TWI806150B - 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 - Google Patents

穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 Download PDF

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TWI806150B
TWI806150B TW110133255A TW110133255A TWI806150B TW I806150 B TWI806150 B TW I806150B TW 110133255 A TW110133255 A TW 110133255A TW 110133255 A TW110133255 A TW 110133255A TW I806150 B TWI806150 B TW I806150B
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concentration
sucrose
mfi
pharmaceutical composition
citrate
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TW110133255A
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TW202146049A (zh
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惠湘 張
查爾斯 伯林
艾洛克 K. 庫爾司拉斯薩
宇鴻 曾
力 萬
拉曼 阿拉尼
彼得 賽斯提格
沃納 舒密特
瑪格麗特 吉凱法
詹姆斯 瓦柏頓
安德列斯 維奇賽柏格
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瑞士商諾華公司
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/567—Framework region [FR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW110133255A 2014-11-07 2015-10-26 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 TWI806150B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462076770P 2014-11-07 2014-11-07
US62/076,770 2014-11-07
US201462088061P 2014-12-05 2014-12-05
US62/088,061 2014-12-05

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TW202146049A TW202146049A (zh) 2021-12-16
TWI806150B true TWI806150B (zh) 2023-06-21

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TW110133255A TWI806150B (zh) 2014-11-07 2015-10-26 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
TW109132401A TWI761959B (zh) 2014-11-07 2015-10-26 治療眼部疾病之方法
TW104135105A TWI738632B (zh) 2014-11-07 2015-10-26 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
TW104135104A TWI705827B (zh) 2014-11-07 2015-10-26 治療眼部疾病之方法

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TW109132401A TWI761959B (zh) 2014-11-07 2015-10-26 治療眼部疾病之方法
TW104135105A TWI738632B (zh) 2014-11-07 2015-10-26 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
TW104135104A TWI705827B (zh) 2014-11-07 2015-10-26 治療眼部疾病之方法

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US (5) US10689438B2 (enExample)
EP (2) EP3215122B1 (enExample)
JP (6) JP6753848B2 (enExample)
KR (4) KR20170082526A (enExample)
CN (4) CN114081951A (enExample)
AU (6) AU2015342815B2 (enExample)
BR (2) BR112017008093A2 (enExample)
CA (2) CA2966646A1 (enExample)
CL (2) CL2017001117A1 (enExample)
CO (1) CO2017004596A2 (enExample)
EA (1) EA201790989A1 (enExample)
EC (1) ECSP17034829A (enExample)
GT (1) GT201700096A (enExample)
IL (5) IL251642B (enExample)
MX (3) MX383808B (enExample)
MY (2) MY183807A (enExample)
NZ (1) NZ730821A (enExample)
PE (1) PE20170780A1 (enExample)
PH (3) PH12021550147A1 (enExample)
RU (1) RU2722643C2 (enExample)
SG (3) SG10201913565RA (enExample)
TN (1) TN2017000128A1 (enExample)
TW (4) TWI806150B (enExample)
WO (2) WO2016073915A1 (enExample)

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