MXPA04001468A - Compuestos de liposomas y microesfera de gas. - Google Patents

Compuestos de liposomas y microesfera de gas.

Info

Publication number
MXPA04001468A
MXPA04001468A MXPA04001468A MXPA04001468A MXPA04001468A MX PA04001468 A MXPA04001468 A MX PA04001468A MX PA04001468 A MXPA04001468 A MX PA04001468A MX PA04001468 A MXPA04001468 A MX PA04001468A MX PA04001468 A MXPA04001468 A MX PA04001468A
Authority
MX
Mexico
Prior art keywords
gas
microsphere
filled
lipid
microsphere liposome
Prior art date
Application number
MXPA04001468A
Other languages
English (en)
Inventor
P Carpenter Alan Jr
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of MXPA04001468A publication Critical patent/MXPA04001468A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Acoustics & Sound (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen formulaciones que comprenden un compuesto de liposomas y microesfera de gas suspendido en un medio, en donde el compuesto de liposomas y microesfera de gas comprende: una microesfera llena de gas, al menos uno de un lipido y un agente tensioactivo adsorbido sobre la superficie de la microesfera llena de gas; y liposomas llenos de liquido unidos al lipido o agente tensioactivo. Se describen tambien metodos para preparar los mismos y usarlos en la formacion de imagenes por ultrasonido. La presente invencion comprende tambien el uso de los mismos para tratar enfermedades cardiacas, inflamacion, infeccion, cancer o enfermedad tromboembolica en un paciente.
MXPA04001468A 2001-08-16 2001-08-16 Compuestos de liposomas y microesfera de gas. MXPA04001468A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2001/025685 WO2003015831A1 (en) 2001-08-16 2001-08-16 Gas microsphere liposome composites

Publications (1)

Publication Number Publication Date
MXPA04001468A true MXPA04001468A (es) 2004-05-20

Family

ID=21742778

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001468A MXPA04001468A (es) 2001-08-16 2001-08-16 Compuestos de liposomas y microesfera de gas.

Country Status (11)

Country Link
EP (1) EP1416974A1 (es)
JP (1) JP2005505532A (es)
KR (1) KR20040030121A (es)
CN (1) CN1620314A (es)
BR (1) BR0117106A (es)
CA (1) CA2456988A1 (es)
IL (1) IL160228A0 (es)
MX (1) MXPA04001468A (es)
NO (1) NO20040654L (es)
PL (1) PL368072A1 (es)
WO (1) WO2003015831A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9364569B2 (en) 2003-02-04 2016-06-14 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
AU2004255160A1 (en) * 2003-06-13 2005-01-20 Imarx Therapeutics, Inc. Non-invasive intravascular thrombolyisis using modified ultrasound techniques
JP2005154282A (ja) * 2003-11-20 2005-06-16 Mebiopharm Co Ltd ガス封入リポソームの製造法
WO2005063305A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
AU2004308757B2 (en) * 2003-12-22 2010-06-17 Bracco Suisse S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
WO2007008220A2 (en) * 2004-08-05 2007-01-18 Baylor Research Institute Gene or drug delivery system
EP1784228B1 (en) 2004-08-18 2016-10-05 Bracco Suisse SA Gas-filled microvesicles composition for contrast imaging
KR20070052747A (ko) * 2004-09-10 2007-05-22 도레이 가부시끼가이샤 의약품제제
EP1853916A4 (en) * 2005-02-16 2008-03-26 Univ California BUBBLE ARCHITECTURES AND METHODS OF OBTAINING AND USING SAME
EP1884232A1 (en) * 2005-05-23 2008-02-06 Mebiopharm Co., Ltd. Method of producing liposomes containing gas enclosed therein
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
US20090155345A1 (en) * 2005-12-08 2009-06-18 Ben Gurion University Of The Negev Research And Development Authority Methods for affecting liposome composition ultrasound irradiation
WO2008079834A2 (en) * 2006-12-21 2008-07-03 Lantheus Medical Imaging, Inc. Preparation of paramagnetic nanoparticles conjugated to leukotriene b4 (ltb4) receptor antagonists, and their use as mri contrast agents for the detection of infection and inflammation
DE102007008484A1 (de) * 2007-02-19 2008-08-21 Epo Experimentelle Pharmakologie & Onkologie Berlin-Buch Gmbh Pharmazeutische Zubereitung zur Bekämpfung von Metastasen
US9446150B2 (en) 2007-10-09 2016-09-20 Washington University Particles for imaging
WO2009049089A1 (en) 2007-10-09 2009-04-16 Washington University In St. Louis Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
KR101006347B1 (ko) * 2008-08-05 2011-01-10 주식회사 이엠따블유 스피커 일체형 안테나
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
US9764043B2 (en) * 2009-12-17 2017-09-19 Washington University Antithrombotic nanoparticle
AU2011239414A1 (en) 2010-04-15 2012-11-08 The Washington University Prodrug compositions, prodrug nanoparticles, and methods of use thereof
WO2012098937A1 (ja) * 2011-01-21 2012-07-26 国立大学法人 神戸大学 リポソームの製造方法
US20130123781A1 (en) * 2011-08-24 2013-05-16 California Institute Of Technology Targeting microbubbles
CN102764456B (zh) * 2012-07-24 2014-10-15 上海交通大学 血管栓塞剂及其用途、制备方法
WO2015133828A1 (ko) * 2014-03-07 2015-09-11 주식회사 퍼시픽시스템 약물 전달을 위해 기포를 포함하는 미셀 및 이를 제작하는 방법
WO2016205359A2 (en) 2015-06-17 2016-12-22 Smith & Nephew, Inc. Surgical instrument with phase change cooling
CN105169420B (zh) * 2015-09-02 2018-01-05 上海市第十人民医院 一种新型射频诊疗剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620689A (en) * 1989-10-20 1997-04-15 Sequus Pharmaceuuticals, Inc. Liposomes for treatment of B-cell and T-cell disorders
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
EP0717617B1 (de) * 1993-09-09 2000-10-25 Schering Aktiengesellschaft Wirkstoffe und gas enthaltende mikropartikel
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
ES2244169T3 (es) * 1998-02-09 2005-12-01 Bracco International B.V. Suministro direccionado de medios biologicamente activos.

Also Published As

Publication number Publication date
CA2456988A1 (en) 2003-02-27
IL160228A0 (en) 2004-07-25
WO2003015831A1 (en) 2003-02-27
EP1416974A1 (en) 2004-05-12
JP2005505532A (ja) 2005-02-24
CN1620314A (zh) 2005-05-25
KR20040030121A (ko) 2004-04-08
BR0117106A (pt) 2004-08-17
PL368072A1 (en) 2005-03-21
NO20040654L (no) 2004-05-14

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