TW225531B - - Google Patents

Info

Publication number
TW225531B
TW225531B TW082101304A TW82101304A TW225531B TW 225531 B TW225531 B TW 225531B TW 082101304 A TW082101304 A TW 082101304A TW 82101304 A TW82101304 A TW 82101304A TW 225531 B TW225531 B TW 225531B
Authority
TW
Taiwan
Application number
TW082101304A
Other languages
Chinese (zh)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of TW225531B publication Critical patent/TW225531B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26Separation; Purification; Stabilisation; Use of additives
    • C07C319/28Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
TW082101304A 1992-02-27 1993-02-24 TW225531B (en, 2012)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27

Publications (1)

Publication Number Publication Date
TW225531B true TW225531B (en, 2012) 1994-06-21

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082101304A TW225531B (en, 2012) 1992-02-27 1993-02-24

Country Status (37)

Country Link
US (4) US5541180A (en, 2012)
EP (1) EP0639192B1 (en, 2012)
JP (1) JP2779268B2 (en, 2012)
KR (1) KR100190300B1 (en, 2012)
CN (1) CN1038032C (en, 2012)
AP (1) AP416A (en, 2012)
AT (1) ATE138064T1 (en, 2012)
AU (1) AU664237B2 (en, 2012)
BG (1) BG62052B1 (en, 2012)
CA (1) CA2117483C (en, 2012)
CZ (1) CZ282092B6 (en, 2012)
DE (1) DE69302687T2 (en, 2012)
DK (1) DK0639192T3 (en, 2012)
EE (1) EE03029B1 (en, 2012)
ES (1) ES2087721T3 (en, 2012)
FI (1) FI109122B (en, 2012)
GR (1) GR3019927T3 (en, 2012)
HR (1) HRP930235B1 (en, 2012)
HU (2) HU222495B1 (en, 2012)
IL (1) IL104868A (en, 2012)
LT (1) LT3049B (en, 2012)
LV (1) LV10715B (en, 2012)
MX (1) MX9301053A (en, 2012)
MY (1) MY110627A (en, 2012)
NO (1) NO306255B1 (en, 2012)
NZ (1) NZ249124A (en, 2012)
OA (1) OA10095A (en, 2012)
PH (1) PH31295A (en, 2012)
PL (1) PL174736B1 (en, 2012)
RO (1) RO115630B1 (en, 2012)
RU (1) RU2121999C1 (en, 2012)
SG (1) SG47763A1 (en, 2012)
SI (1) SI9300097B (en, 2012)
SK (1) SK280166B6 (en, 2012)
TW (1) TW225531B (en, 2012)
WO (1) WO1993017017A1 (en, 2012)
ZA (1) ZA931404B (en, 2012)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226525B1 (en) * 1993-08-19 2009-03-30 Janssen Pharmaceutica Nv Vasocontrictive dihydrobenzopyran derivatives, pharmaceutical compositions containing them and process for preparing them
BR9407298A (pt) * 1993-08-19 1996-10-01 Janssen Pharmaceutica Nv Diidropiranopiridinas vasoconstritoras substituidas
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
EP0707007B1 (en) * 1994-10-14 2001-12-12 MERCK PATENT GmbH (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane as CNS active agent
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
AU6003896A (en) * 1995-06-08 1997-01-09 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
RU2134108C1 (ru) * 1998-10-06 1999-08-10 Заславская Рина Михайловна Средство для лечения артериальной гипертонии, способ лечения артериальной гипертонии
FR2787789B1 (fr) * 1998-12-29 2002-06-14 Lipha Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
NZ515478A (en) * 1999-06-02 2003-03-28 Janssen Pharmaceutica Nv Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
US6864273B1 (en) * 1999-06-02 2005-03-08 Janssen Pharmaceutica N.V. Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
ES2292636T3 (es) * 2000-11-29 2008-03-16 Eli Lilly And Company 1-(2-m-metanosulfanomidofeniletil)-4-(m-trifluorometilfenil)piper.
SK10542003A3 (sk) * 2001-02-23 2004-03-02 Merck & Co., Inc. N-Substituované nearylové heterocyklické zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
ES2280602T3 (es) 2001-07-26 2007-09-16 Merck Patent Gmbh Uso de 2-(5-(4-fluorofenil)-3-piridilmetilaminometil)-cromano y sus sales fisiologicamente aceptables.
JP4615857B2 (ja) * 2001-09-19 2011-01-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換アミノメチルクロマンの新規な使用
WO2004069296A1 (en) * 2003-01-31 2004-08-19 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
CN101475528A (zh) * 2003-03-31 2009-07-08 大正制药株式会社 新的喹啉、四氢喹唑啉和嘧啶衍生物以及与其应用有关的治疗方法
US20050197350A1 (en) * 2003-03-31 2005-09-08 Taisho Pharmaceutical Co., Ltd. Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森(商丘)药业有限公司 一种硫酸胍生合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE636238A (en, 2012) * 1962-08-20
FR1366479A (fr) * 1962-08-20 1964-07-10 Res Lab Dr C Janssen Nv Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels
FR1366472A (fr) * 1962-09-29 1964-07-10 Glaverbel Dispositif pour la fabrication du verre en feuille
GB1411531A (en) * 1972-10-24 1975-10-29 Lafon Labor Amino derivatives of 1,4-benzodioxan
GR71865B (en, 2012) * 1978-03-20 1983-07-07 Ciba Geigy
US4405922A (en) * 1979-05-23 1983-09-20 Hitachi Koki Company, Limited Failure detection circuit for impact printers or the like
US4405622A (en) * 1980-10-16 1983-09-20 Syntex (U.S.A.) Inc. [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants
FR2524887A1 (fr) * 1982-04-08 1983-10-14 Bouchara Emile Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
CA2011899A1 (en) * 1989-03-13 1990-09-13 Masaaki Toda Benzopyran derivatives
WO1994017017A1 (en) * 1991-07-15 1994-08-04 Exxon Research And Engineering Company Benzene removal from gasoline boiling range streams
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Also Published As

Publication number Publication date
IL104868A0 (en) 1993-06-10
MY110627A (en) 1998-09-30
RU94041210A (ru) 1996-07-10
EP0639192B1 (en) 1996-05-15
JP2779268B2 (ja) 1998-07-23
HU211742A9 (en) 1995-12-28
DE69302687D1 (de) 1996-06-20
HUT71129A (en) 1995-11-28
NO943186L (no) 1994-08-29
US5541180A (en) 1996-07-30
SG47763A1 (en) 1998-04-17
RU2121999C1 (ru) 1998-11-20
GR3019927T3 (en) 1996-08-31
LV10715A (lv) 1995-06-20
FI109122B (fi) 2002-05-31
SK102994A3 (en) 1995-07-11
AP416A (en) 1995-09-29
KR100190300B1 (ko) 1999-06-01
HU9402464D0 (en) 1994-10-28
MX9301053A (es) 1994-03-31
DK0639192T3 (da) 1996-08-19
CA2117483C (en) 2001-01-09
BG62052B1 (bg) 1999-01-29
FI943928A0 (fi) 1994-08-26
AU3499193A (en) 1993-09-13
CA2117483A1 (en) 1993-09-02
ZA931404B (en) 1994-08-26
LTIP367A (lt) 1994-04-25
ATE138064T1 (de) 1996-06-15
SI9300097B (en) 2001-12-31
BG98870A (bg) 1995-03-31
FI943928A7 (fi) 1994-08-26
CS202094A3 (en) 1995-01-18
EE03029B1 (et) 1997-08-15
CZ282092B6 (cs) 1997-05-14
OA10095A (en) 1996-12-18
PH31295A (en) 1998-07-06
WO1993017017A1 (en) 1993-09-02
HRP930235A2 (en) 1997-10-31
NZ249124A (en) 1995-08-28
PL174736B1 (pl) 1998-09-30
SK280166B6 (sk) 1999-09-10
RO115630B1 (ro) 2000-04-28
ES2087721T3 (es) 1996-07-16
US5688952A (en) 1997-11-18
DE69302687T2 (de) 1996-11-14
HU222495B1 (hu) 2003-07-28
IL104868A (en) 1998-01-04
NO943186D0 (no) 1994-08-29
AP9300493A0 (en) 1993-04-30
CN1038032C (zh) 1998-04-15
HRP930235B1 (en) 1999-04-30
NO306255B1 (no) 1999-10-11
LT3049B (en) 1994-10-25
CN1079470A (zh) 1993-12-15
SI9300097A (en) 1993-09-30
LV10715B (en) 1995-12-20
EP0639192A1 (en) 1995-02-22
JPH07504408A (ja) 1995-05-18
AU664237B2 (en) 1995-11-09
US5624952A (en) 1997-04-29
US5607949A (en) 1997-03-04

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Legal Events

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MK4A Expiration of patent term of an invention patent