ATE469660T1 - Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden - Google Patents
Gasgefüllte mikrovesikel mit polymer- modifizierten lipidenInfo
- Publication number
- ATE469660T1 ATE469660T1 AT07803220T AT07803220T ATE469660T1 AT E469660 T1 ATE469660 T1 AT E469660T1 AT 07803220 T AT07803220 T AT 07803220T AT 07803220 T AT07803220 T AT 07803220T AT E469660 T1 ATE469660 T1 AT E469660T1
- Authority
- AT
- Austria
- Prior art keywords
- gas
- filled microvesicles
- polymer
- modified lipids
- hydrophilic polymer
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title abstract 3
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical group 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
- A61K51/1251—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06120109 | 2006-09-05 | ||
| PCT/EP2007/059256 WO2008028917A1 (en) | 2006-09-05 | 2007-09-04 | Gas-filled microvesicles with polymer-modified lipids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE469660T1 true ATE469660T1 (de) | 2010-06-15 |
Family
ID=37834117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07803220T ATE469660T1 (de) | 2006-09-05 | 2007-09-04 | Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9446156B2 (de) |
| EP (1) | EP2061517B1 (de) |
| JP (1) | JP5420410B2 (de) |
| CN (1) | CN101528268B (de) |
| AT (1) | ATE469660T1 (de) |
| AU (1) | AU2007293888B2 (de) |
| CA (1) | CA2662087C (de) |
| DE (1) | DE602007006968D1 (de) |
| IL (1) | IL197380A (de) |
| WO (1) | WO2008028917A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2485976C2 (ru) * | 2011-05-17 | 2013-06-27 | Государственное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГОУ ВПО СибГМУ Минздравсоцразвития России) | Контрастное средство для ультразвуковой визуализации |
| WO2014012168A1 (en) | 2012-07-19 | 2014-01-23 | Anirban Ghosh | Method for the isolation of microvesicles |
| TWI552761B (zh) | 2013-05-03 | 2016-10-11 | 博信生物科技股份有限公司 | 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置 |
| CN104353088A (zh) * | 2014-09-30 | 2015-02-18 | 东南大学 | 一种脂质气泡的制备方法 |
| CN107206065A (zh) * | 2014-12-22 | 2017-09-26 | 博莱科瑞士股份有限公司 | 用作疫苗的气体填充的微囊 |
| JPWO2017110772A1 (ja) * | 2015-12-21 | 2018-09-13 | 富士フイルム株式会社 | リポソーム及びリポソーム組成物 |
| WO2017136475A1 (en) | 2016-02-01 | 2017-08-10 | Trust Biosonics Inc. | Lipid microbubbles and process of making thereof |
| RU2619353C1 (ru) * | 2016-05-27 | 2017-05-15 | государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СибГМУ Минздрава России) | Газосодержащее контрастное средство для ультразвуковой диагностики |
| WO2020127816A1 (en) * | 2018-12-21 | 2020-06-25 | Bracco Suisse Sa | Gas-filled microvesicles with ligand |
| CN110272868B (zh) * | 2019-07-25 | 2023-10-20 | 深圳博雅感知药业有限公司 | 制备用于细胞分选的链霉亲和素偶联微泡冻干制剂的方法 |
| CN110272867B (zh) * | 2019-07-25 | 2023-10-20 | 深圳博雅感知药业有限公司 | 用于细胞分选的链霉亲和素偶联微泡的液体制剂 |
| CN110358731B (zh) * | 2019-07-25 | 2023-11-10 | 深圳博雅感知药业有限公司 | 从外周血中直接分离目标细胞的方法 |
| CN110272869B (zh) * | 2019-07-25 | 2023-10-20 | 深圳博雅感知药业有限公司 | 细胞分选用链霉亲和素偶联微泡的冻干制剂和用途 |
| CN111265675A (zh) * | 2020-02-10 | 2020-06-12 | 上海市东方医院（同济大学附属东方医院） | 一种用于标记间充质干细胞的超声微泡造影剂及其制备方法 |
| CN114323863B (zh) * | 2021-12-31 | 2023-12-22 | 吉林大学 | 一种外泌体阵列捕获探针的制备方法与应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| IN172208B (de) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
| US5464696A (en) | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| EP0711179B2 (de) | 1993-07-30 | 2010-09-01 | IMCOR Pharmaceutical Co. | Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie |
| US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US5833948A (en) | 1995-06-15 | 1998-11-10 | Bracco Research S.A. | Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant |
| JP4418033B2 (ja) | 1996-02-19 | 2010-02-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤のまたはそれに関する改良 |
| EE9800248A (et) | 1996-02-19 | 1999-02-15 | Nycomed Imaging As | Külmkuivatatud, vesiikuleid sisaldav ultraheli kontrastaine, selle valmistamismeetod ning ladustamise ja transpordi meetod, ultraheli kontrastaine keskkond ja selle valmistamismeetod ning külmkuivatuse stabilisaatorite kasutamine |
| WO1998018501A2 (en) | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| ATE318618T1 (de) * | 1996-10-28 | 2006-03-15 | Amersham Health As | Verbesserungen an oder in verbindung mit diagnotischen/therapeutischen verbindungen |
| US6261537B1 (en) * | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
| US6416740B1 (en) * | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| ATE296113T1 (de) | 1998-02-09 | 2005-06-15 | Bracco Research Sa | Zielgerichtete abgabe von biologische-aktive medien |
| GB9809084D0 (en) | 1998-04-28 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| EP1341497A4 (de) * | 2000-11-02 | 2005-10-19 | Smithkline Beecham Corp | Rezeptor-antagonisten-lipid-konjugate und diese enthaltende abgabeträger |
| AU2002248222B2 (en) | 2000-12-23 | 2006-04-27 | Dyax Corp. | Fibrin binding polypeptides useful inter alia in medical imaging processes |
| JP2005519980A (ja) | 2002-03-01 | 2005-07-07 | ブラッコ インターナショナル ビー．ヴイ． | 治療および診断用途の多価構成物 |
| AU2003213730A1 (en) | 2002-03-01 | 2003-09-16 | Bracco International B.V. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| WO2004069284A2 (en) * | 2003-02-04 | 2004-08-19 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| US20050025710A1 (en) * | 2003-07-29 | 2005-02-03 | Michel Schneider | Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging |
| ES2531751T3 (es) | 2003-12-22 | 2015-03-18 | Bracco Suisse Sa | Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste |
| JP5513708B2 (ja) | 2003-12-22 | 2014-06-04 | ブラッコ・シュイス・ソシエテ・アノニム | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
| JP2006063052A (ja) | 2004-08-30 | 2006-03-09 | Konica Minolta Medical & Graphic Inc | リポソーム含有超音波造影剤およびその製造方法 |
| EP1884232A1 (de) | 2005-05-23 | 2008-02-06 | Mebiopharm Co., Ltd. | Verfahren zur herstellung von liposomen mit darin eingeschlossenem gas |
| CN1814305A (zh) * | 2005-12-09 | 2006-08-09 | 重庆医科大学 | 载基因或药物的超声微泡造影剂及其制备方法 |
-
2007
- 2007-09-04 US US12/440,009 patent/US9446156B2/en active Active
- 2007-09-04 AT AT07803220T patent/ATE469660T1/de not_active IP Right Cessation
- 2007-09-04 DE DE602007006968T patent/DE602007006968D1/de active Active
- 2007-09-04 CN CN2007800390886A patent/CN101528268B/zh active Active
- 2007-09-04 CA CA2662087A patent/CA2662087C/en active Active
- 2007-09-04 JP JP2009527133A patent/JP5420410B2/ja active Active
- 2007-09-04 AU AU2007293888A patent/AU2007293888B2/en not_active Ceased
- 2007-09-04 WO PCT/EP2007/059256 patent/WO2008028917A1/en active Application Filing
- 2007-09-04 EP EP07803220A patent/EP2061517B1/de active Active
-
2009
- 2009-03-03 IL IL197380A patent/IL197380A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL197380A (en) | 2011-01-31 |
| CN101528268B (zh) | 2012-07-04 |
| JP2010502671A (ja) | 2010-01-28 |
| DE602007006968D1 (de) | 2010-07-15 |
| JP5420410B2 (ja) | 2014-02-19 |
| US9446156B2 (en) | 2016-09-20 |
| AU2007293888B2 (en) | 2013-05-02 |
| CA2662087C (en) | 2015-01-06 |
| EP2061517B1 (de) | 2010-06-02 |
| CN101528268A (zh) | 2009-09-09 |
| AU2007293888A1 (en) | 2008-03-13 |
| EP2061517A1 (de) | 2009-05-27 |
| WO2008028917A1 (en) | 2008-03-13 |
| CA2662087A1 (en) | 2008-03-13 |
| US20090263330A1 (en) | 2009-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |