TWI799725B - 植入式微型生物感測器及其操作方法 - Google Patents

植入式微型生物感測器及其操作方法 Download PDF

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Publication number
TWI799725B
TWI799725B TW109125968A TW109125968A TWI799725B TW I799725 B TWI799725 B TW I799725B TW 109125968 A TW109125968 A TW 109125968A TW 109125968 A TW109125968 A TW 109125968A TW I799725 B TWI799725 B TW I799725B
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Taiwan
Prior art keywords
implantable miniature
miniature biosensor
biosensor
implantable
miniature
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TW109125968A
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TW202107086A (zh
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黃椿木
陳界行
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華廣生技股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A61B5/14735—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter comprising an immobilised reagent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0462—Apparatus with built-in sensors
    • A61B2560/0468—Built-in electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A61B2562/0215—Silver or silver chloride containing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A61B2562/0217—Electrolyte containing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
TW109125968A 2019-08-02 2020-07-31 植入式微型生物感測器及其操作方法 TWI799725B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962882162P 2019-08-02 2019-08-02
US62/882162 2019-08-02
US202062988549P 2020-03-12 2020-03-12
US62/988549 2020-03-12

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TW202107086A TW202107086A (zh) 2021-02-16
TWI799725B true TWI799725B (zh) 2023-04-21

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Application Number Title Priority Date Filing Date
TW109125968A TWI799725B (zh) 2019-08-02 2020-07-31 植入式微型生物感測器及其操作方法
TW109125964A TWI755803B (zh) 2019-08-02 2020-07-31 植入式微型生物感測器及其製法
TW109125962A TWI755802B (zh) 2019-08-02 2020-07-31 植入式微型生物感測器
TW109126213A TWI770571B (zh) 2019-08-02 2020-08-03 降低微型生物感測器量測干擾的方法
TW109126240A TWI736383B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW109126241A TWI805938B (zh) 2019-08-02 2020-08-03 生物感測器及用於決定其對電極尺寸和延長其壽命的方法
TW109126238A TWI783249B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW111132569A TWI784921B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW111132568A TWI788274B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW109126239A TWI783250B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW109126201A TWI757811B (zh) 2019-08-02 2020-08-03 微型生物感測器及其用於降低量測干擾的方法

Family Applications After (10)

Application Number Title Priority Date Filing Date
TW109125964A TWI755803B (zh) 2019-08-02 2020-07-31 植入式微型生物感測器及其製法
TW109125962A TWI755802B (zh) 2019-08-02 2020-07-31 植入式微型生物感測器
TW109126213A TWI770571B (zh) 2019-08-02 2020-08-03 降低微型生物感測器量測干擾的方法
TW109126240A TWI736383B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW109126241A TWI805938B (zh) 2019-08-02 2020-08-03 生物感測器及用於決定其對電極尺寸和延長其壽命的方法
TW109126238A TWI783249B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW111132569A TWI784921B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW111132568A TWI788274B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW109126239A TWI783250B (zh) 2019-08-02 2020-08-03 微型生物感測器及其量測方法
TW109126201A TWI757811B (zh) 2019-08-02 2020-08-03 微型生物感測器及其用於降低量測干擾的方法

Country Status (9)

Country Link
US (11) US12023150B2 (zh)
EP (10) EP3771411A1 (zh)
JP (6) JP7198243B2 (zh)
KR (5) KR102506277B1 (zh)
CN (9) CN112305040B (zh)
AU (5) AU2020294358B2 (zh)
CA (5) CA3088582C (zh)
TW (11) TWI799725B (zh)
WO (4) WO2021024132A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12023150B2 (en) * 2019-08-02 2024-07-02 Bionime Corporation Implantable micro-biosensor
WO2021180229A1 (zh) * 2020-03-12 2021-09-16 华广生技股份有限公司 回复生物传感器的方法及使用此方法的装置
EP3928697A1 (en) 2020-06-23 2021-12-29 Roche Diabetes Care GmbH Analyte sensor and a method for producing an analyte sensor
EP4296385A4 (en) 2021-03-08 2024-08-07 Kobe Steel Ltd METHOD FOR MANUFACTURING STEEL SHEET
CO2021005504A1 (es) * 2021-04-27 2022-10-31 Pontificia Univ Javeriana Dispositivo para la medición electrónica y electroquímica de concentraciones de analitos en muestras biológicas
CN115670453A (zh) * 2021-07-22 2023-02-03 华广生技股份有限公司 微型生物传感器及其感测结构
CN114748208B (zh) * 2022-04-15 2024-01-12 柔脉医疗(深圳)有限公司 一种可原位检测多种化学、生物成分的组织工程支架
WO2024023000A1 (en) * 2022-07-26 2024-02-01 F. Hoffmann-La Roche Ag A method and an analyte sensor system for detecting at least one analyte
CN115541670A (zh) * 2022-10-09 2022-12-30 深圳市优维健康科技有限公司 动态血糖仪传感器的制备方法及植入式传感器
CN116421191B (zh) * 2023-03-08 2024-08-06 宁波康麦隆医疗器械有限公司 柔性一体化生物电信号传感器、检测方法及装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102803947A (zh) * 2010-03-16 2012-11-28 美敦力迷你迈德公司 葡萄糖传感器
US20130245412A1 (en) * 2009-07-02 2013-09-19 Dexcom, Inc. Analyte sensor with increased reference capacity
TW201805624A (zh) * 2016-08-08 2018-02-16 友達光電股份有限公司 感測裝置及該感測裝置之電極試片
WO2019146788A1 (ja) * 2018-01-29 2019-08-01 Ｐｈｃホールディングス株式会社 バイオセンサプローブ用保護膜材料

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719576A (en) * 1971-01-29 1973-03-06 Gen Electric Electrode for measuring co2 tension in blood and other liquid and gaseous environments
US3957612A (en) * 1974-07-24 1976-05-18 General Electric Company In vivo specific ion sensor
JPS6423155A (en) * 1987-07-17 1989-01-25 Daikin Ind Ltd Electrode refreshing device for biosensor
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5078854A (en) * 1990-01-22 1992-01-07 Mallinckrodt Sensor Systems, Inc. Polarographic chemical sensor with external reference electrode
WO1995004272A1 (en) * 1993-07-28 1995-02-09 Novo Nordisk A/S Reference electrode
AUPN363995A0 (en) * 1995-06-19 1995-07-13 Memtec Limited Electrochemical cell
US6002954A (en) * 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
DE19605739C1 (de) * 1996-02-16 1997-09-04 Wolfgang Dr Fleckenstein Gehirn-pO2-Meßvorrichtung
US20050033132A1 (en) * 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
CA2294610A1 (en) * 1997-06-16 1998-12-23 George Moshe Katz Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods
US6134461A (en) * 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6587705B1 (en) * 1998-03-13 2003-07-01 Lynn Kim Biosensor, iontophoretic sampling system, and methods of use thereof
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8688188B2 (en) * 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) * 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6338790B1 (en) * 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
EP1192269A2 (en) 1999-06-18 2002-04-03 Therasense, Inc. MASS TRANSPORT LIMITED i IN VIVO /i ANALYTE SENSOR
US6682649B1 (en) * 1999-10-01 2004-01-27 Sophion Bioscience A/S Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
WO2001088534A2 (en) * 2000-05-16 2001-11-22 Cygnus, Inc. Methods for improving performance and reliability of biosensors
US6872297B2 (en) * 2001-05-31 2005-03-29 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
TWI244550B (en) * 2001-06-21 2005-12-01 Hmd Biomedical Inc Electrochemistry test unit, biological sensor, the manufacturing method, and the detector
US20030032874A1 (en) * 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US6964871B2 (en) * 2002-04-25 2005-11-15 Home Diagnostics, Inc. Systems and methods for blood glucose sensing
US7736309B2 (en) * 2002-09-27 2010-06-15 Medtronic Minimed, Inc. Implantable sensor method and system
US7504020B2 (en) * 2002-10-31 2009-03-17 Panasonic Corporation Determination method for automatically identifying analyte liquid and standard solution for biosensor
JP4535741B2 (ja) * 2003-01-30 2010-09-01 株式会社タニタ 化学センサによる測定方法、ならびに化学センサ型測定装置
US7132041B2 (en) * 2003-02-11 2006-11-07 Bayer Healthcare Llc Methods of determining the concentration of an analyte in a fluid test sample
US9763609B2 (en) * 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
WO2005012873A2 (en) 2003-07-25 2005-02-10 Dexcom, Inc. Electrode systems for electrochemical sensors
CN1867826B (zh) * 2003-08-21 2010-12-08 埃葛梅崔克斯股份有限公司 化验电化学性质的方法和设备
US20050067277A1 (en) * 2003-09-30 2005-03-31 Pierce Robin D. Low volume electrochemical biosensor
SG135191A1 (en) * 2003-10-29 2007-09-28 Agency Science Tech & Res Biosensor
PT1678489E (pt) * 2003-10-31 2007-06-19 Lifescan Scotland Ltd Método de redução do efeito da corrente de interferência directa numa tira de teste electroquímica
EP1711790B1 (en) * 2003-12-05 2010-09-08 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US11633133B2 (en) * 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7125382B2 (en) 2004-05-20 2006-10-24 Digital Angel Corporation Embedded bio-sensor system
CN101023343A (zh) * 2004-08-20 2007-08-22 诺和诺德公司 用于生产细小传感器的制造工艺
KR100698961B1 (ko) * 2005-02-04 2007-03-26 주식회사 아이센스 전기화학적 바이오센서
ES2293493T3 (es) * 2005-03-03 2008-03-16 Apex Biotechnology Corporation Un metodo para reducir la desviacion de medicion de biosensores amperimetricos.
US7695600B2 (en) * 2005-06-03 2010-04-13 Hypoguard Limited Test system
MX2008000836A (es) 2005-07-20 2008-03-26 Bayer Healthcare Llc Amperimetria regulada.
US7846311B2 (en) * 2005-09-27 2010-12-07 Abbott Diabetes Care Inc. In vitro analyte sensor and methods of use
ES2326286T3 (es) 2005-12-19 2009-10-06 F. Hoffmann-La Roche Ag Sensor tipo sandwich para determinar la concentracion de un analito.
JP4394654B2 (ja) * 2006-02-24 2010-01-06 三菱重工環境・化学エンジニアリング株式会社 高含水有機物炭化処理システムの熱分解ガス処理方法及びその装置
US7887682B2 (en) * 2006-03-29 2011-02-15 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US8346335B2 (en) * 2008-03-28 2013-01-01 Abbott Diabetes Care Inc. Analyte sensor calibration management
EP2008088B1 (en) * 2006-04-10 2011-06-29 Bayer HealthCare LLC Correction of oxygen effect in test sensor using reagents
GB0607205D0 (en) * 2006-04-10 2006-05-17 Diagnoswiss Sa Miniaturised biosensor with optimized anperimetric detection
JP5121822B2 (ja) * 2006-05-08 2013-01-16 バイエル・ヘルスケア・エルエルシー バイオセンサ用異常出力検出システム
US20070299617A1 (en) * 2006-06-27 2007-12-27 Willis John P Biofouling self-compensating biosensor
CA2664480A1 (en) * 2006-10-04 2008-04-10 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP3753481B1 (en) * 2006-10-24 2024-07-17 Ascensia Diabetes Care Holdings AG Transient decay amperometry device
US20080214912A1 (en) * 2007-01-10 2008-09-04 Glucose Sensing Technologies, Llc Blood Glucose Monitoring System And Method
US8808515B2 (en) * 2007-01-31 2014-08-19 Abbott Diabetes Care Inc. Heterocyclic nitrogen containing polymers coated analyte monitoring device and methods of use
US20200037874A1 (en) * 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
CN101755043B (zh) * 2007-07-23 2013-06-19 埃葛梅崔克斯股份有限公司 电化学试条
CN101520428B (zh) 2008-02-25 2013-05-01 华广生技股份有限公司 电化学式感测方法与试片
US20090247855A1 (en) * 2008-03-28 2009-10-01 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) * 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8155722B2 (en) 2008-06-02 2012-04-10 Abbott Diabetes Care Inc. Reference electrodes having an extended lifetime for use in long term amperometric sensors
US8280474B2 (en) * 2008-06-02 2012-10-02 Abbott Diabetes Care Inc. Reference electrodes having an extended lifetime for use in long term amperometric sensors
US8620398B2 (en) 2008-06-02 2013-12-31 Abbott Diabetes Care Inc. Reference electrodes having an extended lifetime for use in long term amperometric sensors
US20100025238A1 (en) * 2008-07-31 2010-02-04 Medtronic Minimed, Inc. Analyte sensor apparatuses having improved electrode configurations and methods for making and using them
US8700114B2 (en) 2008-07-31 2014-04-15 Medtronic Minmed, Inc. Analyte sensor apparatuses comprising multiple implantable sensor elements and methods for making and using them
JP5228891B2 (ja) * 2008-11-21 2013-07-03 株式会社リコー センサデバイス
US20100169035A1 (en) * 2008-12-29 2010-07-01 Medtronic Minimed, Inc. Methods and systems for observing sensor parameters
WO2010093803A2 (en) * 2009-02-12 2010-08-19 Keimar, Inc. Physiological parameter sensors
EP4252639A3 (en) * 2009-02-26 2024-01-03 Abbott Diabetes Care Inc. Method of calibrating an analyte sensor
CN104825171B (zh) * 2009-02-26 2017-08-04 雅培糖尿病护理公司 改进的分析物传感器及其制造和使用方法
US20100219085A1 (en) * 2009-02-27 2010-09-02 Edwards Lifesciences Corporation Analyte Sensor Offset Normalization
GR1007310B (el) * 2009-03-09 2011-06-10 Αχιλλεας Τσουκαλης Εμφυτευσιμος βιοαισθητηρας με αυτοματη βαθμονομηση
US8359081B2 (en) * 2009-04-28 2013-01-22 Abbott Diabetes Care Inc. Service-detectable analyte sensors and methods of using and making same
WO2011031751A1 (en) * 2009-09-08 2011-03-17 Bayer Healthcare Llc Electrochemical test sensor
CN102712946A (zh) * 2009-10-30 2012-10-03 爱德华兹生命科学公司 传感器层和与其相关的方法
US8500979B2 (en) * 2009-12-31 2013-08-06 Intel Corporation Nanogap chemical and biochemical sensors
EP4066731A1 (en) * 2010-03-24 2022-10-05 Abbott Diabetes Care, Inc. Medical device inserters
JP5785937B2 (ja) * 2010-04-16 2015-09-30 アークレイ株式会社 センサ及び干渉物質の除去方法
JP5753720B2 (ja) * 2010-04-22 2015-07-22 アークレイ株式会社 バイオセンサ
US8476079B2 (en) * 2010-04-30 2013-07-02 Abbott Point Of Care Inc. Reagents for reducing leukocyte interference in immunoassays
JP2012026910A (ja) * 2010-07-26 2012-02-09 Arkray Inc バイオセンサユニットおよびバイオセンサシステム
FI3954781T3 (fi) * 2010-12-09 2024-10-08 Abbott Diabetes Care Inc Analyyttiantureita, joissa on havaintopinta, jossa on pieniä havaintopisteitä
WO2012114389A1 (ja) * 2011-02-25 2012-08-30 パナソニック株式会社 変換ストリッピング法により化学物質を定量する方法およびそのために用いられるセンサチップ
US8399262B2 (en) * 2011-03-23 2013-03-19 Darrel A. Mazzari Biosensor
US9008744B2 (en) * 2011-05-06 2015-04-14 Medtronic Minimed, Inc. Method and apparatus for continuous analyte monitoring
EP2764352A4 (en) * 2011-10-03 2015-03-11 Cpfilms Inc METHOD FOR ACTIVATION OF NOBLE METAL TO MEASURE GLUCOSE, AND BIOCAPTOR ELECTRODE THEREOF
US9493807B2 (en) * 2012-05-25 2016-11-15 Medtronic Minimed, Inc. Foldover sensors and methods for making and using them
KR101466222B1 (ko) * 2012-06-01 2014-12-01 주식회사 아이센스 정확도가 향상된 전기화학적 바이오센서
US9861746B2 (en) * 2012-06-08 2018-01-09 Medtronic Minimed, Inc. Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods
US10881339B2 (en) * 2012-06-29 2021-01-05 Dexcom, Inc. Use of sensor redundancy to detect sensor failures
US10598627B2 (en) * 2012-06-29 2020-03-24 Dexcom, Inc. Devices, systems, and methods to compensate for effects of temperature on implantable sensors
US9201038B2 (en) * 2012-07-24 2015-12-01 Lifescan Scotland Limited System and methods to account for interferents in a glucose biosensor
CN104641227B (zh) * 2012-09-19 2016-10-05 松下健康医疗控股株式会社 生物传感器及生物传感器的制造方法
US8965478B2 (en) * 2012-10-12 2015-02-24 Google Inc. Microelectrodes in an ophthalmic electrochemical sensor
US9265455B2 (en) * 2012-11-13 2016-02-23 Medtronic Minimed, Inc. Methods and systems for optimizing sensor function by the application of voltage
US20140275903A1 (en) * 2013-03-14 2014-09-18 Lifescan Scotland Limited System and method for quick-access physiological measurement history
CN103462615B (zh) * 2013-09-13 2015-12-16 上海移宇科技有限公司 微米尺度葡萄糖传感器微电极
JP6635789B2 (ja) * 2013-11-27 2020-01-29 Ｐｈｃホールディングス株式会社 血液成分量の測定方法
US9861747B2 (en) * 2013-12-05 2018-01-09 Lifescan, Inc. Method and system for management of diabetes with a glucose monitor and infusion pump to provide feedback on bolus dosing
US9603561B2 (en) * 2013-12-16 2017-03-28 Medtronic Minimed, Inc. Methods and systems for improving the reliability of orthogonally redundant sensors
US20150196224A1 (en) * 2014-01-16 2015-07-16 Dermal Therapy (Barbados) Inc. Implantable Sensor and Method for Such Sensor
JP2017513017A (ja) * 2014-03-12 2017-05-25 グルコベーション, インコーポレーテッドGlucovation, Inc. 電気化学センシングシステム
EP3128902B1 (en) * 2014-04-10 2023-08-30 Dexcom, Inc. Sensor for continuous analyte monitoring
US10238322B2 (en) * 2014-06-06 2019-03-26 Dexcom, Inc. Fault discrimination and responsive processing based on data and context
CN105445339B (zh) 2014-07-31 2018-07-06 天津大学 一种柔性差分式阵列电化学葡萄糖传感器及使用方法
WO2016033204A2 (en) * 2014-08-26 2016-03-03 Echo Therapeutics, Inc. Differential biosensor system
DE102014014942A1 (de) * 2014-10-07 2016-04-07 Neuroloop GmbH Implantierbare Anordnung
KR101703948B1 (ko) * 2014-10-27 2017-02-07 광운대학교 산학협력단 인체 삽입형 플렉시블 바이오센서, 및 그 제조방법
US10722160B2 (en) * 2014-12-03 2020-07-28 The Regents Of The University Of California Non-invasive and wearable chemical sensors and biosensors
JP6410308B2 (ja) * 2014-12-12 2018-10-24 国立大学法人東北大学 センサチップ、検出システム、及び、検出方法
CN104535627B (zh) * 2014-12-17 2017-01-04 浙江大学 葡萄糖传感系统
US20160235347A1 (en) 2015-02-13 2016-08-18 Maarij Baig Artificial sensors and methods of manufacture thereof
US20160249840A1 (en) * 2015-02-26 2016-09-01 Medtronic Minimed, Inc. Ph microsensor for glucose and other analyte sensor fault detection
US10575767B2 (en) * 2015-05-29 2020-03-03 Medtronic Minimed, Inc. Method for monitoring an analyte, analyte sensor and analyte monitoring apparatus
GB2539224A (en) * 2015-06-09 2016-12-14 Giuseppe Occhipinti Luigi Method of forming a chemical sensor device and device
CN107743584B (zh) 2015-06-15 2021-02-19 豪夫迈·罗氏有限公司 电化学检测体液样品中至少一种被分析物的方法和测试元件
GB201510765D0 (en) * 2015-06-18 2015-08-05 Inside Biometrics Ltd Method, apparatus and electrochemical test device
US20170079568A1 (en) * 2015-09-17 2017-03-23 Greg GERHARDT Dual-Sided Biomorphic Bioflex Polymer-based Microelectrode Array and Fabrication Thereof
CN105445345B (zh) * 2015-11-12 2018-06-05 三诺生物传感股份有限公司 一种柔性植入电极的制备方法
US20170185733A1 (en) * 2015-12-28 2017-06-29 Medtronic Minimed, Inc. Retrospective sensor systems, devices, and methods
JP6983765B2 (ja) * 2015-12-30 2021-12-17 デックスコム・インコーポレーテッド 分析物センサのための酵素固定化接着層
SI3220137T1 (sl) * 2016-03-14 2019-05-31 F. Hoffmann-La Roche Ag Postopek za odkrivanje doprinosa interferenta v biosenzorju
JP2017173014A (ja) 2016-03-22 2017-09-28 大日本印刷株式会社 電極構造の製造方法、電気化学センサの製造方法、電極構造および電気化学センサ
TWM528727U (zh) * 2016-03-25 2016-09-21 Hong Yue Technology Corp 穿戴式生理量測儀
CN105891297B (zh) * 2016-05-09 2018-07-06 三诺生物传感股份有限公司 一种电化学测量方法
US11298059B2 (en) * 2016-05-13 2022-04-12 PercuSense, Inc. Analyte sensor
EP3263712A1 (en) * 2016-06-29 2018-01-03 Roche Diabetes Care GmbH Galvanically functionalized sensors
JP2018019826A (ja) * 2016-08-02 2018-02-08 セイコーエプソン株式会社 検出素子、測定装置、薬剤供給装置および検出素子の製造方法
CN106290530B (zh) * 2016-08-31 2018-10-30 微泰医疗器械(杭州)有限公司 一种可自纠正干扰信号的电化学分析物传感系统及方法
CN107817337B (zh) 2016-09-13 2020-09-22 华广生技股份有限公司 一种分析物量测模块
WO2018057695A1 (en) * 2016-09-21 2018-03-29 University Of Cincinnati Accurate enzymatic sensing of sweat analytes
TWI631330B (zh) * 2016-10-03 2018-08-01 國立清華大學 非酶葡萄糖感測器及其製造方法與金屬奈米觸媒的製造方法
EP3529612A4 (en) * 2016-10-24 2020-05-20 H. Hoffnabb-La Roche Ag METHODS OF CORRECTING UNCENSATED RESISTORS IN CONDUCTIVE ELEMENTS OF BIOSENSORS, AS WELL AS DEVICES AND SYSTEMS
CN106725470B (zh) * 2016-11-22 2023-12-19 南通九诺医疗科技有限公司 一种连续或非连续的生理参数分析系统
CN207202871U (zh) * 2016-11-22 2018-04-10 南通九诺医疗科技有限公司 一种连续或非连续的生理参数分析系统
CN110418605A (zh) * 2017-01-19 2019-11-05 德克斯康公司 柔性分析物传感器
US20180217079A1 (en) * 2017-01-31 2018-08-02 Cilag Gmbh International Determining an analyte concentration of a physiological fluid having an interferent
CN107122703B (zh) * 2017-03-15 2019-12-17 深圳信炜科技有限公司 生物信息传感装置、电子设备和共模干扰检测方法
AU2018249498B2 (en) * 2017-04-03 2023-12-14 Presidio Medical, Inc. Systems and methods for direct current nerve conduction block
US20180306744A1 (en) * 2017-04-20 2018-10-25 Lifescan Scotland Limited Analyte measurement system and method
CN107064261A (zh) * 2017-05-01 2017-08-18 台州亿联健医疗科技有限公司 一种基于葡萄糖脱氢酶的生物传感器及检测方法
TW201903404A (zh) * 2017-06-03 2019-01-16 暐世生物科技股份有限公司 金屬電極試片及其製作方法
CN107064266A (zh) * 2017-06-07 2017-08-18 杭州暖芯迦电子科技有限公司 一种多工作电极葡萄糖传感器及其制造方法
KR101979257B1 (ko) * 2017-06-29 2019-05-16 주식회사 아이센스 CGMS 센서용 AgCl 보충시스템 및 보충방법
US11311217B2 (en) * 2017-09-13 2022-04-26 Medtronic Minimed, Inc. Methods, systems, and devices for calibration and optimization of glucose sensors and sensor output
CN109920922B (zh) * 2017-12-12 2020-07-17 京东方科技集团股份有限公司 有机发光器件及其制备方法、显示基板、显示驱动方法
US20200392473A1 (en) * 2017-12-22 2020-12-17 The Broad Institute, Inc. Novel crispr enzymes and systems
CN111818849A (zh) * 2018-02-05 2020-10-23 雅培糖尿病护理股份有限公司 与分析物传感器相关联的注释和事件日志信息
US11583213B2 (en) 2018-02-08 2023-02-21 Medtronic Minimed, Inc. Glucose sensor electrode design
US11284816B2 (en) * 2018-02-13 2022-03-29 PercuSense, Inc. Multi-analyte continuous glucose monitoring
CN109298032A (zh) * 2018-08-15 2019-02-01 浙江大学 一种基于叉指结构的去干扰电化学纸基试片及其测试方法
CN109283234A (zh) * 2018-08-15 2019-01-29 浙江大学 一种去干扰纸基电化学传感器及其测试方法
US11638543B2 (en) * 2019-07-16 2023-05-02 Dexcom, Inc. Analyte sensor electrode arrangements
US12023150B2 (en) * 2019-08-02 2024-07-02 Bionime Corporation Implantable micro-biosensor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130245412A1 (en) * 2009-07-02 2013-09-19 Dexcom, Inc. Analyte sensor with increased reference capacity
CN102803947A (zh) * 2010-03-16 2012-11-28 美敦力迷你迈德公司 葡萄糖传感器
TW201805624A (zh) * 2016-08-08 2018-02-16 友達光電股份有限公司 感測裝置及該感測裝置之電極試片
WO2019146788A1 (ja) * 2018-01-29 2019-08-01 Ｐｈｃホールディングス株式会社 バイオセンサプローブ用保護膜材料

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EP3771415B1 (en) 2022-11-23
US11766193B2 (en) 2023-09-26
US12023150B2 (en) 2024-07-02
KR20210016292A (ko) 2021-02-15
EP3771421B1 (en) 2024-04-24
CN112294318A (zh) 2021-02-02
CN112294310B (zh) 2024-07-26
CA3127420C (en) 2024-01-02
JP2022167894A (ja) 2022-11-04
AU2020324193A1 (en) 2021-05-06
CN112294322A (zh) 2021-02-02
KR102506277B1 (ko) 2023-03-07
TWI736383B (zh) 2021-08-11
EP3771430A1 (en) 2021-02-03
AU2020210301B2 (en) 2021-12-16
KR102446995B1 (ko) 2022-09-23
KR102497046B1 (ko) 2023-02-09
EP3771414A1 (en) 2021-02-03
EP3771419B1 (en) 2024-04-10

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