TW201936638A - 雙特異性異質二聚體雙功能抗體及彼等之用途 - Google Patents
雙特異性異質二聚體雙功能抗體及彼等之用途 Download PDFInfo
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- C07K—PEPTIDES
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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2015
- 2015-06-26 RU RU2016151645A patent/RU2016151645A/ru not_active Application Discontinuation
- 2015-06-26 MX MX2016017393A patent/MX2016017393A/es unknown
- 2015-06-26 KR KR1020167036814A patent/KR20170010863A/ko not_active Ceased
- 2015-06-26 BR BR112016030740-2A patent/BR112016030740A2/pt not_active Application Discontinuation
- 2015-06-26 CA CA2895659A patent/CA2895659A1/en not_active Abandoned
- 2015-06-26 WO PCT/IB2015/054829 patent/WO2016001810A1/en not_active Ceased
- 2015-06-26 SG SG11201609707WA patent/SG11201609707WA/en unknown
- 2015-06-26 CN CN201580035515.8A patent/CN106661119A/zh active Pending
- 2015-06-26 AU AU2015283704A patent/AU2015283704A1/en not_active Abandoned
- 2015-06-26 EP EP15741347.7A patent/EP3164417A1/en not_active Withdrawn
- 2015-06-26 PE PE2016002813A patent/PE20170286A1/es unknown
- 2015-06-26 JP JP2016575335A patent/JP2017520575A/ja active Pending
- 2015-06-26 US US14/751,704 patent/US9884921B2/en not_active Expired - Fee Related
- 2015-06-29 TW TW107142295A patent/TW201936638A/zh unknown
- 2015-06-29 TW TW104120955A patent/TWI659042B/zh not_active IP Right Cessation
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2016
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- 2017-01-03 CO CONC2017/0000016A patent/CO2017000016A2/es unknown
- 2017-12-13 US US15/840,019 patent/US20180155452A1/en not_active Abandoned
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| AU2015283704A1 (en) | 2016-12-15 |
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| CN106661119A (zh) | 2017-05-10 |
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| EP3164417A1 (en) | 2017-05-10 |
| US20160002357A1 (en) | 2016-01-07 |
| BR112016030740A2 (pt) | 2018-02-20 |
| RU2016151645A3 (enExample) | 2019-02-20 |
| JP2017520575A (ja) | 2017-07-27 |
| US20180155452A1 (en) | 2018-06-07 |
| IL249889A0 (en) | 2017-03-30 |
| RU2016151645A (ru) | 2018-08-03 |
| TWI659042B (zh) | 2019-05-11 |
| SG11201609707WA (en) | 2017-01-27 |
| TW201612194A (en) | 2016-04-01 |
| MX2016017393A (es) | 2017-09-05 |
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