EA201070087A1 - СПОСОБ СИНТЕЗА 9α-ГИДРОКСИСТЕРОИДОВ - Google Patents

СПОСОБ СИНТЕЗА 9α-ГИДРОКСИСТЕРОИДОВ

Info

Publication number
EA201070087A1
EA201070087A1 EA201070087A EA201070087A EA201070087A1 EA 201070087 A1 EA201070087 A1 EA 201070087A1 EA 201070087 A EA201070087 A EA 201070087A EA 201070087 A EA201070087 A EA 201070087A EA 201070087 A1 EA201070087 A1 EA 201070087A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
hydroxysteroids
bioconversion
group
general formula
Prior art date
Application number
EA201070087A
Other languages
English (en)
Other versions
EA015734B1 (ru
Inventor
Каталин Олац
Анико Тегдеш
Валериа Ганчош
Габор Хантош
Кальман Кенцель
Габор Балог
Шандор Эрдейи
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of EA201070087A1 publication Critical patent/EA201070087A1/ru
Publication of EA015734B1 publication Critical patent/EA015734B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

Настоящее изобретение относится к новому селективному способу синтеза производных 9α-гидроксистероида общей формулы (I)где -А-А- представляет собой -СН-СН- или -СН=СН-группу, посредством биоконверсии соединений общей формулы (II)где -А-А- представляет собой -СН-СН- или -СН=СН- группу, посредством использования в качестве гидроксилирующего микроорганизма при биоконверсии штамма бактерии Nocardiafarcinica, депозитарный номер которого представляет собой NCAIM (Р) - В 001342.
EA201070087A 2007-07-04 2008-06-30 СПОСОБ СИНТЕЗА 9α-ГИДРОКСИСТЕРОИДОВ EA015734B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700461A HU227304B1 (en) 2007-07-04 2007-07-04 Process for producing 9alpha-hydroxy-steroids
PCT/HU2008/000078 WO2009004394A2 (en) 2007-07-04 2008-06-30 PROCESS FOR THE SYNTHESIS OF 9α-HYDROXY-STEROIDS

Publications (2)

Publication Number Publication Date
EA201070087A1 true EA201070087A1 (ru) 2010-08-30
EA015734B1 EA015734B1 (ru) 2011-10-31

Family

ID=89987625

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070087A EA015734B1 (ru) 2007-07-04 2008-06-30 СПОСОБ СИНТЕЗА 9α-ГИДРОКСИСТЕРОИДОВ

Country Status (10)

Country Link
US (1) US8367394B2 (ru)
EP (1) EP2173761B1 (ru)
JP (1) JP2010531660A (ru)
KR (1) KR20100038297A (ru)
CN (1) CN101687903A (ru)
CA (1) CA2689422A1 (ru)
EA (1) EA015734B1 (ru)
HU (1) HU227304B1 (ru)
UA (1) UA98151C2 (ru)
WO (1) WO2009004394A2 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103343155B (zh) * 2013-06-26 2015-04-01 山西祖源工贸有限公司 一种制备9a-羟基雄烯二酮的方法
CN103361394B (zh) * 2013-08-07 2016-08-17 中国科学院上海高等研究院 利用微生物转化制备9α-羟基-雄烯二酮的方法
CN108277170B (zh) * 2017-09-29 2020-06-05 沈阳博泰生物制药有限公司 一种新金分枝杆菌及其在制备9-羟基黄体酮中的应用
CN110564652B (zh) * 2019-10-01 2022-06-14 江苏佳尔科药业集团股份有限公司 分枝杆菌及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035236A (en) 1975-10-24 1977-07-12 The Upjohn Company Process for preparing 9α-hydroxyandrostenedione
US4029549A (en) 1976-03-26 1977-06-14 The Upjohn Company Process of producing 9α-hydroxy-3-ketobisnorchol-4-en-22-oic with mycobacterium fortuitum
US4397947A (en) 1981-06-12 1983-08-09 G. D. Searle & Co. Microbial process for 9α-hydroxylation of steroids
DK0973791T3 (da) * 1995-12-11 2007-09-17 Searle Llc Fremgangsmåde til fremstilling af en epoxyforbindelse

Also Published As

Publication number Publication date
KR20100038297A (ko) 2010-04-14
UA98151C2 (ru) 2012-04-25
WO2009004394A8 (en) 2010-01-14
HUP0700461A2 (en) 2010-01-28
US8367394B2 (en) 2013-02-05
HU227304B1 (en) 2011-02-28
WO2009004394A3 (en) 2009-05-07
US20100209967A1 (en) 2010-08-19
HU0700461D0 (en) 2007-08-28
EP2173761B1 (en) 2013-04-10
CN101687903A (zh) 2010-03-31
EA015734B1 (ru) 2011-10-31
CA2689422A1 (en) 2009-01-08
EP2173761A2 (en) 2010-04-14
WO2009004394A2 (en) 2009-01-08
JP2010531660A (ja) 2010-09-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU