AR076850A1 - Derivados sustituidos de indazol y aza-indazol como moduladores de la gamma secretasa. - Google Patents
Derivados sustituidos de indazol y aza-indazol como moduladores de la gamma secretasa.Info
- Publication number
- AR076850A1 AR076850A1 ARP100101549A ARP100101549A AR076850A1 AR 076850 A1 AR076850 A1 AR 076850A1 AR P100101549 A ARP100101549 A AR P100101549A AR P100101549 A ARP100101549 A AR P100101549A AR 076850 A1 AR076850 A1 AR 076850A1
- Authority
- AR
- Argentina
- Prior art keywords
- halo
- hydrogen
- alkyl
- alkyloxy
- substituents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Estos compuestos son utiles como moduladores de la gamma secretasa. Se proveen además composiciones farmacéuticas que comprenden dichos compuestos como ingrediente activo como así también con el uso de dichos compuestos como medicamento para el tratamiento de la enfermedad de Alzheimer y otras formas de demencia. Reivindicacion 1: Un compuesto de formula (1) y formas estereoisoméricas del mismo, en donde R1 es alquilo C1-6 opcionalmente sustituido con uno o más sustituyentes cada uno independientemente seleccionado del grupo que consiste de halo, alquiloxi C1-4, cicloalquilo C3-7, tetrahidropiranilo, tetrahidrofuranilo y fenilo; cicloalquilo C3-7; tetrahidropiranilo; tetrahidrofuranilo; 1,3-benzodioxolilo; o fenilo; en donde cada fenilo independientemente es opcionalmente sustituido con uno o más sustituyentes cada uno independientemente seleccionado del grupo que consiste de halo, ciano, alquilo C1-4 opcionalmente sustituido con uno o más sustituyentes halo, y alquiloxi C1-4 opcionalmente sustituido con uno o más sustituyentes halo; R2 es hidrogeno; ciano; o alquilo C1-4 opcionalmente sustituido con uno o más sustituyentes cada uno independientemente seleccionado del grupo que consiste de alquiloxi C1-4, halo y NR3R4; X1 es CH o N; X2 es CR5 o N; R5 es hidrogeno; halo; ciano; alquiloxi C1-4 o alquilo C1-4 opcionalmente sustituido con uno o más sustituyentes cada uno independientemente seleccionado del grupo que consiste de halo, alquiloxi C1-4 y NR3R4; X3 es CR6 o N; R6 es hidrogeno; halo; ciano; alquiloxi C1-4 o alquilo C1-4 opcionalmente sustituido con uno o más sustituyentes cada uno independientemente seleccionado del grupo que consiste de halo, alquiloxi C1-4 y NR3R4, en donde cada R3 es independientemente hidrogeno; alquilo C1-4; o acilo C1-4; en donde cada R4 es independientemente hidrogeno; alquilo C1-4, o acilo C1-4; con la condicion de que no más de dos de X1, X2 y X3 sean N; A1 es CR7 o N; en donde R7 es hidrogeno, halo o alquiloxi C1-4; A2, A3 y A4 cada uno independientemente son CH o N; con la condicion de que no más de dos de A1, A2, A3 y A4 sean N; Het1 es un heterociclo aromático de miembros, de formula (a-1), (a-2), (a-3) o (a-4), R8 es hidrogeno o alquilo C1-4; R9 es hidrogeno o alquilo C1-4; R10 es hidrogeno o alquilo C1-4; R11 es hidrogeno o alquilo C1-4; R12 es alquilo C1-4; G1 es O o S; G2 es CH o N; y sales de adicion, y los solvatos farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09159615 | 2009-05-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR076850A1 true AR076850A1 (es) | 2011-07-13 |
Family
ID=40786448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101549A AR076850A1 (es) | 2009-05-07 | 2010-05-06 | Derivados sustituidos de indazol y aza-indazol como moduladores de la gamma secretasa. |
Country Status (20)
Country | Link |
---|---|
US (1) | US8835482B2 (es) |
EP (1) | EP2427453B1 (es) |
JP (1) | JP5559309B2 (es) |
KR (1) | KR20120024555A (es) |
CN (1) | CN102439005B (es) |
AR (1) | AR076850A1 (es) |
AU (1) | AU2010262036B2 (es) |
BR (1) | BRPI1011190A8 (es) |
CA (1) | CA2755467A1 (es) |
EA (1) | EA019702B1 (es) |
ES (1) | ES2431619T3 (es) |
IL (1) | IL216113A (es) |
MX (1) | MX2011011753A (es) |
MY (1) | MY152998A (es) |
NZ (1) | NZ596843A (es) |
SG (1) | SG175317A1 (es) |
TW (1) | TWI461419B (es) |
UA (1) | UA105377C2 (es) |
WO (1) | WO2010145883A1 (es) |
ZA (1) | ZA201108117B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
BRPI1008473A2 (pt) | 2009-02-06 | 2019-04-02 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
BRPI1011190A8 (pt) | 2009-05-07 | 2016-11-16 | Janssen Pharmaceuticals Inc | Derivados de indazol e aza-indazol substituídos como moduladores de gama secretase |
KR20120050450A (ko) | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
JP5824464B2 (ja) | 2010-01-15 | 2015-11-25 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | γセクレターゼ調節物質としての新規置換トリアゾール誘導体 |
WO2012126984A1 (en) | 2011-03-24 | 2012-09-27 | Janssen Pharmaceuticals, Inc. | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
ES2555167T3 (es) | 2011-07-15 | 2015-12-29 | Janssen Pharmaceuticals, Inc. | Nuevos derivados de indol sustituidos como moduladores de gamma secretasa |
MX355164B (es) | 2012-05-16 | 2018-04-06 | Janssen Pharmaceuticals Inc | Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia). |
EP2953949B1 (en) | 2012-12-20 | 2016-09-28 | Janssen Pharmaceutica NV | Novel tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
WO2014111457A1 (en) | 2013-01-17 | 2014-07-24 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
EP2958918B1 (en) * | 2013-02-21 | 2016-12-07 | Boehringer Ingelheim International GmbH | Dihydropteridinones ii |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
CN103880683B (zh) * | 2014-02-26 | 2018-06-22 | 南通大学 | 一种3-溴-2-硝基苯甲醛的化学合成方法 |
EP3347363B1 (en) * | 2015-09-09 | 2020-01-01 | H. Hoffnabb-La Roche Ag | N-(3-azabicyclo[3.2.1]octan-8-yl)-8-(4-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[l,5-a]pyridin-2-amine derivatives as gamma-secretase modulators for treating alzheimer's disease |
CN105585547A (zh) * | 2016-03-09 | 2016-05-18 | 中国科学院广州生物医药与健康研究院 | 一种4-五氟化硫苯酚类化合物及制备方法以及五氟化硫取代苯并吡喃类化合物的制备方法 |
CN114195702A (zh) * | 2020-09-18 | 2022-03-18 | 瑞博(杭州)医药科技有限公司 | 一种用于合成抗肿瘤药物尼拉帕利的中间体及其制备方法 |
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TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
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2010
- 2010-05-05 BR BRPI1011190A patent/BRPI1011190A8/pt not_active IP Right Cessation
- 2010-05-05 AU AU2010262036A patent/AU2010262036B2/en not_active Ceased
- 2010-05-05 WO PCT/EP2010/056074 patent/WO2010145883A1/en active Application Filing
- 2010-05-05 KR KR1020117024948A patent/KR20120024555A/ko not_active Application Discontinuation
- 2010-05-05 EP EP10719325.2A patent/EP2427453B1/en active Active
- 2010-05-05 MX MX2011011753A patent/MX2011011753A/es active IP Right Grant
- 2010-05-05 SG SG2011077518A patent/SG175317A1/en unknown
- 2010-05-05 UA UAA201110540A patent/UA105377C2/uk unknown
- 2010-05-05 MY MYPI2011005324 patent/MY152998A/en unknown
- 2010-05-05 JP JP2012509024A patent/JP5559309B2/ja not_active Expired - Fee Related
- 2010-05-05 CA CA2755467A patent/CA2755467A1/en not_active Abandoned
- 2010-05-05 US US13/263,860 patent/US8835482B2/en active Active
- 2010-05-05 NZ NZ596843A patent/NZ596843A/xx not_active IP Right Cessation
- 2010-05-05 EA EA201171363A patent/EA019702B1/ru not_active IP Right Cessation
- 2010-05-05 ES ES10719325T patent/ES2431619T3/es active Active
- 2010-05-05 CN CN201080020131.6A patent/CN102439005B/zh not_active Expired - Fee Related
- 2010-05-06 AR ARP100101549A patent/AR076850A1/es not_active Application Discontinuation
- 2010-05-06 TW TW099114456A patent/TWI461419B/zh not_active IP Right Cessation
-
2011
- 2011-11-03 IL IL216113A patent/IL216113A/en not_active IP Right Cessation
- 2011-11-04 ZA ZA2011/08117A patent/ZA201108117B/en unknown
Also Published As
Publication number | Publication date |
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KR20120024555A (ko) | 2012-03-14 |
ZA201108117B (en) | 2015-06-24 |
EA201171363A1 (ru) | 2012-04-30 |
AU2010262036A1 (en) | 2011-09-22 |
UA105377C2 (uk) | 2014-05-12 |
CA2755467A1 (en) | 2010-12-23 |
WO2010145883A1 (en) | 2010-12-23 |
JP2012526078A (ja) | 2012-10-25 |
MY152998A (en) | 2014-12-31 |
EP2427453A1 (en) | 2012-03-14 |
JP5559309B2 (ja) | 2014-07-23 |
TW201105658A (en) | 2011-02-16 |
EA019702B1 (ru) | 2014-05-30 |
TWI461419B (zh) | 2014-11-21 |
IL216113A (en) | 2015-02-26 |
BRPI1011190A2 (pt) | 2016-03-15 |
BRPI1011190A8 (pt) | 2016-11-16 |
CN102439005A (zh) | 2012-05-02 |
MX2011011753A (es) | 2011-11-29 |
NZ596843A (en) | 2012-12-21 |
AU2010262036B2 (en) | 2014-10-30 |
US20120095036A1 (en) | 2012-04-19 |
ES2431619T3 (es) | 2013-11-27 |
US8835482B2 (en) | 2014-09-16 |
SG175317A1 (en) | 2011-11-28 |
EP2427453B1 (en) | 2013-07-17 |
IL216113A0 (en) | 2012-01-31 |
CN102439005B (zh) | 2015-07-22 |
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