NO965483L - Dinukleosid-5',5'-pyrofosfater - Google Patents

Dinukleosid-5',5'-pyrofosfater

Info

Publication number
NO965483L
NO965483L NO965483A NO965483A NO965483L NO 965483 L NO965483 L NO 965483L NO 965483 A NO965483 A NO 965483A NO 965483 A NO965483 A NO 965483A NO 965483 L NO965483 L NO 965483L
Authority
NO
Norway
Prior art keywords
riboside
dldeoxy
dideoxy
azido
pyrophosphates
Prior art date
Application number
NO965483A
Other languages
English (en)
Other versions
NO965483D0 (no
Inventor
Antonio De Flora
Umberto Benatti
Marco Giovine
Original Assignee
Lepetit Spa
Univ Degli Studi Genova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa, Univ Degli Studi Genova filed Critical Lepetit Spa
Publication of NO965483D0 publication Critical patent/NO965483D0/no
Publication of NO965483L publication Critical patent/NO965483L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

5' ,5'-pyrofosfater av ikke-naturlig forekommende , nukleosider valgt fra tymin-3'-azido-2',3'-dldeoksy-D- ribosld, 5-fluoruracil-2'-deoksy-D-rlbosid, uracil-3'- ! azido-2',3'-dideoksy-D-ribosid, guanin-2',3'-dideoksy- D-ribosid, hypoksantin-2',3'-dldeoksy-D-ribosld, i cytosin-2',3'-dldeoksy-D-ribosid og adenin-2',3'- ! dldeoksy-D-rlbosid, blir beskrevet såvel som deres , fremstilling og anvendelse som terapeutiske midler mot i tumorer og retrivirale infeksjoner inkludert HIV- : infeksjoner. Forbindelsene kan bli administrert som de i aktive ingrediensene av farmasøytiske sammensetninger | eller som pro-medikamenter innkapslet i biologiske j bærere, f.eks. transformerte erytrocyter, for målrett- I ing til spesifikke cellepopulasjoner som er ansvarlig ; for utvikling av de patologiske forstyrrelsene.
NO965483A 1994-07-15 1996-12-19 Dinukleosid-5',5'-pyrofosfater NO965483L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94202059 1994-07-15
PCT/EP1995/002676 WO1996002554A1 (en) 1994-07-15 1995-07-10 Dinucleoside-5',5'-pyrophosphates

Publications (2)

Publication Number Publication Date
NO965483D0 NO965483D0 (no) 1996-12-19
NO965483L true NO965483L (no) 1997-01-28

Family

ID=8217039

Family Applications (1)

Application Number Title Priority Date Filing Date
NO965483A NO965483L (no) 1994-07-15 1996-12-19 Dinukleosid-5',5'-pyrofosfater

Country Status (15)

Country Link
US (2) US6040297A (no)
EP (1) EP0773951B1 (no)
JP (1) JPH10502655A (no)
AT (1) ATE177431T1 (no)
AU (1) AU688552B2 (no)
CA (1) CA2195091A1 (no)
DE (1) DE69508255T2 (no)
ES (1) ES2129893T3 (no)
FI (1) FI970081A0 (no)
HU (1) HUT76331A (no)
IL (1) IL114520A0 (no)
NO (1) NO965483L (no)
NZ (1) NZ290127A (no)
WO (1) WO1996002554A1 (no)
ZA (1) ZA955826B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69834392T2 (de) 1997-02-06 2007-02-08 Inspire Pharmaceuticals, Inc. Dinukleotide und ihre verwendungen
US7078391B2 (en) * 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US7223744B2 (en) * 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US6596725B2 (en) 1997-02-10 2003-07-22 Inspire Pharmaceuticals, Inc. Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
WO2001012644A1 (en) * 1999-08-17 2001-02-22 Adani, Alexander Dinucleoside 5',5'-tetraphosphates as inhibitors of viral reverse transcriptases and viruses
BRPI0003386B8 (pt) * 2000-08-08 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda pró-droga homo ou heterodiméricas úteis no tratamento de doenças ou disfunções mediadas por fosfodiesterases; composições farmacêuticas contendo a pró-droga ou seus sais farmacêuticos aceitáveis; processo de obtenção destas pró-drogas
US6555675B2 (en) 2000-08-21 2003-04-29 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7790037B2 (en) * 2003-06-25 2010-09-07 University of Pittsburgh—of the Commonwealth System of Higher Education Separation of compounds using tagging moieties including varying numbers of repeat units
EP4028408A4 (en) * 2019-09-05 2023-10-18 Mitorainbow Therapeutics, Inc. TREATMENT OF MITOCHONDRIAL DNA DEPLETION DISORDERS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3321462A (en) * 1963-07-15 1967-05-23 Syntex Corp Process for the preparation of nucleoside polyphosphates
US3506478A (en) * 1968-08-29 1970-04-14 Budd Co Method of balancing a brake drum
US4855304A (en) * 1985-01-10 1989-08-08 Repligen Corporation Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals
US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods
IL86650A0 (en) * 1987-06-30 1988-11-30 Biophor Corp Animal derived cells and liposomes,having an antigenic protein incorporated into their membrane
WO1990006319A1 (en) * 1988-12-05 1990-06-14 Schering Corporation Antiviral dimers and trimers
NZ233197A (en) * 1989-04-13 1991-11-26 Richard Thomas Walker Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions
ES2109260T3 (es) * 1991-06-14 1998-01-16 Europ Communities Eritrocitos transformados, procedimiento para prepararlos y su utilizacion en composiciones farmaceuticas.
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide

Also Published As

Publication number Publication date
EP0773951A1 (en) 1997-05-21
CA2195091A1 (en) 1996-02-01
HUT76331A (en) 1997-08-28
NZ290127A (en) 1998-05-27
MX9700360A (es) 1998-03-31
EP0773951B1 (en) 1999-03-10
FI970081A (fi) 1997-01-08
FI970081A0 (fi) 1997-01-08
AU688552B2 (en) 1998-03-12
ZA955826B (en) 1996-02-21
JPH10502655A (ja) 1998-03-10
ATE177431T1 (de) 1999-03-15
IL114520A0 (en) 1995-11-27
NO965483D0 (no) 1996-12-19
AU3076695A (en) 1996-02-16
DE69508255T2 (de) 1999-10-14
US6040297A (en) 2000-03-21
HU9700118D0 (en) 1997-02-28
WO1996002554A1 (en) 1996-02-01
ES2129893T3 (es) 1999-06-16
DE69508255D1 (de) 1999-04-15
US6080731A (en) 2000-06-27

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