BRPI0519624A2 - processos para produÇço de ansamitocinas - Google Patents

processos para produÇço de ansamitocinas

Info

Publication number
BRPI0519624A2
BRPI0519624A2 BRPI0519624-8A BRPI0519624A BRPI0519624A2 BR PI0519624 A2 BRPI0519624 A2 BR PI0519624A2 BR PI0519624 A BRPI0519624 A BR PI0519624A BR PI0519624 A2 BRPI0519624 A2 BR PI0519624A2
Authority
BR
Brazil
Prior art keywords
production
processes
anthamytocin
ansamitocins
ansamytocins
Prior art date
Application number
BRPI0519624-8A
Other languages
English (en)
Inventor
Cynthia Kuo
Graham S Byng
Wayne C Widdison
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36692550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0519624(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of BRPI0519624A2 publication Critical patent/BRPI0519624A2/pt
Publication of BRPI0519624B1 publication Critical patent/BRPI0519624B1/pt
Publication of BRPI0519624B8 publication Critical patent/BRPI0519624B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCESSOS PARA PRODUÇçO DE ANSAMITOCINAS. A presente invenção refere-se a um processo de fermentação em larga escala de cepas altamente produtivas na produção de Ansamitocinas. Um método para isolar Ansamitocinas brutas. Um método para purificar Ansamitocinas.
BRPI0519624A 2005-01-19 2005-12-12 processo para preparação de ansamitocinas purificadas BRPI0519624B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/037,104 US7432088B2 (en) 2003-05-08 2005-01-19 Methods for the production of ansamitocins
US11/037,104 2005-01-19
PCT/US2005/044783 WO2006078368A1 (en) 2005-01-19 2005-12-12 Methods for the production of ansamitocins

Publications (3)

Publication Number Publication Date
BRPI0519624A2 true BRPI0519624A2 (pt) 2009-02-25
BRPI0519624B1 BRPI0519624B1 (pt) 2021-01-19
BRPI0519624B8 BRPI0519624B8 (pt) 2021-05-25

Family

ID=36692550

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519624A BRPI0519624B8 (pt) 2005-01-19 2005-12-12 processo para preparação de ansamitocinas purificadas

Country Status (27)

Country Link
US (1) US7432088B2 (pt)
EP (2) EP1838863A4 (pt)
JP (1) JP5106120B2 (pt)
KR (3) KR20070099576A (pt)
CN (2) CN104745655A (pt)
AU (1) AU2005325166B2 (pt)
BR (1) BRPI0519624B8 (pt)
CA (2) CA2595024C (pt)
CR (1) CR9228A (pt)
CY (1) CY1121372T1 (pt)
DK (1) DK2514828T3 (pt)
EA (1) EA012524B1 (pt)
ES (1) ES2710875T3 (pt)
HK (1) HK1211985A1 (pt)
HU (1) HUE042312T2 (pt)
IL (2) IL183918A (pt)
LT (1) LT2514828T (pt)
MX (1) MX2007008069A (pt)
NO (1) NO342876B1 (pt)
NZ (2) NZ583446A (pt)
PL (1) PL2514828T3 (pt)
PT (1) PT2514828T (pt)
SG (1) SG158905A1 (pt)
SI (1) SI2514828T1 (pt)
TR (1) TR201901647T4 (pt)
WO (1) WO2006078368A1 (pt)
ZA (1) ZA200704918B (pt)

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WO2007067698A2 (en) * 2005-12-08 2007-06-14 Millennium Pharmaceuticals, Inc. Isolation of ansamitocins
EP2046470A2 (en) * 2006-07-10 2009-04-15 Sicor, Inc. Apparatus for the separation of a resin from a reaction mixture
CN100420754C (zh) * 2006-10-26 2008-09-24 浙江海正药业股份有限公司 一种制备蒽莎姆菌素的方法
WO2008091701A2 (en) 2007-01-25 2008-07-31 Dana-Farber Cancer Institute Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
JP5618549B2 (ja) 2007-03-15 2014-11-05 ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤
JP2010533495A (ja) 2007-07-16 2010-10-28 ジェネンテック， インコーポレイテッド ヒト化ＣＤ７９ｂ抗体およびイムノコンジュゲートならびにそれらの使用
PT2176296E (pt) 2007-07-16 2012-05-14 Genentech Inc Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
JP5532486B2 (ja) 2007-08-14 2014-06-25 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途
MY157403A (en) 2008-01-31 2016-06-15 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
ES2545977T3 (es) 2008-03-18 2015-09-17 Genentech, Inc. Combinaciones de un conjugado de anticuerpo-fármaco anti-HER2 y agentes quimioterapéuticos, y métodos de uso
CN101319241B (zh) * 2008-07-17 2011-03-30 上海交通大学 安丝菌素的固体发酵方法
JP6132548B2 (ja) 2009-04-01 2017-05-24 ジェネンテック， インコーポレイテッド 抗ＦｃＲＨ５抗体および免疫接合体および使用方法
AR079256A1 (es) 2009-12-04 2012-01-04 Genentech Inc Metodo para el tratamiento del cancer de mama metastasico con trastuzumab-mcc-dm1
CN101921817A (zh) * 2010-09-07 2010-12-22 上海交通大学 安莎霉素发酵产量提高方法
CA2816426A1 (en) 2010-11-17 2012-06-07 Genentech, Inc. Alaninyl maytansinol antibody conjugates
US8852435B2 (en) * 2011-11-29 2014-10-07 Therapeutics Proteins International, LLC Purification and separation treatment assembly (PASTA) for biological products
CN103255184B (zh) * 2012-02-15 2016-01-27 百奥泰生物科技(广州)有限公司 生产安丝菌素的发酵培养基
CN103805648B (zh) * 2012-11-13 2017-09-15 百奥泰生物科技(广州)有限公司 高产安丝菌素发酵工艺
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
TWI541022B (zh) 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
TW201711702A (zh) 2015-06-04 2017-04-01 應克隆公司 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
HUE044139T2 (hu) 2015-07-07 2019-09-30 Hoffmann La Roche Kombinált terápia egy HER2-ellenes antitest-gyógyszer konjugátummal és bcl-2 inhibitorral
CN105907681B (zh) * 2016-05-30 2019-11-19 苏州康聚生物科技有限公司 一种高产安丝菌素p-3的突变株及安丝菌素p-3的制备方法
CN108276427A (zh) * 2018-01-14 2018-07-13 常州大学 一种安丝菌素p-3的提取与分离纯化方法
CN108330113B (zh) * 2018-03-08 2019-05-28 山东省医药生物技术研究中心（山东省病毒研究所） 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用
CN113444106A (zh) * 2020-03-25 2021-09-28 重庆乾泰生物医药有限公司 一种高纯度安丝菌素的制备方法
CN112630368A (zh) * 2020-12-18 2021-04-09 卓和药业集团有限公司 安丝菌素含量的高效液相色谱检测分析方法
CN117597450A (zh) * 2021-06-18 2024-02-23 杭州中美华东制药有限公司 安丝菌素p-3的提纯方法
CN115477658A (zh) * 2022-10-12 2022-12-16 道中道（菏泽）制药有限公司 一种有效降低安丝菌素p-3杂质的结晶方法

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Also Published As

Publication number Publication date
MX2007008069A (es) 2007-08-21
US20050170475A1 (en) 2005-08-04
CA2595024C (en) 2014-02-04
KR20130051019A (ko) 2013-05-16
EP2514828A3 (en) 2013-07-03
CN104745655A (zh) 2015-07-01
BRPI0519624B1 (pt) 2021-01-19
PL2514828T3 (pl) 2019-04-30
EP1838863A4 (en) 2011-10-05
NZ555437A (en) 2010-04-30
SI2514828T1 (sl) 2019-03-29
IL183918A0 (en) 2007-10-31
ZA200704918B (en) 2008-11-26
AU2005325166B2 (en) 2012-02-02
ES2710875T3 (es) 2019-04-29
LT2514828T (lt) 2019-02-25
KR20120099734A (ko) 2012-09-11
AU2005325166A1 (en) 2006-07-27
IL183918A (en) 2013-07-31
NZ583446A (en) 2011-08-26
NO342876B1 (no) 2018-08-20
CY1121372T1 (el) 2020-05-29
IL215686A0 (en) 2011-11-30
DK2514828T3 (en) 2019-03-11
EA012524B1 (ru) 2009-10-30
HUE042312T2 (hu) 2019-06-28
SG158905A1 (en) 2010-02-26
CN101103120A (zh) 2008-01-09
BRPI0519624B8 (pt) 2021-05-25
CA2595024A1 (en) 2006-07-27
CA2834033C (en) 2017-01-24
PT2514828T (pt) 2019-02-15
EP2514828A2 (en) 2012-10-24
JP2008526267A (ja) 2008-07-24
TR201901647T4 (tr) 2019-02-21
CA2834033A1 (en) 2006-07-27
CR9228A (es) 2008-03-31
IL215686A (en) 2013-07-31
NO20074222L (no) 2007-10-18
US7432088B2 (en) 2008-10-07
EP2514828B1 (en) 2018-11-14
JP5106120B2 (ja) 2012-12-26
HK1211985A1 (en) 2016-06-03
KR20070099576A (ko) 2007-10-09
EA200701310A1 (ru) 2008-06-30
EP1838863A1 (en) 2007-10-03
WO2006078368A1 (en) 2006-07-27
KR101515873B1 (ko) 2015-04-29

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: REF. A RPI NO 2153 DE 10/04/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO.

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
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