные производные индазола и азаиндазола как модуляторы гамма-секретазы

Country Status (20)

Country Link
US (1) US8835482B2 (ru)
EP (1) EP2427453B1 (ru)
JP (1) JP5559309B2 (ru)
KR (1) KR20120024555A (ru)
CN (1) CN102439005B (ru)
AR (1) AR076850A1 (ru)
AU (1) AU2010262036B2 (ru)
BR (1) BRPI1011190A8 (ru)
CA (1) CA2755467A1 (ru)
EA (1) EA019702B1 (ru)
ES (1) ES2431619T3 (ru)
IL (1) IL216113A (ru)
MX (1) MX2011011753A (ru)
MY (1) MY152998A (ru)
NZ (1) NZ596843A (ru)
SG (1) SG175317A1 (ru)
TW (1) TWI461419B (ru)
UA (1) UA105377C2 (ru)
WO (1) WO2010145883A1 (ru)
ZA (1) ZA201108117B (ru)

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Also Published As

Publication number Publication date
SG175317A1 (en) 2011-11-28
ZA201108117B (en) 2015-06-24
WO2010145883A1 (en) 2010-12-23
ES2431619T3 (es) 2013-11-27
NZ596843A (en) 2012-12-21
EA019702B1 (ru) 2014-05-30
BRPI1011190A2 (pt) 2016-03-15
EA201171363A1 (ru) 2012-04-30
KR20120024555A (ko) 2012-03-14
BRPI1011190A8 (pt) 2016-11-16
AU2010262036A1 (en) 2011-09-22
CA2755467A1 (en) 2010-12-23
MX2011011753A (es) 2011-11-29
IL216113A0 (en) 2012-01-31
CN102439005B (zh) 2015-07-22
US20120095036A1 (en) 2012-04-19
TWI461419B (zh) 2014-11-21
US8835482B2 (en) 2014-09-16
EP2427453A1 (en) 2012-03-14
JP5559309B2 (ja) 2014-07-23
TW201105658A (en) 2011-02-16
MY152998A (en) 2014-12-31
AR076850A1 (es) 2011-07-13
EP2427453B1 (en) 2013-07-17
CN102439005A (zh) 2012-05-02
IL216113A (en) 2015-02-26
AU2010262036B2 (en) 2014-10-30
JP2012526078A (ja) 2012-10-25

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