SU1316559A3 - Способ получени производных имидазола или их кислотно-аддитивных солей - Google Patents

Способ получени производных имидазола или их кислотно-аддитивных солей Download PDF

Info

Publication number
SU1316559A3
SU1316559A3 SU833606327A SU3606327A SU1316559A3 SU 1316559 A3 SU1316559 A3 SU 1316559A3 SU 833606327 A SU833606327 A SU 833606327A SU 3606327 A SU3606327 A SU 3606327A SU 1316559 A3 SU1316559 A3 SU 1316559A3
Authority
SU
USSR - Soviet Union
Prior art keywords
methoxy
found
calculated
eine
acid
Prior art date
Application number
SU833606327A
Other languages
English (en)
Russian (ru)
Inventor
Хауэль Норберт
Аустель Фолкхард
Хейдер Иоахим
Рейффен Манфред
Дидерен Вилли
Original Assignee
Др.Карл Томэ.Гмбх (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Др.Карл Томэ.Гмбх (Фирма) filed Critical Др.Карл Томэ.Гмбх (Фирма)
Application granted granted Critical
Publication of SU1316559A3 publication Critical patent/SU1316559A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SU833606327A 1982-07-01 1983-06-21 Способ получени производных имидазола или их кислотно-аддитивных солей SU1316559A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823224512 DE3224512A1 (de) 1982-07-01 1982-07-01 Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
SU1316559A3 true SU1316559A3 (ru) 1987-06-07

Family

ID=6167285

Family Applications (2)

Application Number Title Priority Date Filing Date
SU833606327A SU1316559A3 (ru) 1982-07-01 1983-06-21 Способ получени производных имидазола или их кислотно-аддитивных солей
SU843699112A SU1179924A3 (ru) 1982-07-01 1984-02-01 "cпocoб пoлучehия пpoизboдhыx иmидaзoлa или иx taуtomepob,или kиcлotho-aддиtиbhыx coлeй"

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU843699112A SU1179924A3 (ru) 1982-07-01 1984-02-01 "cпocoб пoлучehия пpoизboдhыx иmидaзoлa или иx taуtomepob,или kиcлotho-aддиtиbhыx coлeй"

Country Status (23)

Country Link
US (2) US4582837A (enExample)
EP (1) EP0098448A3 (enExample)
JP (1) JPS5927875A (enExample)
KR (1) KR840005432A (enExample)
AU (1) AU1642883A (enExample)
CS (1) CS254319B2 (enExample)
DD (1) DD210271A5 (enExample)
DE (1) DE3224512A1 (enExample)
DK (1) DK301383A (enExample)
ES (3) ES523709A0 (enExample)
FI (1) FI832022A7 (enExample)
GB (1) GB2122995B (enExample)
GR (1) GR78598B (enExample)
HU (1) HU192152B (enExample)
IL (1) IL69111A0 (enExample)
NO (1) NO832356L (enExample)
NZ (1) NZ204766A (enExample)
PH (1) PH20810A (enExample)
PL (2) PL142880B1 (enExample)
PT (1) PT76968B (enExample)
SU (2) SU1316559A3 (enExample)
YU (1) YU143283A (enExample)
ZA (1) ZA834777B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256287B2 (en) 2002-09-12 2007-08-14 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
US7282518B2 (en) 2001-03-12 2007-10-16 Avanir Pharmaceuticals Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
US7375118B2 (en) 2002-09-12 2008-05-20 Avanir Pharmaceuticals Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation
RU2424233C2 (ru) * 2006-06-29 2011-07-20 Ф.Хоффманн-Ля Рош Аг Производные бензимидазола, методы их получения, применение их в качестве агонистов фарнезоид-х-рецептора (fxr) и содержащие их фармацевтические препараты
RU2493153C2 (ru) * 2007-12-21 2013-09-20 Ф.Хоффманн-Ля Рош Аг Карбоксил- или гидроксилзамещенные производные бензимидазола
RU2672880C2 (ru) * 2014-03-07 2018-11-20 Сумитомо Кемикал Компани, Лимитед Конденсированное гетероциклическое соединение и его применение для борьбы с вредителями

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3346575A1 (de) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
ZA851236B (en) * 1984-02-24 1986-09-24 Lilly Co Eli 2-arylimidazo 4,5-cpyridines
GR851085B (enExample) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
NZ217755A (en) * 1985-10-09 1989-08-29 Chemie Linz Ag 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and pharmaceutical compositions
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5466704A (en) * 1991-02-26 1995-11-14 E. R. Squibb & Sons, Inc. N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
FR2677020B1 (fr) * 1991-05-31 1993-08-27 Cird Galderma Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
US6919366B2 (en) * 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
WO2000035886A2 (en) 1998-12-18 2000-06-22 Axys Pharmaceuticals, Inc. (hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors
GB9914825D0 (en) * 1999-06-24 1999-08-25 Smithkline Beecham Spa Novel compounds
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
DE10015866A1 (de) * 2000-03-30 2001-10-11 Bayer Ag Aryl- und Heteroarylsulfonate
BR0111544A (pt) * 2000-06-14 2003-07-01 Warner Lambert Co Heterociclos bicìclicos 6,5-fundidos
AU2003211942A1 (en) * 2002-02-14 2003-09-04 Shionogi And Co., Ltd. Process for production of 2,3-diaminopyridine derivatives
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
AU2004263190A1 (en) * 2003-08-08 2005-02-17 Avanir Pharmaceuticals Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
JPWO2007004688A1 (ja) * 2005-07-01 2009-01-29 日本ケミファ株式会社 キサンチンオキシダーゼ阻害剤
MX2008002166A (es) * 2005-08-15 2008-04-22 Irm Llc Compuestos y composiciones como mimeticos de trombopoietina (tpo).
WO2008067426A1 (en) * 2006-11-30 2008-06-05 Wyeth Process for the synthesis of monosulfated derivatives of substituted benzoxazoles
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151630A2 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
UA117046C2 (uk) 2013-12-19 2018-06-11 Новартіс Аг [1,2,4]ТРИАЗОЛО[1,5-a]ПІРИМІДИНОВІ ПОХІДНІ ЯК ІНГІБІТОРИ ПРОТОЗОЙНИХ ПРОТЕАСОМ ДЛЯ ЛІКУВАННЯ ПАРАЗИТАРНИХ ЗАХВОРЮВАНЬ, ТАКИХ ЯК ЛЕЙШМАНІОЗ
JP2019503342A (ja) * 2015-11-16 2019-02-07 シンジェンタ パーティシペーションズ アーゲー 硫黄含有置換基を有する殺有害生物的に活性な複素環式誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
DE2305339C3 (de) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
JPS5721375A (en) * 1980-07-14 1982-02-04 Yamanouchi Pharmaceut Co Ltd 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation
DE3273461D1 (en) * 1981-08-19 1986-10-30 Merck Patent Gmbh 2-arylimidazopyridines
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Эльдерфиильд Р. Гетероциклические соед инени . Т. 5. - М.: Иност- раниа литература, 1960, с, 219. *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7282518B2 (en) 2001-03-12 2007-10-16 Avanir Pharmaceuticals Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
US7256287B2 (en) 2002-09-12 2007-08-14 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
US7375118B2 (en) 2002-09-12 2008-05-20 Avanir Pharmaceuticals Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation
RU2424233C2 (ru) * 2006-06-29 2011-07-20 Ф.Хоффманн-Ля Рош Аг Производные бензимидазола, методы их получения, применение их в качестве агонистов фарнезоид-х-рецептора (fxr) и содержащие их фармацевтические препараты
RU2493153C2 (ru) * 2007-12-21 2013-09-20 Ф.Хоффманн-Ля Рош Аг Карбоксил- или гидроксилзамещенные производные бензимидазола
RU2672880C2 (ru) * 2014-03-07 2018-11-20 Сумитомо Кемикал Компани, Лимитед Конденсированное гетероциклическое соединение и его применение для борьбы с вредителями

Also Published As

Publication number Publication date
PT76968A (de) 1983-07-01
ES8500056A1 (es) 1984-10-01
YU143283A (en) 1986-06-30
SU1179924A3 (ru) 1985-09-15
ES529174A0 (es) 1984-10-01
PH20810A (en) 1987-04-24
DE3224512A1 (de) 1984-01-05
ES8500242A1 (es) 1984-10-01
DK301383D0 (da) 1983-06-30
GB2122995A (en) 1984-01-25
GR78598B (enExample) 1984-09-27
ES523709A0 (es) 1984-10-01
FI832022L (fi) 1984-01-02
GB2122995B (en) 1986-02-12
PT76968B (de) 1986-04-09
PL144589B1 (en) 1988-06-30
KR840005432A (ko) 1984-11-12
JPS5927875A (ja) 1984-02-14
US4582837A (en) 1986-04-15
FI832022A7 (fi) 1984-01-02
PL242770A1 (en) 1986-10-21
IL69111A0 (en) 1983-10-31
ZA834777B (en) 1985-03-27
NZ204766A (en) 1986-09-10
DD210271A5 (de) 1984-06-06
ES529175A0 (es) 1984-10-01
GB8317732D0 (en) 1983-08-03
AU1642883A (en) 1984-01-05
DK301383A (da) 1984-01-02
PL142880B1 (en) 1987-12-31
CS254319B2 (en) 1988-01-15
EP0098448A2 (de) 1984-01-18
EP0098448A3 (de) 1985-04-03
US4696931A (en) 1987-09-29
ES8500241A1 (es) 1984-10-01
HU192152B (en) 1987-05-28
NO832356L (no) 1984-01-02
FI832022A0 (fi) 1983-06-06

Similar Documents

Publication Publication Date Title
SU1316559A3 (ru) Способ получени производных имидазола или их кислотно-аддитивных солей
EP0042593A1 (de) Aryloxypropanolamine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0263352A1 (de) Neue Imidazo-benzoxazinone, ihre Herstellung und diese Verbindungen enthaltende Arzneimittel
DD224851A5 (de) Verfahren zur herstellung von imidazolen
EP0880524A1 (de) Neue triazolopurine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FUJII et al. Purines. V. The Dimroth Rearrangement of 1-Alkoxyadenines: The Synthesis of N-Alkoxyadenines
DE3346575A1 (de) Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
EP0179408B1 (de) Neue Amidoalkylmelamine und Aminoalkylmelamine und Verfahren zu ihrer Herstellung
Okafor et al. Synthesis of analogues of the 2, 3, 6,‐triazaphenothiazine ring system
HU193067B (en) Process for the production of new pyridazinon-derivatives and of their salts
HU201059B (en) Process for producing 6-oxo-pyridazine derivatives and pharmaceutical compositions containing them
EP0207483B1 (de) Neue Benzimidazole, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel sowie Zwischenprodukte
DE4008858A1 (de) Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
US3378564A (en) Certain pyridyl tetrazole derivatives
CN104497085B (zh) 腺苷衍生物及其用途
EP0189898A1 (de) 1,6-Naphthyridinon-Derivate und Verfahren zu deren Herstellung
Ozerov et al. Synthesis of 1-(aryloxyalkyl)-5-(arylamino) uracils
WO1990009998A1 (de) Neue acyclische nucleosid-analoga, verfahren zu ihrer herstellung und verwendung dieser verbindungen als antivirale arzneimittel
EP0189883A1 (de) 5-Oxo-pyrido(4,3-d)pyrimidin-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
Ram et al. Synthesis of potential antifilarial agents 2. methyl 2‐substituted purine 8‐carbamates and related compounds
AT397091B (de) Verfahren zur herstellung von neuen mitosan-derivaten
DE1067030B (de) Verfahren zur Her stellung von 4,6 disubsütuierten 1-Pyra zolo (3 4-d) pynmidmen
Cliffe et al. 119. Synthetic antimalarials. Part XXIII. 2-Arylguanidino-4-aminoalkylaminopyrimidines. Further variations
JPH0539293A (ja) 免疫調節剤及びチアゾロピリミジン誘導体
EP0589335A1 (de) N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel