EA199800739A1 - Термически стабилизированный контрастный агент - Google Patents

Термически стабилизированный контрастный агент

Info

Publication number
EA199800739A1
EA199800739A1 EA199800739A EA199800739A EA199800739A1 EA 199800739 A1 EA199800739 A1 EA 199800739A1 EA 199800739 A EA199800739 A EA 199800739A EA 199800739 A EA199800739 A EA 199800739A EA 199800739 A1 EA199800739 A1 EA 199800739A1
Authority
EA
Eurasian Patent Office
Prior art keywords
contrast agent
thermally stabilized
freeze
stabilized contrast
resistant
Prior art date
Application number
EA199800739A
Other languages
English (en)
Other versions
EA000900B1 (ru
Inventor
Марит Сверд-Нордмо
Пер Хельге Гулликсен
Йорунн Ундхейм Бренден
Анне Кьерсти Фахльвик
Original Assignee
Никомед Имеджинг Ас
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9624919.8A external-priority patent/GB9624919D0/en
Application filed by Никомед Имеджинг Ас filed Critical Никомед Имеджинг Ас
Publication of EA199800739A1 publication Critical patent/EA199800739A1/ru
Publication of EA000900B1 publication Critical patent/EA000900B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Abstract

Настоящее изобретение относится к ультразвуковым контрастным агентам, высушенным вымораживанием и содержащим везикулы, которые содержат стабилизатор сушки вымораживанием и являются термостойкими при температурах более 20°С.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800739A 1996-02-19 1997-02-19 Термически стабилизированный контрастный агент EA000900B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9624919.8A GB9624919D0 (en) 1996-11-29 1996-11-29 Product
PCT/GB1997/000458 WO1997029782A1 (en) 1996-02-19 1997-02-19 Thermally stabilized contrast agent

Publications (2)

Publication Number Publication Date
EA199800739A1 true EA199800739A1 (ru) 1999-02-25
EA000900B1 EA000900B1 (ru) 2000-06-26

Family

ID=27268136

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800739A EA000900B1 (ru) 1996-02-19 1997-02-19 Термически стабилизированный контрастный агент

Country Status (18)

Country Link
EP (1) EP0885016B1 (ru)
JP (1) JP4250747B2 (ru)
KR (1) KR100501863B1 (ru)
CN (1) CN1092988C (ru)
AT (1) ATE237362T1 (ru)
AU (1) AU722735B2 (ru)
CA (1) CA2246778A1 (ru)
CZ (1) CZ262698A3 (ru)
DE (1) DE69720979T2 (ru)
EA (1) EA000900B1 (ru)
EE (1) EE9800248A (ru)
ES (1) ES2197331T3 (ru)
HU (1) HUP9900812A3 (ru)
IL (1) IL125800A0 (ru)
NO (1) NO313815B1 (ru)
NZ (1) NZ331372A (ru)
PL (1) PL328309A1 (ru)
WO (1) WO1997029782A1 (ru)

Families Citing this family (42)

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WO1998005364A2 (en) * 1996-08-02 1998-02-12 Marsden, John, Christopher Improvements in or relating to contrast agents
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
US6815435B2 (en) 2000-07-13 2004-11-09 Daiichi Pharmaceutical Co., Ltd. Pharmaceutical compositions containing DDS compounds
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
ATE299378T1 (de) * 2001-01-31 2005-07-15 Bracco Research Sa Lyophilisierbares kontrastmittel, gasgefüllte mikrobläschen enthaltend
EP1572001A1 (en) 2002-11-29 2005-09-14 Amersham Health AS Ultrasound triggering method
KR101076053B1 (ko) * 2003-02-04 2011-10-21 브라코 인터내셔날 비.브이. 초음파 조영제 및 그것의 제조방법
EP1701745B1 (en) 2003-12-22 2014-12-10 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
CA2575677C (en) 2004-08-18 2013-01-22 Bracco Research Sa Gas-filled microvesicles composition for contrast imaging
WO2006076826A1 (fr) * 2005-01-18 2006-07-27 Institute Of Pharmacology Toxicology, Academy Of Military Medical Sciences Composition de contraste pour ultrasons utilisant un phospholipide filmogene et procede de preparation de celle-ci
US9446156B2 (en) 2006-09-05 2016-09-20 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
WO2008075192A2 (en) 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
EP2187934A1 (en) 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Use of fertirelin and delta-endorphin as therapeutic agents
US20100204142A1 (en) 2007-09-11 2010-08-12 Dorian Bevec Use of the peptide phpfhlfvy (renin inhibitor) as a therapeutic agent
RU2010113979A (ru) 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) Применение bubuc и необязательно eaa-marti (26-35) в качестве терапевтического средства для лечения инфекций hcmv
KR20100056509A (ko) 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드의 용도
RU2010113992A (ru) 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) Применение урокортина и кортиколиберина в качестве терапевтических средств
KR20100057050A (ko) 2007-09-11 2010-05-28 몬도바이오테크 래보래토리즈 아게 치료제로서의 데슬로렐린 및 마스토파란의 용도
CA2699039A1 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of bpp-b as a therapeutic agent
WO2009033794A2 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of endothelin-1, optionally in combination with obestatin, as a therapeutic agent
US20100204109A1 (en) 2007-09-11 2010-08-12 Dorian Bevec Use of c-type natriuretic peptide, alone or in combination with neuropeptide af, as a therapeutic agent
WO2009033807A2 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Therapeutic uses of b-type natriuretic peptide and human growth hormone 1-43
WO2009043526A2 (en) 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
KR20100061478A (ko) 2007-09-11 2010-06-07 몬도바이오테크 래보래토리즈 아게 치료제로서의 세크레틴 및 임의의 유로딜라틴의 용도
EP2090322A1 (en) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of fsh receptor ligands for diagnosis and therapy of cancer
US9192685B2 (en) 2008-10-07 2015-11-24 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same
CN101649293B (zh) * 2009-09-02 2012-07-18 中国农业大学 一种微生物冷冻干燥保护剂及其应用
EP2603242B1 (en) 2010-08-09 2018-03-14 Bracco Suisse SA Targeted gas-filled microvesicles
EP2426202A1 (en) 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kinases as targets for anti-diabetic therapy
EP2654788B1 (en) 2010-12-24 2018-03-14 Bracco Suisse SA Gas-filled microvesicles for use as vaccine
CN104114156A (zh) 2011-10-21 2014-10-22 切拉托尔制药公司 冻干脂质体
EP2589383A1 (en) 2011-11-06 2013-05-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin FKBP subtype-specific rapamycin analogue for use in treatment of diseases
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
GB201411423D0 (en) * 2014-06-26 2014-08-13 Ge Healthcare As Lipid sterilisation method
EP3020813A1 (en) 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
CN107206065A (zh) 2014-12-22 2017-09-26 博莱科瑞士股份有限公司 用作疫苗的气体填充的微囊
JP2021516684A (ja) 2018-03-07 2021-07-08 ブラッコ・スイス・ソシエテ・アノニム サイズが制御された微小胞の調製
DK3990033T3 (da) * 2019-06-25 2023-12-18 Bracco Suisse Sa Frysetørret sammensætning til fremstilling af kalibrerede gasfyldte mikrovesikler
EP3990032B1 (en) 2019-06-25 2023-12-06 Bracco Suisse SA Freeze-dried composition for preparing calibrated gas-filled microvesicles
US10953023B1 (en) * 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
CN112891565A (zh) * 2021-04-09 2021-06-04 上海师范大学 锌-二甲基吡啶胺在制备诊断血栓性疾病药物中的应用
EP4105328A1 (en) 2021-06-15 2022-12-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Antisense-oligonucleotides for prevention of kidney dysfunction promoted by endothelial dysfunction by ephrin-b2 suppression

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US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
JPH06211645A (ja) * 1993-01-14 1994-08-02 Mitsubishi Kasei Corp リポソーム凍結乾燥製剤

Also Published As

Publication number Publication date
ES2197331T3 (es) 2004-01-01
KR100501863B1 (ko) 2005-09-27
NO983584L (no) 1998-10-16
DE69720979T2 (de) 2004-02-26
ATE237362T1 (de) 2003-05-15
PL328309A1 (en) 1999-01-18
HUP9900812A3 (en) 1999-11-29
CN1092988C (zh) 2002-10-23
EP0885016A1 (en) 1998-12-23
JP4250747B2 (ja) 2009-04-08
CA2246778A1 (en) 1997-08-21
AU1805197A (en) 1997-09-02
NO313815B1 (no) 2002-12-09
KR19990082670A (ko) 1999-11-25
NO983584D0 (no) 1998-08-05
EE9800248A (et) 1999-02-15
EA000900B1 (ru) 2000-06-26
AU722735B2 (en) 2000-08-10
WO1997029782A1 (en) 1997-08-21
HUP9900812A2 (hu) 1999-07-28
EP0885016B1 (en) 2003-04-16
JP2000506122A (ja) 2000-05-23
NZ331372A (en) 2000-01-28
CN1213971A (zh) 1999-04-14
CZ262698A3 (cs) 1999-03-17
IL125800A0 (en) 1999-04-11
DE69720979D1 (de) 2003-05-22

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU