DE602007006968D1 - Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden - Google Patents

Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden

Info

Publication number
DE602007006968D1
DE602007006968D1 DE602007006968T DE602007006968T DE602007006968D1 DE 602007006968 D1 DE602007006968 D1 DE 602007006968D1 DE 602007006968 T DE602007006968 T DE 602007006968T DE 602007006968 T DE602007006968 T DE 602007006968T DE 602007006968 D1 DE602007006968 D1 DE 602007006968D1
Authority
DE
Germany
Prior art keywords
gas
filled microvesicles
polymer
lipides
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007006968T
Other languages
English (en)
Inventor
Stephane Gorgerat
Christian Guillot
Feng Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Research SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Research SA filed Critical Bracco Research SA
Publication of DE602007006968D1 publication Critical patent/DE602007006968D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A61K51/1251—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules
DE602007006968T 2006-09-05 2007-09-04 Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden Active DE602007006968D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06120109 2006-09-05
PCT/EP2007/059256 WO2008028917A1 (en) 2006-09-05 2007-09-04 Gas-filled microvesicles with polymer-modified lipids

Publications (1)

Publication Number Publication Date
DE602007006968D1 true DE602007006968D1 (de) 2010-07-15

Family

ID=37834117

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007006968T Active DE602007006968D1 (de) 2006-09-05 2007-09-04 Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden

Country Status (10)

Country Link
US (1) US9446156B2 (de)
EP (1) EP2061517B1 (de)
JP (1) JP5420410B2 (de)
CN (1) CN101528268B (de)
AT (1) ATE469660T1 (de)
AU (1) AU2007293888B2 (de)
CA (1) CA2662087C (de)
DE (1) DE602007006968D1 (de)
IL (1) IL197380A (de)
WO (1) WO2008028917A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2485976C2 (ru) * 2011-05-17 2013-06-27 Государственное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГОУ ВПО СибГМУ Минздравсоцразвития России) Контрастное средство для ультразвуковой визуализации
WO2014012168A1 (en) 2012-07-19 2014-01-23 Anirban Ghosh Method for the isolation of microvesicles
TWI552761B (zh) 2013-05-03 2016-10-11 博信生物科技股份有限公司 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置
CN104353088A (zh) * 2014-09-30 2015-02-18 东南大学 一种脂质气泡的制备方法
CN107206065A (zh) * 2014-12-22 2017-09-26 博莱科瑞士股份有限公司 用作疫苗的气体填充的微囊
JPWO2017110772A1 (ja) * 2015-12-21 2018-09-13 富士フイルム株式会社 リポソーム及びリポソーム組成物
WO2017136475A1 (en) 2016-02-01 2017-08-10 Trust Biosonics Inc. Lipid microbubbles and process of making thereof
RU2619353C1 (ru) * 2016-05-27 2017-05-15 государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СибГМУ Минздрава России) Газосодержащее контрастное средство для ультразвуковой диагностики
WO2020127816A1 (en) * 2018-12-21 2020-06-25 Bracco Suisse Sa Gas-filled microvesicles with ligand
CN110272868B (zh) * 2019-07-25 2023-10-20 深圳博雅感知药业有限公司 制备用于细胞分选的链霉亲和素偶联微泡冻干制剂的方法
CN110272867B (zh) * 2019-07-25 2023-10-20 深圳博雅感知药业有限公司 用于细胞分选的链霉亲和素偶联微泡的液体制剂
CN110358731B (zh) * 2019-07-25 2023-11-10 深圳博雅感知药业有限公司 从外周血中直接分离目标细胞的方法
CN110272869B (zh) * 2019-07-25 2023-10-20 深圳博雅感知药业有限公司 细胞分选用链霉亲和素偶联微泡的冻干制剂和用途
CN111265675A (zh) * 2020-02-10 2020-06-12 上海市东方医院（同济大学附属东方医院） 一种用于标记间充质干细胞的超声微泡造影剂及其制备方法
CN114323863B (zh) * 2021-12-31 2023-12-22 吉林大学 一种外泌体阵列捕获探针的制备方法与应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
EP0711179B2 (de) 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
JP4418033B2 (ja) 1996-02-19 2010-02-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤のまたはそれに関する改良
EE9800248A (et) 1996-02-19 1999-02-15 Nycomed Imaging As Külmkuivatatud, vesiikuleid sisaldav ultraheli kontrastaine, selle valmistamismeetod ning ladustamise ja transpordi meetod, ultraheli kontrastaine keskkond ja selle valmistamismeetod ning külmkuivatuse stabilisaatorite kasutamine
WO1998018501A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
ATE318618T1 (de) * 1996-10-28 2006-03-15 Amersham Health As Verbesserungen an oder in verbindung mit diagnotischen/therapeutischen verbindungen
US6261537B1 (en) * 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
ATE296113T1 (de) 1998-02-09 2005-06-15 Bracco Research Sa Zielgerichtete abgabe von biologische-aktive medien
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
EP1341497A4 (de) * 2000-11-02 2005-10-19 Smithkline Beecham Corp Rezeptor-antagonisten-lipid-konjugate und diese enthaltende abgabeträger
AU2002248222B2 (en) 2000-12-23 2006-04-27 Dyax Corp. Fibrin binding polypeptides useful inter alia in medical imaging processes
JP2005519980A (ja) 2002-03-01 2005-07-07 ブラッコ インターナショナル ビー．ヴイ． 治療および診断用途の多価構成物
AU2003213730A1 (en) 2002-03-01 2003-09-16 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
WO2004069284A2 (en) * 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
US20050025710A1 (en) * 2003-07-29 2005-02-03 Michel Schneider Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
ES2531751T3 (es) 2003-12-22 2015-03-18 Bracco Suisse Sa Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste
JP5513708B2 (ja) 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
JP2006063052A (ja) 2004-08-30 2006-03-09 Konica Minolta Medical & Graphic Inc リポソーム含有超音波造影剤およびその製造方法
EP1884232A1 (de) 2005-05-23 2008-02-06 Mebiopharm Co., Ltd. Verfahren zur herstellung von liposomen mit darin eingeschlossenem gas
CN1814305A (zh) * 2005-12-09 2006-08-09 重庆医科大学 载基因或药物的超声微泡造影剂及其制备方法

Also Published As

Publication number Publication date
IL197380A (en) 2011-01-31
CN101528268B (zh) 2012-07-04
JP2010502671A (ja) 2010-01-28
ATE469660T1 (de) 2010-06-15
JP5420410B2 (ja) 2014-02-19
US9446156B2 (en) 2016-09-20
AU2007293888B2 (en) 2013-05-02
CA2662087C (en) 2015-01-06
EP2061517B1 (de) 2010-06-02
CN101528268A (zh) 2009-09-09
AU2007293888A1 (en) 2008-03-13
EP2061517A1 (de) 2009-05-27
WO2008028917A1 (en) 2008-03-13
CA2662087A1 (en) 2008-03-13
US20090263330A1 (en) 2009-10-22

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BRACCO SUISSE SA, MANNO, CH