TWI729028B - 寡核苷酸的製造方法 - Google Patents

寡核苷酸的製造方法 Download PDF

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Publication number
TWI729028B
TWI729028B TW105137671A TW105137671A TWI729028B TW I729028 B TWI729028 B TW I729028B TW 105137671 A TW105137671 A TW 105137671A TW 105137671 A TW105137671 A TW 105137671A TW I729028 B TWI729028 B TW I729028B
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Taiwan
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group
solid
alkyl
protecting group
alkenyl
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TW105137671A
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English (en)
Chinese (zh)
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TW201731861A (zh
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菅原祐大
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日商日產化學工業股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW105137671A 2015-11-17 2016-11-17 寡核苷酸的製造方法 TWI729028B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015224617 2015-11-17
JP2015-224617 2015-11-17

Publications (2)

Publication Number Publication Date
TW201731861A TW201731861A (zh) 2017-09-16
TWI729028B true TWI729028B (zh) 2021-06-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW105137671A TWI729028B (zh) 2015-11-17 2016-11-17 寡核苷酸的製造方法

Country Status (6)

Country Link
US (1) US11548910B2 (https=)
EP (1) EP3378869A4 (https=)
JP (3) JP6950529B2 (https=)
CN (1) CN108350018A (https=)
TW (1) TWI729028B (https=)
WO (1) WO2017086397A1 (https=)

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CN108350018A (zh) * 2015-11-17 2018-07-31 日产化学工业株式会社 寡核苷酸的制造方法
WO2017104836A1 (ja) 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド
JPWO2017111137A1 (ja) 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
WO2017221929A1 (ja) * 2016-06-21 2017-12-28 株式会社ジーンデザイン リボ核酸ｈ－ホスホネートモノマーの合成方法および本モノマーを用いたオリゴヌクレオチド合成
TW201906855A (zh) * 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法
WO2018212236A1 (ja) * 2017-05-16 2018-11-22 日産化学株式会社 オリゴヌクレオチドの製造方法
US11891412B2 (en) 2017-12-27 2024-02-06 Knc Laboratories Co., Ltd. Production of highly fat-soluble phosphoramidite
CN108586449A (zh) * 2018-06-08 2018-09-28 山东阳谷华泰化工股份有限公司 一种n-（2-巯基苯并噻唑）邻苯二甲酰亚胺及其制备方法和应用
JP7296636B2 (ja) * 2018-07-20 2023-06-23 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
JP6770553B2 (ja) 2018-07-20 2020-10-14 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
WO2020166705A1 (ja) 2019-02-15 2020-08-20 味の素株式会社 オリゴヌクレオチドの製造方法
JP7632276B2 (ja) * 2019-03-28 2025-02-19 味の素株式会社 ホスホロチオエート化部位を有するオリゴヌクレオチドの製造方法
CN113924309A (zh) * 2019-05-21 2022-01-11 株式会社纳蒂亚斯 寡核苷酸合成中使用的多氟嵌段聚体以及使用其的寡核苷酸合成方法
AU2021377229A1 (en) * 2020-11-11 2023-06-29 Biogen Ma Inc. Oligonucleotides, reagents and preparation thereof
KR20240028416A (ko) * 2021-07-06 2024-03-05 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머를 함유하는 조성물
JP7220439B1 (ja) * 2022-03-14 2023-02-10 国立大学法人東北大学 キメラ分子の製造方法
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
CN120813558A (zh) 2023-03-06 2025-10-17 斯佩拉制药株式会社 长链烯氧基取代的苯甲酰衍生物及使用该衍生物的寡核苷酸合成方法
JPWO2024228396A1 (https=) 2023-05-01 2024-11-07
JP7433684B1 (ja) 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
EP4695265A1 (en) 2023-10-16 2026-02-18 Bachem Holding AG Method and composition for oligonucleotide synthesis

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WO2005028494A1 (ja) * 2003-09-02 2005-03-31 Takeshi Wada ５'-ホスフィチル化モノマーおよびh-ホスホネートオリゴヌクレオチド誘導体の製造方法
US20120296074A1 (en) * 2011-05-17 2012-11-22 Ajinomoto Co., Inc. Production method of oligonucleotide
EP2816053A1 (en) * 2012-02-17 2014-12-24 Ajinomoto Co., Inc. Base-protected oligonucleotide

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EP2921499B1 (en) * 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
EP3263579B1 (en) * 2015-01-21 2022-11-30 Ajinomoto Co., Inc. Precipitation promoter and precipitation method in which same is used
CN108350018A (zh) * 2015-11-17 2018-07-31 日产化学工业株式会社 寡核苷酸的制造方法
WO2017104836A1 (ja) * 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド

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WO2005028494A1 (ja) * 2003-09-02 2005-03-31 Takeshi Wada ５'-ホスフィチル化モノマーおよびh-ホスホネートオリゴヌクレオチド誘導体の製造方法
US20120296074A1 (en) * 2011-05-17 2012-11-22 Ajinomoto Co., Inc. Production method of oligonucleotide
EP2816053A1 (en) * 2012-02-17 2014-12-24 Ajinomoto Co., Inc. Base-protected oligonucleotide

Also Published As

Publication number Publication date
US20190169223A1 (en) 2019-06-06
EP3378869A1 (en) 2018-09-26
JP2023100975A (ja) 2023-07-19
EP3378869A4 (en) 2019-09-18
WO2017086397A1 (ja) 2017-05-26
JP6950529B2 (ja) 2021-10-13
CN108350018A (zh) 2018-07-31
JP2022000444A (ja) 2022-01-04
US11548910B2 (en) 2023-01-10
JP7531018B2 (ja) 2024-08-08
JPWO2017086397A1 (ja) 2018-09-06
TW201731861A (zh) 2017-09-16

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