IN2013MN01438A - - Google Patents
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- Publication number
- IN2013MN01438A IN2013MN01438A IN1438MUN2013A IN2013MN01438A IN 2013MN01438 A IN2013MN01438 A IN 2013MN01438A IN 1438MUN2013 A IN1438MUN2013 A IN 1438MUN2013A IN 2013MN01438 A IN2013MN01438 A IN 2013MN01438A
- Authority
- IN
- India
- Prior art keywords
- heavy chains
- covalent link
- identical heavy
- region
- fab region
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161453591P | 2011-03-17 | 2011-03-17 | |
| PCT/IL2012/050093 WO2012123949A1 (en) | 2011-03-17 | 2012-03-15 | Bi- and monospecific, asymmetric antibodies and methods of generating the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013MN01438A true IN2013MN01438A (enExample) | 2015-06-12 |
Family
ID=45999923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1438MUN2013 IN2013MN01438A (enExample) | 2011-03-17 | 2012-03-15 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9624291B2 (enExample) |
| EP (1) | EP2686348B1 (enExample) |
| JP (1) | JP2014510084A (enExample) |
| KR (1) | KR20140019385A (enExample) |
| CN (1) | CN103429619B (enExample) |
| AU (1) | AU2012227883A1 (enExample) |
| BR (1) | BR112013023653A2 (enExample) |
| CA (1) | CA2827188C (enExample) |
| IN (1) | IN2013MN01438A (enExample) |
| MX (1) | MX342135B (enExample) |
| WO (1) | WO2012123949A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2580017C2 (ru) | 2010-07-26 | 2016-04-10 | Трианни, Инк. | Трансгенные животные и способы применения |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| IN2013MN01438A (enExample) | 2011-03-17 | 2015-06-12 | Univ Ramot | |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US9465889B2 (en) * | 2012-07-05 | 2016-10-11 | Physion Consulting, LLC | Method and system for identifying data and users of interest from patterns of user interaction with existing data |
| CN112079929A (zh) | 2012-11-21 | 2020-12-15 | 武汉友芝友生物制药有限公司 | 双特异性抗体 |
| US9605084B2 (en) * | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| KR101763345B1 (ko) * | 2013-01-24 | 2017-08-14 | 주식회사 앱틀라스 | 단백질 조합 기반의 Fv 라이브러리 및 이의 제조 방법 |
| KR101989551B1 (ko) * | 2013-02-15 | 2019-09-30 | 알-팜 인터내셔널, 엘엘씨. | IL-1β 억제제 조성물 및 이의 용도 |
| EP2975061A4 (en) | 2013-03-13 | 2017-03-01 | Ibentrus Inc. | Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| SG10201809385RA (en) | 2013-12-17 | 2018-11-29 | Genentech Inc | Anti-cd3 antibodies and methods of use |
| KR102378289B1 (ko) * | 2014-02-10 | 2022-03-23 | 아이쥐엠 바이오사이언스 인코포레이티드 | IgA 다중-특이적 결합 분자 |
| EP3725812B1 (en) * | 2014-03-03 | 2023-09-27 | Academia Sinica | Bi-specific antibodies and uses thereof |
| US12180264B2 (en) | 2014-03-24 | 2024-12-31 | R-Pharm Overseas, Inc. | IL1-R1 derived inhibitor of IL-1β and use thereof |
| US20170022291A1 (en) | 2014-04-01 | 2017-01-26 | Adimab, Llc | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
| AU2015252866B2 (en) * | 2014-05-02 | 2021-01-28 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
| PE20170286A1 (es) | 2014-07-01 | 2017-03-30 | Pfizer | Diacuerpos heterodimericos biespecificos y sus usos |
| US10927185B2 (en) | 2014-11-21 | 2021-02-23 | Astellas Pharma Inc. | Bispecific antibody format |
| CN110894240B (zh) | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| JP2018526972A (ja) | 2015-06-16 | 2018-09-20 | ジェネンテック， インコーポレイテッド | 抗ｃｄ３抗体及び使用方法 |
| CN108138200A (zh) | 2015-08-24 | 2018-06-08 | 特里安尼公司 | 增强的免疫球蛋白产生 |
| WO2017055398A2 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for a costimulatory tnf receptor |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| IL260743B2 (en) | 2016-02-04 | 2024-03-01 | Trianni Inc | Advanced production of antibodies |
| EP3423572B1 (en) | 2016-03-02 | 2023-11-29 | Momenta Pharmaceuticals, Inc. | Methods related to engineered fc constructs |
| US11623964B2 (en) | 2016-05-23 | 2023-04-11 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
| CN109475627B (zh) | 2016-05-26 | 2023-01-06 | 齐鲁普吉湾生物治疗公司 | 抗体混合物 |
| CA3029890A1 (en) * | 2016-07-07 | 2018-01-11 | Acceleron Pharma Inc. | Tgf-beta superfamily heteromultimers and uses thereof |
| SG11201900373WA (en) | 2016-07-19 | 2019-02-27 | Ibentrus Inc | Bispecific proteins and methods for preparing same |
| CN110312523B (zh) | 2016-11-08 | 2024-04-26 | 齐鲁皮吉特湾生物治疗有限公司 | 抗pd1和抗ctla4抗体 |
| CN106496331B (zh) * | 2016-11-08 | 2020-03-13 | 北京智岭生物医药科技有限公司 | 一种FSH-Fc融合蛋白及其制备方法和用途 |
| WO2018093821A1 (en) | 2016-11-15 | 2018-05-24 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| US11220531B2 (en) | 2017-01-06 | 2022-01-11 | Janssen Biotech, Inc. | Engineered Fc constructs |
| UY37758A (es) | 2017-06-12 | 2019-01-31 | Novartis Ag | Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos |
| AU2018353420A1 (en) | 2017-10-20 | 2020-04-16 | F. Hoffmann-La Roche Ag | Method for generating multispecific antibodies from monospecific antibodies |
| CA3089287A1 (en) | 2018-02-08 | 2019-08-15 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
| TWI848953B (zh) | 2018-06-09 | 2024-07-21 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
| CN113490690A (zh) * | 2018-12-29 | 2021-10-08 | 南通壹宸生物医药科技有限公司 | 异源二聚体融合蛋白 |
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| JP7716473B2 (ja) | 2020-11-04 | 2025-07-31 | ジェネンテック， インコーポレイテッド | 抗ｃｄ２０／抗ｃｄ３二重特異性抗体の皮下投薬 |
| KR20230095113A (ko) | 2020-11-04 | 2023-06-28 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체들과 항-cd79b 항체 약물 접합체들을 이용한 치료를 위한 투약 |
| WO2022098638A2 (en) | 2020-11-04 | 2022-05-12 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| AU2021384022A1 (en) | 2020-11-18 | 2023-06-01 | Novartis Ag | Bispecific antibodies for use in treatment of nlrc4-gof inflammasomapathy |
| EP4305067A1 (en) | 2021-03-09 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| TW202310871A (zh) | 2021-05-14 | 2023-03-16 | 美商建南德克公司 | 用莫蘇妥珠單抗及帕羅托珠單抗維多汀治療ｃｄ２０陽性增生性失調之方法 |
| CN113480645B (zh) * | 2021-07-16 | 2022-11-11 | 甘肃中科博瑞生物工程有限公司 | 一种抗幽门螺旋杆菌重组抗体、制备方法及用途 |
| JP7579481B2 (ja) | 2022-04-13 | 2024-11-07 | ジェネンテック， インコーポレイテッド | モスネツズマブの医薬組成物および使用方法 |
| CN115232214A (zh) * | 2022-08-16 | 2022-10-25 | 广州市拜沃思生物科技有限公司 | 一种双特异性抗体及其制备方法和应用 |
| CN116789836B (zh) * | 2023-08-14 | 2024-01-05 | 浙江时迈药业有限公司 | 针对dll3的抗体及其用途 |
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| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| CN102015770A (zh) | 2008-02-29 | 2011-04-13 | 特拉维夫大学拉莫特有限公司 | 免疫球蛋白组合物和生产其的方法 |
| JP2012503612A (ja) | 2008-09-26 | 2012-02-09 | ロシュ グリクアート アクチェンゲゼルシャフト | 二重特異性抗ｅｇｆｒ／抗ｉｇｆ−１ｒ抗体 |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| JP4694610B2 (ja) | 2008-10-30 | 2011-06-08 | シャープ株式会社 | 承認者決定装置及び当該承認者決定装置を有するファクシミリ装置 |
| BRPI1014089A2 (pt) * | 2009-04-02 | 2016-04-19 | Roche Glycart Ag | anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples |
| BRPI1014474A2 (pt) * | 2009-04-07 | 2017-06-27 | Roche Glycart Ag | anticorpos biespecíficos anti-erbb-1/anti-c-met. |
| ES2537100T3 (es) | 2009-04-07 | 2015-06-02 | Roche Glycart Ag | Anticuerpos biespecíficos trivalentes |
| US8796759B2 (en) | 2010-07-15 | 2014-08-05 | Taiwan Semiconductor Manufacturing Company, Ltd. | Fin-like field effect transistor (FinFET) device and method of manufacturing same |
| IN2013MN01438A (enExample) | 2011-03-17 | 2015-06-12 | Univ Ramot |
-
2012
- 2012-03-15 IN IN1438MUN2013 patent/IN2013MN01438A/en unknown
- 2012-03-15 KR KR1020137027330A patent/KR20140019385A/ko not_active Ceased
- 2012-03-15 MX MX2013010590A patent/MX342135B/es active IP Right Grant
- 2012-03-15 WO PCT/IL2012/050093 patent/WO2012123949A1/en not_active Ceased
- 2012-03-15 EP EP12716657.7A patent/EP2686348B1/en active Active
- 2012-03-15 AU AU2012227883A patent/AU2012227883A1/en not_active Abandoned
- 2012-03-15 CA CA2827188A patent/CA2827188C/en active Active
- 2012-03-15 JP JP2013558572A patent/JP2014510084A/ja active Pending
- 2012-03-15 US US14/005,580 patent/US9624291B2/en active Active
- 2012-03-15 BR BR112013023653A patent/BR112013023653A2/pt not_active IP Right Cessation
- 2012-03-15 CN CN201280013666.XA patent/CN103429619B/zh active Active
-
2017
- 2017-03-02 US US15/447,244 patent/US10822428B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013010590A (es) | 2014-05-27 |
| KR20140019385A (ko) | 2014-02-14 |
| AU2012227883A8 (en) | 2013-11-07 |
| WO2012123949A1 (en) | 2012-09-20 |
| CN103429619B (zh) | 2017-07-28 |
| CA2827188A1 (en) | 2012-09-20 |
| CA2827188C (en) | 2020-02-11 |
| BR112013023653A2 (pt) | 2016-12-13 |
| EP2686348B1 (en) | 2015-12-30 |
| US20170174791A1 (en) | 2017-06-22 |
| JP2014510084A (ja) | 2014-04-24 |
| WO2012123949A8 (en) | 2013-03-14 |
| AU2012227883A1 (en) | 2013-10-24 |
| CN103429619A (zh) | 2013-12-04 |
| US9624291B2 (en) | 2017-04-18 |
| EP2686348A1 (en) | 2014-01-22 |
| MX342135B (es) | 2016-09-14 |
| US10822428B2 (en) | 2020-11-03 |
| US20140010814A1 (en) | 2014-01-09 |
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