ATE237362T1 - Thermostabilisiertes kontrastmittel - Google Patents

Thermostabilisiertes kontrastmittel

Info

Publication number
ATE237362T1
ATE237362T1 AT97903507T AT97903507T ATE237362T1 AT E237362 T1 ATE237362 T1 AT E237362T1 AT 97903507 T AT97903507 T AT 97903507T AT 97903507 T AT97903507 T AT 97903507T AT E237362 T1 ATE237362 T1 AT E237362T1
Authority
AT
Austria
Prior art keywords
contrast agent
thermostabilized
freeze
excess
temperatures
Prior art date
Application number
AT97903507T
Other languages
English (en)
Inventor
Marit Swaerd-Nordmo
Per Helge Gulliksen
Jorunn Undheim Braenden
Anne Kjersti Fahlvik
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9624919.8A external-priority patent/GB9624919D0/en
Application filed by Amersham Health As filed Critical Amersham Health As
Application granted granted Critical
Publication of ATE237362T1 publication Critical patent/ATE237362T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Light Receiving Elements (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT97903507T 1996-02-19 1997-02-19 Thermostabilisiertes kontrastmittel ATE237362T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9624919.8A GB9624919D0 (en) 1996-11-29 1996-11-29 Product
PCT/GB1997/000458 WO1997029782A1 (en) 1996-02-19 1997-02-19 Thermally stabilized contrast agent

Publications (1)

Publication Number Publication Date
ATE237362T1 true ATE237362T1 (de) 2003-05-15

Family

ID=27268136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97903507T ATE237362T1 (de) 1996-02-19 1997-02-19 Thermostabilisiertes kontrastmittel

Country Status (18)

Country Link
EP (1) EP0885016B1 (de)
JP (1) JP4250747B2 (de)
KR (1) KR100501863B1 (de)
CN (1) CN1092988C (de)
AT (1) ATE237362T1 (de)
AU (1) AU722735B2 (de)
CA (1) CA2246778A1 (de)
CZ (1) CZ262698A3 (de)
DE (1) DE69720979T2 (de)
EA (1) EA000900B1 (de)
EE (1) EE9800248A (de)
ES (1) ES2197331T3 (de)
HU (1) HUP9900812A3 (de)
IL (1) IL125800A0 (de)
NO (1) NO313815B1 (de)
NZ (1) NZ331372A (de)
PL (1) PL328309A1 (de)
WO (1) WO1997029782A1 (de)

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GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
CN1556712A (zh) 2000-07-13 2004-12-22 ��һ��������ҩ��ʽ���� 含dds化合物的药用组合物
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
DE60111917T2 (de) * 2001-01-31 2006-04-20 Bracco International B.V. Lyophilisierbares Kontrastmittel, gasgefüllte Mikrobläschen enthaltend
JP4748564B2 (ja) 2002-11-29 2011-08-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ 超音波トリガ法
WO2004069284A2 (en) 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
JP5513708B2 (ja) 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
CN101005858A (zh) 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物
WO2006076826A1 (fr) * 2005-01-18 2006-07-27 Institute Of Pharmacology Toxicology, Academy Of Military Medical Sciences Composition de contraste pour ultrasons utilisant un phospholipide filmogene et procede de preparation de celle-ci
AU2007293888B2 (en) 2006-09-05 2013-05-02 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
EP2117603A2 (de) 2006-12-19 2009-11-18 Bracco International B.V. Targeting und therapeutische verbindungen und gasgefüllte mikrovesikel mit diesen verbindungen
WO2009039966A2 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
WO2009033700A1 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of secretin and optionally urodilatin as therapeutic agents
EP2197465A2 (de) 2007-09-11 2010-06-23 Mondobiotech Laboratories AG Verwendung von angiotensin-ii als therapeutisches mittel bei der behandlung von infektionen mit z.b. s. pneumoniae
US20100184698A1 (en) 2007-09-11 2010-07-22 Dorian Bevec Use of a deslorelin and mastoparan as a therapeutic agent
JP2010539007A (ja) 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのペプチドの使用
JP2010538978A (ja) 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのオクトレオチドの使用
US20100210568A1 (en) 2007-09-11 2010-08-19 Mondobiotech Laboratories Ag Thyrotropin releasing hormone for therapeutic applications
US20100190717A1 (en) 2007-09-11 2010-07-29 Dorian Bevec Use of melanin concentrating hormone and met-enkephalin as therapeutic agents
WO2009040031A2 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
WO2009043436A2 (en) 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of af12198 as a therapeutic agent
US20100184680A1 (en) 2007-09-11 2010-07-22 Dorian Bevec Therapeutic uses of b-type natriuretic peptide and human growth hormone 1-43
KR20100064367A (ko) 2007-09-11 2010-06-14 몬도바이오테크 래보래토리즈 아게 치료제로서의 ｉｌ－１ 수용체 펩티드 단독 또는 ｄ－ａｌａ－ｇｌｎ－옥타데실 에스테르와의 배합물의 용도
EP2090322A1 (de) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs
US9192685B2 (en) 2008-10-07 2015-11-24 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same
CN101649293B (zh) * 2009-09-02 2012-07-18 中国农业大学 一种微生物冷冻干燥保护剂及其应用
KR101893423B1 (ko) 2010-08-09 2018-08-31 브라코 스위스 에스.에이. 표적화 기체-충전 미세소포
EP2426202A1 (de) 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kinasen als Targets für antidiabetische Therapien
CN103269717B (zh) 2010-12-24 2016-08-03 博莱科瑞士股份有限公司 气体填充微囊泡用作疫苗
KR102076069B1 (ko) 2011-08-24 2020-02-11 캘리포니아 인스티튜트 오브 테크놀로지 타기팅 미세버블
CN104114156A (zh) 2011-10-21 2014-10-22 切拉托尔制药公司 冻干脂质体
EP2589383A1 (de) 2011-11-06 2013-05-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
GB201411423D0 (en) 2014-06-26 2014-08-13 Ge Healthcare As Lipid sterilisation method
EP3020813A1 (de) 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-Oligonukleotide als Inhibitoren der TGF-R-Signalgebung
CN107206065A (zh) 2014-12-22 2017-09-26 博莱科瑞士股份有限公司 用作疫苗的气体填充的微囊
WO2017184672A1 (en) * 2016-04-19 2017-10-26 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
CA3091952A1 (en) 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
DK3990033T3 (da) * 2019-06-25 2023-12-18 Bracco Suisse Sa Frysetørret sammensætning til fremstilling af kalibrerede gasfyldte mikrovesikler
ES2967186T3 (es) 2019-06-25 2024-04-29 Bracco Suisse Sa Composición liofilizada para preparar microvesículas llenas de gas calibradas
US10953023B1 (en) 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
CN112891565A (zh) * 2021-04-09 2021-06-04 上海师范大学 锌-二甲基吡啶胺在制备诊断血栓性疾病药物中的应用
EP4105328A1 (de) 2021-06-15 2022-12-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Antisense-oligonukleotide zur prävention von nierenfunktionsstörungen, die durch endotheliale dysfunktion gefördert werden, durch unterdrückung von ephrin-b2
CN117797279B (zh) * 2023-11-07 2025-08-26 浙江普利药业有限公司 一种荧光-磁共振双模态造影剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
JPH06211645A (ja) * 1993-01-14 1994-08-02 Mitsubishi Kasei Corp リポソーム凍結乾燥製剤

Also Published As

Publication number Publication date
AU1805197A (en) 1997-09-02
KR100501863B1 (ko) 2005-09-27
WO1997029782A1 (en) 1997-08-21
EP0885016A1 (de) 1998-12-23
JP4250747B2 (ja) 2009-04-08
EA000900B1 (ru) 2000-06-26
CN1213971A (zh) 1999-04-14
PL328309A1 (en) 1999-01-18
JP2000506122A (ja) 2000-05-23
NO983584L (no) 1998-10-16
HUP9900812A3 (en) 1999-11-29
DE69720979D1 (de) 2003-05-22
HUP9900812A2 (hu) 1999-07-28
KR19990082670A (ko) 1999-11-25
NO983584D0 (no) 1998-08-05
EP0885016B1 (de) 2003-04-16
EA199800739A1 (ru) 1999-02-25
CZ262698A3 (cs) 1999-03-17
CN1092988C (zh) 2002-10-23
NZ331372A (en) 2000-01-28
AU722735B2 (en) 2000-08-10
CA2246778A1 (en) 1997-08-21
EE9800248A (et) 1999-02-15
DE69720979T2 (de) 2004-02-26
NO313815B1 (no) 2002-12-09
IL125800A0 (en) 1999-04-11
ES2197331T3 (es) 2004-01-01

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Legal Events

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