TW201446806A - 抗體藥物結合物 - Google Patents

抗體藥物結合物 Download PDF

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Publication number
TW201446806A
TW201446806A TW103109292A TW103109292A TW201446806A TW 201446806 A TW201446806 A TW 201446806A TW 103109292 A TW103109292 A TW 103109292A TW 103109292 A TW103109292 A TW 103109292A TW 201446806 A TW201446806 A TW 201446806A
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TW
Taiwan
Prior art keywords
seq
antibody
ckit
drug conjugate
chain variable
Prior art date
Application number
TW103109292A
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English (en)
Chinese (zh)
Inventor
Tinya Abrams
Steven Cohen
Christie P Fanton
Thomas Huber
Kathy Miller
Siew Ho Schleyer
Kathrin Ulrike Tissot-Daguette
Catrin Finner
Original Assignee
Novartis Ag
Irm Llc
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Publication date
Application filed by Novartis Ag, Irm Llc filed Critical Novartis Ag
Publication of TW201446806A publication Critical patent/TW201446806A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K39/39591—Stabilisation, fragmentation
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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