TR201901647T4 - Saflaştırılmış ansamitosinlerin hazırlanmasına yönelik proses. - Google Patents
Saflaştırılmış ansamitosinlerin hazırlanmasına yönelik proses. Download PDFInfo
- Publication number
- TR201901647T4 TR201901647T4 TR2019/01647T TR201901647T TR201901647T4 TR 201901647 T4 TR201901647 T4 TR 201901647T4 TR 2019/01647 T TR2019/01647 T TR 2019/01647T TR 201901647 T TR201901647 T TR 201901647T TR 201901647 T4 TR201901647 T4 TR 201901647T4
- Authority
- TR
- Turkey
- Prior art keywords
- ansamitocin
- purified
- preparation
- enamitocin
- crude
- Prior art date
Links
- PVNFMCBFDPTNQI-UIBOPQHZSA-N [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] acetate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 3-methylbutanoate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-methylpropanoate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] propanoate Chemical compound CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(C)=O)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2.CCC(=O)O[C@H]1CC(=O)N(C)c2cc(C\C(C)=C\C=C\[C@@H](OC)[C@@]3(O)C[C@H](OC(=O)N3)[C@@H](C)C3O[C@@]13C)cc(OC)c2Cl.CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)C(C)C)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2.CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)CC(C)C)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2 PVNFMCBFDPTNQI-UIBOPQHZSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/037,104 US7432088B2 (en) | 2003-05-08 | 2005-01-19 | Methods for the production of ansamitocins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201901647T4 true TR201901647T4 (tr) | 2019-02-21 |
Family
ID=36692550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/01647T TR201901647T4 (tr) | 2005-01-19 | 2005-12-12 | Saflaştırılmış ansamitosinlerin hazırlanmasına yönelik proses. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7432088B2 (enExample) |
| EP (2) | EP2514828B1 (enExample) |
| JP (1) | JP5106120B2 (enExample) |
| KR (3) | KR20120099734A (enExample) |
| CN (2) | CN101103120A (enExample) |
| AU (1) | AU2005325166B2 (enExample) |
| BR (1) | BRPI0519624B8 (enExample) |
| CA (2) | CA2595024C (enExample) |
| CR (1) | CR9228A (enExample) |
| CY (1) | CY1121372T1 (enExample) |
| DK (1) | DK2514828T3 (enExample) |
| EA (1) | EA012524B1 (enExample) |
| ES (1) | ES2710875T3 (enExample) |
| HK (1) | HK1211985A1 (enExample) |
| HU (1) | HUE042312T2 (enExample) |
| IL (2) | IL183918A (enExample) |
| LT (1) | LT2514828T (enExample) |
| MX (1) | MX2007008069A (enExample) |
| NO (1) | NO342876B1 (enExample) |
| NZ (2) | NZ583446A (enExample) |
| PL (1) | PL2514828T3 (enExample) |
| PT (1) | PT2514828T (enExample) |
| SG (1) | SG158905A1 (enExample) |
| SI (1) | SI2514828T1 (enExample) |
| TR (1) | TR201901647T4 (enExample) |
| WO (1) | WO2006078368A1 (enExample) |
| ZA (1) | ZA200704918B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE446317T1 (de) | 2001-05-11 | 2009-11-15 | Ludwig Inst For Cancer Res Ltd | Spezifische bindungsproteine und ihre verwendung |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| WO2007044576A1 (en) * | 2005-10-07 | 2007-04-19 | Steward Environmental Solutions, Llc | Method to remove an agent using a magnetic carrier |
| US20070135629A1 (en) * | 2005-12-08 | 2007-06-14 | Millennium Pharmaceuticals, Inc. | Isolation of ansamitocins |
| EP2046470A2 (en) * | 2006-07-10 | 2009-04-15 | Sicor, Inc. | Apparatus for the separation of a resin from a reaction mixture |
| CN100420754C (zh) * | 2006-10-26 | 2008-09-24 | 浙江海正药业股份有限公司 | 一种制备蒽莎姆菌素的方法 |
| CN101711284A (zh) | 2007-01-25 | 2010-05-19 | 达娜-法勃肿瘤研究所 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| ES2542152T3 (es) | 2007-03-15 | 2015-07-31 | Ludwig Institute For Cancer Research Ltd. | Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas |
| JP5469600B2 (ja) | 2007-07-16 | 2014-04-16 | ジェネンテック， インコーポレイテッド | 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法 |
| SG183044A1 (en) | 2007-07-16 | 2012-08-30 | Genentech Inc | Humanized anti-cd79b antibodies and immunoconjugatesand methods of use |
| WO2009023265A1 (en) | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
| UA106586C2 (uk) | 2008-01-31 | 2014-09-25 | Дженентек, Інк. | Анти-cd79b антитіла, і імунокон'югати та способи їх застосування |
| KR20160125535A (ko) | 2008-03-18 | 2016-10-31 | 제넨테크, 인크. | 항-ｈｅｒ２ 항체-약물 접합체와 화학요법제의 병용물, 및 사용 방법 |
| CN101319241B (zh) * | 2008-07-17 | 2011-03-30 | 上海交通大学 | 安丝菌素的固体发酵方法 |
| BRPI1012676A2 (pt) | 2009-04-01 | 2016-04-05 | Genentech Inc | anticorpos anti-fcrh5 e imunoconjugados e métodos de uso |
| AR079256A1 (es) | 2009-12-04 | 2012-01-04 | Genentech Inc | Metodo para el tratamiento del cancer de mama metastasico con trastuzumab-mcc-dm1 |
| CN101921817A (zh) * | 2010-09-07 | 2010-12-22 | 上海交通大学 | 安莎霉素发酵产量提高方法 |
| CA2816426A1 (en) | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
| US8852435B2 (en) * | 2011-11-29 | 2014-10-07 | Therapeutics Proteins International, LLC | Purification and separation treatment assembly (PASTA) for biological products |
| CN103255184B (zh) * | 2012-02-15 | 2016-01-27 | 百奥泰生物科技(广州)有限公司 | 生产安丝菌素的发酵培养基 |
| CN103805648B (zh) * | 2012-11-13 | 2017-09-15 | 百奥泰生物科技(广州)有限公司 | 高产安丝菌素发酵工艺 |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| TWI541022B (zh) | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法 |
| TW201711702A (zh) | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法 |
| CN113607945B (zh) | 2015-07-07 | 2025-01-28 | 豪夫迈·罗氏有限公司 | 抗HER2抗体-药物缀合物和Bcl-2抑制剂的组合疗法 |
| CN105907681B (zh) * | 2016-05-30 | 2019-11-19 | 苏州康聚生物科技有限公司 | 一种高产安丝菌素p-3的突变株及安丝菌素p-3的制备方法 |
| CN110234348B (zh) | 2016-12-16 | 2024-06-25 | 蓝鳍生物医药公司 | 抗-含cub结构域蛋白1(cdcp1)抗体、抗体药物缀合物及其使用方法 |
| CN108276427A (zh) * | 2018-01-14 | 2018-07-13 | 常州大学 | 一种安丝菌素p-3的提取与分离纯化方法 |
| CN108330113B (zh) * | 2018-03-08 | 2019-05-28 | 山东省医药生物技术研究中心（山东省病毒研究所） | 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用 |
| CN113444106A (zh) * | 2020-03-25 | 2021-09-28 | 重庆乾泰生物医药有限公司 | 一种高纯度安丝菌素的制备方法 |
| CN112630368A (zh) * | 2020-12-18 | 2021-04-09 | 卓和药业集团有限公司 | 安丝菌素含量的高效液相色谱检测分析方法 |
| CN117597450A (zh) * | 2021-06-18 | 2024-02-23 | 杭州中美华东制药有限公司 | 安丝菌素p-3的提纯方法 |
| CN115477658A (zh) * | 2022-10-12 | 2022-12-16 | 道中道（菏泽）制药有限公司 | 一种有效降低安丝菌素p-3杂质的结晶方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2241418A1 (de) | 1972-08-23 | 1974-03-07 | S Morris Kupchan | Antileukaemische ansamakrolide |
| US4162940A (en) | 1977-03-31 | 1979-07-31 | Takeda Chemical Industries, Ltd. | Method for producing Antibiotic C-15003 by culturing nocardia |
| JPS53130495A (en) * | 1977-04-01 | 1978-11-14 | Takeda Chem Ind Ltd | Antibiotic substance c-15003 |
| JPS6034556B2 (ja) * | 1977-03-31 | 1985-08-09 | 武田薬品工業株式会社 | 抗生物質ｃ−１５００３ |
| JPS6010718B2 (ja) | 1977-03-31 | 1985-03-19 | 武田薬品工業株式会社 | メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法 |
| JPS53124692A (en) | 1977-04-01 | 1978-10-31 | Takeda Chem Ind Ltd | Preparation of maytansinol, maytansine, and maytansinol, propionate |
| US4151042A (en) * | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| JPS6016236B2 (ja) | 1977-11-18 | 1985-04-24 | 武田薬品工業株式会社 | 抗生物質ｃ―１５００３ ｐ―３の製造法 |
| US4307016A (en) * | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| JPS5529972A (en) | 1978-08-24 | 1980-03-03 | Takeda Chem Ind Ltd | Preparation of maytansinol |
| JPS55102583A (en) * | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) * | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JPS56102793A (en) * | 1979-12-28 | 1981-08-17 | Takeda Chem Ind Ltd | Preparation of antibiotic c-15003 p-3 |
| JPS57192389A (en) * | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| CA2006408A1 (en) | 1988-12-27 | 1990-06-27 | Susumu Iwasa | Bispecific monoclonal antibody, its production and use |
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| DE10012120A1 (de) | 2000-03-13 | 2001-09-27 | Ktb Tumorforschungs Gmbh | Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel |
| US6573074B2 (en) * | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
| WO2001095943A2 (en) | 2000-06-14 | 2001-12-20 | Medarex, Inc. | Prodrug compounds with an oligopeptide having an isoleucine residue |
| US6333410B1 (en) * | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US20020156274A1 (en) * | 2001-03-16 | 2002-10-24 | Terfloth Gerald J. | Process for preparing maytansinol |
| US6441163B1 (en) * | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US6790954B2 (en) * | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
| WO2005020883A2 (en) * | 2003-05-08 | 2005-03-10 | Immunogen, Inc. | Methods for the production of ansamitocins |
| US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
-
2005
- 2005-01-19 US US11/037,104 patent/US7432088B2/en not_active Expired - Lifetime
- 2005-12-12 DK DK12002069.8T patent/DK2514828T3/en active
- 2005-12-12 CN CNA2005800468716A patent/CN101103120A/zh active Pending
- 2005-12-12 EA EA200701310A patent/EA012524B1/ru not_active IP Right Cessation
- 2005-12-12 PT PT12002069T patent/PT2514828T/pt unknown
- 2005-12-12 AU AU2005325166A patent/AU2005325166B2/en not_active Expired
- 2005-12-12 KR KR1020127016486A patent/KR20120099734A/ko not_active Ceased
- 2005-12-12 HU HUE12002069A patent/HUE042312T2/hu unknown
- 2005-12-12 NZ NZ583446A patent/NZ583446A/en unknown
- 2005-12-12 CA CA2595024A patent/CA2595024C/en not_active Expired - Lifetime
- 2005-12-12 PL PL12002069T patent/PL2514828T3/pl unknown
- 2005-12-12 SI SI200532244T patent/SI2514828T1/sl unknown
- 2005-12-12 KR KR1020077014650A patent/KR20070099576A/ko not_active Ceased
- 2005-12-12 SG SG201000399-4A patent/SG158905A1/en unknown
- 2005-12-12 ES ES12002069T patent/ES2710875T3/es not_active Expired - Lifetime
- 2005-12-12 EP EP12002069.8A patent/EP2514828B1/en not_active Expired - Lifetime
- 2005-12-12 KR KR1020137010509A patent/KR101515873B1/ko not_active Expired - Lifetime
- 2005-12-12 CA CA2834033A patent/CA2834033C/en not_active Expired - Lifetime
- 2005-12-12 MX MX2007008069A patent/MX2007008069A/es active IP Right Grant
- 2005-12-12 EP EP05853651A patent/EP1838863A4/en not_active Withdrawn
- 2005-12-12 WO PCT/US2005/044783 patent/WO2006078368A1/en not_active Ceased
- 2005-12-12 NZ NZ555437A patent/NZ555437A/en unknown
- 2005-12-12 BR BRPI0519624A patent/BRPI0519624B8/pt active IP Right Grant
- 2005-12-12 ZA ZA200704918A patent/ZA200704918B/xx unknown
- 2005-12-12 JP JP2007552126A patent/JP5106120B2/ja not_active Expired - Lifetime
- 2005-12-12 LT LTEP12002069.8T patent/LT2514828T/lt unknown
- 2005-12-12 TR TR2019/01647T patent/TR201901647T4/tr unknown
- 2005-12-12 CN CN201510127907.9A patent/CN104745655A/zh active Pending
-
2007
- 2007-06-14 IL IL183918A patent/IL183918A/en active IP Right Grant
- 2007-07-04 CR CR9228A patent/CR9228A/es unknown
- 2007-08-17 NO NO20074222A patent/NO342876B1/no unknown
-
2011
- 2011-10-10 IL IL215686A patent/IL215686A/en active IP Right Grant
-
2015
- 2015-12-29 HK HK15112783.9A patent/HK1211985A1/xx unknown
-
2019
- 2019-02-13 CY CY20191100195T patent/CY1121372T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR201901647T4 (tr) | Saflaştırılmış ansamitosinlerin hazırlanmasına yönelik proses. | |
| WO2009062119A3 (en) | Microorganisms and methods for increased hydrogen production | |
| CY1109428T1 (el) | Μεθοδοι για το διαχωρισμο της μοδαφινιλης | |
| WO2010002693A3 (en) | Systems and methods for producing oil and/or gas | |
| BRPI0613543B8 (pt) | Método para produção de 1,3-propanodiol usando glicerol bruto, um subproduto da produção de biodiesel | |
| HUP0402444A2 (en) | Process for enhancing the biogas production of thermophyl anaerobic fermenter | |
| MX2007010716A (es) | Purificacion de rapamicina. | |
| EA201001010A1 (ru) | Способ превращения спирта (спиртов) в спирт (спирты) с более длинной углеродной цепью | |
| WO2010058427A3 (en) | Process for production and purification of polymyxin b sulfate | |
| WO2009076948A3 (de) | Reduktone zur erzeugung von biogas | |
| IL184041A0 (en) | Enzymatic transformation of a prostaglandin (bimatoprost) intermediate | |
| EP2099734A4 (en) | PROCESS FOR THE PRODUCTION OF MONO-IODE BENZOLE BY TRANSIODINATION | |
| TW200728310A (en) | Process for the preparation of ferri-succinylcasein | |
| PL1692256T3 (pl) | Fermentor wielkowymiarowy do wytwarzania biogazu z biomasy | |
| WO2007080470A3 (en) | A method for the purification of levetiracetam | |
| EA201070087A1 (ru) | СПОСОБ СИНТЕЗА 9α-ГИДРОКСИСТЕРОИДОВ | |
| EP2186886B8 (en) | Process for production of purified lipase | |
| TW200728267A (en) | Processes and intermediates for the preparation of prostaglandins | |
| MY161959A (en) | Continuous production of high purity carbon dioxide | |
| ITMI20052430A1 (it) | Nessuna | |
| TW200745341A (en) | A method for preparing cercosporamide | |
| MX2009014191A (es) | Procedimiento para la preparacion de derivados de dioxazina. | |
| EA200701105A1 (ru) | Способ получения высоких уровней интерферона-бета | |
| WO2006105843A3 (de) | Verfahren zur herstellung von rhamnose und aglyconen durch die spaltung von rutinosiden unter verwendung von hefen | |
| SI1711468T1 (sl) | Postopek za pripravo očiščenega ciprofloksacina |