TR199801613T2 - Kontrast ajanlarinda ya da bunlarla ilgili iyilestirmeler. - Google Patents

Kontrast ajanlarinda ya da bunlarla ilgili iyilestirmeler.

Info

Publication number
TR199801613T2
TR199801613T2 TR1998/01613T TR9801613T TR199801613T2 TR 199801613 T2 TR199801613 T2 TR 199801613T2 TR 1998/01613 T TR1998/01613 T TR 1998/01613T TR 9801613 T TR9801613 T TR 9801613T TR 199801613 T2 TR199801613 T2 TR 199801613T2
Authority
TR
Turkey
Prior art keywords
contrast agents
microbubbles
stabilized
product
dispersions
Prior art date
Application number
TR1998/01613T
Other languages
English (en)
Inventor
Dugstad Harald
Klaveness Jo
Rongved Pal
Skurtveit Roald
Braenden Jorun
Original Assignee
Nycomed Imaging A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9625663.1A external-priority patent/GB9625663D0/en
Application filed by Nycomed Imaging A/S filed Critical Nycomed Imaging A/S
Publication of TR199801613T2 publication Critical patent/TR199801613T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Fosfolipidlerle stabilize edilmis mikro-kabarcikli dispersiyonlar olup bunlar agirlikli olarak içerdikleri tek tek toplam yüke sahip moleküller sayesinde iyi bir stabilite göstermekte, bu da bu dispersiyonlari etkili kontrast ajanlari olarak yararli hale getirmektedir. Mikrokabarciklar içeren kontrast ajanlarinin üretimi için iyilestirilmis bir islem de açiklanmakta olup bu islemde bir ya da daha fazla zar olusturan lipid ile stabilize edilmis gaz mikro-kabarciklarinin sulu bir dispersiyonu liofilize edilerek kuru bir ürün elde edilmekte, bu ürün enjekte edilebilen bir tasiyici sivi içinde yeniden terkip edilerek mikro-kabarciklar içeren bir kontrast ajani elde edilebilmektedir.
TR1998/01613T 1996-02-19 1997-02-19 Kontrast ajanlarinda ya da bunlarla ilgili iyilestirmeler. TR199801613T2 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9625663.1A GB9625663D0 (en) 1996-12-11 1996-12-11 Improvements in or relating to contrast agents

Publications (1)

Publication Number Publication Date
TR199801613T2 true TR199801613T2 (tr) 1998-11-23

Family

ID=27268137

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01613T TR199801613T2 (tr) 1996-02-19 1997-02-19 Kontrast ajanlarinda ya da bunlarla ilgili iyilestirmeler.

Country Status (25)

Country Link
US (4) US6221337B1 (tr)
EP (2) EP0881915B1 (tr)
JP (1) JP4418033B2 (tr)
KR (1) KR100500334B1 (tr)
CN (1) CN1278740C (tr)
AP (1) AP890A (tr)
AT (1) ATE238072T1 (tr)
AU (1) AU726503B2 (tr)
BG (1) BG102758A (tr)
CA (1) CA2246779C (tr)
CZ (1) CZ293986B6 (tr)
DE (1) DE69721235T2 (tr)
EA (1) EA001135B1 (tr)
EE (1) EE04224B1 (tr)
ES (1) ES2197986T3 (tr)
HK (1) HK1014872A1 (tr)
HU (1) HU229090B1 (tr)
IL (1) IL125748A (tr)
NZ (1) NZ331509A (tr)
OA (1) OA10839A (tr)
PL (1) PL328406A1 (tr)
PT (1) PT881915E (tr)
SK (1) SK284200B6 (tr)
TR (1) TR199801613T2 (tr)
WO (1) WO1997029783A1 (tr)

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Also Published As

Publication number Publication date
CZ262598A3 (cs) 1999-05-12
JP4418033B2 (ja) 2010-02-17
US20050201942A1 (en) 2005-09-15
JP2000511510A (ja) 2000-09-05
AU1884797A (en) 1997-09-02
AP9801319A0 (en) 1998-09-30
HUP9900813A2 (hu) 1999-07-28
DE69721235T2 (de) 2004-02-05
EP1331013A3 (en) 2004-03-24
EP0881915B1 (en) 2003-04-23
OA10839A (en) 2001-08-13
US6221337B1 (en) 2001-04-24
IL125748A0 (en) 1999-04-11
WO1997029783A1 (en) 1997-08-21
EA199800745A1 (ru) 1999-02-25
CN1213972A (zh) 1999-04-14
SK284200B6 (sk) 2004-10-05
US20010010811A1 (en) 2001-08-02
EA001135B1 (ru) 2000-10-30
DE69721235D1 (de) 2003-05-28
EE9800249A (et) 1999-02-15
HK1014872A1 (en) 1999-10-08
AP890A (en) 2000-11-13
SK112698A3 (en) 1999-04-13
CZ293986B6 (cs) 2004-09-15
KR19990082669A (ko) 1999-11-25
NZ331509A (en) 2000-04-28
IL125748A (en) 2002-05-23
CA2246779C (en) 2008-04-29
AU726503B2 (en) 2000-11-09
PL328406A1 (en) 1999-01-18
HU229090B1 (en) 2013-07-29
EP1331013A2 (en) 2003-07-30
CN1278740C (zh) 2006-10-11
CA2246779A1 (en) 1997-08-21
PT881915E (pt) 2003-09-30
HUP9900813A3 (en) 1999-11-29
KR100500334B1 (ko) 2005-09-09
EP0881915A1 (en) 1998-12-09
ES2197986T3 (es) 2004-01-16
ATE238072T1 (de) 2003-05-15
EE04224B1 (et) 2004-02-16
US20030202942A1 (en) 2003-10-30
BG102758A (en) 1999-09-30

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