IL125748A - Contrast-containing gases for use in diagnostic imaging - Google Patents
Contrast-containing gases for use in diagnostic imagingInfo
- Publication number
- IL125748A IL125748A IL12574897A IL12574897A IL125748A IL 125748 A IL125748 A IL 125748A IL 12574897 A IL12574897 A IL 12574897A IL 12574897 A IL12574897 A IL 12574897A IL 125748 A IL125748 A IL 125748A
- Authority
- IL
- Israel
- Prior art keywords
- gas
- phospholipid
- dispersion
- microbubble
- lipid
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title claims description 65
- 238000002059 diagnostic imaging Methods 0.000 title claims description 5
- 239000006185 dispersion Substances 0.000 claims abstract description 88
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 84
- 239000000463 material Substances 0.000 claims abstract description 24
- 239000007789 gas Substances 0.000 claims description 142
- 238000000034 method Methods 0.000 claims description 47
- 239000000203 mixture Substances 0.000 claims description 40
- KAVGMUDTWQVPDF-UHFFFAOYSA-N perflubutane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F KAVGMUDTWQVPDF-UHFFFAOYSA-N 0.000 claims description 30
- 239000003570 air Substances 0.000 claims description 25
- 230000008569 process Effects 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 20
- 150000002632 lipids Chemical class 0.000 claims description 18
- 229950003332 perflubutane Drugs 0.000 claims description 18
- 238000009826 distribution Methods 0.000 claims description 15
- 238000003384 imaging method Methods 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 13
- 229930195733 hydrocarbon Natural products 0.000 claims description 13
- 150000002430 hydrocarbons Chemical class 0.000 claims description 13
- 239000000725 suspension Substances 0.000 claims description 13
- 239000012736 aqueous medium Substances 0.000 claims description 12
- 238000002604 ultrasonography Methods 0.000 claims description 12
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 claims description 11
- 229960000909 sulfur hexafluoride Drugs 0.000 claims description 11
- 239000004215 Carbon black (E152) Substances 0.000 claims description 9
- 239000000654 additive Substances 0.000 claims description 9
- 150000008106 phosphatidylserines Chemical class 0.000 claims description 8
- 239000008365 aqueous carrier Substances 0.000 claims description 7
- 239000002577 cryoprotective agent Substances 0.000 claims description 7
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 239000003623 enhancer Substances 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
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- 238000011084 recovery Methods 0.000 claims description 5
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- 235000000346 sugar Nutrition 0.000 claims description 5
- QTJXVIKNLHZIKL-UHFFFAOYSA-N sulfur difluoride Chemical class FSF QTJXVIKNLHZIKL-UHFFFAOYSA-N 0.000 claims description 5
- ABQLAMJAQZFPJI-UHFFFAOYSA-N 3-heptyloxolan-2-one Chemical compound CCCCCCCC1CCOC1=O ABQLAMJAQZFPJI-UHFFFAOYSA-N 0.000 claims description 4
- 239000011261 inert gas Substances 0.000 claims description 4
- 150000002576 ketones Chemical class 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
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- 150000001720 carbohydrates Chemical class 0.000 claims description 3
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- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 claims description 3
- 230000009977 dual effect Effects 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- 150000002321 glycerophosphoglycerophosphoglycerols Chemical class 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001272 nitrous oxide Substances 0.000 claims description 3
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 claims description 3
- 229960004692 perflenapent Drugs 0.000 claims description 3
- 229940067626 phosphatidylinositols Drugs 0.000 claims description 3
- 150000003905 phosphatidylinositols Chemical class 0.000 claims description 3
- 210000003934 vacuole Anatomy 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 230000037396 body weight Effects 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 229960004065 perflutren Drugs 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000008103 phosphatidic acids Chemical class 0.000 claims 1
- 239000000047 product Substances 0.000 description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
- 238000004108 freeze drying Methods 0.000 description 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 19
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 13
- 239000002961 echo contrast media Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 11
- 239000002502 liposome Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 230000008901 benefit Effects 0.000 description 7
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- 238000005406 washing Methods 0.000 description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
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- 239000000787 lecithin Substances 0.000 description 5
- 235000010445 lecithin Nutrition 0.000 description 5
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- 238000012360 testing method Methods 0.000 description 5
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 4
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 239000001569 carbon dioxide Substances 0.000 description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 229940039231 contrast media Drugs 0.000 description 4
- 230000000959 cryoprotective effect Effects 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- ZJIJAJXFLBMLCK-UHFFFAOYSA-N perfluorohexane Chemical class FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F ZJIJAJXFLBMLCK-UHFFFAOYSA-N 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
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- 239000004094 surface-active agent Substances 0.000 description 4
- 229960003853 ultrasound contrast media Drugs 0.000 description 4
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 description 3
- KLFKZIQAIPDJCW-HTIIIDOHSA-N Dipalmitoylphosphatidylserine Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCC KLFKZIQAIPDJCW-HTIIIDOHSA-N 0.000 description 3
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- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 3
- QIYZKVMAFMDRTP-UHFFFAOYSA-N pentafluoro(trifluoromethyl)-$l^{6}-sulfane Chemical compound FC(F)(F)S(F)(F)(F)(F)F QIYZKVMAFMDRTP-UHFFFAOYSA-N 0.000 description 3
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9603466.5A GB9603466D0 (en) | 1996-02-19 | 1996-02-19 | Improvements in or relating to contrast agents |
| GBGB9611894.8A GB9611894D0 (en) | 1996-06-07 | 1996-06-07 | Improvements in or relating to contrast agents |
| GBGB9625663.1A GB9625663D0 (en) | 1996-12-11 | 1996-12-11 | Improvements in or relating to contrast agents |
| PCT/GB1997/000459 WO1997029783A1 (en) | 1996-02-19 | 1997-02-19 | Improvements in or relating to contrast agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL125748A0 IL125748A0 (en) | 1999-04-11 |
| IL125748A true IL125748A (en) | 2002-05-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12574897A IL125748A (en) | 1996-02-19 | 1997-02-19 | Contrast-containing gases for use in diagnostic imaging |
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| US (4) | US6221337B1 (hu) |
| EP (2) | EP1331013A3 (hu) |
| JP (1) | JP4418033B2 (hu) |
| KR (1) | KR100500334B1 (hu) |
| CN (1) | CN1278740C (hu) |
| AP (1) | AP890A (hu) |
| AT (1) | ATE238072T1 (hu) |
| AU (1) | AU726503B2 (hu) |
| BG (1) | BG102758A (hu) |
| CA (1) | CA2246779C (hu) |
| CZ (1) | CZ293986B6 (hu) |
| DE (1) | DE69721235T2 (hu) |
| EA (1) | EA001135B1 (hu) |
| EE (1) | EE04224B1 (hu) |
| ES (1) | ES2197986T3 (hu) |
| HK (1) | HK1014872A1 (hu) |
| HU (1) | HU229090B1 (hu) |
| IL (1) | IL125748A (hu) |
| NZ (1) | NZ331509A (hu) |
| OA (1) | OA10839A (hu) |
| PL (1) | PL328406A1 (hu) |
| PT (1) | PT881915E (hu) |
| SK (1) | SK284200B6 (hu) |
| TR (1) | TR199801613T2 (hu) |
| WO (1) | WO1997029783A1 (hu) |
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| AU784367B2 (en) * | 1996-08-02 | 2006-03-16 | Ge Healthcare As | Improvements in or relating to contrast agents |
| NZ334365A (en) | 1996-08-02 | 1999-10-28 | Nycomed Imaging As | Use of a contrast agent comprising microbubbles of biocompatible gas stabilised by opsonisable amphiphilic material for ultrasound imaging of the liver |
| CA2268324C (en) * | 1997-08-12 | 2007-06-12 | Bracco Research S.A. | Administrable compositions and methods for magnetic resonance imaging |
| GB9717476D0 (en) * | 1997-08-18 | 1997-10-22 | Nycomed Imaging As | Process |
| GB9717588D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| GB9717542D0 (en) | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Process |
| GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| GB9726773D0 (en) | 1997-12-18 | 1998-02-18 | Nycomed Imaging As | Improvements in or relating to ultrasonagraphy |
| WO1999055837A2 (en) * | 1998-04-28 | 1999-11-04 | Nycomed Imaging As | Improvements in or relating to separation processes |
| GB9813568D0 (en) | 1998-06-23 | 1998-08-19 | Nycomed Imaging As | Improvements in or relating to cardiac imaging |
| US6514209B1 (en) | 1999-06-07 | 2003-02-04 | Drexel University | Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals |
| US20030103960A1 (en) * | 1999-12-22 | 2003-06-05 | Pierre Philippart | Sealant and bone generating product |
| EP2286843A3 (en) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Compounds for targeting endothelial cells |
| NO20004795D0 (no) | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
| KR100373712B1 (ko) * | 2000-12-23 | 2003-02-25 | 사회복지법인삼성생명공익재단(삼성서울병원) | 초음파 조영제 및 그의 제조방법 |
| US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| WO2002080774A2 (en) | 2001-04-06 | 2002-10-17 | Bracco Research S.A. | Method for improved measurement of local physical parameters in afluid-filled cavity |
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