BR0117106A - Compostos de lipossoma de microesfera de gás - Google Patents

Compostos de lipossoma de microesfera de gás

Info

Publication number
BR0117106A
BR0117106A BR0117106-2A BR0117106A BR0117106A BR 0117106 A BR0117106 A BR 0117106A BR 0117106 A BR0117106 A BR 0117106A BR 0117106 A BR0117106 A BR 0117106A
Authority
BR
Brazil
Prior art keywords
gas
microsphere
filled
microsphere liposome
lipid
Prior art date
Application number
BR0117106-2A
Other languages
English (en)
Inventor
Alan P Carpenter
Gregory C Slack
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of BR0117106A publication Critical patent/BR0117106A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Acoustics & Sound (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSTOS DE LIPOSSOMA DE MICROESFERA DE GáS". São descritas formulações compreendendo um composto de lipossoma de microesfera de gás suspenso em um meio, onde o composto de lipossoma de microesfera de gás compreende: uma microesfera cheia de gás; pelo menos um de lipídeo e tensoativo adsorvido na superfície da microesfera cheia de gás; e lipossomas cheios de líquido anexados ao lipídeo ou tensoativo. São também descritos processos para preparação das formulações e uso das mesmas na formação de imagem de ultra-som. A presente invenção também compreende o uso das mesmas no tratamento de doenças do coração, inflamação, infecção, câncer ou doença tromboembólica em um paciente.
BR0117106-2A 2001-08-16 2001-08-16 Compostos de lipossoma de microesfera de gás BR0117106A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2001/025685 WO2003015831A1 (en) 2001-08-16 2001-08-16 Gas microsphere liposome composites

Publications (1)

Publication Number Publication Date
BR0117106A true BR0117106A (pt) 2004-08-17

Family

ID=21742778

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0117106-2A BR0117106A (pt) 2001-08-16 2001-08-16 Compostos de lipossoma de microesfera de gás

Country Status (11)

Country Link
EP (1) EP1416974A1 (pt)
JP (1) JP2005505532A (pt)
KR (1) KR20040030121A (pt)
CN (1) CN1620314A (pt)
BR (1) BR0117106A (pt)
CA (1) CA2456988A1 (pt)
IL (1) IL160228A0 (pt)
MX (1) MXPA04001468A (pt)
NO (1) NO20040654L (pt)
PL (1) PL368072A1 (pt)
WO (1) WO2003015831A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004029010D1 (de) 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
CA2529304A1 (en) * 2003-06-13 2005-01-20 Imarx Therapeutics, Inc. Non-invasive intravascular thrombolysis using modified ultrasound techniques
JP2005154282A (ja) * 2003-11-20 2005-06-16 Mebiopharm Co Ltd ガス封入リポソームの製造法
EP1701745B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
AU2004308757B2 (en) * 2003-12-22 2010-06-17 Bracco Suisse S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
JP2008509890A (ja) * 2004-08-05 2008-04-03 ベイラー・リサーチ・インスチチユート 遺伝子または薬剤送達系
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
JPWO2006028129A1 (ja) * 2004-09-10 2008-05-08 東レ株式会社 医薬品製剤
AU2006214046A1 (en) * 2005-02-16 2006-08-24 Hyo-Jick Choi Bubble architectures and methods of making and using thereof
EP1884232A1 (en) * 2005-05-23 2008-02-06 Mebiopharm Co., Ltd. Method of producing liposomes containing gas enclosed therein
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
CN101365424A (zh) * 2005-12-08 2009-02-11 耶路撒冷希伯来大学伊森姆研究发展公司 通过超声辐射改变脂质体组成的方法
US20080213181A1 (en) * 2006-12-21 2008-09-04 Bristol-Myers Squibb Pharma Company Preparation of Paramagnetic Nanoparticles Conjugated to Leukotriene B4 (LTB4) Receptor Antagonists, and Their Use as MRI Contrast Agents for the Detection of Infection and Inflammation
DE102007008484A1 (de) * 2007-02-19 2008-08-21 Epo Experimentelle Pharmakologie & Onkologie Berlin-Buch Gmbh Pharmazeutische Zubereitung zur Bekämpfung von Metastasen
WO2009049083A1 (en) 2007-10-09 2009-04-16 Washington University In St. Louis Particles for imaging
WO2009049089A1 (en) 2007-10-09 2009-04-16 Washington University In St. Louis Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
KR101006347B1 (ko) * 2008-08-05 2011-01-10 주식회사 이엠따블유 스피커 일체형 안테나
AU2010339809B2 (en) * 2009-12-17 2016-05-05 The Washington University Antithrombotic nanoparticle
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
JP2013527157A (ja) 2010-04-15 2013-06-27 ワシントン・ユニバーシティ プロドラッグ組成物、プロドラッグナノ粒子およびその使用方法
WO2012098937A1 (ja) * 2011-01-21 2012-07-26 国立大学法人 神戸大学 リポソームの製造方法
EP2748299B1 (en) * 2011-08-24 2018-03-14 The Regents of The University of California Targeting microbubbles
CN102764456B (zh) * 2012-07-24 2014-10-15 上海交通大学 血管栓塞剂及其用途、制备方法
WO2015133828A1 (ko) * 2014-03-07 2015-09-11 주식회사 퍼시픽시스템 약물 전달을 위해 기포를 포함하는 미셀 및 이를 제작하는 방법
WO2016205359A2 (en) 2015-06-17 2016-12-22 Smith & Nephew, Inc. Surgical instrument with phase change cooling
CN105169420B (zh) * 2015-09-02 2018-01-05 上海市第十人民医院 一种新型射频诊疗剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620689A (en) * 1989-10-20 1997-04-15 Sequus Pharmaceuuticals, Inc. Liposomes for treatment of B-cell and T-cell disorders
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
HUT74509A (en) * 1993-09-09 1997-01-28 Schering Ag Active principles and gas containing microparticles, their use for realising active principles in ultrasonically controlled manner, and process for preparing them
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
AU753196B2 (en) * 1998-02-09 2002-10-10 Bracco Research S.A. Targeted delivery of biologically active media

Also Published As

Publication number Publication date
WO2003015831A1 (en) 2003-02-27
IL160228A0 (en) 2004-07-25
PL368072A1 (en) 2005-03-21
EP1416974A1 (en) 2004-05-12
CN1620314A (zh) 2005-05-25
NO20040654L (no) 2004-05-14
JP2005505532A (ja) 2005-02-24
CA2456988A1 (en) 2003-02-27
MXPA04001468A (es) 2004-05-20
KR20040030121A (ko) 2004-04-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A, 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2021 DE 29/09/2009.