TW200732476A - Functional influenza virus like particles (VLPs) - Google Patents

Functional influenza virus like particles (VLPs)

Info

Publication number
TW200732476A
TW200732476A TW095138390A TW95138390A TW200732476A TW 200732476 A TW200732476 A TW 200732476A TW 095138390 A TW095138390 A TW 095138390A TW 95138390 A TW95138390 A TW 95138390A TW 200732476 A TW200732476 A TW 200732476A
Authority
TW
Taiwan
Prior art keywords
vlps
influenza virus
particles
proteins
functional influenza
Prior art date
Application number
TW095138390A
Other languages
English (en)
Other versions
TWI488968B (zh
Inventor
Gale Smith
Rick Bright
Peter Pushko
Jinyou Zhang
Kutub Mahmood
Original Assignee
Novavax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novavax Inc filed Critical Novavax Inc
Publication of TW200732476A publication Critical patent/TW200732476A/zh
Application granted granted Critical
Publication of TWI488968B publication Critical patent/TWI488968B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/11—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
TW095138390A 2005-10-18 2006-10-18 功能性流行性感冒類病毒顆粒（ＶＬＰｓ） TWI488968B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US72751305P 2005-10-18 2005-10-18
US78084706P 2006-03-10 2006-03-10
US80000606P 2006-05-15 2006-05-15
US83119606P 2006-07-17 2006-07-17
US83211606P 2006-07-21 2006-07-21
US84549506P 2006-09-19 2006-09-19

Publications (2)

Publication Number Publication Date
TW200732476A true TW200732476A (en) 2007-09-01
TWI488968B TWI488968B (zh) 2015-06-21

Family

ID=37963272

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095138390A TWI488968B (zh) 2005-10-18 2006-10-18 功能性流行性感冒類病毒顆粒（ＶＬＰｓ）

Country Status (20)

Country Link
EP (1) EP1937301B1 (zh)
JP (5) JP5714799B2 (zh)
KR (1) KR101359723B1 (zh)
CN (2) CN103865892B (zh)
AU (1) AU2006304640B2 (zh)
BR (1) BRPI0617486A2 (zh)
CA (1) CA2625406C (zh)
DK (1) DK1937301T3 (zh)
ES (1) ES2543056T3 (zh)
HK (1) HK1121687A1 (zh)
HU (1) HUE026136T2 (zh)
IL (1) IL190775A (zh)
NZ (1) NZ567164A (zh)
PL (1) PL1937301T3 (zh)
PT (1) PT1937301E (zh)
RU (1) RU2483751C2 (zh)
SG (1) SG2014012868A (zh)
SI (1) SI1937301T1 (zh)
TW (1) TWI488968B (zh)
WO (1) WO2007047831A2 (zh)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0250488A (ja) * 1988-08-11 1990-02-20 Nec Corp 超伝導配線
US8551756B2 (en) 2003-07-11 2013-10-08 Novavax, Inc. Avian influenza chimeric VLPS
WO2007130327A2 (en) 2006-05-01 2007-11-15 Technovax, Inc. Influenza virus-like particle (vlp) compositions
US9101578B2 (en) 2006-05-01 2015-08-11 Technovax, Inc. Polyvalent influenza virus-like particle (VLP) compositions
CA2659275C (en) * 2006-07-27 2017-01-10 Ligocyte Pharmaceuticals, Inc. Chimeric influenza virus-like particles
US8202967B2 (en) 2006-10-27 2012-06-19 Boehringer Ingelheim Vetmedica, Inc. H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
CA2615372A1 (en) * 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
EP2175883A4 (en) * 2007-07-19 2011-11-30 Novavax Inc CHIMERIC VARICELLA ZOSTER VIRUS-VIRUSUAL PARTICLES
KR101255419B1 (ko) 2007-11-12 2013-04-17 이노비오 파마수티컬즈, 인크. 인플루엔자 바이러스의 다중 아형에 대한 신규 백신
PT2610345E (pt) 2007-11-27 2016-01-11 Medicago Inc Partículas semelhantes ao vírus (vlps) da gripe recombinantes produzidas em plantas transgénicas que expressam hemaglutinina
CN105753948A (zh) 2008-07-08 2016-07-13 麦迪卡格公司 可溶性重组流感抗原
EP2318530B1 (en) 2008-07-18 2016-06-22 Medicago Inc. New influenza virus immunizing epitope
US8394384B2 (en) * 2008-11-28 2013-03-12 Merial Limited Recombinant avian influenza vaccine and uses thereof
JP2012525134A (ja) * 2009-04-30 2012-10-22 サイトス バイオテクノロジー アーゲー インフルエンザ赤血球凝集素の組成物とその使用
CN102414313B (zh) * 2009-05-01 2014-04-02 雷德生物科技股份公司 多基因载体编码的重组病毒样颗粒
TW201738562A (zh) * 2009-05-28 2017-11-01 亞培生物股份有限公司 體外病原體檢驗技術
NZ597401A (en) 2009-06-24 2013-09-27 Medicago Inc Chimeric influenza virus-like particles comprising hemagglutinin
NO2480560T3 (zh) 2009-09-22 2018-07-21
WO2011102900A1 (en) * 2010-02-18 2011-08-25 Technovax, Inc. Universal virus-like particle (vlp) influenza vaccines
JP2012036154A (ja) * 2010-08-11 2012-02-23 Goshu Yakuhin Kk 食品
CN101947317B (zh) * 2010-09-27 2012-05-30 武汉大学 一种h5n1禽流感病毒样颗粒疫苗的规模化制备方法
US20140004146A1 (en) * 2011-03-17 2014-01-02 Institut Pasteur Of Shanghai, Chinese Academy Of Sciences Method for producing virus-like particle by using drosophila cell and applications thereof
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
EA016866B1 (ru) * 2011-06-06 2012-08-30 Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") Вакцина для специфической профилактики гриппа
KR101302245B1 (ko) * 2011-06-27 2013-09-02 조지아 스테이트 유니버시티 리서치 파운데이션, 인코포레이티드 넓은 범위의 교차 방어능력을 갖는 신규한 보강 인플루엔자 백신
AR088028A1 (es) * 2011-08-15 2014-05-07 Boehringer Ingelheim Vetmed Proteinas h5, de h5n1 para un uso medicinal
JP2014527799A (ja) 2011-08-26 2014-10-23 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス
JP5884100B2 (ja) * 2011-08-31 2016-03-15 公益財団法人東京都医学総合研究所 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子を有するＤＩｓ株由来組換えワクシニアウイルス
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
AU2012315421C1 (en) * 2011-09-30 2019-12-05 Medicago Inc. Increasing virus-like particle yield in plants
EP3520809A1 (en) * 2012-02-03 2019-08-07 Emory University Immunostimulatory compositions.
RU2485973C1 (ru) * 2012-02-28 2013-06-27 Общество с ограниченной ответственностью "НТфарма" Рекомбинантная трехвалентная вакцина от гриппа человека
MX360137B (es) * 2013-02-21 2018-10-24 Boehringer Ingelheim Vetmedica Gmbh Proteínas h5 del virus de la influenza h5n1 para usarse como un medicamento.
US9649375B2 (en) * 2013-03-14 2017-05-16 The Administrators Of The Tulane Educational Fund Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith
WO2014153674A1 (en) * 2013-03-28 2014-10-02 Medicago Inc. Influenza virus-like particle production in plants
CN105980561B (zh) 2014-01-10 2020-06-02 莫迪卡戈公司 Cpmv增强子元件
CN103740655A (zh) * 2014-01-20 2014-04-23 瑞鑫百奥生物科技（深圳）有限公司 H5n1禽流感病毒样颗粒及其应用和制备方法、疫苗
AU2015234595B2 (en) 2014-03-27 2021-03-25 Medicago Inc. Modified CPMV enhancer elements
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
CN106559986A (zh) * 2014-06-20 2017-04-05 美国政府(由卫生和人类服务部的部长所代表) 多价流感病毒样颗粒(vlp)及其作为疫苗的用途
US10494613B2 (en) 2015-08-28 2019-12-03 Wisconsin Alumni Research Foundation (Warf) Generation of infectious influenza viruses from virus-like particles
RU2639491C2 (ru) * 2015-08-31 2017-12-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Вирионы и вирусоподобные частицы вируса мозаики альтернантеры как усилители иммунного ответа
EP3445398A4 (en) * 2016-04-18 2020-04-01 Emerging Viral Vaccine (HK) Limited LIVE ATTENUATED VACCINE WITHOUT VIRULENCE FACTOR AND SUITABLE FOR COLD SUITABLE FOR MUCOSAL ADMINISTRATION
CN107353328A (zh) * 2017-08-23 2017-11-17 上海市动物疫病预防控制中心 一种重组的h9n2亚型禽流感病毒样颗粒及其制备方法和用途
CN110240634B (zh) * 2018-03-08 2022-09-06 普莱柯生物工程股份有限公司 一种禽流感病毒样颗粒疫苗、及其制备方法和应用
CN108409842A (zh) * 2018-03-15 2018-08-17 山东省农业科学院畜牧兽医研究所 一种单克隆抗体及其制备方法
US11851648B2 (en) 2019-02-08 2023-12-26 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
WO2021041624A2 (en) 2019-08-27 2021-03-04 Yoshihiro Kawaoka Recombinant influenza viruses with stabilized ha for replication in eggs
KR102151962B1 (ko) * 2020-03-24 2020-09-04 안병철 어린 포유동물의 전염성 질병을 예방 또는 치료하기 위한 혈청 조성물의 제조방법, 상기 방법에 의해 제조된 혈청 조성물 및 이의 용도
BR112022018160A2 (pt) * 2020-03-24 2022-10-25 Byung Chul Ahn Método de produção de composição de soro para prevenir ou tratar doenças infecciosas relacionadas à mucosa em mamíferos jovens, composição de soro produzida por ele, e uso da mesma
CN113461786B (zh) * 2020-03-30 2022-09-13 普莱柯生物工程股份有限公司 一种禽流感病毒样颗粒疫苗、及其制备方法和应用
AU2021262999A1 (en) 2020-05-01 2023-01-19 Sinocelltech Ltd. Method for improving immunogenicity of protein/peptide antigen
CN112342149A (zh) * 2020-11-12 2021-02-09 新疆畜牧科学院兽医研究所（新疆畜牧科学院动物临床医学研究中心） 一种禽流感病毒样颗粒组装表达系统及其应用
CN112979796A (zh) * 2021-04-27 2021-06-18 军事科学院军事医学研究院军事兽医研究所 马抗甲型h5n1虎源流感病毒免疫球蛋白和特异性免疫球蛋白及其精制方法
CN113862284B (zh) * 2021-09-13 2023-05-26 华南农业大学 一种编码重组禽流感病毒ha蛋白的基因、病毒样颗粒、疫苗及制备与应用
CN114262720B (zh) * 2021-12-27 2023-07-25 河南兴华生物技术有限公司 杆状病毒表达系统的信号肽及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866034A (en) 1982-05-26 1989-09-12 Ribi Immunochem Research Inc. Refined detoxified endotoxin
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4911928A (en) 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
US6387373B1 (en) 1993-01-15 2002-05-14 Novavax, Inc. Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants
US5629021A (en) 1995-01-31 1997-05-13 Novavax, Inc. Micellar nanoparticles
BRPI0111830B8 (pt) * 2000-06-23 2021-05-25 American Cyanamid Co método de produção de partículas semelhantes ao vírus da influenza (vlps), vlps da influenza, vlps quiméricas, composições imunogênica e farmacêutica, e, usos de vlps da influenza e de vlps quiméricas
WO2003068163A2 (en) 2002-02-14 2003-08-21 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
US8592197B2 (en) * 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)

Also Published As

Publication number Publication date
CN101325966A (zh) 2008-12-17
AU2006304640A1 (en) 2007-04-26
EP1937301A2 (en) 2008-07-02
TWI488968B (zh) 2015-06-21
CA2625406A1 (en) 2007-04-26
JP5714799B2 (ja) 2015-05-07
IL190775A0 (en) 2008-11-03
JP2012157367A (ja) 2012-08-23
EP1937301B1 (en) 2015-04-22
CN101325966B (zh) 2014-04-09
NZ567164A (en) 2012-06-29
CN103865892B (zh) 2017-04-12
WO2007047831A2 (en) 2007-04-26
WO2007047831A3 (en) 2007-07-19
PL1937301T3 (pl) 2015-10-30
JP2016135142A (ja) 2016-07-28
IL190775A (en) 2016-04-21
HK1121687A1 (zh) 2009-04-30
BRPI0617486A2 (pt) 2011-07-26
EP1937301A4 (en) 2009-06-24
RU2008119501A (ru) 2009-11-27
PT1937301E (pt) 2015-09-14
JP5771558B2 (ja) 2015-09-02
SI1937301T1 (sl) 2015-08-31
AU2006304640B2 (en) 2012-10-11
CA2625406C (en) 2016-08-09
JP2017189178A (ja) 2017-10-19
RU2483751C2 (ru) 2013-06-10
JP2009511084A (ja) 2009-03-19
ES2543056T3 (es) 2015-08-14
SG2014012868A (en) 2014-09-26
JP2015083018A (ja) 2015-04-30
DK1937301T3 (en) 2015-07-20
CN103865892A (zh) 2014-06-18
KR101359723B1 (ko) 2014-02-05
KR20080081901A (ko) 2008-09-10
HUE026136T2 (en) 2016-05-30

Similar Documents

Publication Publication Date Title
TW200732476A (en) Functional influenza virus like particles (VLPs)
WO2008061243A3 (en) Respiratory syncytial virus-virus like particle (vlps)
WO2017136575A8 (en) Compositions of influenza hemagglutinin with heterologous epitopes and/or altered maturation cleavage sites
WO2008103819A3 (en) Chimeric newcastle disease virus vlps
WO2006113214A3 (en) Vaccine against pandemic strains of influenza viruses
MX2021001053A (es) Vacunas contra virus de la influenza y sus usos.
CO6480995A2 (es) Construcciones novedosas de proteina del virus de pailoma humano (hpv) y su uso en la prevencion de la enfermedad por el hpv
MX341842B (es) Virus de la influenza capaces de infectar canidos y usos de los mismos.
WO2009026397A3 (en) Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods
WO2007095318A3 (en) Influenza antigens, vaccine compositions, and related methods
MX342639B (es) Virus de la influenza recombinantes de alta titulacion para vacunas y terapia genica.
TW200801187A (en) Chimeric viruses presenting non-native surface proteins and uses thereof
RS53723B1 (en) HUMAN VIRUS VIRUS, ASSOCIATED WITH ITS PREPARATION AND PROCEDURES
WO2008148104A8 (en) Novel vlps derived from cells that do not express a viral matrix or core protein
PH12017500450A1 (en) Flavivirus virus like particle
PH12015000376A1 (en) Hand, foot, and mouth vaccines and methods of manufacture and use thereof
NZ739260A (en) Inactivated canine influenza vaccines and methods of making and uses thereof
PH12020500569A1 (en) Influenza virus vaccines and uses thereof
EA201290897A1 (ru) Вакцины для пандемического гриппа
MX2020011586A (es) Virus vaccinia quimerico sintetico.
WO2020109780A3 (en) Polypeptide and uses thereof
GB2429711A (en) Heart and skeletal muscle inflammation (HSMI) virus
MX2018000023A (es) Particulas semejantes a virus recombinantes que utilizan la proteina gag del virus de inmunodeficiencia bovina.
WO2012058493A3 (en) Recombinant hemagglutinin protein of influenza virus and vaccine containing the same
MX2016009747A (es) Vacunas contra el reovirus aviar.