EE04224B1 - Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon - Google Patents
Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioonInfo
- Publication number
- EE04224B1 EE04224B1 EE9800249A EE9800249A EE04224B1 EE 04224 B1 EE04224 B1 EE 04224B1 EE 9800249 A EE9800249 A EE 9800249A EE 9800249 A EE9800249 A EE 9800249A EE 04224 B1 EE04224 B1 EE 04224B1
- Authority
- EE
- Estonia
- Prior art keywords
- contrast medium
- ultrasonic contrast
- microbubbles
- dispersion
- matrix
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title 2
- 239000006185 dispersion Substances 0.000 title 1
- 239000011159 matrix material Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9603466.5A GB9603466D0 (en) | 1996-02-19 | 1996-02-19 | Improvements in or relating to contrast agents |
GBGB9611894.8A GB9611894D0 (en) | 1996-06-07 | 1996-06-07 | Improvements in or relating to contrast agents |
GBGB9625663.1A GB9625663D0 (en) | 1996-12-11 | 1996-12-11 | Improvements in or relating to contrast agents |
PCT/GB1997/000459 WO1997029783A1 (en) | 1996-02-19 | 1997-02-19 | Improvements in or relating to contrast agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9800249A EE9800249A (et) | 1999-02-15 |
EE04224B1 true EE04224B1 (et) | 2004-02-16 |
Family
ID=27268137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9800249A EE04224B1 (et) | 1996-02-19 | 1997-02-19 | Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon |
Country Status (25)
Country | Link |
---|---|
US (4) | US6221337B1 (tr) |
EP (2) | EP0881915B1 (tr) |
JP (1) | JP4418033B2 (tr) |
KR (1) | KR100500334B1 (tr) |
CN (1) | CN1278740C (tr) |
AP (1) | AP890A (tr) |
AT (1) | ATE238072T1 (tr) |
AU (1) | AU726503B2 (tr) |
BG (1) | BG102758A (tr) |
CA (1) | CA2246779C (tr) |
CZ (1) | CZ293986B6 (tr) |
DE (1) | DE69721235T2 (tr) |
EA (1) | EA001135B1 (tr) |
EE (1) | EE04224B1 (tr) |
ES (1) | ES2197986T3 (tr) |
HK (1) | HK1014872A1 (tr) |
HU (1) | HU229090B1 (tr) |
IL (1) | IL125748A (tr) |
NZ (1) | NZ331509A (tr) |
OA (1) | OA10839A (tr) |
PL (1) | PL328406A1 (tr) |
PT (1) | PT881915E (tr) |
SK (1) | SK284200B6 (tr) |
TR (1) | TR199801613T2 (tr) |
WO (1) | WO1997029783A1 (tr) |
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AU784367B2 (en) * | 1996-08-02 | 2006-03-16 | Ge Healthcare As | Improvements in or relating to contrast agents |
CA2262908A1 (en) * | 1996-08-02 | 1998-02-12 | David Johnson | Contrast agents for ultrasound imaging of the liver |
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GB9717588D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
GB9717542D0 (en) | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Process |
GB9726773D0 (en) | 1997-12-18 | 1998-02-18 | Nycomed Imaging As | Improvements in or relating to ultrasonagraphy |
WO1999055837A2 (en) * | 1998-04-28 | 1999-11-04 | Nycomed Imaging As | Improvements in or relating to separation processes |
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US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
US6962071B2 (en) | 2001-04-06 | 2005-11-08 | Bracco Research S.A. | Method for improved measurement of local physical parameters in a fluid-filled cavity |
US20050239746A1 (en) * | 2002-02-01 | 2005-10-27 | Penkler Lawrence J | Pharmaceutical composition |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
CA2513044A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
EP2014310B8 (en) | 2002-03-01 | 2012-12-26 | Dyax Corp. | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
NO20024755D0 (no) * | 2002-10-03 | 2002-10-03 | Amersham Health As | Metode |
KR20050072496A (ko) | 2002-11-29 | 2005-07-11 | 아머샴 헬스 에이에스 | 초음파 촬영 방법 |
MXPA05007730A (es) * | 2003-02-04 | 2006-01-31 | Bracco Int Bv | Agentes de contraste para ultrasonido y proceso para la preparacion de los mismos. |
US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
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US20060222694A1 (en) * | 2003-06-27 | 2006-10-05 | Oh Choon K | Stabilized topotecan liposomal composition and methods |
US20050019379A1 (en) | 2003-07-22 | 2005-01-27 | Kimberly-Clark Worldwide, Inc. | Wipe and methods for improving skin health |
NO20035401D0 (no) * | 2003-12-04 | 2003-12-04 | Amersham Health As | Metode |
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ATE469660T1 (de) | 2006-09-05 | 2010-06-15 | Bracco Research Sa | Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden |
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JP2010005512A (ja) * | 2008-06-25 | 2010-01-14 | Kao Corp | 微細気泡前駆体組成物 |
GB0811856D0 (en) * | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
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AU2013283409B2 (en) | 2012-06-26 | 2017-06-08 | Ge Healthcare As | Preparation of composition comprising gas microbubbles |
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US10010630B2 (en) | 2012-12-21 | 2018-07-03 | Bracco Suisse S.A. | Gas-filled microvesicles |
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DK3233136T3 (da) | 2014-12-18 | 2019-05-20 | Bracco Suisse Sa | Formulering med målrettede gasfyldte mikrovesikler |
WO2016199430A1 (ja) * | 2015-06-10 | 2016-12-15 | 学校法人帝京大学 | セラノスティクス用のバブル製剤(tb)及びその使用方法 |
CN107233583B (zh) * | 2016-03-29 | 2020-04-24 | 北京飞锐达医疗科技有限公司 | 一种具有超长持续时间的超声造影剂及其制备方法 |
GB201821049D0 (en) * | 2018-12-21 | 2019-02-06 | Ge Healthcare As | Ultrasound contrast agent and methods for use therof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
IN172208B (tr) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
DE4328642A1 (de) * | 1993-08-26 | 1995-03-02 | Byk Gulden Lomberg Chem Fab | Ultraschallkontrastmittel |
GB9511488D0 (en) * | 1995-06-07 | 1995-08-02 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US5846517A (en) * | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
-
1997
- 1997-02-19 NZ NZ331509A patent/NZ331509A/xx unknown
- 1997-02-19 CN CNB971931895A patent/CN1278740C/zh not_active Expired - Lifetime
- 1997-02-19 CA CA002246779A patent/CA2246779C/en not_active Expired - Lifetime
- 1997-02-19 JP JP52913197A patent/JP4418033B2/ja not_active Expired - Lifetime
- 1997-02-19 PT PT97905222T patent/PT881915E/pt unknown
- 1997-02-19 AP APAP/P/1998/001319A patent/AP890A/en active
- 1997-02-19 KR KR10-1998-0706415A patent/KR100500334B1/ko active IP Right Grant
- 1997-02-19 EA EA199800745A patent/EA001135B1/ru active IP Right Revival
- 1997-02-19 EE EE9800249A patent/EE04224B1/xx not_active IP Right Cessation
- 1997-02-19 TR TR1998/01613T patent/TR199801613T2/tr unknown
- 1997-02-19 WO PCT/GB1997/000459 patent/WO1997029783A1/en not_active Application Discontinuation
- 1997-02-19 AU AU18847/97A patent/AU726503B2/en not_active Ceased
- 1997-02-19 PL PL97328406A patent/PL328406A1/xx unknown
- 1997-02-19 ES ES97905222T patent/ES2197986T3/es not_active Expired - Lifetime
- 1997-02-19 SK SK1126-98A patent/SK284200B6/sk unknown
- 1997-02-19 EP EP97905222A patent/EP0881915B1/en not_active Expired - Lifetime
- 1997-02-19 AT AT97905222T patent/ATE238072T1/de not_active IP Right Cessation
- 1997-02-19 HU HU9900813A patent/HU229090B1/hu unknown
- 1997-02-19 IL IL12574897A patent/IL125748A/en not_active IP Right Cessation
- 1997-02-19 EP EP03008699A patent/EP1331013A3/en not_active Withdrawn
- 1997-02-19 CZ CZ19982625A patent/CZ293986B6/cs not_active IP Right Cessation
- 1997-02-19 DE DE69721235T patent/DE69721235T2/de not_active Expired - Lifetime
-
1998
- 1998-08-14 OA OA9800144A patent/OA10839A/en unknown
- 1998-08-19 US US09/136,410 patent/US6221337B1/en not_active Expired - Lifetime
- 1998-09-09 BG BG102758A patent/BG102758A/xx unknown
-
1999
- 1999-01-08 HK HK99100075A patent/HK1014872A1/xx unknown
-
2001
- 2001-02-15 US US09/783,793 patent/US20010010811A1/en not_active Abandoned
-
2002
- 2002-11-22 US US10/302,800 patent/US20030202942A1/en not_active Abandoned
-
2005
- 2005-03-04 US US11/073,027 patent/US20050201942A1/en not_active Abandoned
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Legal Events
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KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
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MM4A | Lapsed by not paying the annual fees |
Effective date: 20050219 |