HUP9900813A2 - Továbbfejlesztett kontrasztanyagok - Google Patents

Továbbfejlesztett kontrasztanyagok

Info

Publication number
HUP9900813A2
HUP9900813A2 HU9900813A HUP9900813A HUP9900813A2 HU P9900813 A2 HUP9900813 A2 HU P9900813A2 HU 9900813 A HU9900813 A HU 9900813A HU P9900813 A HUP9900813 A HU P9900813A HU P9900813 A2 HUP9900813 A2 HU P9900813A2
Authority
HU
Hungary
Prior art keywords
gas
relating
microbeads
stone
aqueous dispersion
Prior art date
Application number
HU9900813A
Other languages
English (en)
Inventor
Jorun Brenden
Harald Dugstad
Jo Klaveness
Pćl Rongved
Roald Skurtveit
Original Assignee
Nycomed Imaging A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9625663.1A external-priority patent/GB9625663D0/en
Application filed by Nycomed Imaging A/S filed Critical Nycomed Imaging A/S
Publication of HUP9900813A2 publication Critical patent/HUP9900813A2/hu
Publication of HUP9900813A3 publication Critical patent/HUP9900813A3/hu
Publication of HU229090B1 publication Critical patent/HU229090B1/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgya gázmikrőbűbőrékők vizes diszperziója, amelyben agázmikrőbűbőrékők amfifil anyaggal vannak stabilizálva, amely anyagfőszfőlipid-mőlekűlákat tartalmaz, amely mőlekűlák túlnyőmórésztmindegyike átlagős nettó töltéssel rendelkezik. A találmány vőnatkőziktővábbá a találmány szerinti gázmikrőbűbőrék vizes diszperzióttartalmazó kőntrasztanyag előállítására, valamint magára akőntrasztanyagra is, amely különösen alkalmas űltrahangősdiagnősztikai eljárásőknál történő felhasználásra. ŕ
HU9900813A 1996-02-19 1997-02-19 Improvements in or relating to contrast agents HU229090B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9625663.1A GB9625663D0 (en) 1996-12-11 1996-12-11 Improvements in or relating to contrast agents
PCT/GB1997/000459 WO1997029783A1 (en) 1996-02-19 1997-02-19 Improvements in or relating to contrast agents

Publications (3)

Publication Number Publication Date
HUP9900813A2 true HUP9900813A2 (hu) 1999-07-28
HUP9900813A3 HUP9900813A3 (en) 1999-11-29
HU229090B1 HU229090B1 (en) 2013-07-29

Family

ID=27268137

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900813A HU229090B1 (en) 1996-02-19 1997-02-19 Improvements in or relating to contrast agents

Country Status (25)

Country Link
US (4) US6221337B1 (hu)
EP (2) EP0881915B1 (hu)
JP (1) JP4418033B2 (hu)
KR (1) KR100500334B1 (hu)
CN (1) CN1278740C (hu)
AP (1) AP890A (hu)
AT (1) ATE238072T1 (hu)
AU (1) AU726503B2 (hu)
BG (1) BG102758A (hu)
CA (1) CA2246779C (hu)
CZ (1) CZ293986B6 (hu)
DE (1) DE69721235T2 (hu)
EA (1) EA001135B1 (hu)
EE (1) EE04224B1 (hu)
ES (1) ES2197986T3 (hu)
HK (1) HK1014872A1 (hu)
HU (1) HU229090B1 (hu)
IL (1) IL125748A (hu)
NZ (1) NZ331509A (hu)
OA (1) OA10839A (hu)
PL (1) PL328406A1 (hu)
PT (1) PT881915E (hu)
SK (1) SK284200B6 (hu)
TR (1) TR199801613T2 (hu)
WO (1) WO1997029783A1 (hu)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU784367B2 (en) * 1996-08-02 2006-03-16 Ge Healthcare As Improvements in or relating to contrast agents
CA2262908A1 (en) * 1996-08-02 1998-02-12 David Johnson Contrast agents for ultrasound imaging of the liver
ES2209167T3 (es) * 1997-08-12 2004-06-16 Bracco Research S.A. Composiciones administrables y metodo para produccion de imagenes por resonancia magnetica.
GB9717476D0 (en) * 1997-08-18 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9726773D0 (en) 1997-12-18 1998-02-18 Nycomed Imaging As Improvements in or relating to ultrasonagraphy
WO1999055837A2 (en) * 1998-04-28 1999-11-04 Nycomed Imaging As Improvements in or relating to separation processes
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US20030103960A1 (en) * 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
EP2286843A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
KR100373712B1 (ko) * 2000-12-23 2003-02-25 사회복지법인삼성생명공익재단(삼성서울병원) 초음파 조영제 및 그의 제조방법
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
US6962071B2 (en) 2001-04-06 2005-11-08 Bracco Research S.A. Method for improved measurement of local physical parameters in a fluid-filled cavity
US20050239746A1 (en) * 2002-02-01 2005-10-27 Penkler Lawrence J Pharmaceutical composition
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
EP2014310B8 (en) 2002-03-01 2012-12-26 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
NO20024755D0 (no) * 2002-10-03 2002-10-03 Amersham Health As Metode
KR20050072496A (ko) 2002-11-29 2005-07-11 아머샴 헬스 에이에스 초음파 촬영 방법
MXPA05007730A (es) * 2003-02-04 2006-01-31 Bracco Int Bv Agentes de contraste para ultrasonido y proceso para la preparacion de los mismos.
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
ES2557286T3 (es) 2003-03-03 2016-01-25 Dyax Corp. Usos de péptidos que se unen específicamente al receptor del HGF (cMet)
US20060222694A1 (en) * 2003-06-27 2006-10-05 Oh Choon K Stabilized topotecan liposomal composition and methods
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
NO20035401D0 (no) * 2003-12-04 2003-12-04 Amersham Health As Metode
WO2005063306A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Assembly of gas-filled microvesicle with active component for contrast imaging
US9750821B2 (en) * 2003-12-22 2017-09-05 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
CN101005858A (zh) 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物
WO2006044997A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for localized measurement and imaging of viscosity of tissues
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
CN100427142C (zh) * 2005-01-10 2008-10-22 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用助剂及其筛选方法
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
WO2007035721A2 (en) * 2005-09-19 2007-03-29 The Trustees Of Columbia University In The City Of New York Ultrasound method to open blood brain barrier
DK2359864T3 (da) 2005-12-09 2019-07-08 Bracco Suisse Sa Målrettende vektor-phospholipid-konjugater
EP1797919A1 (en) 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
WO2007088051A2 (en) 2006-01-31 2007-08-09 Bayer Schering Pharma Aktiengesellschaft Modulation of mdl-1 activity for treatment of inflammatory disease
US7967753B2 (en) 2006-08-01 2011-06-28 Stichting Voor de Technische Wetenschappen of Van Vollenhovenlaan Pulse inversion sequences for nonlinear imaging
WO2008027520A2 (en) * 2006-08-30 2008-03-06 The Trustees Of Columbia University In The City Of New York Systems and methods for composite elastography and wave imaging
ATE469660T1 (de) 2006-09-05 2010-06-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
WO2011035312A1 (en) 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010014977A1 (en) * 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
WO2010030779A1 (en) * 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Isolation of microbubbles of selected size range from polydisperse microbubbles
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
US10058837B2 (en) 2009-08-28 2018-08-28 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
EP2477550A4 (en) * 2009-09-15 2013-12-04 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR MICROBULLES
US9700640B2 (en) * 2009-09-21 2017-07-11 Drexel University Stabilized ultrasound contrast agent
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
EP2600771A1 (en) 2010-08-06 2013-06-12 The Trustees of Columbia University in the City of New York Medical imaging contrast devices, methods, and systems
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
WO2013164269A1 (en) 2012-04-30 2013-11-07 Ge Healthcare As Method for filling a container with a foamable composition
AU2013283409B2 (en) 2012-06-26 2017-06-08 Ge Healthcare As Preparation of composition comprising gas microbubbles
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
US10010630B2 (en) 2012-12-21 2018-07-03 Bracco Suisse S.A. Gas-filled microvesicles
US9255907B2 (en) 2013-03-14 2016-02-09 Empire Technology Development Llc Identification of surgical smoke
WO2014144708A1 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
DK3233136T3 (da) 2014-12-18 2019-05-20 Bracco Suisse Sa Formulering med målrettede gasfyldte mikrovesikler
WO2016199430A1 (ja) * 2015-06-10 2016-12-15 学校法人帝京大学 セラノスティクス用のバブル製剤(tb)及びその使用方法
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (hu) * 1990-04-02 1993-05-01 Sint Sa
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
DE4328642A1 (de) * 1993-08-26 1995-03-02 Byk Gulden Lomberg Chem Fab Ultraschallkontrastmittel
GB9511488D0 (en) * 1995-06-07 1995-08-02 Nycomed Imaging As Improvements in or relating to contrast agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator

Also Published As

Publication number Publication date
US20010010811A1 (en) 2001-08-02
HU229090B1 (en) 2013-07-29
PL328406A1 (en) 1999-01-18
BG102758A (en) 1999-09-30
KR100500334B1 (ko) 2005-09-09
NZ331509A (en) 2000-04-28
SK112698A3 (en) 1999-04-13
EP1331013A3 (en) 2004-03-24
WO1997029783A1 (en) 1997-08-21
EP0881915B1 (en) 2003-04-23
ES2197986T3 (es) 2004-01-16
AP9801319A0 (en) 1998-09-30
HK1014872A1 (en) 1999-10-08
EP0881915A1 (en) 1998-12-09
OA10839A (en) 2001-08-13
IL125748A (en) 2002-05-23
CN1278740C (zh) 2006-10-11
CZ293986B6 (cs) 2004-09-15
US6221337B1 (en) 2001-04-24
EA001135B1 (ru) 2000-10-30
DE69721235T2 (de) 2004-02-05
JP2000511510A (ja) 2000-09-05
CA2246779C (en) 2008-04-29
ATE238072T1 (de) 2003-05-15
EE9800249A (et) 1999-02-15
HUP9900813A3 (en) 1999-11-29
US20030202942A1 (en) 2003-10-30
EP1331013A2 (en) 2003-07-30
JP4418033B2 (ja) 2010-02-17
CA2246779A1 (en) 1997-08-21
TR199801613T2 (xx) 1998-11-23
DE69721235D1 (de) 2003-05-28
AU1884797A (en) 1997-09-02
CZ262598A3 (cs) 1999-05-12
EE04224B1 (et) 2004-02-16
SK284200B6 (sk) 2004-10-05
KR19990082669A (ko) 1999-11-25
CN1213972A (zh) 1999-04-14
EA199800745A1 (ru) 1999-02-25
US20050201942A1 (en) 2005-09-15
PT881915E (pt) 2003-09-30
AP890A (en) 2000-11-13
AU726503B2 (en) 2000-11-09
IL125748A0 (en) 1999-04-11

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