SU466684A3 - Способ получени производных 2-нитроимидазола - Google Patents
Способ получени производных 2-нитроимидазолаInfo
- Publication number
- SU466684A3 SU466684A3 SU1812193A SU1812193A SU466684A3 SU 466684 A3 SU466684 A3 SU 466684A3 SU 1812193 A SU1812193 A SU 1812193A SU 1812193 A SU1812193 A SU 1812193A SU 466684 A3 SU466684 A3 SU 466684A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- methyl
- nitro
- solution
- residue
- added
- Prior art date
Links
- 150000004959 2-nitroimidazoles Chemical class 0.000 title description 4
- 238000000034 method Methods 0.000 title description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 239000012285 osmium tetroxide Substances 0.000 description 6
- 229910000489 osmium tetroxide Inorganic materials 0.000 description 6
- 150000001299 aldehydes Chemical class 0.000 description 5
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- PTLILCRCEWAQGA-UHFFFAOYSA-N 3-methyl-2-nitroimidazole-4-carbaldehyde Chemical compound CN1C(C=O)=CN=C1[N+]([O-])=O PTLILCRCEWAQGA-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229910000033 sodium borohydride Inorganic materials 0.000 description 4
- 239000012279 sodium borohydride Substances 0.000 description 4
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- -1 heterocyclic radical Chemical class 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 239000012286 potassium permanganate Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- JEHCHYAKAXDFKV-UHFFFAOYSA-J lead tetraacetate Chemical compound CC(=O)O[Pb](OC(C)=O)(OC(C)=O)OC(C)=O JEHCHYAKAXDFKV-UHFFFAOYSA-J 0.000 description 2
- 229910052987 metal hydride Inorganic materials 0.000 description 2
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- WXSSUDRHAJTESR-UHFFFAOYSA-N (3-methyl-2-nitroimidazol-4-yl)methanol Chemical compound CN1C(CO)=CN=C1[N+]([O-])=O WXSSUDRHAJTESR-UHFFFAOYSA-N 0.000 description 1
- CYCZTKORVZMFEY-UHFFFAOYSA-N 1-(3-methyl-2-nitroimidazol-4-yl)ethanone Chemical compound CC(=O)C1=CN=C([N+]([O-])=O)N1C CYCZTKORVZMFEY-UHFFFAOYSA-N 0.000 description 1
- YTCXUSUYDAJXFV-UHFFFAOYSA-N 1-ethyl-2-nitro-5-(2-phenylethenyl)imidazole Chemical compound N1=C([N+]([O-])=O)N(CC)C(C=CC=2C=CC=CC=2)=C1 YTCXUSUYDAJXFV-UHFFFAOYSA-N 0.000 description 1
- NIZHAUDFIOIGPX-UHFFFAOYSA-N 1-ethyl-5-methyl-2-nitroimidazole Chemical compound CCN1C(C)=CN=C1[N+]([O-])=O NIZHAUDFIOIGPX-UHFFFAOYSA-N 0.000 description 1
- WUKJZHIPZPZBLS-BQYQJAHWSA-N 1-methyl-2-nitro-5-[(e)-2-phenylethenyl]imidazole Chemical compound N1=C([N+]([O-])=O)N(C)C(\C=C\C=2C=CC=CC=2)=C1 WUKJZHIPZPZBLS-BQYQJAHWSA-N 0.000 description 1
- ZQEXIXXJFSQPNA-UHFFFAOYSA-N 1h-imidazole-5-carbaldehyde Chemical compound O=CC1=CNC=N1 ZQEXIXXJFSQPNA-UHFFFAOYSA-N 0.000 description 1
- VRHJYURWCPSFRK-UHFFFAOYSA-N 2,3-dimethyl-2-nitro-1H-imidazole Chemical compound CN1C=CNC1(C)N(=O)=O VRHJYURWCPSFRK-UHFFFAOYSA-N 0.000 description 1
- MSBCVLHFCWIVTP-UHFFFAOYSA-N 2-nitro-1h-imidazole-5-carbaldehyde Chemical compound [O-][N+](=O)C1=NC(C=O)=CN1 MSBCVLHFCWIVTP-UHFFFAOYSA-N 0.000 description 1
- YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical class [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 description 1
- NZPWAZZKZMQLTL-UHFFFAOYSA-N 5-ethenyl-1-methyl-2-nitroimidazole Chemical compound CN1C(C=C)=CN=C1[N+]([O-])=O NZPWAZZKZMQLTL-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- TUCNEACPLKLKNU-UHFFFAOYSA-N acetyl Chemical compound C[C]=O TUCNEACPLKLKNU-UHFFFAOYSA-N 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- QFWPJPIVLCBXFJ-UHFFFAOYSA-N glymidine Chemical compound N1=CC(OCCOC)=CN=C1NS(=O)(=O)C1=CC=CC=C1 QFWPJPIVLCBXFJ-UHFFFAOYSA-N 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229960005235 piperonyl butoxide Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4297871 | 1971-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU466684A3 true SU466684A3 (ru) | 1975-04-05 |
Family
ID=11254772
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1812193A SU466684A3 (ru) | 1971-07-30 | 1972-07-25 | Способ получени производных 2-нитроимидазола |
| SU1812191A SU463263A3 (ru) | 1971-07-30 | 1972-07-25 | Способ получени производных 5-иминометил-2-нитроимидазол |
| SU7301932092A SU581863A3 (ru) | 1971-07-30 | 1973-06-27 | Способ получени производных 2нитроимидазола |
| SU7301978810A SU567404A3 (ru) | 1971-07-30 | 1973-12-24 | Способ получени производных 2-нитроимидазола |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1812191A SU463263A3 (ru) | 1971-07-30 | 1972-07-25 | Способ получени производных 5-иминометил-2-нитроимидазол |
| SU7301932092A SU581863A3 (ru) | 1971-07-30 | 1973-06-27 | Способ получени производных 2нитроимидазола |
| SU7301978810A SU567404A3 (ru) | 1971-07-30 | 1973-12-24 | Способ получени производных 2-нитроимидазола |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US3954789A (enExample) |
| JP (2) | JPS528832B1 (enExample) |
| AR (4) | AR199084A1 (enExample) |
| AT (3) | AT323736B (enExample) |
| AU (1) | AU462723B2 (enExample) |
| BE (1) | BE785024A (enExample) |
| CA (1) | CA997340A (enExample) |
| CH (4) | CH580596A5 (enExample) |
| CS (1) | CS180585B2 (enExample) |
| DD (2) | DD99996A5 (enExample) |
| DE (2) | DE2229223C3 (enExample) |
| DK (1) | DK154295C (enExample) |
| ES (3) | ES405341A1 (enExample) |
| FI (1) | FI57255C (enExample) |
| FR (1) | FR2148073B1 (enExample) |
| GB (1) | GB1362444A (enExample) |
| HU (2) | HU167622B (enExample) |
| IE (1) | IE36530B1 (enExample) |
| IL (1) | IL39880A (enExample) |
| LU (1) | LU65816A1 (enExample) |
| NL (2) | NL148602B (enExample) |
| NO (2) | NO135591C (enExample) |
| PL (4) | PL82980B1 (enExample) |
| RO (6) | RO63453A (enExample) |
| SE (3) | SE392615B (enExample) |
| SU (4) | SU466684A3 (enExample) |
| ZA (1) | ZA724723B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1480192A (en) * | 1975-01-15 | 1977-07-20 | Lepetit Spa | 1-methyl-2-nitro-imidazole-5-methanol derivatives |
| GB1526451A (en) * | 1976-01-27 | 1978-09-27 | Lepetit Spa | Alpha,alpha,1-trimethyl-2-nitroimidazole-5-methanol derivatives |
| US4218460A (en) * | 1976-09-29 | 1980-08-19 | Basf Aktiengesellschaft | Nitroimidazoles |
| US4199592A (en) * | 1978-08-29 | 1980-04-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-nitroimidazoles |
| ZW24982A1 (en) * | 1981-11-30 | 1983-06-15 | Hoffmann La Roche | 2-nitroimidazoles |
| JPH10338673A (ja) * | 1997-06-04 | 1998-12-22 | Nippon Bayeragrochem Kk | イソニコチン酸ヒドラジド誘導体および有害生物防除剤 |
| ZA200507752B (en) | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| ZA200800314B (en) | 2005-06-29 | 2009-09-30 | Threshold Pharmaceuticals Inc | Phosphoramidate alkylator prodrugs |
| US8552048B2 (en) | 2006-12-26 | 2013-10-08 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs for the treatment of cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL124627C (enExample) * | 1964-08-12 | |||
| NL143227B (nl) * | 1968-11-15 | 1974-09-16 | Lepetit Spa | Werkwijze ter bereiding van imidazoolderivaten met bactericide werking. |
| US3583985A (en) * | 1969-04-09 | 1971-06-08 | Richardson Merrell Inc | Nitroimidazolyl nitrones |
| US3711495A (en) * | 1970-01-07 | 1973-01-16 | Merck & Co Inc | Isoxazalin-3-yl-substituted-5-nitroimidazoles |
-
1972
- 1972-06-15 DE DE2229223A patent/DE2229223C3/de not_active Expired
- 1972-06-15 DE DE2229248A patent/DE2229248C3/de not_active Expired
- 1972-06-16 BE BE785024A patent/BE785024A/xx not_active IP Right Cessation
- 1972-06-30 FI FI1864/72A patent/FI57255C/fi active
- 1972-07-05 IE IE944/72A patent/IE36530B1/xx unknown
- 1972-07-05 AU AU44228/72A patent/AU462723B2/en not_active Expired
- 1972-07-11 ZA ZA724723A patent/ZA724723B/xx unknown
- 1972-07-11 IL IL39880A patent/IL39880A/en unknown
- 1972-07-13 GB GB3288672A patent/GB1362444A/en not_active Expired
- 1972-07-20 AR AR243172A patent/AR199084A1/es active
- 1972-07-20 AR AR243170A patent/AR193999A1/es active
- 1972-07-20 AR AR243171A patent/AR193885A1/es active
- 1972-07-25 SU SU1812193A patent/SU466684A3/ru active
- 1972-07-25 SU SU1812191A patent/SU463263A3/ru active
- 1972-07-26 DK DK369072A patent/DK154295C/da not_active IP Right Cessation
- 1972-07-26 US US05/275,415 patent/US3954789A/en not_active Expired - Lifetime
- 1972-07-27 NO NO2693/72A patent/NO135591C/no unknown
- 1972-07-27 NO NO2694/72A patent/NO135592C/no unknown
- 1972-07-27 NL NL727210339A patent/NL148602B/xx not_active IP Right Cessation
- 1972-07-27 NL NL727210340A patent/NL149491B/xx not_active IP Right Cessation
- 1972-07-27 JP JP47075508A patent/JPS528832B1/ja active Pending
- 1972-07-27 JP JP47075507A patent/JPS5038111B1/ja active Pending
- 1972-07-27 CS CS7200005305A patent/CS180585B2/cs unknown
- 1972-07-28 CH CH1127672A patent/CH580596A5/xx not_active IP Right Cessation
- 1972-07-28 CH CH1127772A patent/CH572040A5/xx not_active IP Right Cessation
- 1972-07-28 SE SE7209898A patent/SE392615B/xx unknown
- 1972-07-28 HU HULE663A patent/HU167622B/hu unknown
- 1972-07-28 AT AT686873A patent/AT323736B/de not_active IP Right Cessation
- 1972-07-28 RO RO7200075751A patent/RO63453A/ro unknown
- 1972-07-28 RO RO7200079770A patent/RO63048A/ro unknown
- 1972-07-28 AT AT652872A patent/AT315164B/de not_active IP Right Cessation
- 1972-07-28 RO RO7200079769A patent/RO63047A/ro unknown
- 1972-07-28 RO RO7200079771A patent/RO63049A/ro unknown
- 1972-07-28 LU LU65816D patent/LU65816A1/xx unknown
- 1972-07-28 RO RO71769A patent/RO62787A/ro unknown
- 1972-07-28 PL PL1972156990A patent/PL82980B1/pl unknown
- 1972-07-28 RO RO71770A patent/RO61517A/ro unknown
- 1972-07-28 PL PL1972156989A patent/PL85190B1/pl unknown
- 1972-07-28 CH CH1521175A patent/CH574934A5/xx not_active IP Right Cessation
- 1972-07-28 PL PL1972163819A patent/PL87673B1/pl unknown
- 1972-07-28 SE SE7209897A patent/SE417711B/xx unknown
- 1972-07-28 DD DD164752A patent/DD99996A5/xx unknown
- 1972-07-28 PL PL1972175045A patent/PL84350B1/pl unknown
- 1972-07-28 CH CH1521075A patent/CH574933A5/xx not_active IP Right Cessation
- 1972-07-28 HU HULE664A patent/HU164926B/hu unknown
- 1972-07-28 AT AT652772A patent/AT316545B/de not_active IP Right Cessation
- 1972-07-28 FR FR7227293A patent/FR2148073B1/fr not_active Expired
- 1972-07-28 DD DD164754A patent/DD99995A5/xx unknown
- 1972-07-29 ES ES405341A patent/ES405341A1/es not_active Expired
- 1972-07-29 ES ES405343A patent/ES405343A1/es not_active Expired
- 1972-07-31 CA CA148,336A patent/CA997340A/en not_active Expired
-
1973
- 1973-06-27 SU SU7301932092A patent/SU581863A3/ru active
- 1973-08-02 AR AR249413A patent/AR199680A1/es active
- 1973-09-20 ES ES418921A patent/ES418921A1/es not_active Expired
- 1973-12-24 SU SU7301978810A patent/SU567404A3/ru active
-
1975
- 1975-03-18 SE SE7503080A patent/SE417200B/xx not_active IP Right Cessation
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