LT2514828T - Išgrynintų ansamitocinų gavimo būdas - Google Patents

Išgrynintų ansamitocinų gavimo būdas

Info

Publication number
LT2514828T
LT2514828T LTEP12002069.8T LT12002069T LT2514828T LT 2514828 T LT2514828 T LT 2514828T LT 12002069 T LT12002069 T LT 12002069T LT 2514828 T LT2514828 T LT 2514828T
Authority
LT
Lithuania
Prior art keywords
preparing purified
purified ansamitocins
ansamitocins
preparing
purified
Prior art date
Application number
LTEP12002069.8T
Other languages
English (en)
Inventor
Wayne C. Widdison
Original Assignee
Immunogen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36692550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2514828(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen, Inc. filed Critical Immunogen, Inc.
Publication of LT2514828T publication Critical patent/LT2514828T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LTEP12002069.8T 2005-01-19 2005-12-12 Išgrynintų ansamitocinų gavimo būdas LT2514828T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/037,104 US7432088B2 (en) 2003-05-08 2005-01-19 Methods for the production of ansamitocins

Publications (1)

Publication Number Publication Date
LT2514828T true LT2514828T (lt) 2019-02-25

Family

ID=36692550

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP12002069.8T LT2514828T (lt) 2005-01-19 2005-12-12 Išgrynintų ansamitocinų gavimo būdas

Country Status (27)

Country Link
US (1) US7432088B2 (lt)
EP (2) EP1838863A4 (lt)
JP (1) JP5106120B2 (lt)
KR (3) KR20120099734A (lt)
CN (2) CN104745655A (lt)
AU (1) AU2005325166B2 (lt)
BR (1) BRPI0519624B8 (lt)
CA (2) CA2834033C (lt)
CR (1) CR9228A (lt)
CY (1) CY1121372T1 (lt)
DK (1) DK2514828T3 (lt)
EA (1) EA012524B1 (lt)
ES (1) ES2710875T3 (lt)
HK (1) HK1211985A1 (lt)
HU (1) HUE042312T2 (lt)
IL (2) IL183918A (lt)
LT (1) LT2514828T (lt)
MX (1) MX2007008069A (lt)
NO (1) NO342876B1 (lt)
NZ (2) NZ555437A (lt)
PL (1) PL2514828T3 (lt)
PT (1) PT2514828T (lt)
SG (1) SG158905A1 (lt)
SI (1) SI2514828T1 (lt)
TR (1) TR201901647T4 (lt)
WO (1) WO2006078368A1 (lt)
ZA (1) ZA200704918B (lt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
ES2552281T3 (es) 2001-05-11 2015-11-26 Ludwig Institute For Cancer Research Ltd. Proteínas de unión específica y usos de las mismas
WO2007044576A1 (en) * 2005-10-07 2007-04-19 Steward Environmental Solutions, Llc Method to remove an agent using a magnetic carrier
US20070135629A1 (en) * 2005-12-08 2007-06-14 Millennium Pharmaceuticals, Inc. Isolation of ansamitocins
US20080023046A1 (en) * 2006-07-10 2008-01-31 Ermenegildo Restelli Apparatus for the separation of a resin from a reaction mixture
CN100420754C (zh) * 2006-10-26 2008-09-24 浙江海正药业股份有限公司 一种制备蒽莎姆菌素的方法
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
MX2009009782A (es) 2007-03-15 2010-09-10 Ludwig Inst Cancer Res Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas.
TW200918089A (en) 2007-07-16 2009-05-01 Genentech Inc Humanized anti-CD79b antibodies and immunoconjugates and methods of use
JP5469600B2 (ja) 2007-07-16 2014-04-16 ジェネンテック， インコーポレイテッド 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法
WO2009023265A1 (en) 2007-08-14 2009-02-19 Ludwig Institute For Cancer Research Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof
SI2657253T1 (sl) 2008-01-31 2017-10-30 Genentech, Inc. Protitelesa proti CD79b in imunokonjugati in postopki za uporabo
DK2644194T3 (en) 2008-03-18 2017-07-03 Genentech Inc Combinations of an anti-HER2 antibody-drug conjugate and docetaxel
CN101319241B (zh) * 2008-07-17 2011-03-30 上海交通大学 安丝菌素的固体发酵方法
AU2010236787A1 (en) 2009-04-01 2011-11-10 Genentech, Inc. Anti-FcRH5 antibodies and immunoconjugates and methods of use
TW201129380A (en) 2009-12-04 2011-09-01 Genentech Inc Methods of treating metastatic breast cancer with trastuzumab-MCC-DM1
CN101921817A (zh) * 2010-09-07 2010-12-22 上海交通大学 安莎霉素发酵产量提高方法
US20120121615A1 (en) 2010-11-17 2012-05-17 Flygare John A Alaninyl maytansinol antibody conjugates
US8852435B2 (en) * 2011-11-29 2014-10-07 Therapeutics Proteins International, LLC Purification and separation treatment assembly (PASTA) for biological products
CN103255184B (zh) * 2012-02-15 2016-01-27 百奥泰生物科技(广州)有限公司 生产安丝菌素的发酵培养基
CN103805648B (zh) * 2012-11-13 2017-09-15 百奥泰生物科技(广州)有限公司 高产安丝菌素发酵工艺
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
TWI541022B (zh) 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
TW201711702A (zh) 2015-06-04 2017-04-01 應克隆公司 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
ES2731377T3 (es) 2015-07-07 2019-11-15 Hoffmann La Roche Politerapia con un conjugado anticuerpo anti-HER2-fármaco y un inhibidor de bcl-2
CN105907681B (zh) * 2016-05-30 2019-11-19 苏州康聚生物科技有限公司 一种高产安丝菌素p-3的突变株及安丝菌素p-3的制备方法
CN108276427A (zh) * 2018-01-14 2018-07-13 常州大学 一种安丝菌素p-3的提取与分离纯化方法
CN108330113B (zh) * 2018-03-08 2019-05-28 山东省医药生物技术研究中心（山东省病毒研究所） 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用
CN113444106A (zh) * 2020-03-25 2021-09-28 重庆乾泰生物医药有限公司 一种高纯度安丝菌素的制备方法
CN112630368A (zh) * 2020-12-18 2021-04-09 卓和药业集团有限公司 安丝菌素含量的高效液相色谱检测分析方法
CN117597450A (zh) * 2021-06-18 2024-02-23 杭州中美华东制药有限公司 安丝菌素p-3的提纯方法
CN115477658A (zh) * 2022-10-12 2022-12-16 道中道（菏泽）制药有限公司 一种有效降低安丝菌素p-3杂质的结晶方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2241418A1 (de) 1972-08-23 1974-03-07 S Morris Kupchan Antileukaemische ansamakrolide
US4162940A (en) 1977-03-31 1979-07-31 Takeda Chemical Industries, Ltd. Method for producing Antibiotic C-15003 by culturing nocardia
JPS6034556B2 (ja) * 1977-03-31 1985-08-09 武田薬品工業株式会社 抗生物質ｃ−１５００３
JPS53124692A (en) 1977-04-01 1978-10-31 Takeda Chem Ind Ltd Preparation of maytansinol, maytansine, and maytansinol, propionate
JPS53130495A (en) * 1977-04-01 1978-11-14 Takeda Chem Ind Ltd Antibiotic substance c-15003
JPS6010718B2 (ja) 1977-03-31 1985-03-19 武田薬品工業株式会社 メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法
US4151042A (en) * 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
US4137230A (en) 1977-11-14 1979-01-30 Takeda Chemical Industries, Ltd. Method for the production of maytansinoids
JPS6016236B2 (ja) 1977-11-18 1985-04-24 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―３の製造法
US4307016A (en) * 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
JPS5529972A (en) 1978-08-24 1980-03-03 Takeda Chem Ind Ltd Preparation of maytansinol
JPS55102583A (en) * 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) * 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS5645483A (en) * 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
JPS56102793A (en) * 1979-12-28 1981-08-17 Takeda Chem Ind Ltd Preparation of antibiotic c-15003 p-3
JPS57192389A (en) * 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
CA2006408A1 (en) 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
US5208020A (en) * 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
DE10012120A1 (de) 2000-03-13 2001-09-27 Ktb Tumorforschungs Gmbh Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel
US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
WO2001095943A2 (en) 2000-06-14 2001-12-20 Medarex, Inc. Prodrug compounds with an oligopeptide having an isoleucine residue
US6333410B1 (en) * 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US20020156274A1 (en) * 2001-03-16 2002-10-24 Terfloth Gerald J. Process for preparing maytansinol
US6441163B1 (en) * 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US6790954B2 (en) * 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production
WO2005020883A2 (en) * 2003-05-08 2005-03-10 Immunogen, Inc. Methods for the production of ansamitocins
US7276497B2 (en) * 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids

Also Published As

Publication number Publication date
SG158905A1 (en) 2010-02-26
KR101515873B1 (ko) 2015-04-29
IL215686A (en) 2013-07-31
JP5106120B2 (ja) 2012-12-26
CA2595024C (en) 2014-02-04
AU2005325166A1 (en) 2006-07-27
AU2005325166B2 (en) 2012-02-02
CA2834033C (en) 2017-01-24
TR201901647T4 (tr) 2019-02-21
HK1211985A1 (en) 2016-06-03
JP2008526267A (ja) 2008-07-24
US20050170475A1 (en) 2005-08-04
PT2514828T (pt) 2019-02-15
CA2595024A1 (en) 2006-07-27
EP2514828A2 (en) 2012-10-24
WO2006078368A1 (en) 2006-07-27
IL183918A (en) 2013-07-31
CA2834033A1 (en) 2006-07-27
CY1121372T1 (el) 2020-05-29
ES2710875T3 (es) 2019-04-29
NZ583446A (en) 2011-08-26
BRPI0519624B8 (pt) 2021-05-25
DK2514828T3 (en) 2019-03-11
SI2514828T1 (sl) 2019-03-29
NO20074222L (no) 2007-10-18
CN104745655A (zh) 2015-07-01
EP2514828A3 (en) 2013-07-03
EP1838863A1 (en) 2007-10-03
ZA200704918B (en) 2008-11-26
IL215686A0 (en) 2011-11-30
NO342876B1 (no) 2018-08-20
MX2007008069A (es) 2007-08-21
EA012524B1 (ru) 2009-10-30
KR20130051019A (ko) 2013-05-16
NZ555437A (en) 2010-04-30
BRPI0519624B1 (pt) 2021-01-19
IL183918A0 (en) 2007-10-31
CN101103120A (zh) 2008-01-09
HUE042312T2 (hu) 2019-06-28
BRPI0519624A2 (pt) 2009-02-25
EP2514828B1 (en) 2018-11-14
KR20070099576A (ko) 2007-10-09
PL2514828T3 (pl) 2019-04-30
EP1838863A4 (en) 2011-10-05
US7432088B2 (en) 2008-10-07
EA200701310A1 (ru) 2008-06-30
KR20120099734A (ko) 2012-09-11
CR9228A (es) 2008-03-31

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