ATE237362T1 - Thermostabilisiertes kontrastmittel - Google Patents

Thermostabilisiertes kontrastmittel

Info

Publication number
ATE237362T1
ATE237362T1 AT97903507T AT97903507T ATE237362T1 AT E237362 T1 ATE237362 T1 AT E237362T1 AT 97903507 T AT97903507 T AT 97903507T AT 97903507 T AT97903507 T AT 97903507T AT E237362 T1 ATE237362 T1 AT E237362T1
Authority
AT
Austria
Prior art keywords
contrast agent
thermostabilized
freeze
excess
temperatures
Prior art date
Application number
AT97903507T
Other languages
English (en)
Inventor
Marit Swaerd-Nordmo
Per Helge Gulliksen
Jorunn Undheim Braenden
Anne Kjersti Fahlvik
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9624919.8A external-priority patent/GB9624919D0/en
Application filed by Amersham Health As filed Critical Amersham Health As
Application granted granted Critical
Publication of ATE237362T1 publication Critical patent/ATE237362T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Light Receiving Elements (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT97903507T 1996-02-19 1997-02-19 Thermostabilisiertes kontrastmittel ATE237362T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9624919.8A GB9624919D0 (en) 1996-11-29 1996-11-29 Product
PCT/GB1997/000458 WO1997029782A1 (en) 1996-02-19 1997-02-19 Thermally stabilized contrast agent

Publications (1)

Publication Number Publication Date
ATE237362T1 true ATE237362T1 (de) 2003-05-15

Family

ID=27268136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97903507T ATE237362T1 (de) 1996-02-19 1997-02-19 Thermostabilisiertes kontrastmittel

Country Status (18)

Country Link
EP (1) EP0885016B1 (de)
JP (1) JP4250747B2 (de)
KR (1) KR100501863B1 (de)
CN (1) CN1092988C (de)
AT (1) ATE237362T1 (de)
AU (1) AU722735B2 (de)
CA (1) CA2246778A1 (de)
CZ (1) CZ262698A3 (de)
DE (1) DE69720979T2 (de)
EA (1) EA000900B1 (de)
EE (1) EE9800248A (de)
ES (1) ES2197331T3 (de)
HU (1) HUP9900812A3 (de)
IL (1) IL125800A0 (de)
NO (1) NO313815B1 (de)
NZ (1) NZ331372A (de)
PL (1) PL328309A1 (de)
WO (1) WO1997029782A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005364A2 (en) * 1996-08-02 1998-02-12 Marsden, John, Christopher Improvements in or relating to contrast agents
GB9717542D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Process
BR0112417A (pt) 2000-07-13 2003-07-01 Daiichi Seiyaku Co Composições farmacêuticas contendo composto dds
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
EP1228770B1 (de) * 2001-01-31 2005-07-13 Bracco Research S.A. Lyophilisierbares Kontrastmittel, gasgefüllte Mikrobläschen enthaltend
WO2004049950A1 (en) 2002-11-29 2004-06-17 Amersham Health As Ultrasound triggering method
WO2004069284A2 (en) 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
ES2531732T3 (es) 2003-12-22 2015-03-18 Bracco Suisse Sa Montaje de microvesícula rellena de gas para imagenología de contraste
CA2575677C (en) 2004-08-18 2013-01-22 Bracco Research Sa Gas-filled microvesicles composition for contrast imaging
WO2006076826A1 (fr) * 2005-01-18 2006-07-27 Institute Of Pharmacology Toxicology, Academy Of Military Medical Sciences Composition de contraste pour ultrasons utilisant un phospholipide filmogene et procede de preparation de celle-ci
EP2061517B1 (de) 2006-09-05 2010-06-02 Bracco Research S.A. Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden
EP2117603A2 (de) 2006-12-19 2009-11-18 Bracco International B.V. Targeting und therapeutische verbindungen und gasgefüllte mikrovesikel mit diesen verbindungen
JP2010539027A (ja) 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのペプチドの使用
AU2008303956A1 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Proadrenomedullin alone or in combination with big gastrin I as a therapeutic agent
WO2009043456A2 (en) 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
AU2008297906A1 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of the peptide Phpfhlfvy (Renin inhibitor) as a therapeutic agent
KR20100075438A (ko) 2007-09-11 2010-07-02 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드의 용도
KR20100058550A (ko) 2007-09-11 2010-06-03 몬도바이오테크 래보래토리즈 아게 녹농균 감염 치료시 치료제로서의 밴드 ３ 단백질 （８２４－８２９） 및／또는 멜라닌세포－자극 호르몬 방출－저해 인자의 용도
AU2008303945A1 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US20100234306A1 (en) 2007-09-11 2010-09-16 Dorian Bevec Use of a peptide as a therapeutic agent
EP2187947A2 (de) 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Verwendung von calcitonin als anti-angiogenes mittel
US20100204114A1 (en) 2007-09-11 2010-08-12 Dorian Bevec Use of a galanin peptide as a therapeutic agent
EP2188016B1 (de) 2007-09-11 2012-08-01 Mondobiotech Laboratories AG Verwendung von octreotid als therapeutisches mittel
WO2009046852A1 (en) 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Therapeutic uses of intermedin 47 and 53 peptides
EP2090322A1 (de) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs
EP2346532B1 (de) 2008-10-07 2020-10-07 Bracco Suisse SA Target-konstrukt mit einem anti-polymer-antikörper und an diesen bindende mikrovesikel
CN101649293B (zh) * 2009-09-02 2012-07-18 中国农业大学 一种微生物冷冻干燥保护剂及其应用
EP2603242B1 (de) 2010-08-09 2018-03-14 Bracco Suisse SA Gasgefüllte gerichtete mikrovesikel
EP2426202A1 (de) 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kinasen als Targets für antidiabetische Therapien
BR112013016244B1 (pt) 2010-12-24 2021-12-21 Bracco Suisse Sa Formulação farmacêutica compreendendo microvesículas cheias de gás e precursor da mesma
KR102076069B1 (ko) 2011-08-24 2020-02-11 캘리포니아 인스티튜트 오브 테크놀로지 타기팅 미세버블
KR102284689B1 (ko) 2011-10-21 2021-08-02 셀라토 파마슈티칼즈, 인코포레이티드 동결건조된 리포좀
EP2589383A1 (de) 2011-11-06 2013-05-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
GB201411423D0 (en) * 2014-06-26 2014-08-13 Ge Healthcare As Lipid sterilisation method
EP3020813A1 (de) 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-Oligonukleotide als Inhibitoren der TGF-R-Signalgebung
WO2016102515A1 (en) 2014-12-22 2016-06-30 Bracco Suisse Sa Gas-filled microvesicles for use as vaccine
WO2017184672A1 (en) * 2016-04-19 2017-10-26 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
AU2019232508B2 (en) 2018-03-07 2024-12-19 Bracco Suisse Sa Preparation of size-controlled microvesicles
JP7712878B2 (ja) * 2019-06-25 2025-07-24 ブラッコ・スイス・ソシエテ・アノニム 校正されたガス充填微小胞を調製するための凍結乾燥組成物
WO2020260423A1 (en) * 2019-06-25 2020-12-30 Bracco Suisse Sa Freeze-dried composition for preparing calibrated gas-filled microvesicles
US10953023B1 (en) 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
CN112891565A (zh) * 2021-04-09 2021-06-04 上海师范大学 锌-二甲基吡啶胺在制备诊断血栓性疾病药物中的应用
EP4105328A1 (de) 2021-06-15 2022-12-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Antisense-oligonukleotide zur prävention von nierenfunktionsstörungen, die durch endotheliale dysfunktion gefördert werden, durch unterdrückung von ephrin-b2
CN117797279B (zh) * 2023-11-07 2025-08-26 浙江普利药业有限公司 一种荧光-磁共振双模态造影剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
JPH06211645A (ja) * 1993-01-14 1994-08-02 Mitsubishi Kasei Corp リポソーム凍結乾燥製剤

Also Published As

Publication number Publication date
AU722735B2 (en) 2000-08-10
EA000900B1 (ru) 2000-06-26
WO1997029782A1 (en) 1997-08-21
IL125800A0 (en) 1999-04-11
EA199800739A1 (ru) 1999-02-25
CN1213971A (zh) 1999-04-14
HUP9900812A3 (en) 1999-11-29
NO313815B1 (no) 2002-12-09
EE9800248A (et) 1999-02-15
CA2246778A1 (en) 1997-08-21
DE69720979T2 (de) 2004-02-26
EP0885016A1 (de) 1998-12-23
PL328309A1 (en) 1999-01-18
JP2000506122A (ja) 2000-05-23
JP4250747B2 (ja) 2009-04-08
AU1805197A (en) 1997-09-02
NZ331372A (en) 2000-01-28
CZ262698A3 (cs) 1999-03-17
NO983584L (no) 1998-10-16
CN1092988C (zh) 2002-10-23
KR19990082670A (ko) 1999-11-25
NO983584D0 (no) 1998-08-05
HUP9900812A2 (hu) 1999-07-28
KR100501863B1 (ko) 2005-09-27
EP0885016B1 (de) 2003-04-16
DE69720979D1 (de) 2003-05-22
ES2197331T3 (es) 2004-01-01

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties