WO2020109780A3 - Polypeptide and uses thereof - Google Patents

Polypeptide and uses thereof Download PDF

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Publication number
WO2020109780A3
WO2020109780A3 PCT/GB2019/053341 GB2019053341W WO2020109780A3 WO 2020109780 A3 WO2020109780 A3 WO 2020109780A3 GB 2019053341 W GB2019053341 W GB 2019053341W WO 2020109780 A3 WO2020109780 A3 WO 2020109780A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
birds
polypeptide
nucleotides
polypeptides
Prior art date
Application number
PCT/GB2019/053341
Other languages
French (fr)
Other versions
WO2020109780A2 (en
Inventor
Mike MCGREW
Helen Sang
Alewo ISAIAH IDOKO-AKOH
Wendy BARCLAY
Jason Long
Original Assignee
The University Court Of The University Of Edinburgh
Imperial College Of Science, Technology And Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Court Of The University Of Edinburgh, Imperial College Of Science, Technology And Medicine filed Critical The University Court Of The University Of Edinburgh
Publication of WO2020109780A2 publication Critical patent/WO2020109780A2/en
Publication of WO2020109780A3 publication Critical patent/WO2020109780A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • C12N2760/16152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to genome modified birds adapted to be resistant to influenza virus infection, methods of generating such birds, and nucleotides and polypeptides for use in such methods
PCT/GB2019/053341 2018-11-26 2019-11-26 Polypeptide and uses thereof WO2020109780A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1819200.5A GB201819200D0 (en) 2018-11-26 2018-11-26 Polypeptide and uses thereof
GB1819200.5 2018-11-26

Publications (2)

Publication Number Publication Date
WO2020109780A2 WO2020109780A2 (en) 2020-06-04
WO2020109780A3 true WO2020109780A3 (en) 2020-07-16

Family

ID=65024662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2019/053341 WO2020109780A2 (en) 2018-11-26 2019-11-26 Polypeptide and uses thereof

Country Status (2)

Country Link
GB (1) GB201819200D0 (en)
WO (1) WO2020109780A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115975001A (en) * 2018-03-02 2023-04-18 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） Application of ANP32 protein in maintaining activity of influenza virus polymerase in host
CN117042600A (en) * 2020-11-16 2023-11-10 猪改良英国有限公司 Anti-influenza a animals with edited ANP32 gene
CN113336829B (en) * 2021-05-08 2023-10-20 武汉大学 ANP32A targeted anti-leukemia small molecular peptide and preparation method and application thereof
WO2023150503A2 (en) * 2022-02-01 2023-08-10 Abs Global, Inc. Gene-editing methods for embryonic stem cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019165957A1 (en) * 2018-03-02 2019-09-06 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） Use of anp32 protein in maintaining influenza virus polymerase activity in host

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019165957A1 (en) * 2018-03-02 2019-09-06 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） Use of anp32 protein in maintaining influenza virus polymerase activity in host

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE Protein [online] 21 September 2015 (2015-09-21), "Pseudopodoces humilis (Tibetan ground jay) (Podoces humilis), Leucine-rich repeat, U2A'/phosphoprotein 32 family A, Leucine-rich repeat domain superfamily", XP002797519, retrieved from NCBI Database accession no. XP_005521718 *
DATABASE Protein [online] 21 September 2015 (2015-09-21), "Zonotrichia albicollis (White-throated sparrow), Leucine-rich repeat, U2A'/phosphoprotein 32 family A, Leucine-rich repeat domain superfamily", XP002797518, retrieved from NCBI Database accession no. XP_014130458 *
FONG LOOI ET AL: "Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza?", VIRUSES, vol. 10, no. 10, 15 October 2018 (2018-10-15), pages 561, XP055666959, DOI: 10.3390/v10100561 *
JASON S. LONG ET AL: "Species difference in ANP32A underlies influenza A virus polymerase host restriction", NATURE, vol. 529, no. 7584, 1 January 2016 (2016-01-01), London, pages 101 - 104, XP055634819, ISSN: 0028-0836, DOI: 10.1038/nature16474 *
TIM DORAN ET AL: "Genome editing in poultry - opportunities and impacts", NATIONAL INSTITUTES OF BIOSCIENCE JOURNAL, vol. 1, no. 0, 15 March 2017 (2017-03-15), XP055500987, DOI: 10.2218/natlinstbiosci.1.2016.1742 *

Also Published As

Publication number Publication date
GB201819200D0 (en) 2019-01-09
WO2020109780A2 (en) 2020-06-04

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