DK2359864T3 - Målrettende vektor-phospholipid-konjugater - Google Patents
Målrettende vektor-phospholipid-konjugaterInfo
- Publication number
- DK2359864T3 DK2359864T3 DK10190163.5T DK10190163T DK2359864T3 DK 2359864 T3 DK2359864 T3 DK 2359864T3 DK 10190163 T DK10190163 T DK 10190163T DK 2359864 T3 DK2359864 T3 DK 2359864T3
- Authority
- DK
- Denmark
- Prior art keywords
- targeting vector
- phospholipid conjugates
- phospholipid
- conjugates
- targeting
- Prior art date
Links
- 150000003904 phospholipids Chemical class 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74924005P | 2005-12-09 | 2005-12-09 | |
| US83334206P | 2006-07-25 | 2006-07-25 | |
| EP06840164.5A EP1966388B1 (en) | 2005-12-09 | 2006-12-08 | Targeting vector-phospholipid conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2359864T3 true DK2359864T3 (da) | 2019-07-08 |
Family
ID=38123651
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06840164.5T DK1966388T3 (da) | 2005-12-09 | 2006-12-08 | Tilsigte vektor-fosfolipidkonjugater |
| DK10190163.5T DK2359864T3 (da) | 2005-12-09 | 2006-12-08 | Målrettende vektor-phospholipid-konjugater |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06840164.5T DK1966388T3 (da) | 2005-12-09 | 2006-12-08 | Tilsigte vektor-fosfolipidkonjugater |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP2359864B1 (da) |
| JP (2) | JP5242408B2 (da) |
| KR (3) | KR20140083052A (da) |
| CN (2) | CN103204911B (da) |
| AU (1) | AU2006321613B2 (da) |
| BR (1) | BRPI0619522B8 (da) |
| CA (3) | CA2631716C (da) |
| DK (2) | DK1966388T3 (da) |
| ES (1) | ES2428964T3 (da) |
| IL (1) | IL191850A (da) |
| MX (1) | MX2008007321A (da) |
| RU (1) | RU2433137C2 (da) |
| WO (1) | WO2007067979A2 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1587944A4 (en) | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| SI2949658T1 (sl) * | 2003-03-03 | 2018-10-30 | Dyax Corp. | Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe |
| CN101094867B (zh) | 2004-10-19 | 2011-08-24 | 隆萨股份公司 | 用于固相肽合成的方法 |
| CA2631716C (en) * | 2005-12-09 | 2013-11-26 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US20110160431A1 (en) * | 2009-04-06 | 2011-06-30 | Novetide, Ltd. | Production of peptides containing poly-gly sequences using fmoc chemistry |
| CN101637613B (zh) * | 2009-08-19 | 2011-09-14 | 王维 | 一种脂质靶向超声造影剂及其制备方法 |
| EP2603242B1 (en) | 2010-08-09 | 2018-03-14 | Bracco Suisse SA | Targeted gas-filled microvesicles |
| CN102286076B (zh) * | 2011-06-23 | 2014-03-12 | 成都圣诺科技发展有限公司 | 比伐卢定的制备方法 |
| WO2014096165A2 (en) * | 2012-12-21 | 2014-06-26 | Bracco Suisse Sa | Gas-filled microvesicles |
| HUE043680T2 (hu) * | 2014-12-18 | 2019-09-30 | Bracco Suisse Sa | Célbajuttató gázzal töltött mikrorészecske készítmény |
| US20190046667A1 (en) * | 2016-02-01 | 2019-02-14 | Trust Biosonics Inc. | Lipid microbubbles and process of making thereof |
| WO2018140425A1 (en) * | 2017-01-24 | 2018-08-02 | Nuvox Pharma Llc | Iso-osmotic and near iso-osmotic oxygen therapeutic formulations and methods thereof |
| EP3360884A1 (en) * | 2017-02-10 | 2018-08-15 | Neuronax | Improved process for the preparation of a dodecapeptide |
| KR20210106418A (ko) | 2018-12-18 | 2021-08-30 | 브라코 스위스 에스.에이. | 다이머 펩타이드-인지질 콘쥬게이트를 위한 최적화 과정 |
| US11717570B2 (en) | 2019-05-15 | 2023-08-08 | Bracco Suisse Sa | Gas-filled microvesicles |
| US20200360289A1 (en) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
| WO2023103963A1 (en) * | 2021-12-06 | 2023-06-15 | Westlake Therapeutics (Shanghai) Co., Limited | Modified cells and uses thereof for delivering agents |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| IN172208B (da) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
| US5338725A (en) * | 1992-06-30 | 1994-08-16 | The Research Foundation Of The State University Of New York | Anti-aggregatory agents for platelets |
| KR100295173B1 (ko) | 1993-12-15 | 2001-09-17 | 엔. 토모브 | 초음파콘트라스트매질로서유용한가스혼합물 |
| IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| EP1444991A1 (en) * | 1995-06-07 | 2004-08-11 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
| EP0881915B1 (en) | 1996-02-19 | 2003-04-23 | Amersham Health AS | Improvements in or relating to contrast agents |
| WO1998005364A2 (en) | 1996-08-02 | 1998-02-12 | Marsden, John, Christopher | Improvements in or relating to contrast agents |
| US6071532A (en) * | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| EE03749B1 (et) | 1996-10-21 | 2002-06-17 | Nycomed Imaging As | Kombineeritud preparaat samaaegseks, eraldi või järjestikuseks kasutamiseks kontrastainena ultrahelikujutamisel |
| WO1998018501A2 (en) | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| EP0991427A2 (en) | 1996-10-28 | 2000-04-12 | Marsden, John Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| WO1998018498A2 (en) | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| ES2257771T3 (es) | 1996-10-28 | 2006-08-01 | Amersham Health As | Agentes de contraste. |
| EP0946202B1 (en) | 1996-10-28 | 2003-09-10 | Amersham Health AS | Contrast agents |
| US6245318B1 (en) | 1997-05-27 | 2001-06-12 | Mallinckrodt Inc. | Selectively binding ultrasound contrast agents |
| GB9809084D0 (en) * | 1998-04-28 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| EP2279757A3 (en) * | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Compounds for targeting endothelial cells |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| CA2477935C (en) * | 2002-03-01 | 2015-01-06 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| EP1587944A4 (en) * | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| JP2006514915A (ja) * | 2002-03-01 | 2006-05-18 | ダイアックス、コープ | Ｋｄｒおよびｖｅｇｆ／ｋｄｒ結合ペプチドならびに診断および治療におけるその使用 |
| KR101076053B1 (ko) | 2003-02-04 | 2011-10-21 | 브라코 인터내셔날 비.브이. | 초음파 조영제 및 그것의 제조방법 |
| FI20031528A0 (fi) * | 2003-10-17 | 2003-10-17 | Ctt Cancer Targeting Tech Oy | Terapeuttinen liposomikoostumus ja menetelmä sen valmistamiseksi |
| CA2631716C (en) * | 2005-12-09 | 2013-11-26 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
-
2006
- 2006-12-08 CA CA2631716A patent/CA2631716C/en active Active
- 2006-12-08 DK DK06840164.5T patent/DK1966388T3/da active
- 2006-12-08 CA CA2947346A patent/CA2947346C/en active Active
- 2006-12-08 JP JP2008544663A patent/JP5242408B2/ja active Active
- 2006-12-08 RU RU2008127836/04A patent/RU2433137C2/ru active IP Right Revival
- 2006-12-08 KR KR1020147014542A patent/KR20140083052A/ko not_active Application Discontinuation
- 2006-12-08 AU AU2006321613A patent/AU2006321613B2/en active Active
- 2006-12-08 EP EP10190163.5A patent/EP2359864B1/en active Active
- 2006-12-08 ES ES06840164T patent/ES2428964T3/es active Active
- 2006-12-08 CN CN201310052906.3A patent/CN103204911B/zh active Active
- 2006-12-08 CN CN2006800522791A patent/CN101374955B/zh active Active
- 2006-12-08 KR KR1020087016674A patent/KR101323849B1/ko active IP Right Grant
- 2006-12-08 KR KR1020137021393A patent/KR101658439B1/ko active IP Right Grant
- 2006-12-08 CA CA2826960A patent/CA2826960A1/en not_active Abandoned
- 2006-12-08 WO PCT/US2006/061793 patent/WO2007067979A2/en active Application Filing
- 2006-12-08 EP EP06840164.5A patent/EP1966388B1/en active Active
- 2006-12-08 MX MX2008007321A patent/MX2008007321A/es active IP Right Grant
- 2006-12-08 DK DK10190163.5T patent/DK2359864T3/da active
- 2006-12-08 BR BRPI0619522A patent/BRPI0619522B8/pt active IP Right Grant
-
2008
- 2008-05-29 IL IL191850A patent/IL191850A/en active IP Right Grant
-
2013
- 2013-02-13 JP JP2013025796A patent/JP5735993B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2359864T3 (da) | Målrettende vektor-phospholipid-konjugater | |
| DK1912671T3 (da) | Beta-glucuronid-linker-lægemiddelkonjugater | |
| DK2444807T3 (da) | Mono- og dinitropyrazolhaptenkonjugater | |
| ATE443753T1 (de) | Nuancierungsmittel | |
| DE602006002527D1 (de) | Versiegelungsvorrichtung | |
| DE112006001565A5 (de) | Nanopartikel-Wirkstoff-Konjugate | |
| BRPI0923047A2 (pt) | "conjugados de proteínas-oligossacarídeos". | |
| DE602007009378D1 (de) | Vr1-benzimidazolmodulatoren | |
| EP1948600A4 (en) | TARGET CONJUGATES ON THE LIVER | |
| DE602006006395D1 (de) | Versiegelungsgerät | |
| DK1960429T3 (da) | Immunglobuliner rettet mod NOGO | |
| DE502007000476D1 (de) | Verbundlenkerachse | |
| ITMI20060108A1 (it) | Dispsotivo avvolgitore | |
| DE502006006589D1 (de) | Teils | |
| SE0501828L (sv) | Rörelsetransformerande arrangemang | |
| DE602006007836D1 (de) | Kontrastmittel | |
| AT505229A3 (de) | Potenzhilfe ''penisschlauch'' | |
| FI20065208A0 (fi) | Peptidikonjugaatteja | |
| DE602005020522D1 (de) | Dreidimensionaler lochfilm | |
| DE502007000078D1 (de) | Verbundlenkerachse | |
| DE502006008206D1 (de) | Steckverbinder | |
| SI1966388T1 (sl) | Konjugati iz ciljnega vektorja in fosfolipidov | |
| SE0501759L (sv) | Smutsavvisande formuleringar | |
| AU2005903324A0 (en) | Targeting vector | |
| UA11461S (uk) | Рекламний щит |